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Vilitra Information
Introduction
Vilitra is a prescription medication used to treat erectile dysfunction (ED) in adult men. Its active ingredient is vardenafil, a phosphodiesterase‑5 (PDE5) inhibitor that improves blood flow to the penis during sexual stimulation. In the United Kingdom, Viltria (produced by Bayer AG) is licensed for men who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity. The drug is part of the broader men’s health therapeutic group, which also includes treatments for other aspects of sexual function.
What is Vilitra?
Vilitra is a tablet formulation containing 5 mg, 10 mg, or 20 mg of vardenafil hydrochloride. It belongs to the PDE5 inhibitor class, a group of medicines that act on the nitric oxide–cGMP pathway to facilitate penile erection. The product was developed by Bayer and received marketing authorisation from the European Medicines Agency (EMA) in 2005. Vilitra is marketed under the same name in many countries, while the same active compound is sold under other brand names such as Levitra (United States) and Staxyn (orodispersible tablet). In the UK, it can be dispensed only with a valid prescription from a qualified prescriber.
How Vilitra Works
Vardenafil selectively inhibits the enzyme phosphodiesterase‑5, which normally degrades cyclic guanosine monophosphate (cGMP) in the smooth muscle of the corpus cavernosum. During sexual arousal released from nerve endings stimulates the production of cGMP, causing smooth‑muscle relaxation and increased arterial inflow. By blocking PDE5, Vilitra prolongs the action of cGMP, allowing the erection to develop and be maintained for a longer period. Onset of effect typically occurs within 30–60 minutes after oral ingestion, with a therapeutic window of up to 4–5 hours. The drug is metabolised primarily via the hepatic CYP3A4 pathway and has an elimination half‑life of approximately 4–5 hours.
Conditions Treated with Vilitra
- Erectile Dysfunction (ED) – The primary and only indication approved by the UK Medicines and Healthcare products Regulatory Agency (MHRA). ED affects an estimated 17 % of men aged 40–70 in the UK, a prevalence that rises with age and comorbidities such as diabetes or cardiovascular disease.
- Secondary use in pulmonary arterial hypertension (off‑label) – Some clinicians employ low‑dose vardenafil to lower pulmonary vascular resistance, although this is not an approved indication in the UK and should only be considered within specialist care.
Vilitra’s efficacy is demonstrated in multiple Phase III trials, where responders achieved satisfactory erections in 70–80 % of participants compared with placebo.
Who is Vilitra For?
- Men with diagnosed erectile dysfunction who have no contraindications to PDE5 inhibition.
- Patients with stable cardiovascular disease (e.g., controlled hypertension, stable angina) where sexual activity is medically permitted, because the drug’s haemodynamic effects are modest.
- Individuals who have not responded adequately to lower‑dose PDE5 inhibitors such as sildenafil, as vardenafil offers a slightly different pharmacokinetic profile and may succeed where others fail.
- Men who require a rapid onset; the 10 mg dose often produces erection within 30 minutes, which may suit couples with spontaneous sexual activity.
Vilitra is not suitable for men who:
- Take nitrates (e.g., nitroglycerin) or nitric oxide donors, due to risk of severe hypotension.
- Have severe uncontrolled hypertension, recent myocardial infarction, or unstable angina.
- Suffer from hereditary retinal disorders (e.g., retinitis pigmentosa).
- Have significant liver impairment that would reduce drug clearance.
Risks, Side Effects, and Interactions
Common
- Headache
- Flushing (warmth or redness of the face or neck)
- Nasal congestion or rhinitis
- Dyspepsia (indigestion)
- Dizziness
These events are usually mild, transient, and resolve without medical intervention.
Rare
- Visual disturbances (e.g., changes in colour perception, blurred vision)
- Auditory impairment (tinnitus or sudden hearing loss)
- Priapism (prolonged erection lasting > 4 hours) – requires urgent medical attention
Serious
- Severe hypotension, particularly when combined with nitrates or potent α‑blockers
- Myocardial infarction or stroke in patients with pre‑existing cardiovascular disease, though a causal link is rare
- Anaphylactic reactions (rash, swelling, bronchospasm)
Clinically Relevant Drug–Drug Interactions
- Nitrates (isosorbide dinitrate, nitroglycerin) – co‑administration can cause profound blood‑pressure falls.
- CYP3A4 inhibitors (ketoconazole, erythromycin, ritonavir) – may increase vardenafil plasma concentrations, heightening side‑effect risk; dose reduction is advised.
- CYP3A4 inducers (rifampicin, carbamazepine, St John’s wort) – may reduce efficacy, potentially necessitating a higher dose.
- α‑blockers (tamsulosin, doxazosin) – concurrent use may lead to additive hypotensive effects; start with the lowest Vilitra dose and monitor blood pressure.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.
Practical Use: Dosing, Missed Dose, Overdose
- Standard starting dose: 10 mg taken orally with water, approximately 30–60 minutes before anticipated sexual activity.
- Dose adjustments: Based on efficacy and tolerability, the dose may be decreased to 5 mg or increased to 20 mg. No more than one tablet should be taken within a 24‑hour period.
- Food considerations: A high‑fat meal can delay absorption and reduce peak plasma levels; taking Vilitra on an empty stomach or with a light meal is recommended for optimal onset.
- Alcohol: Moderate intake (≤ 2 units) does not significantly affect efficacy, but excessive consumption may exacerbate dizziness and hypotension.
- Missed dose: If an erection does not occur, a second dose should not be taken that day. Wait until the next planned sexual activity and adhere to the once‑daily maximum.
- Overdose: Symptoms may include marked hypotension, prolonged erection, and severe headache. Contact emergency services or a poison information centre immediately; supportive measures focus on blood‑pressure monitoring and, if priapism occurs, prompt urological evaluation.
Buying Vilitra from Our Online Pharmacy
Vilitra can be obtained safely through our online pharmacy in the UK. Our service offers several advantages for patients seeking discreet, affordable access to this essential medication:
- Competitive pricing: We source Vilitra close to manufacturer cost, passing savings directly to you without compromising quality.
- Verified quality: All tablets are supplied by licensed overseas pharmacies that adhere to Good Manufacturing Practice (GMP) standards and are verified by our quality‑control team.
- Discreet, reliable delivery: Packages are shipped in unmarked parcels, with express options delivering within 7 days and standard airmail typically arriving in 2‑3 weeks.
- Pharmacy broker model: By partnering with internationally authorised suppliers, we can provide medications that are otherwise limited or unavailable through conventional UK retail channels, while maintaining strict confidentiality of your personal information.
Our online pharmacy is a convenient, cost‑effective route for adults who have a valid prescription and wish to obtain Vilitra without unnecessary delays.
FAQ
-
Can Vilitra be taken with a full meal?
Yes, but a high‑fat meal may slow absorption, delaying the drug’s onset of action by up to an hour. For the quickest effect, it is advisable to take the tablet with a light snack or on an empty stomach. -
What does the tablet look like, and are there imprint codes?
Vilitra tablets are round, film‑coated, and color‑coded by strength: 5 mg (white), 10 mg (blue), and 20 mg (red). Imprint codes typically read “VIL” followed by the dosage number, allowing verification of authenticity. -
Is there a risk of developing tolerance to Vilitra over time?
Clinical data show that tolerance does not develop with regular therapeutic use of PDE5 inhibitors. However, underlying health changes (e.g., worsening diabetes) may reduce efficacy, necessitating dose adjustment. -
How should Vilitra be stored in a hot climate?
Keep the tablets at a controlled room temperature (15‑30 °C) away from direct sunlight and moisture. If you travel to a region with high ambient temperatures, store the medication in a insulated pouch or a climate‑controlled luggage compartment. -
Can I travel internationally with Vilitra in my carry‑on luggage?
Yes, provided you retain the original packaging and a copy of the prescription. Some countries may request proof of a legitimate medical need, so carrying a letter from your prescriber can facilitate customs clearance. -
Are there any known interactions between Vilitra and recreational drugs?
Combining Vilitra with substances that also cause vasodilation—such as nitrite “poppers” or certain illicit stimulants—can increase the likelihood of severe hypotension. It is safest to avoid such combinations. -
What are the key differences between Vilitra and other PDE5 inhibitors like sildenafil?
Vardenafil (Vilitra) has a slightly faster onset (30 minutes) and a shorter half‑life (4‑5 hours) compared with sildenafil. This may benefit men seeking a more spontaneous treatment window, while sildenafil’s longer duration (up to 12 hours) suits planned activities. -
Has Vilitra been studied in men with diabetes?
Yes. Subgroup analyses from Phase III trials demonstrated comparable efficacy in diabetic versus non‑diabetic populations, though response rates can be modestly lower in poorly controlled diabetes due to vascular complications. -
Does Vilitra have any effect on the female partner’s health?
Vilitra acts systemically but at doses used for ED it does not produce significant physiological changes in women. However, the medication can be excreted in semen; no adverse effects have been documented in female partners. -
Is Vilitra approved for use in men over 65 years old?
The medication is authorised for adult males of any age, provided they meet the clinical criteria and have no contraindications. In older men, clinicians may start with the 5 mg dose and monitor haemodynamic responses closely. -
Can Vilitra be crushed or chewed for faster absorption?
The tablet is designed for oral swallowing. Crushing or chewing can alter the release profile, potentially increasing peak concentrations and side‑effect risk. It is recommended to swallow the tablet whole.
Glossary
- Phosphodiesterase‑5 (PDE5) Inhibitor
- A class of drugs that block the enzyme PDE5, preventing the breakdown of cGMP and thereby facilitating smooth‑muscle relaxation in the penis.
- cGMP (Cyclic Guanosine Monophosphate)
- A intracellular messenger that promotes vasodilation in response to nitric oxide; its accumulation is essential for erection development.
- Hypotension
- Abnormally low blood pressure, which can cause dizziness, fainting, or shock if severe; a known risk when combining PDE5 inhibitors with nitrates.
- Priapism
- A prolonged, often painful erection lasting more than four hours, requiring urgent medical treatment to prevent tissue damage.
⚠️ Disclaimer
The information provided about Vilitra is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Vilitra for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.