Buy Generic Uniphyl Cr Online

Generic Uniphyl Cr Information

Introduction

Uniphyl Cr is a prescription‑only medication containing the methylxanthine theophylline. It belongs to the asthma medication group and is used primarily to maintain bronchodilation in chronic respiratory diseases. In the United Kingdom, theophylline remains an option when inhaled therapies are insufficient or not tolerated. The preparation is supplied as a sustained‑release (CR = controlled release) tablet, allowing once‑ or twice‑daily dosing.

What is Uniphyl Cr?

Uniphyl Cr is a generic formulation of theophylline in a controlled‑release tablet. It is classified as a bronchodilator and a phosphodiesterase‑4 inhibitor. The product is marketed by an international pharmaceutical supplier; the specific UK‑based manufacturer is not disclosed on the product label, but the formulation complies with the Medicines and Healthcare products Regulatory Agency (MHRA) standards for quality and safety.

How Uniphyl Cr Works

Theophylline exerts its therapeutic effect through several mechanisms:

• Phosphodiesterase inhibition – The drug blocks phosphodiesterase‑4, leading to an increase in intracellular cyclic‑adenosine‑monophosphate (cAMP). Elevated cAMP relaxes airway smooth muscle and reduces inflammatory cell activation.
• Adenosine‑receptor antagonism – By blocking adenosine receptors, theophylline diminishes bronchoconstriction triggered by endogenous adenosine.
• Histamine release modulation – The compound modestly suppresses histamine release from mast cells, contributing to airway stability.

These actions produce a gradual bronchodilation that begins within 30–60 minutes after ingestion and can last up to 12 hours with the controlled‑release formulation. The drug is metabolised mainly by hepatic CYP1A2; clearance is influenced by age, smoking status, and concomitant medications, which is why serum level monitoring is often recommended.

Conditions Treated with Uniphyl Cr

• Asthma (persistent, moderate‑to‑severe) – Theophylline serves as an add‑on therapy for patients whose symptoms remain uncontrolled despite inhaled corticosteroids (ICS) and long‑acting β2‑agonists (LABA).
• Chronic Obstructive Pulmonary Disease (COPD) – In the UK, COPD affects roughly 1.2 million adults. Theophylline may improve exercise tolerance and reduce exacerbation frequency when used alongside bronchodilators.
• Bronchiectasis (off‑label) – Limited evidence suggests theophylline can aid mucus clearance in selected cases, though it is not a licensed indication.

In each condition, the drug’s long‑acting bronchodilatory effect supports airway patency, allowing better airflow and symptom control.

Suitable Candidates for Uniphyl Cr Treatment

• Adults with chronic asthma whose disease remains uncontrolled on optimal inhaled therapy and who have documented reversible airway obstruction.
• COPD patients with persistent dyspnoea despite maximal inhaled therapy, particularly those who experience frequent exacerbations.
• Individuals intolerant of inhaled steroids due to side‑effects such as oral thrush or systemic glucocorticoid exposure.
• Patients with a documented therapeutic window – Theophylline requires careful dosing; candidates who can attend regular serum‑level checks are preferred.

Contra‑indications include known hypersensitivity to methylxanthines, uncontrolled cardiac arrhythmias, severe liver disease, and active seizures. Caution is advised in the elderly, pregnant or lactating women, and patients taking drugs that strongly induce or inhibit CYP1A2.

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, or abdominal discomfort
• Headache
• Insomnia or restlessness
• Palpitations or mild tachycardia

Rare

• Tremor or muscle weakness
• Diarrhoea
• Skin rash or pruritus
• Hearing disturbances (tinnitus)

Serious

• Cardiac arrhythmias (e.g., atrial fibrillation, ventricular ectopy)
• Severe hypotension or hypertension
• Seizures, especially at serum concentrations > 20 µg · L⁻¹
• Life‑threatening allergic reactions (anaphylaxis)

Drug‑drug interactions

Theophylline metabolism is highly susceptible to CYP1A2 modulation. Notable interacting agents include:

• CYP1A2 inhibitors – erythromycin, ciprofloxacin, fluvoxamine, allopurinol; these can raise serum theophylline to toxic levels.
• CYP1A2 inducers – smoking, carbamazepine, phenobarbital, rifampicin; these may lower concentrations, reducing efficacy.
• Cardiovascular agents – propranolol, quinidine, and digoxin may enhance theophylline‑related cardiac effects.
• CNS stimulants – caffeine, theobromine, and other methylxanthines increase the risk of central nervous system toxicity.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing – Adults usually start with 200 mg once daily, titrating to a maintenance dose of 300–600 mg per day, divided as 150–300 mg twice daily for the controlled‑release formulation. The exact dose is guided by serum theophylline concentration, targeting 10–20 µg · L⁻¹.
• Missed dose – If a dose is missed and the scheduled time is less than 6 hours away, take the missed tablet immediately. If more than 6 hours have elapsed, skip the missed dose and resume the regular schedule. Do not double‑strength the next dose.
• Overdose – Early signs include nausea, vomiting, severe headache, and cardiac palpitations. Ingesting more than 1 g (approximately 10 tablets of a 100 mg dose) constitutes a medical emergency. Immediate contact with emergency services (999 in the UK) is advised; activated charcoal may be administered in a hospital setting.

Practical precautions

• Take the tablet with a full glass of water, preferably after a meal to reduce gastrointestinal irritation.
• Avoid excessive caffeine and alcohol, both of which can increase theophylline plasma levels.
• Smoking cessation is recommended; nicotine induces CYP1A2 and can lower drug concentrations, leading to reduced efficacy.

Buying Uniphyl Cr from Our Online Pharmacy

Uniphyl Cr is available for purchase through our online pharmacy in the UK. Our service combines affordability with assurance of quality:

• Cost‑effective pricing – We source the medication at near‑manufacturer rates, passing the savings to patients who need a budget‑friendly alternative to brand‑name formularies.
• Verified quality – All batches are supplied by licensed overseas pharmacies that adhere to Good Manufacturing Practice (GMP) standards and are inspected by the MHRA or equivalent regulatory bodies.
• Reliable delivery – Orders are dispatched discreetly with standard UK parcel services (typically 3–5 working days) or via express courier for urgent needs (delivered within 7 days). International shipping options are also available, with transparent tracking.
• Privacy‑focused service – As a pharmacy‑broker model, we work with accredited overseas suppliers while maintaining strict confidentiality. Packaging omits any branding that could disclose the medication’s identity, ensuring patient privacy.

Our online platform enables patients who encounter limited availability in local pharmacies or who seek a generic alternative to obtain Uniphyl Cr safely and conveniently.

FAQ

• Is Uniphyl Cr available in both brand‑name and generic forms in the UK?
  Yes. The original brand marketed in some countries is “Theophyllin‑CR.” Uniphyl Cr is a generic version that contains the identical active ingredient, theophylline, but is typically offered at a lower price.

• What does the “CR” designation mean on the tablet?
  “CR” stands for controlled‑release, indicating that the tablet is formulated to dissolve slowly, providing a steadier plasma concentration over 12 hours compared with immediate‑release forms.

• Can I travel internationally with Uniphyl Cr tablets?
  You may carry a personal supply for up to three months, provided you have a copy of the prescription or a physician’s letter. Some countries require declaration at customs; check the destination’s import regulations before travel.

• Does the tablet contain any allergens or excipients of concern?
  Uniphyl Cr tablets typically contain lactose, magnesium stearate, and silicates as inactive ingredients. Patients with severe lactose intolerance or known hypersensitivity to these excipients should consult a pharmacist.

• How should Uniphyl Cr be stored in different climates?
  Store the tablets in a dry place at temperatures between 15 °C and 30 °C. In hot or humid environments, keep the container tightly sealed and avoid direct sunlight to prevent degradation of theophylline.

• Are there any special warnings for patients of Asian descent?
  Some pharmacogenetic studies suggest slower metabolism of theophylline in individuals of East Asian ancestry, potentially leading to higher serum levels. Dose adjustment and closer therapeutic drug monitoring may be warranted.

• What clinical trials established the efficacy of theophylline in asthma?
  Large‑scale, double‑blind trials in the 197s and 198s, such as the “Theophylline Asthma Study,” demonstrated modest improvement in forced expiratory volume (FEV₁) when added to inhaled steroids. More recent systematic reviews confirm its role as an add‑on therapy, especially in patients with severe disease.

• How does theophylline compare with newer biologic agents?
  Biologics (e.g., omalizumab, mepolizumab) target specific inflammatory pathways and are reserved for severe asthma phenotypes. Theophylline offers a broader, non‑specific bronchodilatory effect and is less costly, but it lacks the targeted efficacy of biologics and requires monitoring for toxicity.

• Can theophylline affect drug testing for employment or sports?
  Theophylline is not a prohibited substance in standard anti‑doping panels, but its structural similarity to caffeine may appear in some urine screening assays. Laboratories can differentiate the compounds using specific chromatographic methods if needed.

• Is there a different formulation of theophylline for paediatric use?
  Child‑appropriate formulations, such as liquid suspensions or lower‑dose tablets, exist but are marketed under separate brand names. Uniphyl Cr is formulated for adult dosing and is not approved for children under 12 years of age.

• What is the shelf‑life of Uniphyl Cr tablets after opening the bottle?
  The product retains full potency for up to 24 months when stored as directed. Once the bottle is opened, keep the cap tightly sealed and avoid exposure to moisture; discard any tablets that appear discoloured or crumbly.

• Does theophylline interact with herbal supplements like St John’s wort?
  St John’s wort induces CYP1A2 and may lower serum theophylline concentrations, potentially reducing its therapeutic effect. Patients using herbal products should discuss possible interactions with a pharmacist.

Glossary

Bronchodilator

A class of medication that relaxes the muscles of the airways, increasing airflow to the lungs.

Therapeutic window

The plasma concentration range in which a drug is effective without causing unacceptable side effects.

CYP1A2

An enzyme in the liver responsible for metabolising many drugs, including theophylline; its activity can be increased or decreased by other substances, affecting drug levels.

Controlled‑release (CR)

A formulation designed to release the active ingredient gradually over an extended period, allowing less frequent dosing and more stable blood concentrations.

⚠️ Disclaimer

The information provided about Uniphyl Cr is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Uniphyl Cr for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.