Generic Isoptin
Isoptin is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.
- Category: Blood Pressure
- Active ingredient: Verapamil
- Available Dosage: 40mg, 120mg, 240mg
- Payment options: VISA, Mastercard, Amex, JCB, Dinners
- Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)
Buy Generic Isoptin Online
Package | Price | |
---|---|---|
40mg x 60 pills | CA $60.81 | |
40mg x 90 pills | CA $60.81 |
Package | Price | |
---|---|---|
120mg x 90 pills | CA $109.17 | |
120mg x 60 pills | CA $81.99 |
Package | Price | |
---|---|---|
240mg x 90 pills | CA $240.45 | |
240mg x 60 pills | CA $168.59 | |
240mg x 30 pills | CA $94.68 |
Generic Isoptin information
Introduction
Isoptin is a prescription‑only medication used primarily to manage high blood pressure and certain cardiac rhythm disorders. The product contains the calcium‑channel blocking agent verapamil, which belongs to the broader group of antihypertensive agents. In the United Kingdom, Isoptin is prescribed for hypertension, angina pectoris, and supraventricular tachycardia, often when first‑line agents are insufficient or contraindicated. The drug’s therapeutic role expands to the prevention of migraine attacks and the treatment of premature ventricular contractions in selected patients.
What is Isoptin?
Isoptine is the generic version of the original brand‑name verapamil tablets marketed under names such as Calan, Verelan, and Isoptin‑SR. It contains the same active compound, verapamil, and provides an equivalent pharmacological effect at a lower cost. Our online pharmacy provides this generic alternative as a cost‑effective treatment option. The medication is manufactured by licensed pharmaceutical companies that comply with European Medicines Agency (EMA) quality standards, though specific manufacturer details may vary depending on the source supplier.
How Isoptin Works
Verapamil, the active ingredient in Isoptin, blocks L‑type calcium channels in the cardiac and vascular smooth muscle. By inhibiting calcium influx, it reduces the force of contraction of the heart and dilates peripheral arteries, leading to lower systemic vascular resistance and blood pressure. In the cardiac conduction system, calcium‑channel blockade slows atrioventricular nodal conduction, which is useful for controlling supraventricular tachyarrhythmias.
- Onset of action: Oral tablets begin to lower blood pressure within 1–2 hours after ingestion.
- Duration: Therapeutic effects persist for 6–8 hours, supporting a twice‑daily dosing regimen for most formulations.
- Clearance: Verapamil is metabolised primarily by the hepatic cytochrome P450 3A4 pathway and eliminated via renal excretion. Steady‑state concentrations are typically achieved after 3–4 days of regular dosing.
Conditions Treated with Isoptin
- Essential hypertension: Approximately 30 % of UK adults have elevated blood pressure, and verapamil is an approved third‑line agent when lifestyle modification or ACE‑inhibitors/ARBs are inadequate.
- Angina pectoris: By reducing myocardial oxygen demand and improving coronary blood flow, Isoptin relieves chest pain in chronic stable angina.
- Supraventricular tachycardia (SVT): The drug’s effect on AV‑node conduction makes it useful for termination and prophylaxis of SVT episodes.
- Migraine prophylaxis: Verapamil’s vasodilatory properties can decrease the frequency of migraine attacks in patients who cannot tolerate triptans.
- Premature ventricular contractions (PVCs): In selected cases, calcium‑channel blockade suppresses ectopic ventricular beats.
Who is Isoptin For?
- Adults with hypertension who have not achieved target blood pressure (< 130/80 mmHg) on first‑line therapy.
- Patients with chronic stable angina where beta‑blockers are contraindicated (e.g., asthma) or insufficient.
- Individuals with documented SVT who require a medication that can be titrated to control heart rate without causing excessive hypotension.
- Migraine sufferers intolerant to other prophylactic agents such as propranolol or topiramate.
Isoptin may be unsuitable for patients with severe left‑ventricular dysfunction (ejection fraction < 35 %), advanced heart block, or uncontrolled heart failure, as calcium‑channel blockade can exacerbate these conditions.
Risks, Side Effects, and Interactions
Common
- Constipation: May affect up to 5 % of users; increase dietary fiber and fluid intake.
- Peripheral edema: Particularly in the ankles; dose adjustment or combination with a diuretic may be required.
- Headache: Transient, often resolves within the first week of therapy.
- Dizziness or light‑headedness: Related to orthostatic hypotension; advise rising slowly from seated or supine positions.
Rare
- Bradycardia: Heart rate < 50 bpm in susceptible individuals; monitor ECG when initiating therapy.
- Gingival hyperplasia: Overgrowth of gum tissue, more common with long‑term use; dental hygiene is important.
- Liver enzyme elevation: Mild transaminase increases observed in isolated cases; routine liver function tests advisable for patients with pre‑existing hepatic disease.
Serious
- Severe hypotension: Systolic pressure < 90 mmHg may lead to syncope; emergency medical attention required.
- Heart block (second‑ or third‑degree): Particularly in patients with pre‑existing conduction abnormalities; contraindicates use.
- Life‑threatening allergic reactions: Angio‑edema, urticaria, or anaphylaxis; discontinue immediately and seek urgent care.
Drug–drug interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) increase verapamil plasma concentrations; dose reduction may be necessary.
- CYP3A4 inducers (e.g., rifampicin, carbamazepine) reduce efficacy; consider alternative antihypertensives.
- Concurrent beta‑blockers can amplify negative inotropic effects; monitor cardiac function.
- Digoxin: Verapamil raises digoxin levels; co‑administration requires careful serum level monitoring.
Practical Use: Dosing, Missed Dose, Overdose
- Standard dosing for hypertension: 80 mg orally three times daily or 120 mg twice daily, adjusted based on response and tolerability.
- Angina: 120 mg three times daily, with possible increase to 240 mg twice daily under specialist supervision.
- SVT prophylaxis: 80 mg twice daily; dosage may be escalated to 240 mg once daily for refractory cases.
Missed dose: If a dose is forgotten and more than 6 hours have elapsed, skip the missed dose and resume the regular schedule. Do not double‑dose.
Overdose: Symptoms may include severe hypotension, bradycardia, and cardiac arrhythmias. Seek immediate medical attention; supportive care with intravenous fluids and atropine may be required.
Precautions: Take tablets with food to minimise gastrointestinal irritation. Avoid excessive alcohol, as it can potentiate hypotensive effects. Patients with renal impairment may need dose reduction; monitor serum creatinine periodically.
Buying Isoptin from Our Online Pharmacy
Isoptin can be purchased from our online pharmacy in the United Kingdom. We specialise in delivering verified, high‑quality generic verapamil at prices close to manufacturer cost, making treatment more affordable for patients without extensive insurance coverage.
- Affordable pricing: Our supply chain works directly with overseas licensed pharmacies, allowing us to offer near‑manufacturer rates.
- Verified quality: All batches are sourced from EMA‑approved manufacturers and undergo independent quality checks before dispatch.
- Guaranteed delivery: Discreet packaging is shipped via express courier (delivery within 7 days) or regular airmail (approximately 3 weeks).
- Online‑only access: The service enables patients to obtain international medications that may not be stocked locally, while respecting privacy through a pharmacy‑broker model.
FAQ
-
**Can Isoptin be taken with other antihypertensive agents?
Yes, verapamil is often combined with ACE‑inhibitors, thiazide diuretics, or ARBs to achieve synergistic blood‑pressure control. Co‑administration requires monitoring for additive hypotensive effects. -
**Is there a specific time of day that optimises the effect of Isoptin?
Dosing is usually split into morning and evening administrations to maintain steady plasma levels. Taking the first dose with breakfast and the second with dinner aligns with circadian blood‑pressure patterns. -
**What should I do if I experience severe constipation while on Isoptin?
Increase dietary fibre, hydrate adequately, and consider a mild osmotic laxative after consulting a pharmacist. Persistent constipation warrants medical review. -
**Does Isoptin require refrigeration or special storage conditions?
No, Isoptin tablets should be stored at controlled room temperature (15‑30 °C), protected from moisture and direct sunlight. Do not refrigerate. -
**Are there any differences in tablet appearance between UK and overseas suppliers?
UK‑sourced tablets are typically round, blue‑white, and imprinted with “80 mg” or “120 mg”. Overseas batches may vary in colour or shape but contain the same verapamil content. -
**Can I travel internationally with Isoptin in my hand luggage?
Yes, provided the medication is in its original packaging with a copy of the prescription. Some countries enforce import limits; check local regulations before travel. -
**What are the implications of Isoptin for drug testing in employment?
Verapamil is not a prohibited substance and generally does not appear on standard employment drug panels. However, specific workplace policies should be reviewed. -
**Is Isoptin safe for use during pregnancy or breastfeeding?
Verapamil is classified as pregnancy category C; it should be used only if the potential benefit justifies the risk. Limited data suggest minimal transfer into breast milk, but breastfeeding mothers should consult their obstetrician. -
**How does Isoptin compare with older calcium‑channel blockers such as diltiazem?
Both drugs block L‑type calcium channels, but verapamil has a stronger effect on cardiac conduction, making it more suitable for SVT, whereas diltiazem exerts a greater vasodilatory effect, often preferred for angina. -
**What historical milestones led to the development of verapamil?
Verapamil was first synthesised in the 196s by the pharmaceutical company CVR (now part of Pfizer). Clinical trials in the 197s demonstrated its efficacy in hypertension and angina, leading to its approval in Europe and the United States.
Glossary
- Calcium‑channel blocker
- A class of drugs that inhibit the influx of calcium ions through L‑type channels, leading to vascular smooth‑muscle relaxation and decreased cardiac contractility.
- AV‑node (atrioventricular node)
- A specialized conduction tissue in the heart that delays electrical impulses before they pass to the ventricles, regulating heart rate.
- Orthostatic hypotension
- A drop in blood pressure upon standing, causing dizziness or fainting; commonly assessed by measuring blood pressure after a patient stands for 3 minutes.
⚠️ Disclaimer
The information provided about Isoptin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Isoptin for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.