Buy Avana Online

Avana Information

Introduction

Avana is a phosphodiesterase‑type 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. The medication contains the active compound avanafil, a selective PDE5 inhibitor that has been marketed worldwide under brand names such as Stendra and Spedra. In the United Kingdom, ED affects an estimated 15 % of men aged 40‑70, making effective, fast‑acting oral therapy a common component of men's health management. Avana belongs to the “Bestsellers, Erectile Dysfunction, Men’s Health” therapeutic groups and is prescribed when a rapid onset of action is desired.

What is Avana?

• Classification: Oral selective PDE5 inhibitor.
• Active ingredient: Avanafil, a small‑molecule agent that enhances the nitric‑oxide‑cGMP pathway in penile tissue.
• Development: Avanafil was discovered by pharmaceutical research groups in the early 200s and received its first regulatory approval in the United States in 2012 (as Stendra). Subsequent European approvals followed under the name Spedra.
• Manufacturer: The original branded product is produced by a well‑established global pharmaceutical company; generic versions are supplied by a network of licensed manufacturers that meet UK Medicines and Healthcare products Regulatory Agency (MHRA) standards.

How Avana Works

Avanafil inhibits the enzyme phosphodiesterase‑type 5, which normally degrades cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. During sexual stimulation, nitric oxide released from nerve endings activates guanylate cyclase, raising cGMP levels. Elevated cGMP relaxes smooth muscle, allowing arterial inflow and erection. By blocking PDE5, avanafil sustains cGMP concentrations, prolonging smooth‑muscle relaxation.

Key pharmacologic points:

• Onset of action: Clinical trials show functional erection within 15 minutes for many men, faster than most older PDE5 inhibitors.
• Duration: Efficacy typically persists for up to 6 hours, allowing flexibility in sexual timing.
• Metabolism: Avanafil is metabolised primarily by hepatic CYP3A4 and to a lesser extent CYP2C9; the half‑life is approximately 5 hours.

These properties make Avana suitable for men who value rapid onset and predictable duration without the need for prolonged planning.

Conditions Treated with Avana

• Erectile Dysfunction (ED): The primary and FDA‑approved indication. ED is defined as the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. In the UK, the National Health Service reports that up to 5 million men experience ED at some point.
• Psychogenic ED: Avana’s rapid onset can be advantageous for men whose erectile difficulties are situational or performance‑related, as the medication may be taken shortly before anticipated sexual activity.

Clinical relevance in the UK – The British Society for Sexual Medicine recommends PDE5 inhibitors as first‑line pharmacotherapy for most men with organic or mixed aetiology ED. Avana’s quick onset aligns with patient preferences for spontaneous intimacy, supporting adherence and treatment satisfaction.

Who is Avana For?

Avana is appropriate for adult men who meet the following criteria:

• Diagnosed with mild to moderate or severe erectile dysfunction confirmed by a qualified healthcare professional.
• Able to use oral medication safely, i.e., without contraindications such as nitrate therapy, severe uncontrolled hypertension, recent myocardial infarction, or significant hepatic impairment.
• Desire a rapid‑acting option that can be taken 15–30 minutes before sexual activity.

Situations where Avana is especially recommended

• Men who have previously tried slower‑acting PDE5 inhibitors (e.g., sildenafil, tadalafil) and reported dissatisfaction with onset time.
• Individuals with an active lifestyle that limits advance planning for medication intake.

Scenarios where Avana may be unsuitable

• Patients on nitrates (e.g., nitroglycerin) or nitric‑oxide donors, due to risk of profound hypotension.
• Men with a known hypersensitivity to avanafil or any excipients in the tablet.
• Patients with severe cardiovascular disease where sexual activity itself poses a risk; such men require specialist cardiology assessment before any PDE5 inhibitor use.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing (warmth, redness of face or neck)
• Nasal congestion or runny nose
• Back pain or muscle aches (generally mild)
• Dizziness

These events usually appear within the first hour after dosing and resolve spontaneously within a few hours.

Rare

• Visual disturbances (blurred vision, changes in color perception)
• Hearing loss or sudden tinnitus
• Skin rash or pruritus

Patients experiencing these symptoms should discontinue use and seek medical advice promptly.

Serious

• Priapism (prolonged erection lasting > 4 hours) – a urological emergency requiring immediate treatment to prevent tissue damage.
• Severe hypotension – especially when combined with nitrate medications or potent α‑blockers.
• Cardiovascular events (myocardial infarction, stroke) – rare but reported in men with pre‑existing cardiac disease.

Any sign of these serious reactions warrants urgent medical attention.

Drug–Drug Interactions

• Nitrates (e.g., glyceryl trinitrate, isosorbide mononitrate): Concomitant use can cause dangerous drops in blood pressure.
• α‑Blockers (e.g., doxazosin, tamsulosin): May enhance hypotensive effects; dose spacing of at least 30 minutes is advised.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Can increase avanafil plasma concentrations, potentially heightening side‑effect risk. Dose reduction may be considered.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine): May reduce efficacy by lowering drug levels.

Patients should provide a full medication list to their prescriber before initiating Avana.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing: The usual starting dose is 100 mg taken orally with water, no more than once per day. Depending on efficacy and tolerability, the dose may be increased to 200 mg or decreased to 50 mg.
• Timing: Avana can be taken with or without food. A high‑fat meal may slightly delay onset but does not affect overall efficacy.
• Missed dose: If an erection does not occur, a second dose should not be taken on the same day. Wait until the next scheduled day to resume dosing.
• Overdose: Symptoms may include pronounced dizziness, marked hypotension, or severe headache. If overdose is suspected, seek immediate medical assistance; supportive care (fluid resuscitation, blood pressure monitoring) is the mainstay of treatment.

Precautions:

• Avoid excessive alcohol, which can exacerbate hypotension and impair erection.
• Patients with renal or hepatic impairment should use the lowest effective dose and be monitored closely.

Buying Avana from Our Online Pharmacy

Avana can be obtained safely through our online pharmacy in the UK. Our service offers:

• Affordable pricing: We source generic avanafil at near‑manufacturer cost, passing the savings directly to you.
• Verified quality: All stock is supplied by MHRA‑approved overseas licensed pharmacies that meet stringent Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery: Discreet packaging is dispatched via a secure courier network, with express options delivering within 7 days and standard airmail typically arriving in 2‑3 weeks.
• Pharmacy‑broker model: By partnering with international licensed suppliers, we provide access to medications that may have limited availability in local high‑street pharmacies, while maintaining full compliance with UK import regulations.

Our online platform prioritises privacy; orders are processed without requiring personal health information beyond what is legally necessary. This makes Avana an accessible, cost‑effective option for men seeking a reliable PDE5 inhibitor without undue delay.

FAQ

• Is avanafil available in both brand‑name and generic forms in the UK?
  Yes. The original brand‑name products are marketed as Stendra (USA) and Spedra (EU). Generic avanafil tablets, such as Avana, contain the identical active ingredient and are typically priced lower.

• What is the recommended storage condition for Avana tablets?
  Store at a controlled room temperature between 15 °C and 30 °C. Keep the medication in the original blister pack, away from direct sunlight, moisture, and heat sources.

• Can Avana be taken with alcohol?
  Moderate alcohol consumption does not usually interfere with avanafil’s effectiveness, but excessive intake can increase the risk of dizziness and hypotension. Limiting alcohol to a standard drink or less is advisable on treatment days.

• Does food affect the absorption of Avana?
  A high‑fat meal may delay the onset of action by up to 30 minutes, but overall absorption and efficacy remain unchanged. Taking Avana on an empty stomach yields the fastest onset.

• Are there any differences in tablet appearance between regions?
  In the UK, generic avanafil tablets are often round, film‑coated, and may be pink or white depending on the manufacturer. Brand‑name versions may have distinct markings. Always verify the imprint code on the packaging.

• Is Avana safe for men over 65 years of age?
  Older men can use avanafil, but dose adjustment (starting at 50 mg) and careful cardiovascular assessment are recommended due to higher prevalence of comorbidities and concurrent medications.

• What are the legal requirements for importing avanafil for personal use into the UK?
  Personal import of up to a three‑month supply is permitted when the medication is for a legitimate personal medical need, accompanied by a copy of a valid prescription from a UK‑registered prescriber, and sourced from an authorized overseas pharmacy.

• Does avanafil interfere with routine drug testing?
  Avanafil is not a controlled substance and typically does not appear on standard workplace drug‑screen panels. However, specialized tests could theoretically detect it if specifically requested.

• How long does it take for Avana to be fully cleared from the body?
  Given its half‑life of about 5 hours, avanafil is generally eliminated after approximately 24 hours, assuming normal hepatic function.

• What was the first clinical trial that demonstrated Avana’s rapid onset?
  A Phase III, double‑blind, placebo‑controlled study published in The Journal of Sexual Medicine (2014) showed that 71 % of participants achieved functional erection within 15 minutes of a 100 mg dose, underpinning its rapid‑onset label.

Glossary

Phosphodiesterase‑type 5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby promoting smooth‑muscle relaxation in the penis.

cGMP (Cyclic guanosine monophosphate)

A cellular messenger that mediates smooth‑muscle relaxation; higher levels facilitate erection.

Hypotension

Abnormally low blood pressure, which can cause dizziness, fainting, or shock if severe.

Priapism

A prolonged, often painful erection lasting more than four hours, requiring urgent medical treatment to avoid permanent tissue damage.

⚠️ Disclaimer

The information provided about Avana is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Avana for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.