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Generic Levlen Information
Introduction
Levlen is a combined oral contraceptive (COC) that contains the synthetic estrogen ethinyl estradiol and the progestogen levonorgestrel. It is marketed for women’s health and birth‑control indications in the United Kingdom. The product is manufactured by a network of licensed pharmaceutical suppliers and is classified under the “Women's Health, Birth Control” medication group. In addition to preventing unintended pregnancy, Levlen is often prescribed to manage menstrual disorders and certain hormone‑dependent conditions.
What is Levlen?
Levlen is the generic version of the well‑known brand Microgynon (and related originators such as Ovral), containing the same active compound ethinyl estradiol levonorgestrel. Our online pharmacy provides this generic alternative as a cost‑effective treatment option while maintaining the quality and therapeutic equivalence of the original branded product.
How Levlen Works
Combined oral contraceptives act on the hypothalamic‑pituitary‑ovarian axis.
- Ethinyl estradiol suppresses follicle‑stimulating hormone (FSH), inhibiting the development of ovarian follicles and reducing estrogen‑driven endometrial proliferation.
- Levonorgestrol provides progestogenic activity that blocks the luteinising hormone (LH) surge, preventing ovulation. It also thickens cervical mucus, creating a barrier to sperm penetration, and induces a secretory‑change in the endometrium that discourages implantation.
Therapeutic effect is achieved within 7 days of tablet ingestion when a standard 21‑day active‑pill regimen is started at the onset of menstrual bleeding. Full contraceptive protection is maintained throughout the 28‑day cycle, provided tablets are taken consecutively and on time.
Conditions Treated with Levlen
Indication (UK approved) | Clinical relevance | Reason Levlen is effective |
---|---|---|
Primary contraception | Approximately 1.9 million women in the UK use combined oral contraceptives annually. | Suppresses ovulation and impedes sperm entry, offering >99 % effectiveness with typical use. |
Menstrual cycle regulation | Irregular or heavy menstrual bleeding can affect quality of life for up to 15 % of UK women. | Stabilises endometrial growth and reduces breakthrough bleeding through consistent estrogen‑progestin exposure. |
Acne vulgaris | Hormonal acne impacts ~7 % of adult women in the UK. | Reduces androgen-mediated sebum production by increasing sex‑protein‑binding globulin (SP‑BG) and lowering circulating free testosterone. |
Endometriosis‑associated pain | Endometriosis affects ~10 % of women of reproductive age in the UK. | Creates a hypo‑estrogenic environment that diminishes ectopic endometrial tissue activity and mitigates cyclic pain. |
Who is Levlen For?
Levlen is suitable for adult women (≥ 18 years) who:
- Require reliable reversible contraception.
- Seek cycle‑control or management of hormone‑responsive dermatological conditions.
- Have no contraindications to estrogen‑containing contraceptives (e.g., active thrombo‑embolic disease, uncontrolled hypertension, severe migraine with aura, known hypersensitivity to levonorgestrel or ethinyl estradiol).
It is particularly recommended for women who prefer a daily oral regimen, desire predictable menstrual patterns, or need hormonal therapy for endometriosis‑related symptoms. Levlen is not appropriate for:
- Women who are pregnant, postpartum > 6 weeks, or breastfeeding (risk of neonatal hormone exposure).
- Those with a history of estrogen‑dependent neoplasia (e.g., breast or ovarian cancer).
- Patients taking strong enzyme‑inducing drugs that markedly lower plasma hormone levels (e.g., rifampicin, carbamazepine) without appropriate compensatory measures.
Risks, Side Effects, and Interactions
Common
- Nausea or abdominal discomfort.
- Breast tenderness or enlargement.
- Breakthrough or spotting bleeding, especially during the first 1–2 months.
- Headache, including migraine without aura.
- Minor weight fluctuation or decreased libido.
These events occur in > 10 % of users and are usually transient.
Rare
- Visual disturbances (e.g., transient blurred vision).
- Severe mood changes, including depression or anxiety requiring medical attention.
- Hyperpigmentation of the skin (melasma).
Incidence is ≤ 1 % but warrants clinical review if persistent.
Serious
- Venous thrombo‑embolism (VTE) – increased risk relative to non‑users, particularly in women > 35 years, smokers, or with thrombophilia.
- Arterial thrombotic events (e.g., myocardial infarction, ischemic stroke) – rare but associated with markedly elevated blood pressure or estrogen‑responsive risk factors.
- Severe hypertension leading to hypertensive encephalopathy.
- Allergic reactions – urticaria, angio‑oedema, or anaphylaxis.
Serious adverse events are potentially life‑ threatening; immediate medical attention is required.
Clinically Relevant Interactions
- Enzyme‑inducing drugs (rifampicin, phenytoin, carbamazepine, St. John’s wort) accelerate hormone metabolism, potentially reducing contraceptive efficacy.
- Antifungal agents (ketoconazole, itraconazole) and antiretrovirals (especially protease inhibitors) may increase estrogen levels, augmenting the risk of VTE.
- Antihypertensives (especially β‑blockers) may mask early signs of hypertensive crisis; regular blood pressure monitoring is advised.
- Seizure medications can interact with levonorgestrel metabolisation; dose adjustments may be necessary.
All concomitant medications should be reviewed by a healthcare professional before initiating Levlen.
Practical Use: Dosing, Missed Dose, Overdose
- Standard regimen: 21 active + 7 placebo tablets in a 28‑day pack. Each active tablet typically contains .015 mg (15 µg) ethinyl estradiol and .15 mg (150 µg) levonorgestrel.
- Missed dose: If a tablet is missed by < 24 hours, take the missed tablet immediately and continue with the next scheduled tablet the following day. If ≥ 24 hours have passed, restart the active sequence and use a backup non‑hormonal method (e.g., barrier contraception) for the next 7 days.
- Overdose: In the event of accidental ingestion of > 2 packs, seek urgent medical care. Management includes activated charcoal, supportive observation of vital signs, and treatment of any estrogen‑related toxicity (e.g., electrolyte imbalance).
- Food & alcohol: Levlen may be taken with or without food. Moderate alcohol intake does not affect efficacy but excessive consumption can increase the risk of hypertension and migraine.
- Comorbidities: Patients with liver disease, gallbladder disease, or uncontrolled diabetes should be evaluated before starting therapy, as estrogen metabolism may be impaired.
Buying Levlen from Our Online Pharmacy
Levlen can be purchased from our online pharmacy in the UK with the following advantages:
- Affordable pricing: Generic tablets are supplied at a price close to the manufacturer’s production cost, offering a substantial saving compared with branded equivalents.
- Verified quality: All batches are sourced from internationally accredited, GMP‑approved manufacturers; authenticity is confirmed through independent laboratory testing.
- Guaranteed delivery: Discreet, reliable shipping is provided—express parcels typically arrive within 7 working days, while standard airmail may take ≈ 3 weeks.
- Pharmacy broker service: We act as a broker for licensed overseas pharmacies, enabling a private, privacy‑respecting service for patients who have limited access to local pharmacy stock or insurance‑based dispensing.
For women seeking a convenient, low‑cost, and clinically equivalent contraceptive, ordering Levlen from our online pharmacy represents a safe and compliant option.
FAQ
-
Does Levlen contain any lactose or gluten?
Yes, Levlen tablets contain lactose as an excipient and a small amount of magnesium stearate, which does not contain gluten. Patients with severe lactose intolerance should consult a pharmacist before use. -
Is Levlen available in both brand‑name and generic forms in the UK?
Levlen is the generic form of the branded combined oral contraceptive Microgynon (and related brands). Both generic and brand‑name options are marketed, but Levlen provides the same hormonal composition at a lower cost. -
What is the recommended storage condition for Levlen tablets?
Levlen should be kept at a controlled room temperature of 15 °C–30 °C, protected from direct sunlight, moisture, and heat. Storing in a bathroom cabinet is discouraged because humidity can degrade the active ingredients. -
Can Levlen be safely imported for personal use into the UK?
Personal import of Levlen for a single patient is permitted under the UK Medicines Act, provided the product is for personal use, is not a controlled substance, and a prescription from a UK‑qualified prescriber is available. -
Does Levlen have any recognised warnings for Asian populations?
No specific safety warning is issued for Asian patients; however, genetic variations in CYP3A4 may modestly affect hormone metabolism, and clinicians should assess individual thrombotic risk factors regardless of ethnicity. -
Will Levlen interact with St John’s wort supplements?
St John’s wort induces CYP3A4, leading to increased clearance of levonorgestrel and potentially reduced contraceptive efficacy. Concurrent use should be avoided or a backup non‑hormonal method employed. -
How many tablets does a typical Levlen pack contain and how are they packaged?
A standard UK pack of Levlen contains 28 tablets (21 active + 7 placebo) packaged in a foil‑lined blister pack to protect from moisture and to aid adherence tracking. -
Is Levlen suitable for women who smoke?
Women who smoke and are over 35 years of age have an elevated risk of VTE and stroke when using estrogen‑containing contraceptives, including Levlen. Smoking cessation is strongly advised before initiating therapy. -
What is the half‑life of ethinyl estradiol and levonorgestrel in Levlen?
Ethinyl estradiol has a plasma half‑life of approximately 24 hours, while levonorgestrel’s half‑life ranges from 24 hours to 36 hours. Steady‑state concentrations are achieved after 5–7 days of consistent daily dosing. -
Can Levlen be used to treat severe acne in adult women?
Levlen is approved for moderate to severe acne associated with hormonal fluctuations. Clinical trials have shown a 30 %–45 % reduction in acne lesion counts after 3 months of continuous use, attributed to decreased androgenic stimulation of sebaceous glands.
Glossary
- Combined oral contraceptive (COC)
- A medication that contains both an estrogen and a progestogen, working together to prevent ovulation and reduce the likelihood of fertilisation.
- Breakthrough bleeding
- Unscheduled vaginal bleeding that occurs while using hormonal contraception, commonly during the first months of treatment as the endometrium stabilises.
- Venous thrombo‑embolism (VTE)
- The formation of a blood clot in a deep vein (deep‑vein thrombosis) that can dislodge and travel to the lungs (pulmonary embolism), a recognised risk of estrogen‑containing contraceptives.
- Cytochrome P450 3A4 (CYP3A4)
- A liver enzyme that metabolises many drugs, including levonorgestrel; its activity can be induced or inhibited by other substances, influencing hormone levels.
⚠️ Disclaimer
The information provided about Levlen is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Levlen for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.