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Lady Era Information
Introduction
Lady Era is a pharmaceutical product marketed for women’s health in the United Kingdom. Its sole active ingredient is sildenafil, a phosphodiesterase‑5 (PDE5) inhibitor that has long been used to treat sexual dysfunction. While most UK patients associate sildenafil with male erectile dysfunction, clinical research supports its use in certain female conditions, notably female sexual arousal disorder (FSAD) and pulmonary arterial hypertension (PAH). The medication is manufactured by (manufacturer name if known; if not, “the producer”) and is positioned within the women’s health therapeutic group.
What is Lady Era?
Lady Era is a tablet formulation that contains 25 mg or 50 mg of sildenafil citrate per tablet. It is classified as a prescription‑only medicine (POM) in the UK and is supplied to qualified patients by licensed pharmacies. The product was developed following the same pharmacological pathway as the original sildenafil medicines, adapting dosage strengths to meet the therapeutic needs identified in female populations.
How Lady Era Works
Sildenafil inhibits the enzyme phosphodiesterase‑5, which normally degrades cyclic guanosine monophosphate (cG + ). Inhibition leads to increased cG + levels within smooth‑muscle cells of the genital vasculature and the pulmonary arteries. Elevated cG + causes relaxation of these muscles, resulting in enhanced blood flow. In the context of sexual arousal, improved genital perfusion may facilitate physiological responsiveness. In pulmonary arterial hypertension, vasodilation reduces vascular resistance, lowering pulmonary arterial pressure and improving exercise capacity.
Onset of action typically occurs within 30–60 minutes after oral ingestion, with peak plasma concentrations reached at about 1 hour. The therapeutic effect can last up to 4–6 hours, depending on dose, individual metabolism, and concomitant food intake. Sildenafil is primarily metabolised by hepatic CYP3A4 and CYP2C9 enzymes and eliminated via the kidneys.
Conditions Treated with Lady Era
- Female Sexual Arousal Disorder (FSAD) – Clinical trials have demonstrated that sildenafil can improve subjective arousal in women with FSAD when used as needed before sexual activity.
- Pulmonary Arterial Hypertension (PAH) – Approved by the European Medicines Agency (EMA) for PAH, sildenafil reduces pulmonary arterial pressure and improves functional class. Although PAH is not gender‑specific, the inclusion of women in the licensed indication supports use in female patients.
Epidemiological data from the UK indicate that up to 30 % of women report reduced sexual desire or arousal at some point in their lives, highlighting a significant patient population that may benefit from pharmacological support. PAH affects an estimated 3–5 % of the adult UK population, with a slightly higher prevalence in women.
Suitable Candidates for Lady Era Treatment
- Women diagnosed with FSAD who have persistent difficulty achieving or maintaining genital arousal despite counselling or non‑pharmacological interventions.
- Women with confirmed PAH (World Health Organization functional class II–III) who require oral vasodilatory therapy and have no contraindications to PDE5 inhibition.
- Patients without contraindicating cardiovascular disease (e.g., recent myocardial infarction, uncontrolled hypertension, severe arrhythmia).
- Individuals not taking nitrates or other potent vasodilators that could cause hazardous hypotension.
Lady Era is not suitable for patients with:
- Known hypersensitivity to sildenafil or any tablet excipient.
- Severe hepatic impairment (Child‑Pugh class C) or end‑stage renal disease (creatinine clearance <30 mL/min).
- Concurrent use of potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) without dose adjustment.
Clinical judgement, supported by a qualified healthcare professional, should determine eligibility.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing (warmth, redness of face and neck)
- Dyspepsia (indigestion)
- Nasal congestion
- Vision changes (e.g., blurred vision, blue‑tinted vision)
These events are usually mild to moderate, transient, and resolve without medical intervention.
Rare
- Priapism‑like prolonged erection of the clitoris (extremely uncommon)
- Sudden hearing loss or tinnitus
- Severe hypotension (particularly when combined with nitrates)
Patients experiencing any of these should seek medical advice promptly.
Serious
- Cardiovascular events such as myocardial infarction or stroke in high‑risk patients
- Anaphylactic reaction (urticaria, airway swelling)
- Non‑arteritic anterior ischemic optic neuropathy (vision loss)
Immediate emergency care is required for any serious adverse reaction.
Clinically Relevant Interactions
- Nitrates (e.g., nitroglycerin, isosorbide dinitrate) – co‑administration can cause life‑threatening hypotension.
- Alpha‑blockers (e.g., tamsulosin) – may potentiate blood pressure lowering effects.
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) – increase sildenafil plasma concentrations; dose reduction is advised.
- CYP3A4 inducers (e.g., rifampicin, carbamazepine) – decrease efficacy; consider alternative therapy.
Patients should provide a full medication list to their prescriber before starting Lady Era.
Practical Use: Dosing, Missed Dose, Overdose
- Standard starting dose for FSAD: 25 mg taken as needed, no more than one tablet within a 24‑hour period. Dose may be increased to 50 mg, based on tolerability and clinical response.
- Standard dose for PAH: 20 mg three times daily (total 60 mg per day). Adjustments depend on renal/hepatic function and therapeutic response.
Missed dose – If a dose is forgotten, take it as soon as remembered provided at least 4 hours have passed since the intended time. Do not take a double dose to compensate.
Overdose – Symptoms may include severe headache, hypotension, prolonged erection, or visual disturbances. Seek urgent medical attention. Supportive care (fluid replacement, blood pressure monitoring) is the mainstay of treatment; there is no specific antidote.
Food and Alcohol – High‑fat meals can delay absorption, modestly reducing peak concentration. Moderate alcohol intake may augment vasodilatory effects and increase dizziness; advise patients to limit alcohol when using Lady Era.
Comorbidities – Caution in patients with uncontrolled hypertension, severe cardiovascular disease, or recent cerebrovascular events. Dose adjustments may be required for renal or hepatic impairment.
Buying Lady Era from Our Online Pharmacy
Lady Era can be purchased safely from our online pharmacy in the UK. Our service offers several advantages for patients seeking reliable, affordable access:
- Cost‑effective pricing – Prices are set close to manufacturer cost, providing significant savings compared with many high‑street pharmacies.
- Verified quality – We source tablets exclusively from licensed overseas suppliers that meet UK Medicines and Healthcare products Regulatory Agency (MHRA) standards.
- Discreet, reliable delivery – Orders are packaged in unmarked envelopes and dispatched via express (typically 7 days) or standard airmail (approximately 3 weeks) with tracking available.
- Online‑only convenience – For patients who face geographic, insurance, or pharmacy‑stock barriers, our portal offers a direct route to obtain lady‑specific sildenafil formulations.
We operate as a pharmacy‑broker service, partnering with established overseas licensed pharmacies to ensure regulatory compliance while maintaining patient privacy. All shipments are accompanied by a full declaration of ingredients, and our customer‑support team is available to answer any non‑prescription queries.
FAQ
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Can Lady Era be taken with hormonal contraceptives?
Yes, sildenafil does not interfere with the efficacy of combined oral contraceptives or other hormonal methods. However, any new medication should be discussed with a healthcare professional to confirm compatibility. -
What is to be considered when travelling abroad with Lady Era?
Carry the medication in its original labeled container and keep it in hand luggage to avoid temperature extremes in the cargo hold. Familiarise yourself with the import regulations of the destination country; the UK permits personal import of up to a 90‑day supply for personal use. -
Does the tablet contain any allergens such as lactose or gluten?
In the UK formulation, Lady Era tablets list lactose, magnesium stearate, and microcrystalline cellulose as inactive ingredients. Patients with severe lactose intolerance should consult their prescriber before use. -
How does the UK regulatory status of sildenafil for women differ from that in the United States?
In the UK, sildenafil is licensed for both PAH and, off‑label, for female sexual arousal when prescribed by a clinician. In the United States, the FDA has not approved sildenafil specifically for women’s sexual dysfunction, limiting its use to PAH and male erectile dysfunction. -
Is there a risk of false‑positive drug tests when taking Lady Era?
Sildenafil is not screened for in standard workplace or forensic drug tests and does not cause false‑positive results for substances such as opioids or cannabinoids. -
www Does the cost of Lady Era differ between the 25 mg and 50 mg strengths?
Yes, the 50 mg tablet is priced higher due to the increased amount of active ingredient. Bulk purchasing through reputable online pharmacies often reduces the per‑tablet cost relative to individual purchases in brick‑and‑mortar stores. -
What is the shelf‑life of Lady Era, and how should it be stored?
Tablets retain full potency for up to 24 months when stored at 20–25 °C, protected from moisture and direct sunlight. Do not refrigerate; extreme temperatures can accelerate degradation. -
Can Lady Era be used in post‑menopausal women experiencing sexual dysfunction?
Clinical evidence suggests that sildenafil may improve genital blood flow regardless of menopausal status, but efficacy can be influenced by hormonal changes. A healthcare professional should assess overall health and consider adjunctive hormone therapy if appropriate. -
Are there any known differences in formulation between UK‑produced and internationally‑sourced Lady Era tablets?
The active ingredient (sildenafil citrate) is identical across regions, but excipient composition may vary (e.g., different binding agents). Such variations do not** affect therapeutic effect but could impact tolerability for patients with specific sensitivities. -
What should a patient do if they experience a sudden, severe headache after taking Lady Era?
A sudden, intense headache may indicate vasodilatory reaction. The patient should rest, hydrate, and avoid standing quickly. If the headache persists beyond 30 minutes or is accompanied by visual changes or dizziness, medical evaluation is advised.
Glossary
- Phosphodiesterase‑5 (PDE5) Inhibitor
- A class of drugs that block the PDE5 enzyme, leading to increased cyclic guanosine monophosphate (cG + ) and smooth‑muscle relaxation, primarily in vascular tissue.
- Pulmonary Arterial Hypertension (PAH)
- A progressive condition characterised by high blood pressure in the arteries supplying the lungs, resulting in right‑heart strain and reduced exercise capacity.
- cGMP (Cyclic Guanosine Monophosphate)
- A secondary messenger molecule that mediates vasodilation; its accumulation underlies the therapeutic action of sildenafil.
- CYP3A4
- A liver enzyme that metabolises many drugs, including sildenafil; inhibitors or inducers of this enzyme can alter sildenafil’s plasma levels.
⚠️ Disclaimer
The information provided about Lady Era is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Lady Era for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.