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Generic Cobra-120 Information
Introduction
Cobra-120 is a tablet formulation whose active ingredient is sildenafil, a phosphodiesterase‑5 (PDE‑5) inhibitor. In the United Kingdom it is prescribed primarily for the treatment of erectile dysfunction (ED) and is classified within the men’s health therapeutic area. The medication is manufactured by an international pharmaceutical supplier that adheres to Good Manufacturing Practice (GMP) standards. Sildenafil is also approved for the management of pulmonary arterial hypertension under the brand name Revatio, but the ED indication is the most common use in the UK adult population.
What is Cobra-120?
Cobra-120 is a oral tablet containing a fixed dose of sildenafil citrate. It belongs to the group of PDE‑5 inhibitors, a class of drugs that increase blood flow to specific vascular beds by preventing the degradation of cyclic guanosine monophosphate (cGMP). The product is marketed as a generic alternative to the original brand‑name medication Viagra, which also contains sildenafil. Our online pharmacy provides this generic formulation as a cost‑effective option for men seeking to improve erectile function. The tablet is typically supplied in 25 mg, 50 mg, and 100 mg strengths, each packaged in a sealed blister strip to protect against moisture and light.
How Cobra-120 Works
Sildenafil inhibits the enzyme phosphodiesterase‑5, which is abundant in the corpus cavernosum of the penis and in the pulmonary vasculature. During sexual stimulation, nitric oxide (NO) is released from endothelial cells and nerve endings. NO activates guanylate cyclase, raising intracellular cGMP levels. cGMP relaxes smooth muscle, allowing arterial inflow and venous occlusion, which together produce an erection. By blocking PDE‑5, sildenafil prolongs the action of cGMP, enhancing the natural erectile response.
Typical onset of action occurs within 30–60 minutes after oral ingestion, and the clinical effect can last for up to 4–6 hours. The drug is metabolised primarily by hepatic CYP3A4 and CYP2C9 enzymes, with an elimination half‑life of approximately 3–5 hours. Food, especially high‑fat meals, may delay absorption and reduce peak plasma concentrations, so patients are usually advised to take the tablet on an empty stomach for more predictable results.
Conditions Treated with Cobra-120
- Erectile Dysfunction (ED) – The most common indication. In the UK, prevalence estimates suggest that up to 30 % of men aged 40–70 experience some degree of ED, which can have significant psychological and relational consequences. Sildenafil restores the physiological pathway required for an erection in response to sexual stimulation.
- Pulmonary Arterial Hypertension (PAH) – Although cobra‑120 is not licensed for PAH in the UK, sildenafil’s vasodilatory effect on the pulmonary circulation is the basis for the separate approved product Revatio. Some clinicians may consider off‑label use only under specialist supervision.
The efficacy of sildenafil for ED has been demonstrated in large, double‑blind, placebo‑controlled trials involving thousands of participants. Improvements in the International Index of Erectile Function (IIEF) scores were observed as early as the first week of therapy, with a favourable safety profile compared with older agents such as oral alprostadil.
Who is Cobra-120 For?
- Men with diagnosed erectile dysfunction who have a functional penile blood supply and are able to achieve sexual arousal.
- Patients who have tried lifestyle modifications (e.g., weight loss, reduced alcohol intake, smoking cessation) without sufficient improvement.
- Individuals seeking an on‑demand therapy (taken approximately 30 minutes before sexual activity) rather than a daily regimen.
Caution is advised for men with the following conditions:
- Concurrent use of nitrates (e.g., nitroglycerin) or nitric‑oxide donors, which can precipitate severe hypotension.
- Severe cardiovascular disease where sexual activity itself is contraindicated.
- Uncontrolled hypertension (> 180/110 mmHg) or hypotension (< 90/50 mmHg).
- Known hypersensitivity to sildenafil or any excipients in the tablet formulation.
Patients with hepatic or severe renal impairment may require dose adjustments, and those over 65 years of age should start with the lowest effective dose after clinical evaluation.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing (warmth and redness of the face or upper body)
- Nasal congestion or rhinitis
- Dyspepsia (indigestion)
- Visual disturbances (blurred vision, blue‑tinted vision)
These events are usually mild, transient, and resolve without medical intervention.
Rare
- Priapism (prolonged erection lasting > 4 hours) – requires immediate medical attention.
- Sudden hearing loss or tinnitus.
- Severe hypotension leading to dizziness or syncope.
Serious
- Cardiovascular events such as myocardial infarction or stroke are extremely rare but may occur in patients with pre‑existing heart disease.
- Anaphylactic reaction (urticaria, bronchospasm, angioedema) – emergency care needed.
Drug‑Drug Interactions
- Nitrates (e.g., isosorbide dinitrate, nitroglycerin) – additive vasodilatory effect → potentially life‑threatening hypotension.
- Alpha‑blockers (e.g., tamsulosin, terazosin) – may cause additive blood pressure reduction; start sildenafil at low dose and monitor.
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) – increase plasma sildenafil concentrations, raising risk of adverse effects; dose reduction recommended.
- CYP3A4 inducers (e.g., rifampicin, carbamazepine) – lower sildenafil exposure, possibly reducing efficacy.
Patients should disclose all current medications, including over‑the‑counter supplements, to their healthcare provider before initiating Cobra-120.
Practical Use: Dosing, Missed Dose, Overdose
- Initial dose: 50 mg taken as needed, approximately 30 minutes before anticipated sexual activity.
- Dose adjustment: Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. No more than one tablet should be taken within a 24‑hour period.
- Missed dose: If an erection occurs later than expected, the tablet can be taken later, but the total daily dose must not exceed one tablet.
- Overdose: Symptoms may include severe hypotension, prolonged erection, chest pain, or visual changes. Immediate medical evaluation is required; treatment is supportive, with attention to blood pressure and cardiac monitoring.
Precautions
- Avoid large, high‑fat meals within two hours of dosing, as they may delay absorption.
- Limit alcohol consumption; excessive alcohol can impair erection and increase the risk of hypotension.
- Patients with severe liver disease (Child‑Pugh class C) should use reduced doses (25 mg) and be monitored closely.
Buying Cobra-120 from Our Online Pharmacy
Cobra‑120 is available for purchase through our online pharmacy in the UK. We specialise in providing verified, GMP‑certified generic medications at prices that approach the manufacturer’s cost base. Key benefits of ordering from us include:
- Affordable pricing – generic sildenafil tablets are supplied at a fraction of the cost of branded alternatives.
- Verified quality – all batches are sourced from licensed overseas manufacturers that meet EU and UK quality standards; each shipment is accompanied by a Certificate of Analysis.
- Discreet, guaranteed delivery – packages are shipped in unmarked envelopes with tracking; express delivery typically arrives within 7 days, while standard airmail reaches most locations in 2–3 weeks.
- Pharmacy broker service – we work with a network of internationally accredited pharmacies, enabling access to medications that may not be stocked locally. Our process respects patient privacy and complies with UK import regulations for personal use.
Patients who struggle with limited pharmacy stock, high co‑payments, or insurance restrictions can obtain a reliable supply of Cobra‑120 through our secure, online platform. All orders are processed by qualified pharmacy professionals who verify the legitimacy of the request in line with UK law.
FAQ
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Can Cobra-120 be taken with a high‑fat meal?
Yes, it can be taken after any type of meal, but a high‑fat meal may delay absorption and reduce the peak effect. For more predictable results, the tablet is usually recommended on an empty stomach or after a light meal. -
What does the tablet look like?
Cobra‑120 tablets are round, film‑coated, and colour‑coded by strength: 25 mgblue), 50 mg (white), and 100 mg (pink). The imprint typically includes the dosage and the brand identifier. -
Are there any excipients that people with allergies should be aware of?
Inactive ingredients commonly include lactose, microcrystalline cellulose, magnesium stearate, and titanium dioxide. Patients with severe lactose intolerance or known hypersensitivity to any of these components should consult a pharmacist before use. -
Is it legal to import Cobra-120 for personal use in the UK?
Yes, the UK permits individuals to import a three‑month supply of prescription medication for personal use, provided the product is for a legitimate medical purpose and the importer possesses a valid prescription from a UK‑registered clinician. -
Does travelling abroad affect the stability of Cobra-120?
The tablet is stable at temperatures up to 30 °C (86 °F). When travelling to hot climates, keep the medication in a cool, dry place, such as an insulated pouch, to avoid degradation. -
How does sildenafil differ from older ED treatments like yohimbine?
Sildenafil works by enhancing the nitric‑oxide signalling pathway, producing a rapid and reliable erectile response, whereas yohimbine is an alpha‑2 adrenergic antagonist with modest efficacy and a higher incidence of side effects such as anxiety and hypertension. -
What clinical trials established the efficacy of sildenafil for ED?
The pivotal Phase III trials (e.g., the “VIAGRA” studies) enrolled over 2,000 men with varying degrees of erectile dysfunction. These studies demonstrated statistically significant improvements in IIEF scores versus placebo, with onset of action within 30 minutes. -
Can Cobra-120 improve sexual confidence beyond the physiological effect?
While the medication directly addresses the vascular component of erection, many users report enhanced self‑esteem and reduced performance anxiety when they experience consistent erectile function. Such psychosocial benefits are secondary and vary among individuals. -
Is it safe to combine Cobra-120 with antihypertensive drugs?
Sildenafil can cause a modest reduction in blood pressure. When used with antihypertensives, especially those that also lower blood pressure (e.g., ACE inhibitors, calcium channel blockers), patients should monitor their readings and may require dose adjustments under medical supervision. -
Does the generic formulation have the same bioavailability as the brand name?
Regulatory standards require that generic sildenafil demonstrate bio‑equivalence, meaning its absorption rate and extent fall within 80‑125 % of the reference product. Consequently, the therapeutic effect is expected to be comparable.
Glossary
- Phosphodiesterase‑5 (PDE‑5) inhibitor
- A class of drugs that block the PDE‑5 enzyme, preventing the breakdown of cGMP and thereby enhancing smooth‑muscle relaxation in the penis and pulmonary arteries.
- cGMP (cyclic guanosine monophosphate)
- A secondary messenger molecule that mediates smooth‑muscle relaxation; increased levels lead to vasodilation and erection.
- Priapism
- A prolonged, often painful erection lasting more than four hours, requiring urgent medical treatment to prevent permanent tissue damage.
- Bio‑equivalence
- A regulatory term indicating that a generic product delivers the same amount of active ingredient to the bloodstream at a comparable rate as the original brand‑name drug.
⚠️ Disclaimer
The information provided about Cobra-120 is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cobra-120 for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.