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Bicalutamide treats metastatic prostate cancer and hirsutism in men.

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Generic Bicalutamide Information

Introduction

Bicalutamide is an oral non‑steroidal anti‑androgen used primarily in the management of prostate cancer in adult men. In the United Kingdom it is prescribed as part of androgen‑suppression therapy, either alone or in combination with luteinising‑hormone‑releasing hormone (LHRH) agonists. The active compound is Bicalutamide; the medication falls under the Men’s Health and Cancer therapeutic groups. While its principal indication is for advanced or locally advanced prostate cancer, the drug may also be employed off‑label for certain hormone‑sensitive conditions where androgen blockade is desired.

What is Bicalutamide?

Bicalutamide is the generic version of Casodex (originally developed by AstraZeneca), containing the same active compound Bicalutamide. It is classified as a selective androgen‑receptor antagonist. The molecule was first approved in the United Kingdom in 2002 and has since become a cornerstone of hormonal therapy for prostate cancer. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Bicalutamide Works

Bicalutamide binds competitively to androgen receptors (AR) located in prostate tissue and other androgen‑responsive sites. By occupying the receptor without activating it, the drug blocks the binding of circulating testosterone and dihydrotestosterone, preventing downstream signalling that drives tumour growth. The antagonistic effect is reversible, with a plasma half‑life of approximately 6 days, allowing once‑daily dosing. Clearance occurs mainly via hepatic metabolism (CYP3A4) and renal excretion of metabolites. The therapeutic impact is evident within weeks, as tumour proliferation slows and prostate‑specific antigen (PSA) levels decline.

Conditions Treated with Bicalutamide

  • Advanced or locally advanced prostate cancer – the principal approved indication in the UK. Hormone‑sensitive tumours rely on androgen signalling; Bicalutamide reduces tumour burden when used with LHRH therapy or as monotherapy.
  • Metastatic castration‑resistant prostate cancer (mCRPC) – high‑dose (150 mg daily) monotherapy can be employed when castration‑resistant disease persists despite LHRH agents.
  • Off‑label hormonal management – occasional use in transgender hormone therapy or certain AR‑positive breast cancers, where clinical judgement deems androgen blockade beneficial.

Prostate cancer accounts for roughly 25 % of male cancer diagnoses in the UK, with an estimated 48 000 new cases annually (Cancer Research UK, 2024). Hormonal therapy, including Bicalutamide, remains a first‑line strategy for disease control in the majority of men presenting with locally advanced or metastatic disease.

Who is Bicalutamide For?

Bicalutamide is intended for adult males diagnosed with androgen‑dependent prostate cancer who have an indication for hormonal therapy. Typical candidates include:

  • Men with locally advanced (stage T3–T4) disease where surgical or radiotherapy options are complemented by systemic hormone suppression.
  • Patients with metastatic disease requiring long‑term androgen blockade to control tumour progression.
  • Individuals unsuitable for surgical castration or for whom LHRH agonists alone are insufficient.

Bicalutamide may be inappropriate for patients with severe hepatic impairment, known hypersensitivity to the drug, or those taking strong CYP3A4 inhibitors (e.g., ketoconazole) that could raise systemic exposure. Women are generally excluded from standard indications, although off‑label use may occur under specialist supervision.

Risks, Side Effects, and Interactions

Common

  • Hot flashes and sweating
  • Breast tenderness or gynecomastia
  • Nausea, diarrhoea, or abdominal discomfort
  • Elevated liver enzymes (ALT/AST)

Rare

  • Visual disturbances (blurred vision, colour changes)
  • Mild hepatic dysfunction (transient bilirubin rise)
  • Skin rash or mild pruritus

Serious

  • Severe hepatotoxicity – jaundice, hepatic failure, or hepatitis; requires immediate medical attention.
  • Allergic reactions – angioedema, urticaria, or anaphylaxis.
  • Interstitial lung disease – dyspnoea, cough, and hypoxia; rare but potentially fatal.
Drug–Drug Interactions
  • CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin) can increase Bicalutamide plasma concentrations, raising risk of toxicity.
  • CYP3A4 inducers (rifampicin, carbamazepine, St John’s Wort) may reduce efficacy by lowering drug levels.
  • Warfarin – concurrent use may potentiate anticoagulant effect; INR should be monitored closely.
  • Other anti‑androgens – additive anti‑androgenic effects may increase side‑effect burden.

Patients should disclose all concomitant medications, including herbal preparations and over‑the‑counter products, to their healthcare provider.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard dosing – 50 mg tablet taken orally once daily, usually in combination with an LHRH agonist. For monotherapy in castration‑resistant disease, 150 mg daily (three 50 mg tablets) may be prescribed.
  • Missed dose – If a dose is forgotten, take it as soon as remembered unless it is close to the next scheduled dose; then skip the missed dose and continue with the regular schedule. Do not double‑dose.
  • Overdose – In case of accidental overdose, seek urgent medical advice. Management is supportive, focusing on monitoring hepatic function and treating symptoms such as nausea or vomiting. No specific antidote exists.

Practical precautions – Bicalutamide may be taken with or without food; however, taking it with a light meal can minimise gastrointestinal upset. Alcohol consumption should be moderate; excessive intake can exacerbate liver toxicity. Renal impairment does not usually require dose adjustment, but hepatic dysfunction may necessitate reduced dosing.

Buying Bicalutamide from Our Online Pharmacy

Bicalutamide can be purchased from our online pharmacy in the UK. Our service offers:

  • Affordable pricing – close to manufacturer cost, with transparent generic‑drug discounts.
  • Verified quality – sourced from licensed overseas manufacturers that meet EU‑GMP standards; each batch undergoes independent testing.
  • Guaranteed delivery – discreet packaging shipped within 7 days via express courier for urgent orders, or ~3 weeks by regular airmail for standard processing.
  • Online‑only access – we act as a pharmacy‑broker service, partnering with overseas licensed pharmacies to provide international medications to patients who may lack local availability or face insurance barriers.

All orders are handled with strict privacy controls, ensuring patient confidentiality throughout the fulfilment process.

FAQ

  • Is Bicalutamide available in both brand‑name and generic forms in the UK?
    Yes. The original brand‑name product is marketed as Casodex, while generic versions contain the same active compound Bicalutamide and are typically more affordable.

  • Does Bicalutamide require any special storage conditions?
    The tablets should be stored at room temperature, protected from excessive heat, moisture, and direct sunlight. No refrigeration is needed.

  • What does the packaging of Bicalutamide look like when ordered online?
    Generic tablets are supplied in sealed, child‑resistant blister packs, typically containing 30 or 60 tablets per box. Each pack includes a patient information leaflet in English.

  • Can Bicalutamide be imported for personal use in the UK?
    Yes. Personal import of a single‑patient supply of a licensed medication is permitted under UK law, provided the product is for personal use and the importer holds a valid prescription from a UK‑registered prescriber.

  • Are there any known ethnic‑specific safety warnings for Bicalutamide?
    Clinical data do not indicate a higher risk of adverse events in specific ethnic groups. However, patients with pre‑existing liver disease—regardless of ethnicity—should be monitored closely.

  • Do formulations of Bicalutamide differ between the EU and the US?
    The active ingredient and dosage strength are identical, but some regional products may contain different inactive excipients. EU‑approved tablets are formulated to meet the European Pharmacopoeia specifications.

  • How does Bicalutamide compare to older anti‑androgens such as flutamide?
    Bicalutamide has a longer half‑life, allowing once‑daily dosing, and demonstrates a more favourable safety profile, particularly regarding liver toxicity, compared with flutamide.

  • Is there any risk of Bicalutamide affecting drug testing for employment?
    Standard drug screens do not detect Bicalutamide, as it is not a controlled substance or commonly screened for. However, analytical laboratories can identify it if a specific test is ordered.

  • What is the history of Bicalutamide’s development?
    Discovered in the 199s by AstraZeneca, Bicalutamide was approved by the European Medicines Agency in 2002 after demonstrating efficacy in phase III trials that compared it to surgical castration.

  • Can Bicalutamide be used safely with over‑the‑counter supplements?
    Certain supplements that strongly inhibit CYP3A4 (e.g., grapefruit extracts) may raise plasma levels of Bicalutamide. Patients should discuss any supplement use with their healthcare provider.

  • Does Bicalutamide have any impact on fertility in men?
    By blocking androgen receptors, Bicalutamide can decrease sperm production and lead to temporary infertility. Men desiring future fertility should discuss sperm banking prior to initiating therapy.

Glossary

Androgen‑receptor antagonist
A drug that binds to androgen receptors without activating them, thereby preventing the natural hormones testosterone and dihydrotestosterone from exerting their biological effects.
CYP3A4
An enzyme in the liver responsible for metabolising many medications, including Bicalutamide. Inhibitors or inducers of CYP3A4 can alter the drug’s plasma concentration.
Gynecomastia
Enlargement of breast tissue in males, commonly caused by hormonal imbalance or anti‑androgen therapy.
Half‑life
The time required for the concentration of a drug in the bloodstream to reduce by 50 %. Bicalutamide’s half‑life is about six days, supporting once‑daily dosing.

⚠️ Disclaimer

The information provided about Bicalutamide is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Bicalutamide for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

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