Buy Generic Revatio Online

Generic Revatio Information

Introduction

Revatio contains the phosphodiesterase‑5 (PDE5) inhibitor sildenafil citrate. It is marketed primarily for the treatment of pulmonary arterial hypertension (PAH) in the United Kingdom and belongs to the therapeutic class of medications used in men’s health, most famously for erectile dysfunction. In the UK, Revatio is manufactured by Pfizer and approved by the Medicines and Healthcare products Regulatory Agency (MHRA) for improving exercise capacity and delaying clinical worsening in patients with PAH.

What is Revatio?

Revatio is a branded formulation of sildenafil citrate, the same active molecule found in well‑known products such as Viagra® and generic sildenafil tablets. The medication is supplied as oral tablets, each containing 20 mg of sildenafil. While Viagra is licensed for erectile dysfunction, Revatio is specifically licensed for pulmonary arterial hypertension, a condition characterised by high blood pressure in the arteries that supply the lungs. Our online pharmacy provides this branded option as well as equivalent generic sildenafil, offering a cost‑effective alternative for eligible patients.

How Revatio Works

Sildenafil blocks the enzyme phosphodiesterase‑5 (PDE5). PDE5 normally degrades cyclic guanosine monophosphate (cGMP), a messenger that relaxes smooth muscle. By inhibiting PDE5, Revatio raises cGMP levels in the pulmonary vasculature and, when used for erectile dysfunction, in the corpus cavernosum. Elevated cGMP leads to:

• Pulmonary vessels: Relaxation of smooth‑muscle cells, dilation of the pulmonary arteries, and a reduction in pulmonary vascular resistance.
• Erectile tissue: Enhanced inflow of blood to the penis, facilitating erection when sexual stimulation is present.

The drug is absorbed rapidly after oral administration, with peak plasma concentrations typically reached within 30‑120 minutes. The half‑life of sildenafil is about 3–5 hours, after which the compound is metabolised principally by the hepatic cytochrome P450 system (CYP3A4, CYP2C9). These pharmacokinetic properties explain the usual onset of therapeutic effect within an hour and a duration of action lasting up to 12 hours in many individuals.

Conditions Treated with Revatio

• Pulmonary Arterial Hypertension (PAH).

  • PAH affects approximately 1–2 people per 100 000 in the UK. It is characterised by progressive narrowing of the pulmonary arteries, leading to right‑hand heart failure if untreated. Revatio improves exercise tolerance (6‑minute walk distance) and delays disease progression.

• Erectile Dysfunction (off‑label use).

  • Although Revatio is not the primary brand for this indication, the identical active ingredient means it can be used off‑label for men who experience difficulty achieving or maintaining an erection. Clinical trials of sildenafil for erectile dysfunction report response rates of 70‑80 % in appropriate candidates.

• Other investigational uses.

  • Research is ongoing into the role of sildenafil in conditions such as Raynaud’s phenomenon, high‑altitude pulmonary edema, and certain forms of heart failure. These uses remain experimental and are not approved in the UK.

Who is Revatio For?

• Adults diagnosed with PAH.

  • Confirmed diagnosis by right‑heart catheterisation, WHO functional class II–III, and not responding adequately to other approved PAH therapies.

• Men with erectile dysfunction (when prescribed off‑label).

  • Individuals who have normal cardiovascular status, no contraindications to PDE5 inhibition, and who require an oral, on‑demand treatment.

• Patients who can tolerate oral medication.

  • Those who have adequate hepatic function (Child‑Pugh A‑B) and are not taking contraindicated drugs such as nitrates or strong CYP3A4 inhibitors.

• Patients who are not pregnant or breastfeeding.

  • Sildenafil is contraindicated in pregnancy because of potential fetal effects; women are therefore excluded from treatment.

• Situations where Revatio is not appropriate.

  • Severe hypotension (systolic <90 mmHg), recent myocardial infarction or stroke, retinal disorders (e.g., non‑arteritic anterior ischemic optic neuropathy), or concomitant use of nitrates (e.g., nitroglycerin) which can provoke life‑threatening hypotension.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing of the face or neck
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (blurred vision, colour tinting)

These effects are usually mild, transient, and resolve without medical intervention.

Rare

• Priapism (prolonged erection lasting >4 hours)
• Sudden hearing loss or tinnitus
• Dermatological reactions such as rash or pruritus

Patients experiencing any of these should seek medical advice promptly.

Serious

• Severe hypotension leading to dizziness, syncope, or shock
• Cardiovascular events (myocardial infarction, arrhythmia) in patients with pre‑existing coronary artery disease
• Non‑arteritic anterior ischemic optic neuropathy (NAION) resulting in permanent vision loss

Any of the serious adverse events warrant immediate emergency care.

Clinically Relevant Drug‑Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Co‑administration can cause profound vasodilation and hypotension.
• Alpha‑blockers (e.g., tamsulosin, doxazosin): May amplify blood pressure lowering; dose titration and monitoring are essential.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increase sildenafil plasma concentrations, raising the risk of toxicity; dose reduction is required.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine): Decrease exposure, possibly reducing efficacy; dosing adjustments may be needed.
• Other PDE5 inhibitors (e.g., tadalafil, vardenafil): Concurrent use can lead to additive effects and severe hypotension; avoid combination therapy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for PAH: 20 mg taken three times daily, approximately 4–6 hours apart. Dose may be adjusted based on clinical response and tolerability.
• Erectile dysfunction (off‑label): 50 mg taken as needed, about 30 minutes to 4 hours before sexual activity; not to exceed one dose per day. The 20 mg tablet can be used if lower dosing is required.

Missed dose:

• If a scheduled dose is forgotten and the next dose is more than 4 hours away, take the missed tablet.
• If the next dose is due within 4 hours, skip the missed tablet and resume the regular schedule. Do not double‑dose.

Overdose:

• Symptoms may include severe headache, hypotension, prolonged erection, or visual changes.
• Seek urgent medical attention; supportive care and fluid resuscitation are the mainstays. No specific antidote exists.

Precautions:

• Take Revatio with or without food; a high‑fat meal may delay absorption slightly.
• Limit alcohol intake; excessive alcohol can amplify hypotensive effects.
• Patients with hepatic impairment may require reduced dosing.
• Regular monitoring of blood pressure, liver function tests, and, for PAH, echocardiography is advised.

Buying Revatio from Our Online Pharmacy

Revatio can be purchased safely from our online pharmacy in the UK. We specialise in delivering high‑quality, MHRA‑approved medicines directly to your door. Key benefits include:

• Affordable pricing: Our sourcing model works with vetted overseas licensed suppliers, allowing us to offer prices close to the manufacturer’s cost, often cheaper than traditional high‑street pharmacies.
• Verified quality: Every batch is accompanied by a certificate of analysis and undergoes strict quality control before dispatch.
• Discreet, reliable delivery: Options include 7‑day express service for urgent needs and standard airmail (approximately 3 weeks) for non‑urgent orders. All packages are unmarked and packed securely to protect privacy.
• Pharmacy broker service: We act as an intermediary between you and licensed international pharmacies, ensuring that the medication you receive meets UK safety standards while maintaining confidentiality.

For patients who experience limited availability through local pharmacies or whose insurance does not cover the medication, our service provides a convenient, cost‑effective alternative.

FAQ

• **Is Revatio available in both brand‑name and generic forms in the UK?
  Yes. Revatio is the brand‑name product from Pfizer, while generic sildenafil tablets containing the same 20 mg dose are also licensed and widely available. Both formulations deliver identical therapeutic effects when taken as prescribed.

• **What should I do with Revatio tablets if I travel abroad?
  Keep the medication in its original packaging, store it at room temperature away from moisture, and carry it in hand luggage to avoid temperature extremes in checked baggage. A doctor’s note may be useful when passing through customs, although personal import for personal use is generally permitted in the UK.

• **Does Revatio require special storage conditions?
  Revatio should be stored at 15‑30 °C, protected from light and humidity. Do not store it in bathrooms or near radiators. If the tablets become discoloured or crumble, discard them and obtain a fresh supply.

• **What inactive ingredients are present in Revatio tablets?
  Revatio tablets contain lactose monohydrate, maize starch, magnesium stearate, and microcrystalline cellulose, among other excipients. Patients with severe lactose intolerance or specific allergies should discuss alternatives with their healthcare provider.

• **Can Revatio be imported for personal use in the UK without a prescription?
  Under UK law, personal import of prescription‑only medicines is allowed for a 3‑month supply when the medication is for a serious condition and not available locally, provided you have a valid prescription from a UK‑registered prescriber. Importing without a prescription may breach customs regulations.

• **Are there any differences in formulation between Revatio sold in the US and the UK?
  The active ingredient and dosage strength are identical, but minor variations in inactive fillers may exist due to differing regulatory requirements. These differences do not affect clinical efficacy.

• **How does Revatio compare with older PAH therapies such as epoprostenol?
  Epoprostenol is an intravenous prostacyclin analogue that requires continuous infusion, whereas Revatio is an oral tablet taken three times daily, offering greater convenience and a less invasive administration route. Clinical trials have shown comparable improvements in exercise capacity for many patients, though treatment choice depends on disease severity and individual response.

• **What historical milestones led to the development of sildenafil?
  Sildenafil was first synthesised by Pfizer in the late 198s as a potential antihypertensive agent. Early clinical trials revealed a pronounced effect on penile erection, leading to its 1998 approval as Viagra® for erectile dysfunction. Later, in 2005, the same molecule received approval under the brand name Revatio for pulmonary arterial hypertension.

• **Will taking Revatio affect drug testing for employment or sports?
  Standard drug screens do not typically test for sildenafil. However, certain sports organisations may require disclosure of PDE5 inhibitor use, as it can influence cardiovascular performance. Always check the specific testing policies of your employer or governing body.

• **Is there a risk of developing tolerance to Revatio over time?
  Long‑term studies indicate that tolerance to the haemodynamic effects of sildenafil is uncommon. Dose adjustments are usually made only if disease progression occurs rather than because of reduced drug efficacy.

Glossary

Phosphodiesterase‑5 (PDE5) inhibitor

A class of drugs that block the enzyme responsible for breaking down cGMP, leading to smooth‑muscle relaxation in blood vessels.

Pulmonary arterial hypertension (PAH)

A progressive disorder characterised by elevated pressure in the pulmonary arteries, causing shortness of breath, fatigue, and right‑heart strain.

cGMP (cyclic guanosine monophosphate)

A cellular messenger that mediates vasodilation; its levels are increased when PDE5 is inhibited.

Priapism

A prolonged, often painful erection lasting more than four hours; it is a medical emergency because it can cause permanent damage to penile tissue.

⚠️ Disclaimer

The information provided about Revatio is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Revatio for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.