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Generic Cartia Xt Information
Introduction
Cartia Xt is a prescription medication used primarily to manage hypertension and certain cardiac arrhythmias. Its active ingredient is diltiazem hydrochloride, a calcium‑channel blocker classified under the cardiovascular and blood‑pressure therapeutic groups. In the United Kingdom, diltiazem‑containing products are prescribed to lower elevated blood pressure, control angina, and treat supraventricular tachycardia. The drug is manufactured by various licensed producers, and the formulation is available in immediate‑release and modified‑release tablets.
What is Cartia Xt?
Cartia Xt is a tablet formulation that contains diltiazem HCl as the sole active pharmaceutical ingredient. Diltiazem belongs to the benzothiazepine class of calcium‑channel blockers and works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac nodal tissue. The product is marketed under the generic name “Cartia Xt” and is produced by several GMP‑certified manufacturers that supply the UK market Well‑known brand equivalents include Cardizem, Dilacor, and Tiazac. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for patients who require long‑term blood‑pressure control or rhythm management.
How Cartia Xt Works
Diltiazem blocks L‑type calcium channels located on the cell membranes of vascular smooth muscle and the cardiac conduction system. By reducing calcium entry, the medication produces two principal effects:
- Vasodilation: Relaxation of peripheral arterioles decreases systemic vascular resistance, thereby lowering arterial blood pressure.
- Negative chronotropy and dromotropy: In the sino‑atrial and atrio‑ventricular nodes, calcium‑channel inhibition slows impulse formation and conduction, reducing heart rate and stabilising abnormal rapid rhythms.
The onset of action for immediate‑release tablets is typically within 30–60 minutes, with peak plasma concentrations reached at about 2 hours. Modified‑release formulations provide a more gradual rise in serum levels, allowing once‑daily dosing while maintaining therapeutic concentrations for 24 hours. Diltiazem is metabolised primarily by hepatic CYP3A4 enzymes and eliminated via renal and biliary pathways; its half‑life ranges from 3 to 5 hours for immediate‑release and up to 24 hours for extended‑release products.
Conditions Treated with Cartia Xt
- Essential Hypertension: Elevated blood pressure affects roughly 14 % of the adult UK population. Diltiazem’s vasodilatory action helps patients achieve target systolic and diastolic pressures in accordance with NICE hypertension guidelines.
- Chronic Stable Angina: By reducing myocardial oxygen demand through slower heart rate and decreased afterload, diltiazem alleviates exercise‑induced chest pain.
- Supraventricular Tachycardia (SVT): Diltiazem is indicated for rate control in atrial fibrillation, atrial flutter, and other SVT forms, offering rapid conversion to sinus rhythm in many cases.
- Post‑operative Arrhythmias: In cardiac surgery patients, prophylactic diltiazem can lower the incidence of atrial fibrillation, as supported by multiple randomized trials.
These indications are approved by the Medicines and Healthcare products Regulatory Agency (MHRA) and reflected in the British National Formulary (BNF).
Who is Cartia Xt For?
Cartia Xt is appropriate for adult patients who have been diagnosed with one or more of the following:
- Persistent stage 1 or stage 2 hypertension where lifestyle modification alone is insufficient.
- Symptomatic chronic angina that is not adequately controlled with beta‑blockers or nitrates.
- Documented supraventricular tachyarrhythmias requiring pharmacologic rate control.
Patients with severe hepatic impairment, advanced heart block (second‑ or third‑degree) without a pacemaker, or uncontrolled heart failure (NYHA class III/IV) are generally excluded from diltiazem therapy. Caution is also advised in individuals taking strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole) or medications that also prolong the QT interval.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing or warmth in the face and neck
- Peripheral oedema (ankle swelling)
- Dizziness, especially when (orthostatic hypotension)
- Gastrointestinal discomfort (nausea, abdominal pain)
Rare
- Bradycardia (heart rate < 50 bpm)
- Worsening angina or myocardial ischaemia
- Hepatic enzyme elevations (ALT, AST)
- Skin rash or pruritus
Serious
- Complete heart block (third‑degree) in patients with pre‑existing conduction disease
- Severe hypotension leading to syncope or organ hypoperfusion
- Acute heart failure exacerbation (pulmonary oedema)
- Life‑threatening allergic reactions (anaphylaxis)
Drug–Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can raise diltiazem plasma levels, increasing toxicity risk.
- Beta‑blockers and other negative‑chronotropic agents may cause excessive bradycardia when combined.
- Digoxin concentrations may rise due to reduced renal clearance; monitoring is required.
- Macrolide antibiotics (erythromycin, clarithromycin) may enhance diltiazem’s effects on cardiac conduction.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their healthcare professional before starting Cartia Xt.
Practical Use: Dosing, Missed Dose, Overdose
- Standard Dosing (Immediate‑Release): 30 mg to 120 taken 2–3 times daily, adjusted according to blood‑pressure response and tolerability.
- Standard Dosing (Extended‑Release): 120 mg to 360 mg once daily, with the effective dose preferred for elderly patients.
Missed dose: If a dose is forgotten and the scheduled time is less than 6 hours away, take it as soon as remembered. Skip the missed dose if the next dose is near, and do not double‑dose.
Overdose: Symptoms may include profound hypotension, severe bradycardia, and cardiac arrhythmias. Immediate medical attention is required; treatment is supportive with intravenous fluids, atropine for bradycardia, and, if needed, vasopressor therapy. Activated charcoal may be considered if ingestion is recent and the patient is alert.
Precautions:
- Take tablets with food or a glass of water to minimise gastric irritation.
- Avoid consuming large quantities of grapefruit juice, which can inhibit CYP3A4 metabolism.
- Alcohol may potentiate hypotensive effects; moderate consumption is advised.
- Renal or hepatic impairment may necessitate dose reduction; regular laboratory monitoring is recommended.
Buying Cartia Xt from Our Online Pharmacy
Cartia Xt can be purchased securely from our online pharmacy in the UK. We specialise in providing affordable, high‑quality generic medications sourced from overseas suppliers that meet European GMP standards. Our service offers:
- Cost‑effective pricing: Prices are close to manufacturer cost, delivering substantial savings compared with brand‑name equivalents.
- Verified quality: Every batch is verified for authenticity and potency by third‑party laboratories before dispatch.
- Reliable delivery: Discreet packaging is shipped via express courier (typically 7 days) or standard airmail (approximately 3 weeks), with tracking available for all orders.
- Privacy‑focused broker model: As a pharmacy broker, we collaborate with overseas licensed pharmacies, ensuring a confidential ordering experience that respects patient anonymity.
Our platform is designed for patients who experience limited access to conventional pharmacy services, lack insurance coverage, or seek a more economical alternative to brand‑name diltiazem products.
FAQ
-
Is Cartia Xt available in both immediate‑release and extended‑release formulations?
Yes, the medication is offered in two dosage forms. Immediate‑release tablets are taken two to three times daily, while extended‑release tablets provide 24‑hour coverage with a once‑daily dose. -
What do Cartia Xt tablets look like?
Appearance varies by manufacturer, but most immediate‑release tablets are round, film‑coated, and colour‑coded (e.g., white or pink). Extended‑release tablets are typically oval, slightly larger, and may be amber‑tinted. -
Can I travel internationally with Cartia Xt?
The medication can be carried in personal luggage for personal use, provided you have a copy of the prescription and the medication is in its original packaging. Some countries require a doctor’s note, so check local regulations before departure. -
Does Cartia Xt require refrigeration?
No, the tablets are stable at room temperature (15 °C–30 °C). Store them away from excess heat, moisture, and direct sunlight. -
Are there differences in the inactive ingredients between UK‑sourced and overseas versions?
Inactive components such as lactose, microcrystalline cellulose, and magnesium stearate may vary slightly between manufacturers, but all excipients comply with EU pharmacopeial standards and are unlikely to affect therapeutic efficacy. -
Can Cartia Xt affect drug testing for employment or sport?
Diltiazem is not a prohibited substance on standard workplace drug‑screening panels or most sports anti‑doping lists. However, it may appear in comprehensive pharmacological panels; disclose any medication use if requested. -
What are the specific warnings for elderly patients?
Older adults are more prone to orthostatic hypotension and bradycardia. Initiating therapy at the lowest dose (30 mg immediate‑release or 120 mg extended‑release) and titrating slowly is recommended. -
Is Cartia Xt safe for people with mild asthma?
Calcium‑channel blockers do not typically exacerbate bronchospasm. Nonetheless, patients with airway disease should consult a clinician before starting therapy. -
How does Cartia Xt compare with beta‑blockers for rate control?
Diltiazem lowers heart rate without the negative inotropic effects seen with many beta‑blockers, making it useful in patients who cannot tolerate beta‑blockade due to bronchospasm or severe peripheral vascular disease. -
Has the cost of generic diltiazem changed after Brexit?
Post‑Brexit regulatory adjustments have led to modest price fluctuations, but generic diltiazem remains substantially cheaper than brand‑name alternatives. Our online pharmacy monitors market prices to keep the cost competitive. -
Do any foods interact with Cartia Xt besides grapefruit juice?
High‑fat meals can delay absorption slightly, but they do not alter overall exposure. It is advisable to take the medication consistently with or without food to maintain stable plasma levels. -
What monitoring is recommended while taking Cartia Xt?
Baseline blood pressure, heart rate, and ECG are advisable before initiation. Follow‑up assessments at 2–4 weeks, then periodically, should include blood pressure measurement, pulse evaluation, and liver function tests if high doses are used.
Glossary
- Calcium‑Channel Blocker
- A class of drugs that inhibit the flow of calcium ions into cardiac and smooth‑muscle cells, leading to vasodilation and reduced heart rate.
- Extended‑Release (ER)
- A formulation designed to release the active ingredient slowly over time, allowing once‑daily dosing and more stable blood concentrations.
- CYP3A4
- An enzyme in the liver that metabolises many medications. Inhibitors of CYP3A4 can increase the levels of drugs that are substrates, such as diltiazem.
- Orthostatic Hypotension
- A drop in blood pressure upon standing, causing dizziness or faintness; a common side effect of vasodilating agents.
⚠️ Disclaimer
The information provided about Cartia Xt is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cartia Xt for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.