Buy Generic Lozol Online

Generic Lozol Information

Introduction

Lozol is a diuretic medication whose active ingredient is indapamide. It belongs to the thiazide‑like diuretic class and is primarily used for the management of hypertension and for the removal of excess fluid in conditions such as oedema. In the United Kingdom, indapamide is listed in the British National Formulary (BNF) as a first‑line agent for uncomplicated high blood pressure and for adjunct therapy in heart‑failure‑related fluid overload. While the drug is sometimes available under brand‑name products, Lozol provides the same therapeutic molecule at a lower cost.

What is Lozol?

• Lozol is the generic version of the original brand name Indapamide, which has been marketed under names such as Nolva in several European markets.
• The medication contains the single active compound indapamide, a thiazide‑like diuretic that reduces sodium re‑absorption in the distal renal tubules.
• It is manufactured by licensed pharmaceutical companies that hold marketing authorisation for ind‑based products in the EU/UK. The exact manufacturer may vary, but all suppliers must comply with the Medicines and Healthcare products Regulatory Agency (MHRA) standards.
• Our online pharmacy provides this generic alternative as a cost‑effective treatment option for patients who need to control blood pressure or manage fluid retention.

How Lozol Works

Indapamide inhibits the sodium‑chloride symporter located in the early distal convoluted tubule of the nephron. By blocking this transporter, the drug decreases the re‑absorption of sodium and chloride, which leads to a modest increase in urinary sodium excretion. Water follows the osmotic gradient, producing a net diuretic effect that reduces plasma volume.

The reduction in intravascular volume lowers cardiac preload and, consequently, systemic arterial pressure. In addition, indapamide has a direct vasodilatory action on arterial smooth muscle, which further contributes to blood‑pressure reduction. Onset of diuretic action typically occurs within 2–4 hours after oral dosing, and the antihypertensive effect can be sustained for up to 24 hours due to the drug’s long half‑life (approximately 14 hours). Renal clearance is the principal route of elimination, and the drug is not extensively metabolised, allowing predictable pharmacokinetics across a broad adult population.

Conditions Treated with Lozol

• Essential (primary) hypertension – Indapamide is recommended by the NICE hypertension guideline as a first‑line option, either alone or in combination with a calcium‑channel blocker.
• Congestive heart failure with fluid overload – The diuretic effect reduces peripheral oedema and pulmonary congestion, improving symptoms and exercise tolerance.
• Chronic kidney disease‑related oedema – In patients with reduced glomerular filtration rate (GFR), indapamide provides a gentle diuresis that avoids rapid electrolyte shifts.

In the UK, hypertension affects approximately 30 % of adults (> 45 years), representing a major public‑health burden. Effective blood‑pressure control with agents such as indapamide lowers the risk of stroke, myocardial infarction, and renal impairment.

Who is Lozol For?

• Adults with newly diagnosed primary hypertension – Those who are not yet on any antihypertensive medication and have a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg.
• Patients requiring low‑dose diuresis – Individuals with mild to moderate peripheral oedema, especially when combined with ACE‑inhibitors or ARBs.
• Patients with preserved renal function – Indapamide is safest in those with a creatinine clearance > 30 mL/min; dose adjustment is advised for poorer renal function.
• Patients who prefer a once‑daily regimen – The long‑acting profile permits a single morning dose, improving adherence.

Not appropriate for:

• Severe renal impairment (eGFR < 30 mL/min) without specialist supervision.
• Known hypersensitivity to indapamide or other thiazide‑like diuretics.
• Women who are pregnant or breastfeeding, as safety data are limited.

Risks, Side Effects, and Interactions

Common

• Electrolyte disturbance – Mild hyponatraemia or hypokalaemia may occur, especially when combined with other diuretics.
• Increased uric acid – Can precipitate gout flares in susceptible individuals.
• Headache or dizziness – Often related to volume depletion; advise patients to rise slowly from sitting/lying positions.

Rare

• Photosensitivity – Skin reactions to sunlight have been reported; patients should use sunscreen during outdoor activities.
• Hypoglycaemia – In diabetic patients taking sulfonylureas, indapamide may enhance insulin sensitivity.

Serious

• Severe electrolyte imbalance – Marked hyponatraemia or hypokalaemia can lead to cardiac arrhythmias; laboratory monitoring is recommended after initiation.
• Acute renal failure – Sudden reductions in renal perfusion, particularly in the elderly or those on NSAIDs, may cause kidney injury.
• Allergic reactions – Angio‑edema, urticaria, or anaphylaxis require immediate medical attention.

Drug–Drug Interactions

• ACE‑inhibitors / ARBs – May enhance potassium loss; monitor electrolytes.
• Lithium – Indapamide reduces lithium clearance, raising the risk of lithium toxicity; dose adjustment or alternative therapy is advised.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – Concomitant use can blunt the diuretic effect and increase nephrotoxicity.
• Antidiabetic agents – May potentiate hypoglycaemia; glucose monitoring is advisable.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose for hypertension – 1.5 mg tablet taken once daily in the morning.
• Dose for oedema – 1.5 mg to 2.5 mg daily, depending on clinical response and renal function.
• Missed dose – Take the missed tablet as soon as remembered if it is still within 12 hours of the usual dosing time; otherwise, skip and resume the regular schedule. Do not double‑dose.
• Overdose – Symptoms may include excessive diuresis, dehydration, electrolyte disturbances, and hypotension. Seek urgent medical attention; treatment is supportive with intravenous fluids and electrolyte correction.
• Food / Alcohol – Lozol may be taken with or without food. Alcohol can potentiate hypotension; limit intake while initiating therapy.
• Comorbidities – In patients with diabetes, monitor blood glucose; in gout sufferers, watch uric acid levels.

Buying Lozol from Our Online Pharmacy

Lozol can be purchased safely from our online pharmacy in the UK.

• Affordable pricing – We source the generic product close to manufacturer cost, passing the savings directly to patients.
• Verified quality – All suppliers are MHRA‑licensed and undergo rigorous quality‑control checks before dispatch.
• Guaranteed delivery – Discreet packaging is sent within 7 days using express courier for urgent orders; regular airmail arrives in approximately 3 weeks.
• Online‑only access – The service bridges gaps where local pharmacies lack stock or where insurance formularies restrict availability.
• Pharmacy broker service – We partner with overseas licensed pharmacies, enabling a confidential supply chain that respects patient privacy while complying with UK import regulations.

FAQ

• Is Lozol available in both brand‑name and generic forms in the UK?
  Yes. The active compound indapamide is marketed under brand names such as Nolva and also as generic tablets like Lozol. Generic versions contain the identical molecule and are generally less expensive.

• Does Lozol require special storage conditions?
  Lozol should be stored at controlled‑room temperature (15‑25 °C) in a dry place, protected from direct sunlight and moisture. No refrigeration is needed.

• What does the tablet look like and how is it identified?
  Lozol tablets are typically round, film‑coated, and scored for easy splitting. The imprint usually reads “IND 1.5 mg” along with the manufacturer’s logo. Inactive ingredients may include lactose, microcrystalline cellulose, and magnesium stearate.

• Can I travel internationally with Lozol in my carry‑on luggage?
  Yes, as long as the medication is in its original packaging with a clear label. For flights longer than 4 hours, carry a small supply in a sealed bag and keep the prescription documentation (if required by the destination country) accessible.

• Are there any restrictions on importing Lozol for personal use into the UK?
  The UK allows personal import of a three‑month supply of prescription‑only medicines for personal use, provided the product is from a licensed overseas supplier and the patient holds a valid prescription. Our online pharmacy ensures compliance with these rules.

• Does indapamide have any known differences in formulation between the EU and the US?
  EU formulations of indapamide, including Lozol, typically use film‑coated tablets with a 1.5 mg dose. In the United States, the same dose is often delivered as a immediate‑release tablet, but the active ingredient and pharmacokinetic profile are comparable.

• What clinical trial established indapamide’s efficacy in hypertension?
  The HYVET (Hypertension in the Very Elderly Trial) demonstrated that indapamide, alone or with perindopril, significantly reduced stroke incidence and cardiovascular mortality in patients aged > 80 years. This trial underpins current NICE recommendations.

• How does Lozol compare to older thiazide diuretics like hydrochlorothiazide?
  Indapamide possesses a longer duration of action and a more favorable metabolic profile, causing less potassium loss and lower incidence of glucose intolerance compared with hydrochlorothiazide.

• Is there a risk of a positive drug test for athletes taking Lozol?
  Indapamide is not listed on the World Anti‑Doping Agency (WADA) prohibited substance list. However, athletes should disclose all medications to their anti‑doping authority to avoid inadvertent issues.

• What is the environmental impact of disposing of unused Lozol tablets?
  Unused tablets should be returned to a pharmacy collection point or disposed of according to UK NHS guidelines for pharmaceutical waste. This prevents contamination of waterways and reduces environmental drug load.

Glossary

Thiazide‑like diuretic

A class of drugs that promote sodium and water excretion by inhibiting the sodium‑chloride symporter in the kidney’s distal tubule, leading to lowered blood pressure.

Electrolyte imbalance

A disturbance in the normal concentrations of ions such as sodium, potassium, or calcium in the blood, which can affect nerve function and cardiac rhythm.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and eliminated by the body; key parameters include half‑life, clearance, and bioavailability.

⚠️ Disclaimer

The information provided about Lozol is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Lozol for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.