Buy Generic Urso Online

Generic Urso Information

Introduction

Urso is a pharmaceutical preparation containing the bile‑acid derivative Ursodiol. It belongs to the therapeutic groups Gastro Health and Cholesterol and is primarily prescribed for disorders of bile‑acid metabolism. In the United Kingdom, Urso is used to dissolve cholesterol gallstones, to improve liver function in primary biliary cholangitis (PBC), and, in some cases, to protect the liver after certain surgeries. The medication is manufactured by several licensed producers; one of the most widely recognised brand‑name formulations of the same active compound is Ursofalk (EU) and Actigall (US).

What is Urso?

Urso is a oral tablet formulation that delivers the active compound Ursodiol (also called ursodeoxycholic acid, UDCA). Ursodiol is a naturally occurring secondary bile acid that is isolated from bear bile or manufactured synthetically for pharmaceutical use. The drug is classified as a bile‑acid analogue and is listed under the Anatomical Therapeutic Chemical (ATC) code A05AA02.

Ursodiol was first isolated in the 195s and subsequently developed as a therapeutic agent in the 197s. It is produced by several reputable manufacturers, including Allergan, Mylan, and Teva, under various brand names such as Ursofalk, Actigall, and Stenur.

Urso is the generic version of these well‑known brand products, containing the same active compound Ursodiol. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Urso Works

Ursodiol is a hydrophilic bile acid that modifies the composition of the bile pool. Its principal mechanisms are:

• Cholesterol Solubilisation: Ursodiol reduces the cholesterol saturation of bile by displacing more hydrophobic, lithogenic bile acids (e.g., deoxycholic acid). This creates a more soluble bile environment, facilitating the gradual dissolution of cholesterol gallstones.
• Cytoprotective Effect: In cholangiocytes (bile‑duct cells) and hepatocytes, Ursodiol stabilises cell membranes, reduces oxidative stress, and diminishes the release of inflammatory cytokines. This protective effect slows the progression of autoimmune cholestasis such as primary biliary cholangitis.
• Improved Bile Flow: By stimulating bicarbonate‑rich “hypercholeresis,” Ursodiol enhances bile secretion, which helps to flush toxic bile acids from the liver.

Pharmacokinetically, Ursodiol is absorbed from the small intestine (≈ 40 % oral bioavailability). Peak plasma concentrations are reached within 2–4 hours. The drug undergoes enterohepatic recirculation, extending its hepatic exposure. Approximately 70 % of the dose is excreted unchanged in the faeces, and the elimination half‑life is 3–5 hours, allowing once‑ or twice‑daily dosing.

Conditions Treated with Urso

• Cholesterol Gallstone Dissolution – In patients with radiolucent, non‑calcified cholesterol stones ≤ 15 mm, Ursodiol (10 mg/kg/day) can achieve complete dissolution in 6–24 months. In the UK, an estimated 10 % of the adult population will develop gallstones during their lifetime, making non‑surgical options clinically valuable.
• Primary Biliary Cholangitis (PBC) – Ursodiol is the first‑line disease‑modifying therapy for PBC. Standard dosing (13–15 mg/kg/day) improves liver biochemistry, delays transplant‑free survival, and reduces pruritus. PBC prevalence in the UK is ≈ 40 cases per 100 000 adult females.
• Intra‑hepatic Cholestasis of Pregnancy (ICP) – Although not formally licensed for ICP in the UK, off‑label use of Ursodiol (10–15 mg/kg/day) can lower serum bile‑acid levels and ameliorate pruritus, potentially reducing fetal complications.
• Post‑liver Transplant Biliary Complications – Ursodiol reduces the incidence of cholestasis and improves graft survival when given prophylactically.

Each indication shares a common pathophysiological thread: excessive cholesterol or toxic bile acids that impair hepatic or biliary function. By altering the bile‑acid pool, Urso directly addresses the underlying biochemical abnormality.

Who is Urso For?

• Adults with Confirmed Cholesterol Gallstones – Especially those who are poor surgical candidates (e.g., severe cardiopulmonary disease) or who prefer a non‑invasive approach.
• Patients Diagnosed with Primary Biliary Cholangitis – Women over 40 years of age, the demographic most affected by PBC, who have abnormal alkaline phosphatase and anti‑mitochondrial antibodies.
• Pregnant Women with Symptomatic Intra‑hepatic Cholestasis – When the potential fetal benefit outweighs the limited safety data, under specialist supervision.
• Individuals Awaiting Liver Transplant or Post‑Transplant Recipients – To protect biliary epithelium and reduce cholestatic injury.

Contra‑indications and cautions: Urso should not be used in patients with known hypersensitivity to Ursodiol or any excipients, in those with complete biliary obstruction, or in individuals with severe hepatic impairment (Child‑Pugh C) where the drug’s clearance is markedly reduced.

Risks, Side Effects, and Interactions

Common

• Diarrhoea or loose stools – Reported in up to 15 % of patients; usually mild and transient.
• Nausea and abdominal discomfort – Frequently occurs during the first weeks of therapy.
• Fatigue – A non‑specific symptom noted in clinical trials.

Rare

• Hepatic Enzyme Elevation – Isolated increases in ALT/AST have been observed in < 1 % of users, often reversible on discontinuation.
• Rash or pruritic skin reactions – May indicate a hypersensitivity response.

Serious

• Gallstone‑related complications – Incomplete dissolution can lead to biliary colic or pancreatitis; patients should seek urgent care if severe pain develops.
• Severe hypersensitivity (anaphylaxis) – Extremely rare but requires immediate emergency treatment.

Drug‑Drug Interactions

• Cholestyramine, colestipol, or other bile‑acid binding resins – These agents can reduce Ursodiol absorption by up to 50 %. Administer at least 1 hour before or 4 hours after the resin.
• Cyclosporine – Co‑administration may increase cyclosporine levels; monitor renal function and drug concentrations.
• Oral contraceptives – No clinically significant interaction, but monitoring of liver enzymes is advisable in long‑term use.

Patients should disclose all concomitant medicines, including over‑the‑counter supplements and herbal products, to avoid unforeseen interactions.

Practical Use: Dosing, Missed Dose, Overdose

• Standard Adult Dose for Gallstone Dissolution – 10 mg/kg body weight divided into two daily doses (e.g., a 70 kg adult takes 700 mg per day, usually 350 mg twice daily).
• Standard Adult Dose for PBC – 13–15 mg/kg/day, typically given as 5–10 mg/kg in the morning and the remainder in the evening. Tablets are available in 150 mg and 300 mg strengths, allowing flexible dosing.

Missed Dose
If a dose is missed, take it as soon as you remember, provided it is at least 4 hours before the next scheduled dose. Do not double‑dose to compensate.

Overdose
Acute overdose of Ursodiol is uncommon and generally well tolerated. Symptoms may include diarrhoea, abdominal cramps, or transient elevation of liver enzymes. In case of suspected overdose, seek medical advice; treatment is primarily supportive.

Practical Precautions

• Food – Ursodiol can be taken with or without food; however, taking the tablet with a meal may reduce gastrointestinal upset.
• Alcohol – Moderate alcohol consumption does not significantly affect Ursodiol pharmacokinetics, but excessive intake may worsen underlying liver disease.
• Renal or Hepatic Impairment – Dose adjustment is not routinely required for mild to moderate impairment, but severe hepatic dysfunction warrants closer monitoring.

Buying Urso from Our Online Pharmacy

Patients across the United Kingdom can obtain Urso through our online pharmacy. We specialise in providing high‑quality generic medicines at a price close to the manufacturer’s cost, without compromising on safety.

• Affordable Pricing – Our bulk‑purchase agreements with licensed overseas suppliers enable us to pass substantial savings to you.
• Verified Quality – Each batch of Urso is sourced from GMP‑certified facilities and undergoes independent laboratory testing before dispatch.
• Guaranteed Delivery – Discreet, trackable shipping is available in two options: a 7‑day express service for urgent needs and a standard 2‑3‑week airmail for routine orders.
• Online‑Only Access – We operate as a pharmacy broker service, partnering with overseas licensed pharmacies to bring medications that may be limited or unavailable through traditional UK dispensing routes. This model safeguards your privacy while ensuring you receive authentic products.

Choosing our online pharmacy means you receive a reliable, cost‑effective supply of Urso, with the convenience of home delivery and transparent pricing.

FAQ

• Can Urso be stored in the refrigerator?
  No, Urso should be kept at controlled room temperature (15‑30 °C). Refrigeration is unnecessary and may cause condensation that degrades the tablet coating.

• What do the Urso tablets look like?
  Tablets are typically round, white to off‑white, and may be scored for easier splitting. In the UK formulation, they contain lactose, microcrystalline cellulose, and magnesium stearate as inactive ingredients.

• Is Urso covered by the NHS for PBC treatment?
  In England, NHS England usually funds Ursodiol for primary biliary cholangitis when the prescription follows recognised clinical guidelines. Coverage may vary in Scotland, Wales, and Northern Ireland.

• Do I need to fast before taking Urso?
  Fasting is not required. Taking the tablet with a meal can reduce occasional gastrointestinal discomfort, but the drug’s absorption is not significantly affected by food.

• Can I travel internationally with Urso?
  Yes, Urso can be taken on flights and during overseas trips. Keep the medication in its original packaging, carry a copy of the prescription or a letter from your clinician, and comply with the import limits of the destination country.

• Are there any differences between Urso and the brand‑name Ursofalk?
  No therapeutic differences exist; both contain the same amount of Ursodiol per tablet. The distinction lies in branding and pricing, with generic Urso offering a lower cost option.

• What is the legal status of importing Urso for personal use in the UK?
  The Medicines and Healthcare products Regulatory Agency (MHRA) permits individuals to import a three‑month supply of a prescription‑only medicine for personal use, provided it is obtained from a licensed foreign pharmacy. Our service complies with these regulations.

• Does Urso interact with common herbal supplements such as milk thistle?
  Current data do not show a clinically significant interaction between Ursodiol and milk thistle (silymarin). Nonetheless, discuss any supplement use with your clinician to avoid unforeseen effects.

• How long does it take for gallstones to dissolve with Urso?
  Dissolution is gradual; most patients experience measurable reduction in stone size within 6–12 months, with complete resolution possible after 2–3 years of continuous therapy.

• Is there a pediatric formulation of Urso?
  Ursodiol is approved for use in children with certain cholestatic liver diseases, but the dosage and formulation differ from the adult tablets. Pediatric patients should only use the formulation prescribed by a paediatric hepatologist.

Glossary

Bile‑Acid Analogue

A synthetic compound that mimics the structure and function of natural bile acids, used to modify the composition of bile.

Enterohepatic Recirculation

The process by which bile acids are secreted into the intestine, re‑absorbed, and returned to the liver, extending their physiological activity.

Primary Biliary Cholangitis (PBC)

An autoimmune disease characterised by progressive destruction of intra‑hepatic bile ducts, leading to cholestasis and liver fibrosis.

Lithogenic

Referring to substances that promote the formation of gallstones, particularly cholesterol‑rich bile.

⚠️ Disclaimer

The information provided about Urso is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Urso for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.