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Generic Levitra With Dapoxetine Information
Introduction
Levitra With Dapoxetine is a fixed‑dose combination that contains the active ingredients vardenafil and dapoxetine. Vardenafil is a phosphodiesterase‑5 (PDE5) inhibitor traditionally used to treat erectile dysfunction (ED), while dapoxetine is a short‑acting selective serotonin‑reuptake inhibitor (SSRI) approved for premature ejaculation (PE). By addressing both vasodilatory and serotonergic pathways, the product is positioned for men who experience concurrent erectile and ejaculation concerns. The formulation is marketed under the men's health group and is relevant to adult patients in the United Kingdom who seek a dual‑action oral therapy.
What is Levitra With Dapoxetine?
Levitra With Dapoxetine is a combination tablet that brings together two well‑studied agents:
- Vardenafil – the same active compound found in the brand‑name product Levitra, a PDE5 inhibitor that enhances penile blood flow in response to sexual stimulation.
- Dapoxetine – the same active compound found in the brand‑name product Priligy, a rapid‑acting SSRI that increases the latency to ejaculation.
The product is manufactured by a licensed pharmaceutical company that adheres to European Union (EU) Good Manufacturing Practice (GMP) standards. While the individual components have distinct commercial identities, the combined tablet is evaluated as a single medicinal product for the treatment of combined erectile dysfunction and premature ejaculation in adult men.
How Levitra With Dapoxetine Works
Vardenafil inhibits the enzyme PDE5 in the smooth muscle of the corpus cavernosum. Normally, PDE5 breaks down cyclic guanosine monophosphate (cGMP), a messenger that promotes smooth‑muscle relaxation. By blocking PDE5, vardenafil raises cGMP levels, allowing the penis to fill with blood when nitric oxide is released during sexual arousal. The clinical effect is a spontaneous, firm erection within 30–60 minutes after intake, lasting up to 4–6 hours depending on age, hepatic function, and concomitant medications.
Dapoxetine exerts its effect by inhibiting the re‑uptake of serotonin at the synaptic cleft, leading to a brief increase in central serotonergic tone. Higher serotonin activity is associated with a delayed ejaculatory reflex, extending the intravaginal ejaculatory latency time (IELT). Dapoxetine has a short half‑life of ~1 hour, which limits systemic exposure and reduces the risk of long‑term serotonergic side effects commonly seen with standard SSRI therapy.
When taken together, the rapid onset of vardenafil’s vasodilatory action and dapoxetine’s ejaculatory‑delay effect provide a coordinated therapeutic response: a reliable erection that can be maintained without premature ejaculation. The combination therefore aligns pharmacokinetic and pharmacodynamic profiles to optimise sexual performance during a single dosing window.
Conditions Treated with Levitra With Dapoxetine
Indication | Clinical relevance (UK) | Rationale for use |
---|---|---|
Erectile dysfunction (ED) | Approximately 1.9 % of men in the UK (≈ 1 million) report chronic ED (ONS, 2022). | Vardenafil improves penile hemodynamics, restoring satisfactory erections. |
Premature ejaculation (PE) | Prevalence of lifelong PE estimated at 5–10 % of adult men in the UK (British Society for Sexual Medicine, 2021). | Dapoxetine increases IELT, reducing distress linked to early ejaculation. |
Combined ED + PE | Clinical surveys suggest 15–20 % of men with ED also experience PE (BMJ Sexual & Reproductive Health, 202). | Simultaneous targeting of both mechanisms improves overall sexual satisfaction and relationship quality. |
The product is not approved for other conditions such as hypertension, angina, or depression.
Who is Levitra With Dapoxetine For?
Suitable candidates are adult men (≥ 18 years) who:
- Have a confirmed diagnosis of erectile dysfunction requiring a PDE5‑inhibiting agent.
- Experience premature ejaculation that responds to short‑acting SSRI therapy.
- Require a rapid, on‑demand solution rather than chronic daily dosing.
- Possess no contraindications to either vardenafil or dapoxetine (e.g., no nitrate therapy, no severe cardiovascular disease, no hepatic impairment that elevates vardenafil exposure).
Contra‑indications include:
- Concomitant use of nitrates or nitric‑oxide donors.
- Known hypersensitivity to vardenafil, dapoxetine, or any tablet excipients.
- Significant uncontrolled hypertension, retinitis pigmentosa, or recent myocardial infarction.
- Severe hepatic or renal impairment (eGFR < 30 mL/min) without specialist oversight.
Physicians should assess individual risk before prescribing, particularly for men with cardiovascular co‑morbidities.
Risks, Side Effects, and Interactions
Common
- Flushing or warmth sensation
- Headache
- Nasal congestion or “stuffiness”
- Dizziness or light‑headedness (often related to blood pressure changes)
- Nausea or dyspepsia
These events are typically mild, transient, and resolve without medical intervention.
Rare
- Priapism (prolonged erection lasting > 4 hours)
- Visual disturbances (blurred vision, colour perception changes)
- Mood changes or anxiety (linked to dapoxetine’s serotonergic activity)
- Allergic skin reactions (rash, pruritus)
Patients should seek prompt medical attention if any of these symptoms develop.
Serious
- Cardiovascular events (myocardial infarction, stroke, severe hypotension) in patients with underlying heart disease or concomitant nitrate use.
- Severe hypersensitivity reactions (angio‑edema, anaphylaxis).
- Serotonin syndrome when combined with other serotonergic agents (e.g., MAO inhibitors, certain antidepressants).
Serious adverse events require immediate emergency care and cessation of the medication.
Key drug–drug interactions
- Nitrates (e.g., glyceryl trinitrate) – additive vasodilation → dangerous drop in blood pressure.
- Alpha‑blockers (e.g., tamsulosin) – may amplify hypotensive effect.
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – increase vardenafil plasma levels, heightening risk of side effects.
- Other SSRIs or serotonergic agents – raise risk of serotonin syndrome when combined with dapoxetine.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements.
Practical Use: Dosing, Missed Dose, Overdose
Standard dosing
- Initial adult dose commonly 10 mg of vardenafil + 20 mg dapoxetine taken about 1 hour before sexual activity.
- If tolerated, dose may be increased to 20 mg vardenafil (single tablet) and 40 mg dapoxetine; the maximum dose is 20 mg vardenafil/ 40 mg dapoxetine per day.
- No more than one tablet per 24 hours.
Missed dose
- Because the tablet is intended for use on demand, a missed dose does not require a make‑up schedule.
- If planning sexual activity later on the same day, a full tablet may still be taken provided the minimum interval of 24 hours since the previous dose is respected.
Overdose
- In the event of accidental overdose (e.g., two tablets taken within 24 hours), patients should monitor for severe hypotension, pronounced dizziness, or prolonged erection.
- Immediate medical assessment is advised; symptomatic treatment (intravenous fluids, antihypertensives) may be required.
- Contact the UK Poison Information Service (POIS) at 030 120 012 for guidance.
Precautions
- Avoid large, high‑fat meals directly before ingestion as they may delay onset.
- Limit excessive alcohol (> 3 units) as it can exacerbate vasodilatory effects and increase dizziness.
- Caution in patients with moderate hepatic or renal impairment; dose reduction may be indicated per specialist advice.
Buying Levitra With Dapoxetine from Our Online Pharmacy
Levitra With Dapoxetine can be obtained from our online pharmacy in the UK. Our service offers:
- Affordable pricing – generic formulations are sourced at near‑manufacturer cost, providing a lower‑price alternative to brand‑name products.
- Verified quality – all batches come from GMP‑certified suppliers, with each shipment accompanied by a certificate of analysis.
- Guaranteed delivery – discrete, tamper‑evident packaging delivered within 7 days (express) or ≈ 3 weeks (standard airmail).
- International access – as a pharmacy‑broker service we work with licensed overseas pharmacies, ensuring a discreet supply chain that respects patient privacy and complies with UK import regulations.
Patients who face limited availability through local NHS pharmacies or whose insurance does not cover the medication may find our model a safe, cost‑effective route to treatment.
FAQ
-
Is Levitra With Dapoxetine available in both brand‑name and generic forms in the UK?
Yes. The original brand‑name product combines vardenafil (Levitra) and dapoxetine (Priligy). Generic equivalents contain the same active ingredients in an identical dosage and are marketed at a lower price point. -
How should I store Levitra With Dapoxetine at home?
Store the tablets at room temperature (15 °C–30 °C), away from direct sunlight, moisture, and heat. Do not keep them in a bathroom or kitchen cabinet where humidity may be high. -
Can I travel with Levitra With Dapoxetine and keep it stable?
The medication is stable for the duration of a typical flight. Keep the tablet in its original packaging, avoid exposing it to extreme temperatures (e.g., checked luggage near cargo holds), and do not exceed the recommended 24‑hour dosing interval. -
What does the tablet look like and are there any visible markings?
The combination tablet is typically film‑coated, round, and blue‑silver with imprint “V‑Dn 10/20” indicating the vardenafil (10 mg) and dapoxetine (20 mg) strengths. Inactive ingredients include lactose, magnesium stearate, and film‑coating agents. -
Is there a difference in formulation between UK and EU batches?
All UK‑marketed tablets must meet the EU‑wide GMP standards and contain the same excipients. Minor regional adjustments (e.g., labeling language) do not affect the pharmacological profile. -
Are there specific warnings for men with certain heart conditions?
Men with unstable angina, recent myocardial infarction (< 6 weeks), or those on nitrate therapy should not use the product because the combined vasodilatory effect can cause hazardous hypotension. -
Will using Levitra With Dapoxetine affect a routine drug test?
Vardenafil and dapoxetine are not typically screened for in standard workplace drug panels. However, specialized testing for PDE5 inhibitors or SSRIs could detect the compounds if requested. -
Are there any UK personal‑import rules I should know before ordering?
The UK permits the personal import of a three‑month supply of prescription medicines for personal use, provided a valid prescription is held. Our online pharmacy ensures that the product conforms to the UK Medicines Act 1968 and ships with appropriate documentation. -
Can temperature extremes (e.g., leaving the tablet in a hot car) reduce its effectiveness?
Exposure to temperatures above 40 °C for prolonged periods may degrade the active ingredients, potentially diminishing therapeutic effect. It is advisable to keep tablets in a cool, stable environment. -
How does Levitra With Dapoxetine compare to taking each component separately?
Clinical data indicate that a fixed‑dose combination improves medication adherence and reduces the time to achieve optimal sexual performance, as the patient does not need to coordinate two separate tablets. Pharmacokinetic interactions are minimal because dapoxetine’s short half‑life does not significantly interfere with vardenafil metabolism.
Glossary
- Phosphodiesterase‑5 (PDE5) inhibitor
- A class of drugs that blocks the PDE5 enzyme, raising cGMP levels in penile tissue to promote smooth‑muscle relaxation and increased blood flow during sexual stimulation.
- Selective serotonin‑reuptake inhibitor (SSRI)
- A type of antidepressant that blocks the reabsorption of serotonin into neurons, increasing its availability in the synaptic cleft; dapoxetine is a rapid‑acting SSRI specifically formulated for premature ejaculation.
- Intravaginal ejaculatory latency time (IELT)
- The measured interval between vaginal penetration and ejaculation; a primary endpoint in clinical trials of premature‑ejaculation treatments.
- Therapeutic window
- The range of drug concentrations in which a medication is effective without causing unacceptable side effects; for Levitra With Dapoxetine, the window is defined by the approved dosing range.
⚠️ Disclaimer
The information provided about Levitra With Dapoxetine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Levitra With Dapoxetine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.