Buy Generic Cozaar Online

Generic Cozaar Information

Introduction

Cozaar (losartan potassium) is an angiotensin II receptor blocker (ARB) prescribed primarily for the management of hypertension. In the United Kingdom it is used to reduce high blood pressure, protect the kidneys in patients with type 2 diabetes, and lower the risk of cardiovascular events in individuals with left‑ventricular hypertrophy. The medication belongs to the blood‑pressure therapeutic group and is manufactured by Merck Sharp & Dohme (UK) Ltd.

What is Cozaar?

Cozaar is a tablet formulation that contains the active compound losartan potassium, an ARB that selectively blocks the binding of angiotensin II to the AT₁ receptor. The drug was developed in the early 199s and received marketing authorisation in the UK in 1995. Cozaar is supplied as immediate‑release tablets in strengths of 25 mg, 50 mg and 100 mg. It is the brand‑name product; generic losartan tablets are also available from multiple licensed manufacturers.

How Cozaar Works

Losartan interferes with the renin‑angiotensin‑aldosterone system (RAAS). Angiotensin II is a potent vasoconstrictor that also stimulates aldosterone release, leading to sodium and water retention. By blocking the AT₁ receptor, losartan produces three key therapeutic effects:

• Vasodilation: Blood vessels relax, lowering peripheral resistance and thus arterial pressure.
• Reduced aldosterone secretion: Leads to modest diuresis and decreased plasma volume.
• Attenuation of cardiac‑remodelling: Inhibits the pro‑fibrotic actions of angiotensin II on the myocardium and vasculature.

On oral administration, losartan is rapidly absorbed (peak plasma concentrations in 1–2 hours). It undergoes hepatic metabolism via CYP2C9 and CYP3A4 to an active metabolite (EXP‑3174) that is 10‑ to 40‑fold more potent at the AT₁ receptor. The combined half‑life of losartan and its metabolite is approximately 6–9 hours, supporting once‑daily dosing for most patients.

Conditions Treated with Cozaar

• Essential hypertension: First‑line or add‑on therapy when blood pressure targets (≤ 140/90 mmHg, or ≤ 130/80 mmHg for patients with diabetes or chronic kidney disease) are not achieved with lifestyle measures alone.
• Diabetic nephropathy (type 2 diabetes): Losartan slows the progression of albuminuria and preserves glomerular filtration rate, as demonstrated in the RENAAL and IDNT trials.
• Heart failure with reduced ejection fraction (HFrEF): Used when ACE inhibitors are not tolerated; improves morbidity and all‑cause mortality.
• Left‑ventricular hypertrophy: Reduces left‑ventricular mass and the risk of subsequent cardiovascular events.

In the UK, hypertension affects around 1.5 million adults; a substantial proportion have co‑existing diabetes or chronic kidney disease, making losartan a frequently prescribed ARB.

Suitable Candidates for Cozaar Treatment

Cozaar is appropriate for adult patients who:

• Have a confirmed diagnosis of primary hypertension and require pharmacological blood‑pressure control.
• Have type 2 diabetes with micro‑albuminuria or proteinuria, where renal protection is a clinical goal.
• Have symptomatic heart failure (NYHA class II–III) and cannot tolerate an ACE inhibitor because of cough or angio‑edema.
• Exhibit left‑ventricular hypertrophy on echocardiography and need additional after‑load reduction.

Contra‑indications or cautionary situations include:

• Known hypersensitivity to losartan, any ARB, or excipients in the tablet.
• Pregnancy (especially the second and third trimesters) and lactation – losartan is teratogenic and may impair fetal renal development.
• Severe hepatic impairment – the active metabolite accumulates, increasing the risk of hypotension.
• Bilateral renal artery stenosis – ARBs can precipitate acute renal failure.

Risks, Side Effects, and Interactions

Common

• Dizziness or light‑headedness – usually related to the initial antihypertensive effect.
• Upper respiratory tract infection – mild and self‑limiting.
• Fatigue – often transient during dose titration.

Rare

• Hyperkalaemia – especially when combined with potassium‑sparing diuretics or supplements.
• Elevated liver enzymes – reversible upon discontinuation.
• Dry cough – less frequent than with ACE inhibitors but reported in a minority of patients.

Serious

• Angio‑edema – swelling of the face, lips, tongue or airway; requires immediate medical attention.
• Severe hypotension – may occur in volume‑depleted patients or those on high‑dose diuretics.
• Acute renal failure – particularly in patients with pre‑existing renal artery stenosis or dehydration.

Clinically Relevant Drug–Drug Interactions

• Potassium‑rich supplements or potassium‑sparing diuretics (e.g., spironolactone, amiloride): increase the risk of hyperkalaemia.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive effect and worsen renal function.
• Cytochrome P450 inhibitors (e.g., fluconazole, ketoconazole): can raise losartan plasma concentrations, potentially enhancing hypotensive response.
• Lithium: concurrent use may raise lithium levels and precipitate toxicity; close monitoring is advised.

Practical Use: Dosing, Missed Dose, Overdose

• Initial dosing: 50 mg once daily for most adults. In elderly or renally impaired patients, a starting dose of 25 mg daily is recommended.
• Dose titration: The dose may be increased to 100 mg once daily after 2–4 weeks if blood pressure goals are not met.
• Maximum dose: 100 mg daily for hypertension; in heart failure, clinicians may prescribe up to 150 mg daily in divided doses, though such regimens are less common in the UK.
• Missed dose: Take the missed tablet as soon as remembered unless it is near the time of the next scheduled dose. Do not double‑dose.
• Overdose: Symptoms may include marked hypotension, dizziness, and renal impairment. Contact emergency services (999) and provide details of the ingested amount. Activated charcoal may be considered if presentation is early.

Practical precautions – Cozaar can be taken with or without food. Alcohol may potentiate hypotensive effects and should be limited. Patients with chronic liver disease should have liver function monitored periodically.

Buying Cozaar from Our Online Pharmacy

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FAQ

• Is Cozaar available in both brand‑name and generic forms in the UK?
  Yes. Cozaar is the brand‑name product, while losartan potassium is marketed by numerous generic manufacturers. Generic versions contain the same active ingredient and are usually less expensive.

• What should I do if I travel abroad with Cozaar?
  Keep the medication in its original labelled container, store it at room temperature, and carry a copy of the prescription or a doctor’s letter if required by customs. Avoid exposing the tablets to extreme heat or humidity.

• Does food affect the absorption of Cozaar?
  No. Losartan can be taken with or without meals, and food does not significantly alter its bioavailability.

• Are there differences in tablet appearance between UK and overseas manufacturers?
  Tablet colour, shape, and imprint may vary between manufacturers, but the dosage strength and inactive ingredients are regulated to ensure bioequivalence.

• Can Cozaar be used by people of Asian ancestry without dose adjustment?
  Pharmacokinetic studies show similar exposure across ethnic groups; however, clinicians may start at a lower dose in patients with reduced creatinine clearance, which is more prevalent in some Asian populations.

• What is the legal status of importing Cozaar for personal use into the UK?
  Personal importation of a three‑month supply of a prescription medication is permitted if the product is for personal use, comes from a reputable source, and is not a controlled substance. Our online pharmacy ensures compliance with UK customs regulations.

• Does Cozaar interfere with standard drug‑testing panels?
  Losartan is not typically screened for in routine workplace or sports drug tests, as it is not a performance‑enhancing or prohibited substance.

• How long does it take for blood‑pressure reduction to become evident after starting Cozaar?
  A modest decrease in systolic and diastolic pressure can be observed within 2 weeks, with the full antihypertensive effect usually achieved after 4–6 weeks of consistent therapy.

• What are the key clinical trials that established losartan’s efficacy?
  The major studies include the LIFE trial (Losartan Intervention For Endpoint reduction), which demonstrated superiority over atenolol for reducing cardiovascular morbidity, and the RENAAL trial, which showed renal protection in diabetic patients.

• Is there a pediatric formulation of losartan available in the UK?
  Losartan tablets are licensed for use in adults only. Pediatric use is off‑label and should only be considered under specialist supervision.

Glossary

Angiotensin II receptor blocker (ARB)

A class of drugs that inhibit the action of angiotensin II at the AT₁ receptor, resulting in vasodilation and reduced blood pressure.

Active metabolite (EXP‑3174)

The pharmacologically active product formed from losartan metabolism; it has greater affinity for the AT₁ receptor than the parent compound.

Hyperkalaemia

An elevated plasma potassium level (typically > 5.5 mmol/L) that can cause cardiac arrhythmias if untreated.

GMP (Good Manufacturing Practice)

International quality standards that ensure pharmaceutical products are consistently produced and controlled according to quality criteria.

⚠️ Disclaimer

The information provided about Cozaar is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cozaar for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.