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Generic Inderal La Information
Introduction
Inderal La is a prescription medication supplied in the United Kingdom for the management of cardiovascular conditions. The product contains the non‑selective β‑adrenergic blocker propranolol and belongs to the blood‑pressure therapeutic group. While its primary indication is hypertension, propranolol is also licensed for angina, cardiac arrhythmias and certain types of migraine. The formulation is an extended‑release tablet, allowing once‑daily dosing that maintains steadier plasma concentrations than immediate‑release propranolol.
What is Inderal La?
Inderal La is a branded extended‑release tablet that delivers propranolol, a beta‑blocker first introduced in the 196s. The tablet is manufactured by a licensed pharmaceutical company (the specific manufacturer may vary by market) and is registered with the Medicines and Healthcare products Regulatory Agency (MHRA) for use in the UK.
Propranolol is sold under several well‑known brand names, including Inderal, Inderal‑LA, Hemangeol and generic propranolol tablets. Our online pharmacy provides this medication as a cost‑effective alternative to brand‑name products while meeting the same quality standards required by the MHRA.
How Inderal La Works
Propranolol blocks β₁‑ and β₂‑adrenergic receptors in the heart, lungs and peripheral circulation. By preventing catecholamines (epinephrine and norepinephrine) from stimulating these receptors, the drug reduces:
- Heart rate – slowing the node reduces cardiac output.
- Myocardial contractility – less forceful contraction lowers oxygen demand.
- Renin release – inhibition of renal β₁ receptors diminishes the renin‑angiotensin‑aldosterone cascade, leading to vasodilation and lower blood pressure.
The extended‑release matrix of Inderal La releases propranolol gradually over 24 hours. Peak plasma concentrations are typically reached 6–8 hours after ingestion, providing a smoother therapeutic profile and reducing the likelihood of rebound tachycardia that can occur with short‑acting formulations.
Conditions Treated with Inderal La
- Essential Hypertension – propranolol lowers systolic and diastolic pressure, helping patients achieve UK NICE target values (< 140/90 mmHg).
- Stable Angina Pectoris – reduced heart rate and contractility decrease myocardial oxygen consumption, alleviating chest pain on exertion.
- Cardiac Arrhythmias – particularly supraventricular tachycardia and atrial fibrillation with rapid ventricular response; β‑blockade slows conduction through the AV node.
- Migraine Prophylaxis – propranolol’s central nervous system effects reduce the frequency of migraine attacks in up to 60 % of patients.
- Essential Tremor – attenuation of peripheral β‑adrenergic activity can dampen the kinetic tremor that impairs daily activities.
These indications are recognised by the MHRA and reflected in the Summary of Product Characteristics (SPC) for propranolol. In the United Kingdom, hypertension affects roughly 1.5 million adults; propranolol remains a first‑line option for patients who also require rate control for co‑existing arrhythmia.
Who is Inderal La For?
Inderal La is appropriate for adult patients who:
- Have been diagnosed with primary hypertension and require β‑blockade as part of a combination regimen.
- Experience stable angina where heart‑rate reduction is desirable.
- Present with supra‑ventricular tachyarrhythmias that respond to β‑blockade.
- Require migraine prophylaxis and have no contraindication to non‑selective β‑blockers.
The drug should be avoided or used with caution in:
- Patients with severe chronic obstructive pulmonary disease (COPD) or asthma where β₂‑blockade may precipitate bronchospasm.
- Those with decompensated heart failure (NYHA class IV) or overt bradycardia (< 50 bpm).
- Individuals with uncontrolled diabetes mellitus who rely on tachycardia as a hypoglycaemia warning sign.
- Pregnant or breastfeeding women unless the benefits outweigh potential risks; propranolol crosses the placenta and appears in breast milk.
Risks, Side Effects, and Interactions
Common
- Fatigue or drowsiness – due to reduced cardiac output.
- Cold extremities – peripheral vasoconstriction.
- Gastro‑intestinal upset – nausea or mild abdominal discomfort.
- Mild erectile dysfunction – observed in a minority of male patients.
Rare
- Depression or mood changes – occasional reports in long‑term therapy.
- Hypoglycaemia unawareness – especially in insulin‑treated diabetic patients.
- Raynaud’s phenomenon – exacerbation of pre‑existing vasospastic disorders.
Serious
- Bradycardia (< 40 bpm) – may cause dizziness, syncope, or heart block.
- Severe bronchospasm – can precipitate acute asthma attacks.
- Heart failure decompensation – worsening of fluid retention.
- Allergic reactions – anaphylaxis, though extremely rare.
Drug–Drug Interactions
- Calcium channel blockers (e.g., verapamil, diltiazem) – additive negative inotropic and AV‑node effects; monitor heart rate and blood pressure.
- Antidiabetic agents (insulin, sulfonylureas) – propranolol may mask hypoglycaemic symptoms; adjust glucose monitoring.
- Non‑steroidal anti‑inflammatory drugs (NSAIDs) – can diminish antihypertensive efficacy.
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) – increase propranolol plasma levels; dose reduction may be required.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.
Practical Use: Dosing, Missed Dose, Overdose
- Standard dosing – Inderal La is typically started at 80 mg once daily in the morning. The dose may be titrated to a maximum of 320 mg daily, based on blood‑pressure response and tolerability.
- Administration – swallow the tablet whole with a full glass of water; do not crush or chew, as this compromises the extended‑release matrix.
- Missed dose – if a dose is forgotten, take it as soon as remembered unless it is within 12 hours of the next scheduled dose. In that case, skip the missed tablet and resume the regular schedule. Do not double‑dose.
- Overdose – symptoms may include profound bradycardia, hypotension, bronchospasm, hypoglycaemia and seizures. Immediate medical attention is required; treatment may involve atropine, glucagon, or intravenous fluids, depending on clinical presentation.
Precautions
- Avoid excess alcohol, which can potentiate hypotensive effects.
- Use with caution in patients with hepatic impairment, as propranolol undergoes extensive first‑pass metabolism.
- Regularly monitor blood pressure, heart rate and, where appropriate, blood glucose.
Buying Inderal La from Our Online Pharmacy
Inderal La can be obtained securely from our online pharmacy in the UK. Our service offers several advantages for patients seeking reliable access to this medication:
- Affordable pricing – we source the product near manufacturer cost, translating into lower out‑of‑pocket expense.
- Verified quality – all batches come from MHRA‑approved suppliers; each shipment is accompanied by a certificate of analysis.
- Guaranteed delivery – discreet, tracked parcels arrive within 7 days via express courier for most UK postcodes, with a regular airmail option of approximately 3 weeks for remote areas.
- International medication access – as a pharmacy‑broker service, we collaborate with licensed overseas pharmacies, ensuring continuity of supply when local stock shortages occur.
- Privacy‑focused handling – packaging is unmarked and sealed, respecting patient confidentiality throughout the order journey.
Our platform is designed for adults who may have limited availability of propranolol through traditional community pharmacies or who are looking for a cost‑effective generic alternative without compromising safety.
FAQ
-
Is Inderal La available in both brand‑name and generic forms in the UK?
Yes. The original brand is Inderal‑LA, but generic propranolol tablets are also licensed and widely prescribed. Both contain the same active ingredient and meet MHRA quality standards. -
Can Inderal La be safely stored in a bathroom cabinet?
The medication should be kept at a controlled room temperature (15‑30 °C) and protected from moisture. A bathroom cabinet is often humid, which may degrade the tablet; a dry kitchen drawer or bedroom shelf is preferable. -
What does the tablet look like and how is it marked?
Inderal La tablets are oval, film‑coated, and typically scored In the UK they are pale pink and imprinted with “80 mg LA”. Appearance may vary slightly between manufacturers, but the imprint will always indicate the dose and extended‑release nature. -
Are there any special considerations for travelling with Inderal LA?
Carry the medication in its original packaging with the pharmacy label, and keep it in hand luggage to avoid temperature extremes in the cargo hold. A copy of the prescription or a doctor’s note can be helpful at security checkpoints. -
Does the extended‑release formulation affect drug testing?
Propranolol is not screened for in standard occupational drug tests. However, if a specialised beta‑blocker assay is requested, the presence of the drug may be detected regardless of formulation. -
Can Inderal LA be imported for personal use under UK law?
Personal import of prescription medicines is permitted in limited quantities (up to a three‑month supply) if the patient holds a valid UK prescription. Our online pharmacy ensures all shipments comply with the Medicines Act 1968 and customs regulations. -
How does the UK’s NICE guidance position propranolol for hypertension?
NICE recommends β‑blockers like propranolol as second‑line therapy for patients with hypertension who also need heart‑rate control or have co‑existing coronary artery disease. The guidance emphasises individual risk assessment and tolerability. -
Are there known differences between US and UK propranolol formulations?
The active ingredient is identical, but excipients may vary (e.g., different film‑coating polymers). These differences are not clinically significant for most patients, although rare allergies to certain dyes may necessitate checking the ingredient list. -
What is the history behind propranolol’s development?
Propranolol was synthesised by Sir James Black in the early 196s and received its first approval in 1965. It was the first clinically successful non‑selective β‑blocker and earned Sir James a Nobel Prize for Medicine in 1988. -
Does taking Inderal LA influence vaccination efficacy?
Beta‑blockers do not impair the immune response to routine vaccines. Patients on propranolol can receive influenza, COVID‑19, and other vaccinations without dose adjustment. -
Is there a risk of dependence or withdrawal with Inderal LA?
Physical dependence is uncommon, but abrupt discontinuation can precipitate rebound tachycardia, hypertension, or angina. Tapering the dose over 1–2 weeks under medical supervision is advised. -
What are the inactive ingredients in Inderal LA tablets?
Typical excipients include lactose monohydrate, microcrystalline cellulose, povidone, and magnesium stearate. Patients with lactose intolerance should discuss alternatives with their prescriber.
Glossary
- β‑Blocker
- A class of medication that blocks the action of adrenaline on β‑adrenergic receptors, reducing heart rate, contractility and blood pressure.
- Extended‑Release (ER)
- A pharmaceutical formulation designed to release the active drug slowly over an extended period, allowing once‑daily dosing and more stable blood concentrations.
- First‑Pass Metabolism
- The rapid uptake and conversion of a drug by the liver after oral administration, which can significantly reduce the amount of active drug reaching systemic circulation.
- Bradycardia
- An abnormally slow heart rate, usually defined as fewer than 60 beats per minute in adults.
⚠️ Disclaimer
The information provided about Inderal La is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Inderal La for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.