Buy Generic Prelone Online

Generic Prelone Information

Introduction

Prelone is a glucocorticoid medication containing the active compound prednisolone. In the United Kingdom it is classified primarily within the allergy therapeutic group, although its anti‑inflammatory properties make it useful for a broad range of immune‑mediated conditions. The tablet formulation is manufactured by a licensed pharmaceutical supplier (specific manufacturer details are not publicly disclosed for this generic product). Prednisolone, the ingredient in Prelone, has a long history of use for controlling allergic reactions, asthma exacerbations, dermatological inflammation, and many other acute and chronic disorders that involve inappropriate immune activation.

What is Prelone?

Prelone is the generic version of well‑known brand‑name prednisolone products such as Deltacortril, Orapred and Predsol. It contains the same active molecule, prednisolone, at equivalent strengths, and is therefore therapeutically interchangeable with those branded tablets. Our online pharmacy provides this generic alternative as a cost‑effective treatment option, allowing patients in the UK to obtain high‑quality prednisolone at a price close to the manufacturer’s cost.

• Classification: Synthetic glucocorticoid, oral tablet.
• Therapeutic group: Allergy and anti‑inflammatory agent.
• Development: Prednisolone was first synthesised in the 195s as a more potent derivative of cortisone, and generic formulations have been produced worldwide under strict pharmaco‑regulatory standards.

How Prelone Works

Prednisolone exerts its effect by binding to intracellular glucocorticoid receptors (GR). The drug‑receptor complex then translocates to the cell nucleus, where it interacts with glucocorticoid response elements on DNA. This leads to:

1. Up‑regulation of anti‑inflammatory proteins (e.g., annexin‑1) that inhibit phospholipase A₂, reducing prostaglandin and leukotriene synthesis.
2. Down‑regulation of pro‑inflammatory cytokines such as interleukin‑1, interleukin‑6 and tumour necrosis factor‑α, limiting recruitment and activation of immune cells.

The net result is a rapid suppression of inflammatory pathways, decreasing tissue oedema, erythema and bronchoconstriction. Oral prednisolone is absorbed within 30–60 minutes, reaches peak plasma concentrations in 1–2 hours, and has a biological half‑life of approximately 2–3 hours; however, its anti‑inflammatory actions persist for longer due to downstream gene‑expression changes.

Conditions Treated with Prelone

Prednisolone is approved for, and commonly prescribed in, the following UK indications:

• Acute allergic reactions (e.g., severe urticaria, angio‑edema) – rapid suppression of mast‑cell mediator release curtails swelling and airway compromise.
• Asthma exacerbations – systemic corticosteroids reduce airway inflammation, improve forced expiratory volume (FEV₁) and shorten hospital stays.
• Chronic obstructive pulmonary disease (COPD) flare‑ups – adjunct to bronchodilator therapy, decreasing systemic inflammation and preventing further lung injury.
• Dermatological conditions such as eczema, psoriasis, and severe contact dermatitis – topical prednisolone is standard; oral tablets are used when extensive skin involvement precludes topical control.
• Rheumatological disorders (e.g., rheumatoid arthritis, polymyalgia rheumatica) – oral prednisolone provides rapid pain relief and joint swelling reduction while disease‑modifying agents take effect.
• Autoimmune haematologic diseases (e.g., autoimmune haemolytic anaemia, immune thrombocytopenia) – suppression of auto‑antibody production and complement activation.
• Gastro‑intestinal inflammatory conditions (e.g., ulcerative colitis, Crohn’s disease) – short‑course oral prednisolone induces remission in moderate to severe flares.
• Adrenal insufficiency adjunct – as a replacement when endogenous cortisol production is inadequate, especially during stress.

Epidemiologically, allergic diseases affect up to 20 % of the UK population, asthma prevalence is approximately 5 % (≈3 million adults), and chronic inflammatory disorders collectively impact over 10 % of adults. Prednisolone remains a cornerstone therapy because of its broad efficacy profile, rapid onset, and extensive clinical evidence base.

Who is Prelone For?

Prelone is appropriate for adult patients who require systemic corticosteroid therapy for the conditions listed above, provided that:

• The clinician has determined that the expected therapeutic benefit outweighs the risk of steroid‑related adverse effects.
• There are no absolute contraindications such as uncontrolled systemic fungal infection or known hypersensitivity to prednisolone or any tablet excipients.
• The patient does not have an active, untreated tuberculosis infection, as glucocorticoids can exacerbate mycobacterial dissemination.

Special populations where extra caution is required include:

• Elderly patients – higher susceptibility to osteoporosis, glucose intolerance and neuro‑psychiatric effects.
• Patients with diabetes mellitus – glucocorticoids raise blood glucose; dose adjustment and close monitoring are essential.
• Individuals with a history of peptic ulcer disease – concurrent proton‑pump inhibitor therapy is often advised.

Conversely, Prelone is not suitable for patients with known severe immunosuppression (e.g., AIDS with CD4 < 200 cells/µL) unless the treating physician explicitly balances the risks.

Risks, Side Effects, and Interactions

Common

• Gastro‑intestinal discomfort (nausea, dyspepsia) – often mitigated by taking tablets with food.
• Increased appetite and weight gain – due to fluid retention and altered metabolism.
• Mild mood changes (euphoria, irritability) – usually transient.
• Elevated blood glucose – may require temporary insulin or oral hypoglycaemic adjustment.

Rare

• Severe insomnia or psychosis – reported in <1 % of patients on high‑dose regimens.
• Skin thinning and easy bruising – reflects collagen synthesis inhibition.
• Hypertensive episodes – particularly in patients with pre‑existing hypertension.

Serious

• Adrenal suppression – abrupt cessation after prolonged therapy can precipitate adrenal crisis; tapering is mandatory.
• Opportunistic infections (e.g., Pneumocystis jirovecii pneumonia, candidiasis) – immune suppression may be profound with high, repeated doses.
• Osteonecrosis of the femoral head – rare but catastrophic, linked to cumulative steroid exposure.
• Severe hyperglycaemia leading to diabetic ketoacidosis – requires urgent medical attention.

Drug–Drug Interactions

• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – additive risk of gastrointestinal ulceration and bleeding.
• Anticoagulants (warfarin, direct oral anticoagulants) – glucocorticoids may increase INR; monitoring is advised.
• Vaccines – live attenuated vaccines (e.g., MMR, varicella) may be less effective or unsafe; defer until steroid dose is ≤5 mg prednisolone equivalent.
• Cytochrome P450 inducers (e.g., rifampicin, carbamazepine) – can reduce prednisolone plasma concentrations, diminishing efficacy.
• Potassium‑sparing diuretics (e.g., spironolactone) – risk of hypokalaemia may be heightened.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to allow comprehensive interaction assessment.

Practical Use: Dosing, Missed Dose, Overdose

Standard dosing ranges (adult, oral tablets):

• Mild to moderate allergic reactions: 5–10 mg once daily for 3–5 days.
• Severe asthma or COPD exacerbations: 30–60 mg daily for 5–7 days, followed by a rapid taper.
• Rheumatological flare: 10–20 mg daily, with tapering over 2–4 weeks depending on response.

All dosages must be individualized by a qualified healthcare professional; the figures above are provided for general reference only.

Missed dose: If a dose is forgotten and the scheduled time is less than 6 hours away, take it as soon as remembered. If more than 6 hours have passed, skip the missed dose and resume the regular schedule. Doubling the dose to “make up” for a missed tablet is not recommended because it increases the risk of side‑effects.

Overdose: Symptoms may include severe nausea, vomiting, abdominal pain, confusion, or electrolyte disturbances. Immediate medical attention is required. Supportive care typically involves gastric decontamination (if presentation is within one hour), fluid replacement, correction of electrolyte imbalances, and monitoring of blood glucose and cortisol levels.

Practical precautions:

• Take tablets with a full glass of water, preferably with food to minimise gastrointestinal irritation.
• Avoid excessive alcohol, as it can potentiate gastric bleeding and impair liver metabolism.
• Do not discontinue abruptly after prolonged therapy; a physician‑guided taper reduces adrenal insufficiency risk.
• Monitor blood pressure, blood glucose, and weight regularly during treatment, especially for courses longer than two weeks.

Buying Prelone from Our Online Pharmacy

Prelone can be purchased safely from our online pharmacy in the UK. Our service offers several advantages for patients seeking reliable access to generic prednisolone:

• Affordable pricing: We source Prelone close to manufacturer cost, passing the savings directly to the consumer.
• Verified quality: All tablets are supplied by licensed overseas pharmacies that comply with EU‑GMP (Good Manufacturing Practice) standards; each batch undergoes independent laboratory testing.
• Guaranteed delivery: Discreet packaging is shipped via a 7‑day express service for urgent needs, with a standard airmail option taking approximately 3 weeks. Tracking information is provided for every order.
• Online‑only access: For patients who encounter limited stock in local pharmacies or who reside in remote areas, our platform offers a convenient, privacy‑respecting alternative.

As a pharmacy broker service, we collaborate with multiple regulated suppliers, ensuring a consistent and trustworthy supply chain while respecting patient confidentiality.

FAQ

• Is Prelone available in both brand‑name and generic forms in the UK?
  Yes. The branded versions of prednisolone, such as Deltacortril and Orapred, are marketed alongside generic tablets like Prelone. Both contain the identical active molecule, but generic products are generally less expensive.

• What does a Prelone tablet look like?
  Prelone tablets are round, white to off‑white, and imprinted with the dosage strength (e.g., “5 mg”) on one side. Inactive ingredients may include lactose, microcrystalline cellulose and magnesium stearate, depending on the manufacturer.

• Does Prelone require special storage conditions?
  The medication should be stored at controlled room temperature (15‑30 °C), protected from excess moisture and direct sunlight. No refrigeration is needed, but it should be kept out of reach of children.

• Can I travel internationally with Prelone?
  Yes, provided you carry it in its original packaging with a copy of the prescription (if required by customs). Keep the tablets in your hand luggage to avoid temperature extremes in the cargo hold.

• Are there any differences between prednisolone formulations sold in Europe versus the United States?
  The active ingredient is chemically identical worldwide; however, excipient composition, tablet size and imprint may differ due to regional manufacturing standards. These variations do not affect clinical potency.

• What are the implications of taking Prelone for drug testing?
  Prednisolone is generally not screened for in standard employment drug tests, as it is a prescribed medication rather than a substance of abuse. Specific medical clearance may be required for sports drug testing, where glucocorticoids are sometimes listed.

• Is it safe to use Prelone while breastfeeding?
  Prednisolone does pass into breast milk in low concentrations. Short courses at the lowest effective dose are typically considered compatible with breastfeeding, but a healthcare professional should assess each case.

• How does Prelone compare with older corticosteroids like hydrocortisone?
  Prednisolone is roughly four times more potent than hydrocortisone on a milligram‑to‑milligram basis, providing greater anti‑inflammatory effect with a similar safety profile when dosed appropriately.

• What clinical trials established the efficacy of prednisolone for asthma?
  Large, double‑blind studies such as the 1999 “Prednisone vs. Placebo in Acute Asthma” trial demonstrated significant improvements in peak expiratory flow and reduced hospitalization rates, forming the basis for current guideline recommendations.

• Can the tablet be crushed or divided for dose adjustment?
  Prednisolone tablets are often scored to allow accurate splitting, but crushing is not recommended unless a liquid formulation is medically indicated, as it may alter absorption and increase local gastrointestinal irritation.

Glossary

Glucocorticoid

A class of steroid hormones that bind to glucocorticoid receptors, modulating inflammation and immune responses throughout the body.

Adrenal suppression

Reduced endogenous cortisol production caused by prolonged external steroid use; sudden discontinuation can lead to an adrenal crisis.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and eliminated by the body, influencing onset, duration and dosing intervals.

CYP450 enzymes

A family of liver enzymes that metabolise many medicines; inducers or inhibitors of these enzymes can markedly alter prednisolone blood levels.

⚠️ Disclaimer

The information provided about Prelone is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Prelone for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.