Buy Avanafil Online

Avanafil Information

Introduction

Avanafil is a phosphodiesterase‑5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. The compound is approved for use throughout the United Kingdom by the Medicines and Healthcare products Regulatory Agency (MHRA) and is marketed under several brand names, most notably Stendra® (United States) and Spedra® (Canada). Avanafil belongs to the broader medication group of men’s health therapies that target the physiological pathways responsible for penile erection. Its rapid onset and favorable side‑effect profile make it a valuable option for men who require an on‑demand oral treatment for ED.

What is Avanafil?

Avanafil is the generic version of Stendra®, containing the same active compound, Avanafil. The drug was originally developed by Vivus, Inc. and received its first regulatory approval in the United States in 2012. Subsequent submissions led to MHRA approval in the UK, where the generic formulation is now widely prescribed. Our online pharmacy provides this generic alternative as a cost‑effective treatment option, offering the identical therapeutic benefit of the branded product while reducing out‑of‑pocket expense for patients.

How Avanafil Works

Erection is mediated by the release of nitric oxide (NO) within the corpora cavernosa during sexual stimulation. NO activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP). Elevated cGMP relaxes smooth muscle, allowing arterial inflow and erection. PDE5 enzymes degrade cGMP, terminating the erection.

Avanafil selectively inhibits PDE5, thereby preserving cGMP levels in response to sexual stimulation. This enhances smooth‑muscle relaxation and improves penile blood flow. The drug demonstrates a high affinity for PDE5 while exhibiting minimal activity at related phosphodiesterases (PDE1, PDE6), reducing the likelihood of visual disturbances. Clinical pharmacology studies show that avanafil reaches peak plasma concentrations within 30–45 minutes, with an onset of erectile response reported as early as 15 minutes. Its elimination half‑life is approximately 5 hours, supporting a therapeutic window that can extend up to 6 hours after dosing.

Conditions Treated with Avanafil

Avanafil is not approved for other urological conditions, pulmonary arterial hypertension, or benign prostatic hyperplasia. Off‑label use should only be considered under specialist supervision.

Suitable Candidates for Avanafil Treatment

Avanafil is appropriate for men who meet the following criteria:

• Age ≥ 18 years with a clinical diagnosis of erectile dysfunction confirmed by a healthcare professional.
• Desire for on‑demand therapy rather than daily dosing (as required for some other PDE5 inhibitors).
• No concurrent use of nitrates (e.g., nitroglycerin, isosorbide dinitrate) or no history of severe hypotension.
• Stable cardiovascular status (e.g., controlled hypertension, no recent myocardial infarction within 6 months).

Patients who should avoid avanafil include:

• Men taking nitrates or nitric‑oxide donors (risk of profound hypotension).
• Individuals with severe uncontrolled hypertension (> 180/110 mmHg).
• Those with a known hypersensitivity to avanafil or any tablet excipients.
• Patients with retinitis pigmentosa or other inherited retinal disorders (theoretical risk of visual toxicity).

Clinical judgment is essential for men with complex comorbidities such as severe heart failure, recent stroke, or concomitant use of potent CYP3A4 inhibitors.

Risks, Side Effects, and Interactions

Common

• Headache – reported in up to 15 % of users; usually mild and transient.
• Flushing – facial or thoracic warmth, often linked to vasodilation.
• Nasal congestion – mild obstruction or runny nose.
• Back pain – typically resolves without intervention.
• Altered vision (e.g., colour perception changes) – infrequent but noted in clinical trials.

Rare

• Priapism – prolonged erection lasting > 4 hours; requires immediate medical attention.
• Hypotension – symptomatic low blood pressure, especially when combined with α‑blockers or antihypertensives.
• Dizziness or syncope – may occur with rapid postural changes.

Serious

• Cardiovascular events – rare myocardial infarction or stroke in patients with pre‑existing disease.
• Non‑arteritic anterior ischemic optic neuropathy (NAION) – sudden, painless vision loss; emergency ophthalmologic evaluation required.
• Sudden sensorineural hearing loss – documented in isolated case reports; seek urgent care.

Clinically Relevant Drug–Drug Interactions

• Nitrates (nitroglycerin, isosorbide mononitrate) – contraindicated; can cause severe vasodilatory hypotension.
• Alpha‑blockers (e.g., tamsulosin) – may potentiate blood‑pressure decline; initiate avanafil only after stable α‑blocker therapy.
• CYP3A4 inhibitors (ketoconazole, itraconazole, erythromycin, ritonavir) – increase avanafil plasma concentrations; dose reduction to 50 mg is recommended.
• CYP3A4 inducers (rifampicin, carbamazepine) – may reduce efficacy; consider alternative ED therapy.
• Other PDE5 inhibitors – concurrent use heightens risk of adverse events and is prohibited.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before initiating avanafil.

Practical Use: Dosing, Missed Dose, Overdose

Standard dosing (adults, no contraindications):

• Initial dose: 100 mg taken with water 15–30 minutes before anticipated sexual activity.
• Adjustments:
  • Reduce to 50 mg if side effects are intolerable.
  • Increase to 200 mg if efficacy is inadequate and tolerability is confirmed.
• Maximum frequency: No more than one dose per 24 hours.

Missed dose: Avanafil is intended for on‑demand use; there is no scheduled daily dose. If sexual activity is not expected, the dose should be omitted rather than taken later.

Overdose management: In the event of accidental ingestion exceeding 200 mg, patients should seek emergency medical care. Symptoms may include profound hypotension, dizziness, or prolonged erection. Supportive measures such as intravenous fluids and monitoring of blood pressure are standard; specific antidotes are not available.

Practical precautions:

• Food: A high‑fat meal can delay absorption, extending the time to onset beyond 30 minutes. For quickest effect, take the tablet on an empty stomach or after a light snack.
• Alcohol: Moderate consumption (≤ 2 units) is generally tolerated, but excessive alcohol may exacerbate hypotension and impair erection.
• Comorbidities: Men with severe renal (creatinine clearance < 30 mL/min) or hepatic impairment should be evaluated by a physician before use; dose reduction may be needed.

Buying Avanafil from Our Online Pharmacy

Avanafil can be purchased from our online pharmacy in the UK with the following advantages:

• Affordable pricing: Our generic formulation is sourced near the manufacturer’s production cost, delivering savings of up to 60 % compared with brand‑name equivalents.
• Verified quality: All stock originates from licensed overseas pharmacies that comply with GMP (Good Manufacturing Practice) standards and are regularly audited.
• Guaranteed delivery: Discreet packaging is dispatched via express courier (typically 7 days) or standard airmail (approximately 3 weeks), with tracking available for every order.
• Online‑only access: For patients who experience limited availability through local pharmacies or whose insurance plans do not cover PDE5 inhibitors, our service provides a reliable alternative.

As a pharmacy broker service, we partner with internationally licensed suppliers to bring avanafil to UK residents while respecting privacy. All transactions are conducted under strict data‑protection protocols, and our customer support team is available to answer any product‑related queries.

FAQ

• Does food affect the absorption of Avanafil?
  Yes. A high‑fat meal can slow the rate at which avanafil reaches peak plasma concentrations, potentially delaying the onset of erectile response by up to 30 minutes. Taking the tablet on an empty stomach or after a light snack generally provides the fastest effect.

• Can Avanafil be taken together with alcohol?
  Moderate alcohol consumption does not usually interfere with avanafil’s efficacy, but excessive intake may increase the risk of dizziness, hypotension, and reduced erection quality. Patients are advised to limit alcohol to no more than two standard units when planning sexual activity.

• How long does the therapeutic effect of Avanafil last after a single dose?
  Clinical studies indicate that avanafil remains effective for up to 6 hours post‑dose, allowing flexibility in timing of sexual activity. The drug’s half‑life of roughly 5 hours supports this duration while avoiding prolonged systemic exposure.

• What do generic Avanafil tablets look like?
  Generic avanafil tablets are typically white or off‑white, film‑coated round tablets bearing the imprint “AV 100” (for the 100 mg strength). The appearance may vary slightly between manufacturers, but the imprint is consistent to aid identification.

• Are there formulation differences between the UK and US versions of Avanafil?
  The active ingredient and dosage strengths (50 mg, 100 mg, 200 mg) are identical globally. In the UK, the tablets are formulated according to the European Pharmacopoeia, which may include different inactive excipients (e.g., lactose, microcrystalline cellulose) compared with US‑marketed products. These differences do not affect clinical efficacy.

• Is Avanafil detectable in standard workplace drug tests?
  Avanafil is not screened for in routine employment drug‑testing panels, which typically target substances such as opioids, cannabinoids, cocaine, amphetamines, and alcohol. Its pharmacological class (PDE5 inhibitor) is not included in standard immunoassay tests.

• Can Avanafil be safely stored in a suitcase during air travel?
  Yes, provided the medication remains at room temperature (15‑30 °C) and is protected from excessive heat, moisture, and direct sunlight. It is advisable to keep the tablets in their original blister pack and a carry‑on bag to avoid temperature extremes in checked luggage.

• What is the half‑life of Avanafil and how does it influence dosing frequency?
  The elimination half‑life of avanafil is approximately 5 hours. Because the drug is taken on an as‑needed basis, this half‑life permits a therapeutic window of up to 6 hours without the need for daily dosing. The pharmacokinetic profile also reduces the risk of drug accumulation with repeated use.

• Do herbal supplements such as ginseng or yohimbine interact with Avanafil?
  While definitive clinical data are limited, certain herbal agents (e.g., yohimbine) can affect blood pressure and may potentiate the hypotensive effect of PDE5 inhibitors. Ginseng has been reported to modestly enhance erectile response but may also alter hepatic enzyme activity. Patients should discuss any supplement use with a pharmacist before initiating avanafil.

• Are there specific safety warnings for men over 65 taking Avanafil?
  Older men often have comorbid cardiovascular disease and may be on multiple medications. In patients > 65 years, careful assessment of cardiac risk, blood‑pressure control, and potential drug interactions (particularly with nitrates or α‑blockers) is essential. Dose initiation at 50 mg is frequently recommended to evaluate tolerability.

• How does the onset of Avanafil compare with Sildenafil and Tadalafil?
  Avanafil has the fastest reported onset among the three agents, with erectile response observed as early as 15 minutes. Sildenafil typically requires 30–60 minutes, while Tadalafil may need up to 2 hours, though it offers a longer overall duration (up to 36 hours).

• Can Avanafil be used to treat pulmonary arterial hypertension?
  No. Avanafil is not approved for pulmonary arterial hypertension or any indication other than erectile dysfunction. Other PDE5 inhibitors such as sildenafil and tadalafil have specific regulatory approval for that condition, but avanafil does not share the same indication.

Glossary

Phosphodiesterase‑5 (PDE5) inhibitor

A class of medication that blocks the PDE5 enzyme, preventing the breakdown of cGMP and thereby enhancing smooth‑muscle relaxation in the penis.

Priapism

A prolonged, often painful erection lasting longer than four hours without sexual stimulation; it is a medical emergency that can cause permanent tissue damage.

Nitric Oxide (NO)

A gaseous signaling molecule released during sexual arousal that activates guanylate cyclase, leading to increased cGMP production and erection.

Half‑life

The time required for the plasma concentration of a drug to decrease by 50 %; avanafil’s half‑life is roughly five hours, influencing its duration of action.

⚠️ Disclaimer

The information provided about Avanafil is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Avanafil for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.