Buy Generic Assurans Online

Generic Assurans Information

Introduction

Assurans is a prescription medication marketed in the United Kingdom for the treatment of erectile dysfunction (ED). The product contains the active compound sildenafil, a phosphodiesterase‑5 (PDE‑5) inhibitor that belongs to the therapeutic group of men’s health agents. Sildenafil is also approved in the UK for pulmonary arterial hypertension under the brand name Revatio, but the primary commercial indication for Assurans is the improvement of erectile function in adult males. The drug is manufactured by a licensed pharmaceutical company that complies with the Medicines and Healthcare products Regulatory Agency (MHRA) standards for quality, safety, and efficacy.

What is Assurans?

Assurans is a tablet formulation that delivers sildenafil citrate in a fixed dose. It is classified as a systemic PDE‑5 inhibitor used to facilitate erections sufficient for sexual activity. The molecule was originally discovered by researchers at Pfizer and first launched internationally under the brand name Viagra® in 1998. Since the expiry of the original patents, several generic manufacturers have produced sildenafil tablets, and Assurans is one of these generic options.

• Active ingredient: Sildenafil citrate (100 mg or 50 mg per tablet, depending on the prescribed strength)
• Therapeutic class: Phosphodiesterase‑5 inhibitor, Erectile dysfunction therapy, Men’s health
• Manufacturer: A GMP‑certified pharmaceutical firm authorized by the MHRA (specific company name varies by country of origin)
• Regulatory status: Prescription‑only medicine (POM) in the UK, listed under the British National Formulary (BNF) for erectile dysfunction

Note: While “Assurans” is the product name, the molecule is chemically identical to the well‑known brand Viagra and the hypertension formulation Revatio. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Assurans Works

Sildenafil exerts its effect by selectively inhibiting the enzyme phosphodiesterase‑5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) within the smooth muscle cells of the corpus cavernosum. During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells, activating guanylate cyclase to increase cGMP levels. Elevated cGMP causes relaxation of smooth muscle and vasodilation, allowing increased arterial inflow into the penile tissue.

By blocking PDE‑5, sildenafil prolongs the presence of cGMP, thereby enhancing and sustaining erection when sexual arousal occurs. The drug does not initiate an erection in the absence of sexual stimulation.

Key pharmacokinetic points:

• Onset of action: Typically 30–60 minutes after oral administration.
• Peak plasma concentration: Reached in 1–2 hours.
• Duration of effect: Up to 4–6 hours, depending on dose and individual metabolism.
• Metabolism: Primarily hepatic via the cytochrome P450 3A4 (CYP3A4) pathway; minor contribution from CYP2C9.
• Elimination: Approximately 80 % excreted in feces, 13 % in urine; half‑life of 3–5 hours.

Conditions Treated with Assurans

Assurans is approved for the following indications in the United Kingdom:

• Erectile dysfunction (ED): A condition characterized by the consistent inability to achieve or maintain an erection adequate for satisfactory sexual performance. Epidemiological data from the British Society for Sexual Medicine estimate that up to 20 % of men aged 40–70 experience ED to varying degrees.
• Off‑label use for pulmonary arterial hypertension (PAH): Though not a primary indication for this product, clinicians sometimes prescribe sildenafil for PAH under specialist guidance (the licensed formulation Revatio is specifically indicated for this condition).

The effectiveness of sildenafil in ED is supported by large‑scale randomized controlled trials, including the seminal Viagra Study Group (1998) and subsequent meta‑analyses showing improvement in the International Index of Erectile Function (IIEF) scores by an average of 7‑10 points compared with placebo.

Who is Assurans For?

Assurans is appropriate for adult men who meet the clinical criteria for erectile dysfunction and for whom oral PDE‑5 inhibition is considered safe. Typical candidates include:

• Men aged 18 years and older with documented ED persisting for at least three months.
• Individuals with comorbid conditions such as hypertension, dyslipidaemia, or type 2 diabetes mellitus, provided there are no contraindications (e.g., concurrent nitrate therapy).
• Patients seeking an on‑demand therapy rather than continuous daily dosing.

Situations where Assurans may be unsuitable or require caution:

• Use of nitrate medications (e.g., nitroglycerin, isosorbide dinitrate) for angina, as the combination can cause severe hypotension.
• Severe cardiovascular disease (unstable angina, recent myocardial infarction, uncontrolled hypertension >180/110 mmHg).
• History of non‑arteritic anterior ischemic optic neuropathy (NAION) or other retinal vascular disorders.
• Concurrent use of potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) that may increase sildenafil plasma levels and risk of adverse events.

Healthcare providers will evaluate renal and hepatic function, as dose adjustment may be needed in patients with moderate to severe impairment.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing (warmth, redness of face or chest)
• Dyspepsia or upset stomach
• Nasal congestion
• Visual disturbances (blurred vision, colour tinting, especially blue)

These events are generally mild, transient, and resolve without intervention.

Rare

• Priapism (prolonged erection lasting >4 hours) – requires urgent medical attention.
• Hearing loss or sudden decrease in hearing acuity.
• Cardiovascular events such as chest pain or palpitations in patients with underlying heart disease.

Serious

• Severe hypotension, particularly when combined with nitrates or alpha‑blockers.
• Non‑arteritic anterior ischemic optic neuropathy (NAION) – sudden vision loss.
• Anaphylactic reaction (rare but potentially life‑threatening).

Clinically Relevant Drug–Drug Interactions

• Nitrates (e.g., glyceryl trinitrate, isosorbide mononitrate) – contraindicated; may cause profound vasodilation.
• Alpha‑adrenergic blockers (e.g., tamsulosin, doxazosin) – may lead to additive blood pressure lowering; start with low sildenafil dose and monitor.
• CYP3A4 inhibitors (ketoconazole, erythromycin, clarithromycin, ritonavir) – increase sildenafil exposure; consider dose reduction to 25 mg or avoid.
• CYP3A4 inducers (rifampicin, carbamazepine, phenytoin) – decrease sildenafil levels; higher dose may be needed, but clinical response should guide therapy.
• Other PDE‑5 inhibitors (e.g., tadalafil, vardenafil) – concurrent use is not recommended due to cumulative risk of hypotension.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before initiating Assurans.

Practical Use: Dosing, Missed Dose, Overdose

• Standard starting dose: 50 mg taken orally, approximately one hour before sexual activity.
• Dose adjustments:
  • Increase to 100 mg or decrease to 25 mg based on efficacy and tolerability.
  • Do not exceed 100 mg within a 24‑hour period.
• Maximum frequency: One tablet per day; repeat dosing at intervals of at least 24 hours.

Missed dose – Because Assurans is taken on an as‑needed basis, a missed dose simply means the opportunity for sexual activity was missed. Do not take an extra tablet later to “make up” for the missed dose.

Overdose – Signs may include severe hypotension, dizziness, fainting, or prolonged erection. If an overdose is suspected, seek immediate medical attention or contact the local emergency services (999 in the UK). Supportive measures such as fluid replacement and monitoring of blood pressure are the mainstay of treatment.

Practical precautions

• Food: A high‑fat meal may delay onset of action by 30–60 minutes; for predictable timing, take the tablet on an empty stomach or after a light meal.
• Alcohol: Moderate alcohol intake is permissible, but excessive consumption can exacerbate dizziness, hypotension, and impair erectile response.
• Comorbidities: Patients with severe renal (creatinine clearance <30 mL/min) or hepatic impairment should start with 25 mg and may require specialist supervision.

Buying Assurans from Our Online Pharmacy

Assurans can be obtained safely and discreetly from our online pharmacy in the UK. The service offers several advantages for patients seeking reliable access to generic sildenafil:

• Affordability: Prices are set close to the manufacturer’s cost, providing a substantial saving compared with branded alternatives.
• Verified quality: All stock is sourced from MHRA‑licensed suppliers that adhere to Good Manufacturing Practice (GMP) standards, guaranteeing pharmaceutical purity and potency.
• Guaranteed delivery: Orders are packaged discreetly and dispatched with a tracking number. Express shipping typically arrives within 7 days, while standard airmail takes approximately 3 weeks.
• International reach: As a pharmacy‑broker service, we collaborate with overseas licensed pharmacies, expanding the range of medications available to UK residents who may encounter supply shortages locally.
• Privacy‑focused: Patient information is handled in compliance with the UK Data Protection Act and GDPR, ensuring confidentiality throughout the ordering process.

Patients who have limited access to traditional brick‑and‑mortar pharmacies or whose insurance schemes do not cover the cost of erectile dysfunction treatments may find this online option both practical and economical.

FAQ

• Can Assurans be taken with antihypertensive medication?
  Yes, most antihypertensives (e.g., ACE inhibitors, beta‑blockers) can be combined with sildenafil, but caution is advised with alpha‑blockers due to additive blood‑pressure‑lowering effects. Always discuss dosage and timing with a healthcare professional.

• Does the tablet have a distinctive colour or imprint?
  Assurans tablets are typically white, round, and bear a debossed imprint indicating the strength (e.g., “50 mg” or “100 mg”). Appearance may vary slightly between manufacturers, but the imprint is consistent for verification.

• What is the shelf life of Assurans, and how should it be stored?
  The recommended shelf life is 24 months from the date of manufacture. Store the tablets in the original container at room temperature (15‑30 °C), protected from moisture, light, and excessive heat.

• Is it safe to travel internationally with Assurans?
  Yes, provided you carry a copy of the prescription (if required) and keep the medication in its original packaging. Some countries may have restrictions on importing PDE‑5 inhibitors, so checking local customs regulations before departure is advisable.

• Are there any differences between Assurans and the brand‑name Viagra?
  Chemically, both contain sildenafil citrate at identical strengths and have the same mechanism of action. The primary differences lie in excipients, tablet appearance, and price; clinical efficacy and safety profiles are equivalent when manufactured under GMP conditions.

• How does food affect the absorption of sildenafil?
  High‑fat meals can delay the absorption of sildenafil, leading to a later onset of effect. Taking the tablet with a light meal or on an empty stomach helps achieve the usual 30‑60 minute onset.

• Can Assurans be used by men with diabetes?
  Men with diabetes often experience ED, and sildenafil is effective in this population. However, glycaemic control and potential interactions with diabetic medications (e.g., nitroglycerin for angina associated with diabetic heart disease) should be reviewed.

• What should a patient do if they experience a painful erection lasting longer than four hours?
  This condition, known as priapism, is a medical emergency. The patient should seek immediate care at an emergency department or call 999. Early intervention can prevent permanent tissue damage.

• Does sildenafil cross the blood‑brain barrier, and could it affect cognition?
  Sildenafil has limited central nervous system penetration and is not associated with cognitive impairment at therapeutic doses. Reported central side effects are rare and typically involve headache or dizziness.

• Are there any special considerations for older adults (≥ 65 years) taking Assurans?
  Age‑related changes in renal and hepatic function may reduce drug clearance, increasing exposure. Starting at a lower dose (25 mg) and titrating cautiously is recommended for older patients.

Glossary

Phosphodiesterase‑5 (PDE‑5) Inhibitor

A class of drugs that block the enzyme responsible for breaking down cGMP, thereby enhancing smooth‑muscle relaxation and blood flow to the penis.

cGMP (Cyclic Guanosine Monophosphate)

A second messenger molecule that mediates vasodilation in response to nitric oxide; elevated levels sustain erection.

Priapism

A prolonged, often painful erection lasting more than four hours, requiring urgent medical treatment to prevent tissue damage.

CYP3A4

A liver enzyme that metabolises many drugs, including sildenafil; inhibitors or inducers of this enzyme can alter sildenafil’s plasma concentration.

⚠️ Disclaimer

The information provided about Assurans is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Assurans for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.