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Fildena Information
Introduction
Fildena is an oral medication indicated for the treatment of erectile dysfunction (ED) in adult men. Its active ingredient is sildenafil, a phosphodiesterase‑5 (PDE‑5) inhibitor that belongs to the broader class of medicines used for men’s sexual health. In the United Kingdom, erectile dysfunction affects an estimated 10 % of men aged 40 – 49 and up to 30 % of men over 70, making effective, accessible therapy a public health priority. Fildena provides a therapeutic option that can be obtained through our online pharmacy, offering a cost‑effective alternative to brand‑name products such as Viagra® and Revatio®.
What is Fildena?
Fildena is a tablet formulation that contains 25 mg, 50 mg, or 100 mg of sildenafil citrate. Sildenafil was originally developed by Pfizer and introduced as Viagra® for erectile dysfunction and later as Revatio® for pulmonary arterial hypertension. While the brand name differs, the pharmacological profile of Fildena is identical to that of the original compound. The medication is classified as a PDE‑5 inhibitor and falls under the therapeutic group “Erectile Dysfunction, Men’s Health.” The manufacturer of Fildena varies by source; the tablets are supplied by licensed pharmaceutical partners that meet international Good Manufacturing Practice (GMP) standards.
Fildena is the generic formulation containing the same active compound sildenafil as the well‑known brand Viagra®. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.
How Fildena Works
Sildenafil exerts its effect by selectively inhibiting the enzyme phosphodiesterase‑5, which normally degrades cyclic guanosine monophosphate (cGMP) within the smooth muscle cells of the corpus cavernosum. During sexual stimulation, nitric oxide released from nerve endings stimulates the production of cGMP. Elevated cGMP leads to relaxation of the smooth muscle, increased blood flow into the penile erectile tissue, and erection. By blocking PDE‑5, sildenafil prolongs the action of cGMP, thereby enhancing and sustaining penile erection in response to sexual arousal.
Key pharmacokinetic points relevant to patients:
- Onset of action: typically 30–60 minutes after oral intake.
- Peak plasma concentration: occurs 1–2 hours post‑dose.
- Duration of effect: up to 4–6 hours, depending on dose and individual metabolism.
- Elimination: primarily hepatic via CYP3A4; the terminal half‑life is about 4 hours.
Conditions Treated with Fildena
- Erectile Dysfunction (ED): The principal and FDA‑approved indication. In the UK, ED contributes to reduced quality of life, relationship strain, and increased health‑care utilisation. Sildenafil restores the physiological response required for satisfactory sexual intercourse.
- Off‑label use for Pulmonary Arterial Hypertension (PAH): While Fildena is marketed for ED, sildenafil (under the Revatio® name) is licensed for PAH. Some clinicians prescribe low‑dose sildenafil for PAH, but this is outside the approved scope for Fildena and should be determined by a specialist.
The effectiveness of sildenafil in treating ED is supported by multiple randomised controlled trials, demonstrating improved International Index of Erectile Function (IIEF) scores across diverse age groups and comorbidities, including diabetes and post‑prostatectomy status.
Who is Fildena For?
Fildena is suitable for adult men who:
- Experience consistent difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity.
- Have no contraindications such as concurrent nitrate therapy, severe uncontrolled hypertension, or recent‑onset myocardial infarction.
- Are able to tolerate oral medication and have adequate hepatic function for metabolism.
Clinical scenarios where Fildena is frequently recommended include:
- Primary psychogenic or organic ED, documented after a thorough medical assessment.
- ED associated with diabetes mellitus, where vascular compromise is common.
- Post‑radical prostatectomy or pelvic surgery patients, provided nerve‑sparing techniques have been employed and residual erectile function remains.
Fildena is not appropriate for:
- Men using nitrates (e.g., nitroglycerin, isosorbide dinitrate) for angina, due to risk of severe hypotension.
- Individuals with a history of non‑arteritic anterior ischemic optic neuropathy (NAION) or other serious ocular conditions.
- Patients with severe hepatic impairment (Child‑Pugh class C) or renal failure requiring dialysis, unless dose adjustments are made under specialist supervision.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing
- Dyspepsia (indigestion)
- Nasal congestion
- Visual disturbances (e.g., bluish tint, increased sensitivity to light)
These effects are usually mild to moderate in intensity and resolve without intervention within a few hours.
Rare
- Priapism (erection lasting >4 hours)
- Sudden, unexplained hearing loss or tinnitus
- Non‑arteritic anterior ischemic optic neuropathy (NAION)
Prompt medical evaluation is required if any of these events occur.
Serious
- Severe hypotension, especially when combined with nitrates or potent α‑blockers
- Cardiovascular events (myocardial infarction, stroke) in patients with pre‑existing unstable cardiac disease
- Vision loss (central retinal artery occlusion)
Patients with known cardiovascular disease should discuss risk‑benefit considerations with a healthcare professional before initiating therapy.
Clinically Relevant Drug–Drug Interactions
- Nitrates (nitroglycerin, isosorbide mononitrate, amyl nitrate) → additive vasodilation → life‑threatening hypotension.
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