Buy Feldene Online

Feldene Information

Introduction

Feldene is an oral non‑steroidal anti‑inflammatory drug (NSAID) that contains the active substance piroxicam. It is classified within the arthritis medication group and is primarily prescribed for symptomatic relief of pain and inflammation associated with rheumatic conditions. In the United Kingdom, Feldene is used under the supervision of a prescriber for conditions such as rheumatoid arthritis and osteoarthritis, where the reduction of joint swelling and improvement of mobility are clinically important. The product is manufactured by several approved pharmaceutical firms that hold marketing authorisations from the Medicines and Healthcare products Regulatory Agency (MHRA).

What is Feldene?

Feldene is a tablet formulation of piroxicam, a member of the oxicam class of NSAIDs. It was developed to provide long‑lasting anti‑inflammatory activity with once‑daily dosing. The medication is marketed by licensed manufacturers that have received a UK Human Medicines Licence. While Feldene is a brand‑name product, piroxicam itself is also available as generic equivalents, which are authorised on the same basis as the original licence.

How Feldene Works

Piroxicam exerts its therapeutic effect by reversibly inhibiting cyclo‑oxygenase (CO‑CO) enzymes, predominantly COX‑2, which catalyse the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis leads to decreased sensitisation of nociceptors and attenuation of the inflammatory cascade. The drug has a relatively slow onset of action, usually noticeable within 2–4 hours after ingestion, and a long terminal half‑life of approximately 50 hours, allowing steady plasma concentrations with once‑daily dosing. Clearance is primarily hepatic, with limited renal elimination; thus, hepatic function is a key determinant of drug levels.

Conditions Treated with Feldene

*Rheumatoid arthritis (RA) – RA affects an estimated 30 000–35 000 adults in the UK each year. Feldene reduces joint pain, stiffness and swelling, helping patients maintain functional ability while disease‑modifying therapies (e.g., DMARDs) target underlying pathology.

*Osteoarthritis (OA) – OA is a leading cause of disability in older UK adults, with a prevalence of around 20 % in those over 60 years. Feldene provides analgesia for focal joint pain, allowing improved gait and daily activity.

* Ankylosing spondylitis and other spondyloarthropathies – Although not a first‑line agent, piroxicam can be employed for episodic flares when NSAID therapy is required.

*Post‑operative or traumatic musculoskeletal pain – Off‑label use for short‑term pain control after minor orthopaedic procedures is reported in clinical practice, although prescription must be justified by the treating clinician.

The efficacy of Feldene derives from its ability to moderate inflammatory mediator production, which directly correlates with symptom reduction in these disorders.

Suitable Candidates for Feldene Treatment

Patients who experience moderate to severe inflammatory joint pain and have an established indication for NSAID therapy may be considered for Feldene. Typical scenarios include:

• Individuals with active rheumatoid or osteoarthritis who have either inadequate response to lower‑ potency NSAIDs (e.g., ibuprofen) or require a longer dosing interval.
• Patients who value once‑daily dosing to improve adherence.
• Adults with preserved hepatic function and no contraindications listed in the product’s Summary of Product Characteristics (SPC).

Contra‑indications or cautionary use apply to:

• History of gastrointestinal ulcer or bleeding.
• Significant cardiovascular disease (e.g., recent myocardial infarction, uncontrolled hypertension).
• Impaired renal function (creatinine clearance < 30 mL/min).
• Known hypersensitivity to oxicams or other NSAIDs.
• Concomitant use of drugs that increase bleeding risk (e.g., warfarin, other NSAIDs) without specialist guidance.

Clinicians must evaluate comorbidities, concomitant medications and individual risk before initiating therapy.

Risks, Side Effects, and Interactions

Common adverse events

• Gastro‑intestinal discomfort: dyspepsia, abdominal pain, flatulence.
• Skin reactions: mild rash or pruritus.
• Elevated liver enzymes: transient increases in alanine aminotransferase (ALT) or aspartate aminotransferase (AST).

Rare adverse events

• Severe skin reactions: Stevens‑Johnson syndrome, toxic epidermal necrolysis.
• Hematological abnormalities: eosinophilia, thrombocytopenia.
• Pulmonary manifestations: interstitial lung disease (very infrequent).

Serious adverse events

• Gastro‑intestinal ulceration or bleeding: may present as melena, haematemesis, or occult bleeding; risk heightened with concurrent aspirin or anticoagulants.
• Cardiovascular thrombotic events: myocardial infarction, stroke, especially in patients with established cardiovascular disease.
• Renal compromise: acute kidney injury manifesting as reduced urine output or rising serum creatinine.
• Severe hepatic injury: clinically significant hepatitis with jaundice and markedly elevated transaminases.

Clinically relevant drug–drug interactions

• Anticoagulants (warfarin, direct oral anticoagulants): additive effect on bleeding.
• Other NSAIDs or corticosteroids: synergistic gastrointestinal risk.
• ACE inhibitors, ARBs, diuretics: potentiation of renal impairment, particularly in dehydrated patients.
• Lithium: piroxicam may increase lithium retention and toxicity.
• Methotrexate: reduces renal clearance of methotrexate, raising toxicity potential.
• antihypertensives (beta‑blockers, calcium channel blockers): may blunt hypotensive response.

Patients should be counselled to disclose all concurrent medicines, including over‑the‑counter products and herbal preparations.

Practical Use: Dosing, Missed Dose, Overdose

Standard adult dosing – The typical oral dose for inflammatory arthritis is 10 mg (one tablet) taken once daily with food to minimise gastric irritation. The maximum recommended dose is 10 mg per 24 hours; doses above this increase the risk of adverse events without proven benefit.

Missed dose – If a dose is forgotten, patients should take it as soon as they remember unless the next scheduled dose is within 12 hours. In such cases, the missed dose should be omitted to avoid accidental double dosing.

Overdose – Acute ingestion of more than 40 mg (four tablets) is considered a potential overdose. Immediate medical assessment is required. Management includes activated charcoal if presentation is early, supportive care, and monitoring of gastrointestinal, hepatic, renal and cardiac function. No specific antidote exists.

Precautions –

• Food and alcohol: Taking Feldene with meals is advised; alcohol may exacerbate gastrointestinal bleeding risk.
• Comorbidities: Caution in patients with hypertension, heart failure, or chronic kidney disease; regular laboratory monitoring (liver enzymes, renal function) may be warranted.
• Pregnancy and lactation: NSAIDs are generally contraindicated in the third trimester and may affect fetal renal function; use is avoided unless a specialist determines that benefits outweigh risks.

Buying Feldene from Our Online Pharmacy

Feldene can be obtained from our online pharmacy in the UK. The service offers:

• Affordable pricing – Generic procurement at near‑manufacturer cost, passing savings to the customer.
• Verified quality – All batches are sourced from internationally licensed, MHRA‑registered suppliers ensuring pharmaceutical standard compliance.
• Guaranteed delivery – Discreet, trackable shipping; standard parcels arrive within 7 days, with express options delivering in 48 hours, and regular airmail typically within three weeks.
• Privacy‑first approach – As a pharmacy‑broker service, we work with overseas licensed pharmacies, enabling a discreet fulfillment model that safeguards personal data while providing legitimate medication.

For patients who encounter barriers to conventional pharmacy access, insurance constraints, or limited local stock, the online channel provides a safe, cost‑effective route to receive Feldene under professional oversight.

FAQ

• Is Feldene available in both brand‑name and generic forms in the UK?
  Yes, piroxicam is marketed under the brand name Feldene and also as generic tablets containing the same active substance. Generic versions are authorised by the MHRA and are typically offered at a lower price point.

• Does Feldene require refrigeration?
  No, Feldene tablets should be stored at a controlled room temperature, generally between 15 °C and 30 °C, protected from direct light and moisture.

• What appearance does a Feldene tablet have?
  The standard 10 mg Feldene tablet is white, round, and film‑coated, bearing the imprint “10 mg Piroxicam” along with the manufacturer's logo.

• Can I travel abroad with Feldene on me?
  When travelling within the EU or EEA, it is advisable to carry a copy of the prescription and the original packaging. Some countries outside the EU may have import restrictions for NSAIDs; checking destination regulations before departure is recommended.

• Are there specific warnings for patients of Asian descent?
  No ethnicity‑specific contraindications are listed in the Feldene SPC. However, Asian patients may have a higher prevalence of certain CYP2C9 genotypes that affect NSAID metabolism, so clinicians sometimes monitor for increased gastrointestinal or renal toxicity.

• Does the formulation differ between regions (EU vs. US vs. Asia)?
  While the active ingredient, piroxicam, remains constant, excipients such as lactose or specific film‑coating polymers can vary by market. It is important to review the package leaflet for the exact composition of the product supplied by a particular region.

• How long is the shelf‑life of Feldene tablets?
  The typical expiry period is 24 months from the date of manufacture, provided the storage conditions are adhered to. The exact date is printed on each blister pack.

• Can Feldene be detected in standard drug‑testing panels?
  Routine workplace drug screens do not include piroxicam; however, specialised toxicology panels could identify NSAID metabolites if specifically requested.

• What are the legal limits for personal import of NSAIDs into the UK?
  The UK permits individuals to import a three‑month supply of medication for personal use, provided it has been obtained from a licensed source and holds a valid UK prescription. Import of larger quantities may be subject to customs duties.

• Is there a therapeutic alternative for patients who cannot tolerate Feldene?
  For those with intolerance or contraindications to oxicams, other NSAID classes (e.g., ibuprofen, naproxen, diclofenac) or selective COX‑2 inhibitors may be considered, but choice depends on individual risk–benefit assessment by the prescriber.

Glossary

Cyclo‑oxygenase (COX) enzyme

Enzymes that convert arachidonic acid into prostaglandins, which mediate inflammation, pain and fever.

Oxicams

A subclass of NSAIDs that includes piroxicam; they possess a long plasma half‑life and provide sustained anti‑inflammatory activity.

Therapeutic window

The dose range within which a medication is effective without producing unacceptable toxicity.

Pharmacovigilance

Ongoing monitoring of a drug’s safety profile after it has been released to the market, including the collection of adverse‑event reports.

⚠️ Disclaimer

The information provided about Feldene is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Feldene for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.