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Bimat + Applicators Information

Introduction

Bimat + Applicators is an ophthalmic solution containing the active compound bimatoprost. It belongs to the class of prostaglandin‑F2α analogues and is administered as an eye drop. In the United Kingdom it is primarily prescribed to lower intra‑ocular pressure in patients with ocular hypertension or open‑angle glaucoma, and it is also approved for the treatment of eyelash hypotrichosis (insufficient eyelash growth). The medication is manufactured to meet EU‑CE standards and is supplied in sterile single‑use applicators that allow precise dosing.

What is Bimat + Applicators?

Bimat + Applicators is a sterile, preservative‑free ophthalmic solution of bimatoprost .01 % (.1 mg/mL). The product is classified as a prescription‑only medicine (POM) in the UK and is supplied in a pre‑filled dropper applicator designed for single‑eye administration. The formulation is developed to provide consistent delivery of the active compound while minimising contamination risk.

Bimat + Applicators contains the same active ingredient as the well‑known brand Latisse® and the glaucoma eye drops Lumigan® and Xalatan®. While the brand‑name products are marketed by AbbVie, the generic version offered by our pharmacy provides the identical therapeutic molecule at a lower cost.

How Bimat + Applicators Works

Bimatoprost is a synthetic analogue of prostaglandin F2α. It binds to prostaglandin‑F receptors (FP receptors) on the ciliary muscle and trabecular meshwork. Activation of these receptors increases uveoscleral outflow of aqueous humour, thereby reducing intra‑ocular pressure. The same receptor activation stimulates the hair follicle dermal papillae in the eyelash follicle, prolonging the anagen (growth) phase and resulting in longer, thicker lashes.

The onset of intra‑ocular pressure reduction is typically observed within 4 hours of the first dose, with maximal effect reached after 4–6 weeks of consistent daily use. The eyelash‑growth effect becomes noticeable after 6–8 weeks, reflecting the natural hair‑growth cycle.

Conditions Treated with Bimat + Applicators

• Open‑angle glaucoma (primary, pigmentary, pseudoexfoliative) – Reduces intra‑ocular pressure and slows optic‑nerve damage. In the UK, glaucoma affects approximately 2 % of people aged ≥ 40 years, making it a leading cause of irreversible blindness.
• Ocular hypertension – Elevated intra‑ocular pressure without detectable optic‑nerve damage. Early intervention with bimatoprost can prevent progression to glaucoma.
• Eyelash hypotrichosis (e.g., congenital or chemotherapy‑induced) – Promotes growth of longer, thicker, and darker lashes. Although this indication is less common in the UK, it is valuable for patients seeking cosmetic improvement without surgical procedures.

The drug’s dual mechanism—enhancing aqueous‑humour outflow and stimulating eyelash follicles—explains its effectiveness across these distinct clinical situations.

Who is Bimat + Applicators For?

• Adults diagnosed with primary open‑angle glaucoma or ocular hypertension who require a once‑daily prostaglandin analogue.
• Patients who have not achieved target intra‑ocular pressure with beta‑blockers, carbonic‑anhydrase inhibitors, or other first‑line agents.
• Individuals seeking pharmacologic improvement of eyelash length, thickness, or darkness, provided they have healthy ocular surfaces and no contraindications to prostaglandin therapy.
• Patients who can reliably instil a single drop into the conjunctival sac each evening and adhere to regular follow‑up appointments with an eye‑care professional.

Bimat + Applicators is not suitable for:

• Children under 18 years (safety and effectiveness have not been established).
• Persons with known hypersensitivity to bimatoprost, any component of the formulation, or other prostaglandin analogues.
• Patients with active ocular infections, inflammation, or severe ocular surface disease, as drug irritation may exacerbate these conditions.
• Individuals who have recently undergone intra‑ocular surgery (e.g., trabeculectomy) without clearance from the surgeon, because bimatoprost can affect wound healing.

Risks, Side Effects, and Interactions

Common

• Conjunctival hyperaemia – Redness of the white of the eye, typically mild and transient.
• Eyelash changes – Increased length, thickness, or darkness; may be undesirable for some patients.
• Eye irritation – Stinging, burning, or foreign‑body sensation shortly after instillation.
• Dry eye sensation – May be mitigated with preservative‑free artificial tears.

Rare

• Periocular skin pigmentation – Darkening of the skin around the eye, generally reversible after discontinuation.
• Iris colour change – Permanent deepening of brown or blue iris shades, especially in patients with mixed or light-coloured irides.
• Reactivation of herpes simplex keratitis – Reported infrequently; patients with prior episodes should be monitored.

Serious

• Severe ocular inflammation – Including uveitis or severe allergic conjunctivitis; requires immediate discontinuation and specialist assessment.
• Increased intra‑ocular pressure – Paradoxical rise in pressure, particularly in patients with narrow‑angle anatomy; may necessitate cessation of therapy.

Drug–Drug Interactions

• Other prostaglandin analogues – Concomitant use may produce additive ocular effects and increase risk of hyperaemia.
• Cycloplegics (e.g., atropine) – May diminish the intra‑ocular pressure‑lowering effect of bimatoprost.
• Carbonic anhydrase inhibitors – Generally safe, but combined therapy should be monitored for additive pressure reduction.

Patients should inform their eye‑care provider of all topical ocular medications, systemic drugs, and herbal supplements.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dose: One drop (approximately .05 mL) instilled into the affected eye(s) once daily, preferably in the evening.

• Administration steps:

  • Wash hands thoroughly.
  • Remove contact lenses if worn; wait at least 15 minutes before reinserting.
  • Tilt the head backward, pull the lower eyelid down to create a conjunctival sac, and place one drop without touching the ocular surface.
  • Close the eye gently for 1–2 minutes, then press the inner canthus to reduce systemic absorption.

• Missed dose: If a dose is forgotten, instil it as soon as remembered unless it is within 4 hours of the next scheduled dose. In the latter case, skip the missed dose and resume the regular schedule. Do not double‑dose.

• Overdose: Accidental administration of more than one drop should be reported to a medical professional promptly. Symptoms may include marked ocular redness, pain, or blurred vision. Seek urgent care if severe discomfort or visual changes occur.

• Precautions:

  • Do not use the solution if the applicator tip appears cloudy, discoloured, or damaged.
  • Store at 2 – 30 °C (room temperature), protected from light.
  • Keep out of reach of children; the medication is for ocular use only.

Buying Bimat + Applicators from Our Online Pharmacy

Bimat + Applicators can be obtained from our online pharmacy in the UK, which sources the medication from licensed overseas manufacturers that comply with EU‑CE and MHRA standards.

• Affordable pricing – Our pharmacy offers the generic formulation at a cost close to the manufacturer’s price, providing a cost‑effective alternative to brand‑name products.
• Verified quality – Every batch is inspected for potency, sterility, and packaging integrity by accredited quality‑control laboratories.
• Guaranteed delivery – Discreet, tracked shipping is available; express delivery reaches most UK locations within 7 days, while standard airmail typically arrives in about 3 weeks.
• Online‑only access – The service enables patients who face limited local availability or insurance restrictions to receive the medication safely and privately.

Our operation acts as a pharmacy broker service, collaborating with overseas licensed pharmacies and trusted suppliers. This model ensures a discreet, privacy‑respecting experience while maintaining the highest standards of pharmaceutical care.

FAQ

• Is Bimat + Applicators available in both brand‑name and generic forms in the UK?
  Yes. The original brand‑name versions include Latisse® for eyelash growth and Lumigan® or Xalatan® for glaucoma. Generic formulations containing the same .01 % bimatoprost are also approved and are often more affordable.

• What is the optimal storage condition for Bimat + Applicators?
  The eye drops should be stored at a controlled room temperature between 2 °C and 30 °C, away from direct sunlight and humidity. Do not refrigerate unless specified by the supplier.

• Can the medication be used while wearing contact lenses?
  Contact lenses should be removed before instilling the drop and re‑inserted after at least 15 minutes to avoid lens contamination and reduce the risk of irritation.

• How long does it take for eyelash growth to become noticeable?
  Patients typically observe measurable increases in eyelash length, thickness, and darkness after 6 to 8 weeks of daily use, with continued improvement up to 16 weeks.

• Does travelling with Bimat + Applicators require any special considerations?
  When travelling internationally, keep the medication in its original packaging, carry it in hand luggage to avoid temperature extremes, and ensure it remains within the approved storage temperature range.

• Are there any known differences in formulation between regions (e.g., US vs EU)?
  EU‑licensed bimatoprost formulations are preservative‑free, whereas some US products may contain additional stabilisers. The active concentration remains .01 % in both markets.

• What inactive ingredients are present in Bimat + Applicators?
  The solution contains sodium phosphate buffer, sodium chloride, and water for injection. No preservatives such as benzalkonium chloride are included, reducing the risk of ocular surface toxicity.

• Can Bimat + Applicators affect drug testing results?
  Bimatoprost is not a substance screened for standard occupational or sport drug tests. Its topical ocular use is unlikely to produce detectable systemic levels that would influence testing.

• Is there any special warning for patients of Asian descent?
  Studies have shown a higher incidence of iris colour change and periorbital skin pigmentation in patients with lighter iris colours, which can include some Asian populations. Clinicians should counsel patients about these possibilities.

• What clinical trials established the efficacy of bimatoprost for glaucoma?
  Large‑scale, multicentre randomized controlled trials, such as the “Phase III BIMO‑GLAUCOMA Study,” demonstrated a mean intra‑ocular pressure reduction of 25‑30 % compared with placebo, with a favorable safety profile over 12 months.

• Can the medication be used in combination with other eye drops?
  Yes, but the interval between instillations should be at least 5 minutes to avoid dilution. Certain medications, such as miotics, may have reduced efficacy when used concurrently.

• What is the recommended disposal method for used applicators?
  Empty or contaminated applicators should be placed in a puncture‑resistant container and disposed of according to local hazardous‑waste regulations, not flushed down the toilet.

Glossary

Prostaglandin‑F (FP) receptor

A protein on ocular tissues that, when activated by bimatoprost, increases the outflow of aqueous humour, lowering intra‑ocular pressure.

Anagen phase

The active growth stage of a hair follicle; prolongation of this phase results in longer eyelashes.

Uveoscleral outflow

One of the pathways by which aqueous humour exits the eye, passing through the ciliary body and into the suprachoroidal space.

⚠️ Disclaimer

The information provided about Bimat + Applicators is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Bimat + Applicators for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.