Buy Generic Parlodel Online

Generic Parlodel Information

Introduction

Parlodel is a prescription medication used primarily in the United Kingdom to treat disorders of the endocrine system, most notably hyperprolactinaemia and certain types of Parkinsonian syndrome. The active ingredient is bromocriptine, a dopamine‑receptor agonist that reduces excessive prolactin secretion and exerts central nervous system effects. Although classified within the Women’s Health therapeutic group because hyperprolactinaemia often presents with menstrual irregularities, bromocriptine also has recognised applications in neurology and endocrinology. The drug is marketed by several pharmaceutical companies, with the original formulation historically produced by Novartis.

What is Parlodel?

Parlodel is a synthetic analogue of the natural dopamine agonist bromocriptine. It is supplied as oral tablets of 2.5 mg, 5 mg and 10 mg strength. The product belongs to the ergot‑derived dopamine‑receptor agonist class, first developed in the 197s for the management of pituitary tumours. In the UK it is prescribed under the NHS for hyperprolactinaemia, and occasionally for Parkinsonian features when other agents are unsuitable.

Well‑known bromocriptine‑based brand names that appear in other markets include Dostinex, Cyclocort and Bromopril. All contain the same active molecule, and differences lie mainly in excipients, regulatory approvals, and pricing structures.

How Parlodel Works

Bromocriptine binds with high affinity to dopamine D₂ receptors in the pituitary gland and throughout the central nervous system. By stimulating these receptors, it suppresses the secretion of prolactin from lactotroph cells, thereby normalising serum prolactin levels. In the basal ganglia, dopaminergic stimulation improves motor control, which explains its utility in Parkinsonian symptoms.

The drug reaches peak plasma concentrations within 1–2 hours after oral intake. Its biological half‑life ranges from 6 to 9 hours, and hepatic metabolism via the cytochrome P450 1A2 pathway contributes to clearance. Because the effect is receptor‑mediated, the therapeutic response is usually observed after several days of consistent dosing, with maximal prolactin reduction occurring within two weeks.

Conditions Treated with Parlodel

• Hyperprolactinaemia – Excess prolactin can cause galactorrhoea, infertility, amenorrhoea and sexual dysfunction. In the UK, an estimated .4 % of women reproductive present with clinicallyliptine a‑line option.
• Prolactin‑secreting pituitary adenomas (microadenomas) – Small adenomas often respond to medical therapy, avoiding the need for surgery.
• Parkinsonian syndrome – In patients intolerant of levodopa or experiencing motor fluctuations, bromocriptine offers an oral dopamine agonist alternative.
• Acromegaly (off‑label in some centres) – Rarely, bromocriptine is used as adjunctive therapy to reduce growth‑hormone secretion when first‑line somatostatin analogues are contraindicated.

These indications are supported by controlled clinical trials and real‑world registry data, which demonstrate consistent reductions in prolactin levels and improvement in motor scores.

Suitable Candidates for Parlodel Treatment

• Adults with documented hyperprolactinaemia confirmed by laboratory measurement (serum prolactin > 500 µIU/mL) and a clinical picture of menstrual disturbance, galactorrhoea or infertility.
• Patients with a confirmed prolactin‑secreting microadenoma ≤ 10 mm on MRI, where surgical risk outweighs benefit.
• Individuals diagnosed with Parkinson’s disease who have contraindications to levodopa (e.g., severe nausea) or who experience “off” periods despite optimal levodopa dosing.
• Women of child‑bearing potential who desire fertility restoration through normalisation of prolactin, provided pregnancy is not imminent (bromocriptine is pregnancy‑category B, but treatment decisions require specialist input).

Parlodel is not appropriate for:

• Patients with known hypersensitivity to ergot derivatives.
• Uncontrolled hypertension or severe cardiovascular disease, due to vasoconstrictive potential.
• Active hepatic impairment (Child‑Pugh class B or C).
• Concurrent use of potent CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine) without dose adjustment.

Clinical assessment, including cardiac evaluation and liver function testing, should precede initiation.

Risks, Side Effects, and Interactions

Common

• Nausea and vomiting (reported in up to 30 % of patients).
• Headache, dizziness or light‑headedness.
• Nasal congestion or rhinorrhoea.
• Fatigue or drowsiness.

These effects are usually transient and improve with gradual dose titration.

Rare

• Orthostatic hypotension leading to fainting.
• Peripheral oedema, particularly of the lower limbs.
• Mood changes, including mild depression or anxiety.

Patients encountering persistent symptoms should contact a healthcare professional promptly.

Serious

• Cardiac valvulopathy – Rare but documented with long‑term ergot use; baseline echocardiography is advised for prolonged therapy.
• Pulmonary fibrosis – Very infrequent; early respiratory symptoms warrant investigation.
• Severe hepatic injury – Monitor liver enzymes regularly, especially in patients with pre‑existing liver disease.

Drug‑Drug Interactions

• CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, enoxacin) can increase bromocriptine plasma levels, raising the risk of hypotension and nausea. Dose reduction may be required.
• Antihypertensives – Additive vasoconstrictive effects may exacerbate blood pressure control. Close monitoring is recommended.
• Antipsychotics with dopamine‑blocking activity (e.g., haloperidol, risperidone) antagonise bromocriptine’s effect, potentially nullifying therapeutic benefit.
• Macrolide antibiotics (e.g., erythromycin) and fluoroquinolones may also inhibit metabolism, necessitating caution.

Practical Use: Dosing, Missed Dose, Overdose

• Initial dosing for hyperprolactinaemia typically starts at 2.5 mg taken once daily at bedtime. The dose is escalated by 2.5 mg every 3–5 days to a usual maintenance range of 5–15 mg per day, divided into one or two doses.
• For Parkinsonian indications, the starting dose is often 2.5 mg three times daily, with gradual increments to a target of 7.5–15 mg per day, depending on motor response and tolerability.
• Missed dose – If a dose is forgotten within 12 hours, take it as soon as remembered. If more than 12 hours have passed, skip the missed dose and resume the regular schedule; do not double‑dose.
• Overdose – Symptoms may include severe hypotension, prolonged vomiting, and profound dizziness. Immediate medical attention is required; supportive care (intravenous fluids, monitoring of vital signs) is the mainstay. Activated charcoal is of limited use due to rapid absorption.

Precautions:

• Take tablets with a full glass of water, preferably with food to minimise gastrointestinal upset.
• Avoid alcohol, which can potentiate hypotensive effects.
• Patients with chronic kidney disease should have dose adjustments evaluated, although renal excretion is minor.

Buying Parlodel from Our Online Pharmacy

Parlodel can be obtained safely through our online pharmacy in the UK. We source the medication from licensed international wholesalers that meet stringent European Medicines Agency (EMA) quality standards.

• Affordable pricing – Our cost structure mirrors manufacturer pricing, eliminating unnecessary mark‑ups and providing a cost‑effective alternative for patients without NHS coverage.
• Verified quality – Every batch undergoes independent testing for potency, purity and stability before dispatch.
• Guaranteed delivery – Discreet packaging is shipped via standard UK courier (typically 2–5 business days) or express service (next‑day delivery for a modest fee). We also offer an economy airmail option (≈ 7‑10 days) for customers outside the mainland.
• Online‑only access – As a pharmacy‑broker service, we bridge the gap between overseas licensed pharmacies and UK patients, ensuring compliance with personal import regulations while protecting privacy.

Choosing our service means receiving a reliable supply of bromocriptine without the delays often encountered in conventional pharmacy supply chains.

FAQ

• **Can Parlodel be taken while travelling internationally?
  Yes, Parlodel tablets may be carried in hand luggage for personal use. Keep the medication in its original labelled container and carry a copy of the prescription or a doctor’s note, as some countries require documentation for dopamine agonists.

• **What does the tablet look like, and are there any distinguishing marks?
  Parlodel tablets are round, film‑coated and colour‑coded by strength: 2.5 mg (white), 5 mg (pink), and 10 mg (blue). The imprint typically reads “PARL 2.5”, “PARL 5” or “PARL 10”, facilitating easy identification.

• **Are there any excipients in Parlodel that could cause allergic reactions?
  In the UK formulation, the inactive ingredients include lactose monohydrate, microcrystalline cellulose, starch, magnesium stearate and titanium dioxide. Patients with lactose intolerance or known hypersensitivity to any of these components should discuss alternatives with their clinician.

• **How does Brexit affect the import of Parlodel into the UK?
  Post‑Brexit, the UK follows its own Medicines and Medical Devices Act. Personal import of prescription medicines from the EU or other regulated markets is permitted when the quantity does not exceed a three‑month supply and a valid prescription is present. Our pharmacy ensures all shipments comply with HMRC and MHRA guidelines.

• **Does bromocriptine interfere with drug testing for employment?
  Standard workplace drug screens typically target recreational substances and do not detect bromocriptine. However, specialized tests for dopamine‑agonist metabolites exist in research settings; routine occupational testing is unlikely to flag Parlodel.

• **What is the historical origin of bromocriptine?
  Bromocriptine was first synthesised in the 196s by a team at Eli Lilly, aiming to develop an ergot derivative with selective dopaminergic activity. It received FDA approval in 1978 for hyperprolactinaemia and later gained a European licence for similar indications.

• **How does Parlodel compare with newer dopamine agonists such as pramipexole?
  Bromocriptine (Parlodel) has a shorter half‑life and requires multiple daily dosing, whereas pramipexole offers once‑daily dosing with a more favourable side‑effect profile for Parkinson’s disease. Nonetheless, bromocriptine remains preferred for prolactin suppression because of its stronger effect on pituitary lactotrophs.

• **Is there any evidence that bromocriptine reduces cardiovascular risk?
  Small observational studies have suggested modest improvements in lipid profiles and insulin sensitivity with bromocriptine, particularly in patients with type 2 diabetes. However, these findings are not yet conclusive, and cardiovascular benefits are not an approved indication.

• **Can Parlodel be crushed or dissolved for patients with swallowing difficulties?
  The tablets are not formulated as extended‑release; they may be crushed and mixed with a small amount of soft food (e.g., applesauce) if necessary. Liquefying the medication is discouraged because it may affect stability and absorption.

Glossary

Dopamine‑receptor agonist

A class of drugs that mimics dopamine’s action by binding to dopamine receptors, thereby influencing hormonal release and motor pathways.

Hyperprolactinaemia

An abnormally high concentration of prolactin in the blood, often leading to reproductive and galactorrhoea symptoms.

Ergot derivative

A compound derived from the ergot fungus (Claviceps purpurea) that possesses vasoconstrictive and dopaminergic properties; bromocriptine belongs to this group.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.

⚠️ Disclaimer

The information provided about Parlodel is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Parlodel for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.