Buy Meloset Online

Meloset Information

Introduction

Meloset is a sleep‑aid medication available in the United Kingdom that contains the hormone melatonin as its sole active ingredient. It belongs to the group of sleeping aids and is also marketed for general health benefits related to circadian rhythm regulation. Melatonin is produced naturally by the pineal gland and helps synchronise the sleep–wake cycle. Meloset is used primarily to treat insomnia associated with delayed sleep phase, shift‑work disturbance, and jet lag, and it is sometimes employed to support sleep in older adults whose chief complaint is difficulty initiating sleep.

What is Meloset?

Meloset is a tablet formulation of melatonin, a naturally occurring indoleamine that influences the body’s internal clock. It is classified as a hormone replacement therapy for sleep regulation. The product is manufactured by an international pharmaceutical company that supplies generic medicines to the UK market; the exact manufacturer may vary according to the licensed supplier.

Meloset is the generic version of Circadin, containing the same active compound melatonin. Our online pharmacy provides this generic alternative as a cost‑effective treatment option. Circadin is the most widely recognised brand of prolonged‑release melatonin in Europe and is authorised by the Medicines and Healthcare products Regulatory Agency (MHRA). By offering Meloset, patients obtain an identical pharmacological profile at a substantially lower price.

How Meloset Works

Melatonin exerts its effect by binding to melatonin‑type 1 (MT1) and type 2 (MT2) receptors in the suprachiasmatic nucleus of the hypothalamus, the master regulator of circadian rhythms. Activation of these receptors signals to the brain that night is approaching, which reduces neuronal activity in wake‑promoting pathways and promotes sleep onset.

In prolonged‑release formulations such as Meloset, the tablet disintegrates gradually, providing a sustained elevation of plasma melatonin for 6–8 hours. This mimics the physiological secretion pattern of the hormone, leading to a smoother transition into sleep and a reduced tendency for early morning awakenings. Peak plasma concentrations are typically reached within 60 minutes after oral administration, and the elimination half‑life averages 30–50 minutes, allowing the drug to clear from the system by the next morning.

Conditions Treated with Meloset

• Primary insomnia with delayed sleep phase – characterised by difficulty falling asleep until after midnight. Meloset advances the circadian phase, enabling earlier sleep onset.
• Shift‑work disorder – workers with irregular schedules experience misaligned circadian rhythms. Supplemental melatonin helps realign the sleep window to the work pattern.
• Jet lag – rapid travel across time zones disrupts the internal clock; melatonin shortens the adjustment period.
• Age‑related sleep disturbances – older adults often exhibit reduced endogenous melatonin production, leading to fragmented sleep. Meloset can improve sleep continuity in this population.

In the UK, insomnia affects approximately 13 % of adults, with higher‑risk groups including night‑shift employees and individuals over 65 years. Clinical guidelines from the National Institute for Health and Care Excellence (NICE) recommend melatonin for short‑term management of these conditions when non‑pharmacological measures are insufficient.

Who is Meloset For?

• Adults with documented delayed sleep phase or difficulty initiating sleep who have tried sleep hygiene interventions without satisfactory results.
• Night‑shift workers whose work schedule prevents a regular night‑time sleep pattern, provided they have no contraindications such as uncontrolled hypertension or severe hepatic impairment.
• Travelers crossing five or more time zones who need to reset their circadian rhythm within a few days of arrival.
• People over 55 years who report reduced melatonin production and experience early‑morning awakenings or fragmented sleep.

Meloset is not appropriate for pregnant or breastfeeding women, individuals with severe depression or bipolar disorder, patients taking monoamine oxidase inhibitors (MAOIs), or those with known hypersensitivity to melatonin or any excipients in the tablet. A medical assessment is advised before initiating therapy in these groups.

Risks, Side Effects, and Interactions

Common

• Drowsiness or fatigue (especially if taken late in the evening)
• Headache
• Dizziness
• Nausea or mild gastrointestinal discomfort

Rare

• Vivid dreams or nightmares
• Mood changes, including mild irritability
• Decreased libido

Serious

• Allergic reaction (urticaria, itching, swelling of face or throat, shortness of breath)
• Severe hypertension or tachycardia in patients with pre‑existing cardiovascular disease (rare reports)

If any serious reaction occurs, immediate medical attention is required.

Drug–Drug Interactions

• Anticoagulants (e.g., warfarin) – melatonin may enhance anticoagulant effect; INR monitoring is advisable.
• Immunosuppressants (e.g., cyclosporine) – occasional reports of altered drug levels; dose adjustment may be needed.
• CNS depressants (e.g., benzodiazepines, antihistamines) – additive sedative effect; caution with activities requiring alertness.
• Oral contraceptives – theoretical interaction via hepatic enzyme pathways; clinical significance is low but worth noting.

Patients should disclose all current medications, supplements, and over‑the‑counter products before starting Meloset.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for adults in the UK: 2 mg of prolonged‑release melatonin taken 30–60 minutes before bedtime, with a maximum of one tablet per night.
• Special populations: For individuals over 65 years, a lower dose of 1 mg may be sufficient and better tolerated.
• Missed dose: If a dose is forgotten, it should be taken as soon as remembered provided there is at least 4 hours remaining before the usual bedtime. Otherwise, skip the missed dose and resume the regular schedule; do not double‑dose.
• Overdose: Symptoms may include pronounced drowsiness, confusion, or gastrointestinal upset. In the event of suspected overdose, seek medical advice promptly; supportive care is generally sufficient as melatonin has a wide safety margin.
• Food and alcohol: Meloset can be taken with or without food. Alcohol may increase sedative effects and is best avoided during treatment.
• Comorbidities: Patients with liver disease, epilepsy, or severe depression should use melatonin only under specialist supervision.

Buying Meloset from Our Online Pharmacy

Meloset is available for purchase through our online pharmacy in the United Kingdom. Our service offers:

• Affordable pricing – the cost is close to the manufacturer’s price, providing a genuine generic alternative to higher‑priced brand‑name products.
• Verified quality – every batch is sourced from licensed overseas manufacturers that meet EU‑wide Good Manufacturing Practice (GMP) standards and are inspected by our quality‑control team.
• Guaranteed delivery – discreet packaging is dispatched via express courier (typically 7 days) or regular airmail (approximately 3 weeks), with tracking available for all orders.
• Online‑only access – we specialise in retrieving international medicines that may be scarce in local pharmacies, ensuring patients with limited access can obtain the treatment they need.

As a pharmacy broker service, we collaborate with accredited overseas suppliers while adhering to UK import regulations. This model enables a discreet service that respects patient privacy, delivering Meloset directly to the door of adults who seek a reliable, cost‑effective sleep aid.

FAQ

• Can Meloset be taken on weekends or only on weekdays?
  Yes, Meloset — the dosage schedule is based on the individual’s sleep pattern rather than the calendar. If you maintain a regular bedtime on weekends, continue taking Meloset at the same time to preserve circadian stability.

• Is Meloset available in both immediate‑release and prolonged‑release formulations?
  Meloset is marketed as a prolonged‑release tablet designed to mimic the natural secretion curve of melatonin over the night. Immediate‑release melatonin products exist under other brand names, but they have a shorter duration of action and are not sold as Meloset.

• Does Meloset require refrigeration during storage?
  No, the tablets are stable at room temperature (15‑25 °C). Store them in a dry place away from direct sunlight, moisture, and excessive heat.

• What do the tablets look like, and are there any inactive ingredients that might cause allergies?
  Meloset tablets are typically white, oval‑shaped, and film‑coated. Inactive components may include lactose, microcrystalline cellulose, and magnesium stearate. Patients with severe lactose intolerance or known hypersensitivity should verify the full excipient list before use.

• Can I travel internationally with Meloset in my hand luggage?
  Yes, you may carry the medication in your hand luggage, provided the tablets remain in their original packaging with a clearly legible label. For trips longer than 30 days, consider bringing a written statement from a healthcare professional confirming the medical need for melatonin.

• Is Meloset detectable in standard drug‑testing panels?
  Melatonin is not classified as a controlled substance and is generally not screened for in occupational or sports drug tests. However, a specialist laboratory could detect it if specifically requested.

• Are there any differences between European‑market melatonin and formulations sold in the United States?
  In the EU, melatonin products such as Circadin (and therefore Meloset) are licensed as prescription medicines with a 2 mg prolonged‑release dose. In the United States, melatonin is available over‑the‑counter in a wide range of doses and release profiles, which can lead to variable efficacy.

• What is the historical origin of melatonin as a therapeutic agent?
  The hormone was first isolated in 1958, and its role in regulating sleep was elucidated in the 197s. Clinical trials in the 199‑200 s demonstrated that prolonged‑release melatonin improves sleep latency and quality in older adults, leading to its approval as a prescription medicine in several European countries.

• How does melatonin compare with traditional hypnotics such as zolpidem?
  Melatonin works by restoring physiological circadian signalling rather than directly enhancing GABAergic inhibition. It has a lower risk of dependence, fewer next‑day cognitive effects, and a milder side‑effect profile, though it may be less potent for severe insomnia compared with hypnotics like zolpidem.

• Can melatonin affect blood pressure or glucose control?
  Small studies suggest melatonin may modestly lower nocturnal blood pressure, but the effect is not clinically significant for most patients. There is limited evidence of impact on glucose metabolism; patients with uncontrolled diabetes should monitor their condition when initiating any new medication.

• Is there a maximum duration for using Meloset safely?
  Long‑term studies up to 2 years have shown melatonin to be well tolerated, and guidelines do not impose a strict time limit. Nevertheless, periodic review (e.g., every 6–12 months) with a healthcare professional is recommended to assess ongoing need.

Glossary

Circadian Rhythm

The approximately 24‑hour internal biological clock that regulates sleep, hormone release, body temperature, and other physiological functions.

Prolonged‑Release (PR) Tablet

A dosage form designed to dissolve slowly, maintaining a steady drug concentration in the bloodstream over an extended period.

MT1 and MT2 Receptors

Two subtypes of melatonin receptors located in the brain. Activation of MT1 promotes sleep initiation, while MT2 helps adjust the timing of the circadian clock.

Therapeutic Window

The range of drug doses that produces a desired clinical effect without causing unacceptable adverse effects.

⚠️ Disclaimer

The information provided about Meloset is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Meloset for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.