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Hydroxyzine is an antihistamine used to treat anxiety, allergies, and itching, and also acts as a sedative. It may cause drowsiness and should be used with caution when driving or mixing with other sedatives. Side effects include dry mouth and dizziness. Always follow your doctor’s instructions.

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Generic Hydroxyzine Information

Introduction

Hydroxyzine is a first‑generation antihistamine prescribed primarily for allergic skin conditions, anxiety, and as a sedative before medical procedures. In the United Kingdom it is classified within the allergy medication group and is available in oral tablet, capsule, and injectable formulations. Besides its antihistaminic activity, hydroxyzine is recognised for its anxiolytic and anti‑emetic properties, making it a versatile option for several short‑term therapeutic needs.

What is Hydroxyzine?

Hydroxyzine is the generic version of the brand‑name products Atarax® (Sanofi) and Vistaril® (Pfizer), containing the same active compound, hydroxyzine. Our online pharmacy provides this generic alternative as a cost‑effective treatment option. The drug belongs to the piperazine class of first‑generation H₁‑receptor antagonists and has been on the market since the 195s. It is manufactured by a range of qualified pharmaceutical companies that hold licences for distribution within the EU and the UK.

How Hydroxyzine Works

Hydroxyzine blocks histamine H₁ receptors in peripheral tissues and the central nervous system. By preventing histamine from binding, it reduces the vascular permeability and sensory nerve stimulation that cause itching and urticaria. In the brain, H₁ antagonism leads to sedation and anxiolysis through decreased neuronal excitability. Oral administration typically yields an onset of action within 15–30 minutes, with peak plasma concentrations at 2 hours; the elimination half‑life is 20 hours, allowing once‑ or twice‑daily dosing for many indications.

Conditions Treated with Hydro_xyzine

  • Allergic dermatoses (e.g., urticaria, pruritus): Histamine release during allergic reactions produces intense itching; hydroxyzine’s H₁ blockade directly relieves these symptoms.
  • Anxiety and tension‑related disorders: The sedative effect attenuates central nervous system hyper‑arousal, useful for short‑term management of generalized anxiety or pre‑operative nervousness.
  • Pre‑operative sedation and anesthesia adjunct: Administered intravenously, hydroxyzine reduces anxiety and provides mild hypnosis, facilitating smoother induction of general anaesthesia.
  • Adjunct in nausea and vomiting: By acting on the vestibular system, hydroxyzine can lessen postoperative or drug‑induced nausea.

In the UK, allergic skin conditions affect up to 20 % of the population at some point, and anxiety disorders are reported in roughly 15 % of adults, highlighting the clinical relevance of hydroxyzine for many patients.

Who is Hydroxyzine For?

Hydroxyzine is appropriate for adults who require rapid relief of allergic itching, short‑term anxiety control, or pre‑procedure sedation. It is frequently prescribed to:

  • Individuals with acute urticaria or other histamine‑mediated skin reactions.
  • Patients awaiting minor surgical or dental procedures who need anxiolysis without the depth of general anaesthesia.
  • Adults experiencing transient anxiety episodes, such as those related to stressful life events or situational stressors.

Contraindications include hypersensitivity to hydroxyzine or any piperazine derivative, severe hepatic impairment, and concurrent use of monoamine oxidase inhibitors (MAOIs). Caution is advised in the elderly, those with renal dysfunction, and patients with a history of cardiac arrhythmias.

Risks, Side Effects, and Interactions

Common

  • Drowsiness or somnolence
  • Dry mouth (xerostomia)
  • Headache
  • Dizziness or light‑headedness

These effects are usually mild and decrease with continued use or dose adjustment.

Rare

  • Blurred vision or photophobia
  • Constipation or gastrointestinal upset
  • Urinary retention, especially in patients with prostatic hypertrophy

Serious

  • Anaphylactic reaction (rash, swelling, airway compromise)
  • QT‑interval prolongation leading to cardiac arrhythmias
  • Seizures, particularly in overdose or when combined with other CNS depressants
  • Hepatic injury (elevated transaminases)

Clinically Relevant Interactions

  • CNS depressants: Alcohol, benzodiazepines, opioids, and other sedating antihistamines may potentiate drowsiness and respiratory depression.
  • MAO inhibitors: Concurrent use can precipitate hypertensive crises; a wash‑out period of 14 days is recommended.
  • QT‑prolonging agents: Antipsychotics, certain macrolide antibiotics, and antiarrhythmics may increase the risk of torsades de pointes.
  • Anticholinergic drugs: Additive dry‑mouth and urinary retention effects.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard adult dosing for allergic itching: 25 mg taken orally 3–4 times daily; maximum 100 mg per day.
  • Anxiety: 25–50 mg orally 3–4 times daily, not exceeding 200 mg per day.
  • Intravenous pre‑operative sedation: .5 mg/kg administered slowly over 2–5 minutes.

If a dose is missed, take it as soon as remembered unless the next scheduled dose is near; do not double the dose. In case of suspected overdose, symptoms may include extreme drowsiness, hypotension, tachycardia, and possibly seizures. Seek urgent medical care; treatment may involve gastric lavage, activated charcoal, and supportive measures such as intravenous fluids and cardiac monitoring.

Precautions: Avoid alcohol and operating heavy machinery until the drug’s effects are known. Dose reductions are advised for elderly patients, and for those with moderate hepatic or renal impairment. Hydroxyzine should be used with caution in patients with a history of cardiac arrhythmias.

Buying Hydroxyzine from Our Online Pharmacy

Hydroxyzine can be purchased safely from our online pharmacy in the UK. We source the medication from licensed overseas suppliers who adhere to EU Good Manufacturing Practice (GMP) standards, ensuring the product matches the quality of domestic brands.

  • Affordable pricing: Costs are close to manufacturer‑direct rates, providing a cheaper alternative to branded tablets.
  • Verified quality: Every batch undergoes independent laboratory testing before dispatch.
  • Guaranteed delivery: Discreet packaging is shipped via express service (typically 7 days) or regular airmail (approximately 3 weeks).
  • Pharmacy broker service: We act as an intermediary between you and accredited international pharmacies, guaranteeing privacy and compliance with UK import regulations.

Our service is designed for patients who face limited access through conventional pharmacies or who seek an economical generic option without compromising safety.

FAQ

  • Is Hydroxyzine available in both brand‑name and generic forms in the UK?
    Yes. The drug is marketed under brand names such as Atarax® and Vistaril®, as well as several generic versions produced by different manufacturers. Generic hydroxyzine contains the identical active ingredient and offers a lower cost to patients.

  • How should Hydroxyzine be stored to maintain its efficacy?
    Keep the medication at room temperature, between 15 °C and 30 °C (59 °F–86 °F). Protect it from direct sunlight, excessive heat, and moisture. Do not store it in bathrooms or near kitchen appliances that generate humidity.

  • Can Hydroxyzine be taken with food, and does food affect its absorption?
    Hydroxyzine can be taken with or without food. A meal may slightly delay the onset of action but does not significantly alter overall absorption or effectiveness.

  • What are the inactive ingredients commonly found in Hydroxyzine tablets?
    In the UK, generic tablets often contain lactose, microcrystalline cellulose, magnesium stearate, and povidone. Patients with specific allergies or intolerances should check the product label for the complete excipient list.

  • Is it safe to travel internationally while using Hydroxyzine?
    Yes, provided you keep the medication in its original packaging with the prescription label (if applicable) and carry it in hand luggage. Avoid exposing it to extreme temperatures, such as storing it in an overheated car or unheated cargo hold.

  • Does Hydroxyzine appear on standard drug‑testing panels for employment or sport?
    Hydroxyzine is not typically screened for in routine workplace drug tests, but it may be identified in comprehensive toxicology panels. Athletes should consult their governing body's medication policy, as antihistamines can be permitted but may require declaration.

  • Are there formulation differences between Hydroxyzine products sold in the EU versus the US?
    EU formulations generally use hydroxyzine hydrochloride, while US products may be marketed as hydroxyzine pamoate. Both deliver the same active moiety, but dosage strength may differ; clinicians adjust prescribing accordingly.

  • What historical milestones led to Hydroxyzine’s development?
    Hydroxyzine was first synthesised in the early 195s as a derivative of diphenhydramine, aiming to reduce sedation while retaining antihistaminic activity. It gained FDA approval in 1956 and was later introduced to European markets, where it found additional use as an anxiolytic.

  • How does Hydroxyzine compare with newer antihistamines like cetirizine for itching?
    Hydroxyzine provides stronger sedation and a faster onset of itch relief, which can be advantageous for acute allergic reactions. Newer second‑generation antihistamines have less sedative effect but may require higher or more frequent dosing for severe pruritus.

  • Can Hydroxyzine be used in patients with mild liver disease?
    The drug is metabolised primarily in the liver; mild hepatic impairment usually does not necessitate a dose modification, but clinicians often start with a lower dose and monitor for increased sedation or toxicity.

Glossary

H₁‑receptor antagonist
A substance that blocks histamine H₁ receptors, preventing histamine‑mediated allergic responses such as itching and swelling.
Half‑life
The time required for the plasma concentration of a drug to reduce by 50 %; for hydroxyzine this is approximately 20 hours in healthy adults.
QT prolongation
An extension of the heart’s electrical repolarisation interval, which can increase the risk of dangerous arrhythmias.
Sedative
A medication that depresses central nervous system activity, producing calmness, drowsiness, or sleep.

⚠️ Disclaimer

The information provided about Hydroxyzine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Hydroxyzine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

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