Buy Generic Cardizem Online

Generic Cardizem Information

Introduction

Cardizem is a prescription medication used to manage cardiovascular conditions by relaxing blood vessels and reducing heart workload. Its active ingredient is diltiazem, a calcium‑channel blocker classified under the blood‑pressure and cardiovascular drug groups. In the United Kingdom, Cardizem is prescribed for angina, certain arrhythmias, and hypertension, often when doctors seek a drug that combines rapid onset with a relatively long duration of action. The medication is manufactured by several pharmaceutical companies; its formulation follows the standards set by the Medicines and Healthcare products Regulatory Agency (MHRA).

What is Cardizem?

Cardizem is a brand‑name product that contains the active compound diltiazem hydrochloride. Diltiazem belongs to the benzothiazepine subclass of calcium‑channel blockers, which inhibit the influx of calcium ions into cardiac and smooth‑muscle cells. Cardizem is marketed in immediate‑release tablets (30 – 180 mg), extended‑release tablets (60 – 240 mg), and injectable forms for hospital use.

Other well‑known Diltiazem brand names include Tiazac, Dilacor, Cartia, and Mylocard. Generic diltiazem tablets are widely available across the EU and are typically less expensive while providing identical therapeutic benefit.

Cardizem is the generic version of the original Diltiazem brand, containing the same active compound Diltiazem. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Cardizem Works

Diltiazem blocks L‑type calcium channels located on the membranes of cardiac myocytes and vascular smooth‑muscle cells. By reducing calcium entry:

1. Vasodilation – Arterial smooth muscle relaxes, lowering systemic vascular resistance and thus arterial blood pressure.
2. Negative inotropy and chronotropy – The contractile force and rate of the heart decrease, which lessens myocardial oxygen demand—particularly helpful in angina.
3. Slowed atrioventricular (AV) nodal conduction – The drug prolongs the refractory period of the AV node, stabilising certain supraventricular tachyarrhythmias (e.g., atrial fibrillation with rapid ventricular response).

The onset of action for immediate‑release tablets is typically 30‑60 minutes, with peak plasma concentrations reached within 2‑3 hours. Extended‑release formulations provide a steadier plasma level over 24 hours, allowing once‑daily dosing. Diltiazem is metabolised primarily by hepatic CYP3A4 enzymes and eliminated via the bile; its half‑life ranges from 3 hours (immediate‑release) to 6‑8 hours (extended‑release).

Conditions Treated with Cardizem

• Angina pectoris (stable and variant) – By decreasing myocardial oxygen consumption and improving coronary blood flow, diltiazem reduces frequency and severity of chest pain.
• Hypertension – The vasodilatory effect lowers systolic and diastolic pressure, making it a useful adjunct or monotherapy in adult patients.
• Atrial fibrillation/flutter with rapid ventricular response – AV‑node inhibition slows ventricular rate, improving symptoms and preventing tachycardia‑mediated cardiomyopathy.
• Supraventricular tachycardia (SVT) – In selected cases, diltiazem terminates re‑entrant SVT episodes.

In the UK, cardiovascular disease remains the leading cause of mortality, affecting over 7 million adults. Diltiazem’s dual action on blood pressure and cardiac rhythm makes it a valuable tool in national guidelines for managing chronic coronary syndrome and rhythm control strategies.

Who is Cardizem For?

• Adults with chronic stable angina who require symptom control without compromising exercise tolerance.
• Patients with hypertension inadequately managed by first‑line ACE inhibitors or thiazide diuretics, especially when a combined antihypertensive and anti‑anginal effect is desirable.
• Individuals diagnosed with atrial fibrillation or flutter where rate control is the primary therapeutic goal, and beta‑blockers are contraindicated (e.g., severe asthma).
• Elderly patients who benefit from once‑daily extended‑release dosing, provided renal and hepatic function are within acceptable limits.

Contra‑indications include severe sinus node dysfunction, second‑ or third‑degree AV block (unless a pacemaker is present), unstable heart failure (NYHA class III–IV), and known hypersensitivity to diltiazem or any excipients. Caution is advised in patients taking strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole) or in those with severe hepatic impairment.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing or warmth sensation
• Peripheral edema (especially ankles)
• Dizziness or light‑headedness, particularly after the first dose
• Nausea or mild gastrointestinal upset

Rare

• Bradycardia (heart rate < 50 bpm)
• Hypotension with orthostatic symptoms
• Hepatic enzyme elevation (ALT, AST)
• Rash or pruritus (non‑serious skin reactions)

Serious

• Severe AV block or complete heart block (may require temporary pacing)
• Acute heart failure decompensation (pulmonary oedema, dyspnoea)
• Life‑threatening arrhythmias (ventricular tachycardia) in the context of drug overdose
• Anaphylaxis (extremely rare)

Clinically Relevant Drug–Drug Interactions

• CYP3A4 inhibitors (e.g., macrolide antibiotics, azole antifungals, grapefruit juice) increase diltiazem plasma levels → dose reduction may be needed.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine, St John’s wort) lower concentrations → therapeutic effect may be reduced.
• Concurrent β‑blockers may cause additive bradycardia or AV‑node depression; monitor heart rate closely.
• Digoxin – diltiazem raises digoxin levels; regular serum monitoring is advised.
• Statins metabolised by CYP3A4 (e.g., simvastatin, atorvastatin) may have increased risk of myopathy; consider dose adjustment or alternative statins.

Patients should always disclose all prescribed, over‑the‑counter, and herbal products before starting Cardizem.

Practical Use: Dosing, Missed Dose, Overdose

• Initial adult dosing (immediate‑release tablets): 30 mg three times daily; may be increased to a maximum of 360 mg per day based on clinical response.
• Extended‑release tablets: 120 mg once daily; titrated in 60 mg increments to a usual maintenance dose of 240 mg daily.
• Renal or hepatic impairment: Start at the lowest dose (e.g., 30 mg once daily) and titrate slowly; avoid exceeding 180 mg per day if severe hepatic dysfunction is present.

Missed dose – If a dose is forgotten and more than 4 hours have elapsed, skip the missed dose and resume the regular schedule. Do not double‑dose to compensate.

Overdose – Symptoms may include profound hypotension, bradyarrhythmias, and cardiac arrest. Immediate medical attention is required. Activated charcoal may be administered if presentation is within one hour of ingestion. Supportive measures (intravenous fluids, atropine, temporary pacing) are the mainstay of treatment.

Precautions –

• Take Cardizem with food if gastrointestinal irritation occurs; the extended‑release formulation should be swallowed whole, not crushed.
• Avoid excessive alcohol, which can potentiate hypotensive effects.
• Patients with gout should be aware that diltiazem can increase serum uric acid levels.

Buying Cardizem from Our Online Pharmacy

Cardizem can be purchased from our online pharmacy in the UK with a focus on safety, affordability, and convenience.

• Affordable pricing – We source Cardizem directly from licensed European manufacturers, allowing us to offer prices close to the original wholesale cost.
• Verified quality – Every batch is accompanied by a MHRA‑approved certificate of analysis, ensuring authenticity and consistent potency.
• Guaranteed delivery – Discreet, tracked shipping is available; express delivery typically arrives within 7 days, while regular airmail takes around 3 weeks.
• Online‑only access – Our pharmacy broker service works with overseas licensed pharmacies, giving patients in the UK access to medicines that may be limited in local supply chains.

Our platform respects patient privacy; all orders are packaged without branding and processed through secure, encrypted channels. This service is especially valuable for individuals who face barriers to traditional pharmacy access or who are seeking a reliable generic alternative.

FAQ

• Is Cardizem available in both brand‑name and generic forms in the UK?
  Yes. Cardizem is the brand name, while generic diltiazem tablets contain the same active ingredient and are usually lower in price. Both are regulated by the MHRA and meet the same safety standards.

• What should I do if I need to travel abroad with Cardizem?
  Carry the medication in its original labelled container, keep it in your hand luggage to avoid temperature extremes, and bring a copy of your prescription or a doctor's letter in case customs request verification.

• Does food affect the absorption of extended‑release Cardizem?
  The extended‑release tablet is designed to release diltiazem gradually, and taking it with or without food does not significantly alter its overall absorption. However, swallowing the tablet whole with a full glass of water is recommended.

• Can Cardizem be stored in a refrigerator?
  No. Cardizem should be stored at controlled room temperature (15‑25 °C). Refrigeration or freezing may affect tablet integrity and dissolution characteristics.

• Are there any colour or shape differences between UK and EU Cardizem tablets?
  In the UK, immediate‑release tablets are typically white, round, and biconvex, while extended‑release tablets are beige, oval, and film‑coated. Minor variations can exist between manufacturers, but the imprint code and strength are always printed on each tablet.

• What are the legal limits for importing Cardizem for personal use?
  Under UK law, individuals may import a three‑month supply of a prescription‑only medicine for personal use, provided they hold a valid prescription from a UK‑registered prescriber. Our online pharmacy ensures compliance with these regulations.

• Does diltiazem have any effect on drug screening tests?
  Diltiazem is not a prohibited substance in standard workplace or sports drug tests, and it does not interfere with common immunoassay screenings.

• How was Cardizem discovered and approved for clinical use?
  Diltiazem was first synthesised in the 196s by researchers at SmithKline & French Laboratories. It gained regulatory approval in the United Kingdom in 1976 after demonstrating efficacy in angina and hypertension trials, leading to the commercial launch of Cardizem.

• Is Cardizem more suitable than amlodipine for rate control in atrial fibrillation?
  Diltiazem directly slows AV‑node conduction, making it more effective for rapid ventricular response in atrial fibrillation. Amlodine, a dihydropyridine calcium‑channel blocker, primarily causes vasodilation without significant AV‑node effect.

• Do any excipients in Cardizem cause allergic reactions?
  In the UK formulation, the main inactive ingredients are lactose monohydrate and microcrystalline cellulose. Patients with lactose intolerance generally tolerate the amount present, but rare hypersensitivity to cellulose has been reported.

Glossary

Calcium‑channel blocker

A class of medication that inhibits calcium ions from entering cardiac and smooth‑muscle cells, leading to vasodilation and reduced cardiac contractility.

AV node (atrioventricular node)

A cluster of specialised cardiac cells that regulate the timing of electrical signals between the atria and ventricles; slowing its conduction lowers heart rate.

Extended‑release formulation

A tablet designed to release the active drug gradually over an extended period, allowing once‑daily dosing and more stable blood concentrations.

CYP3A4

An enzyme in the liver responsible for metabolising many drugs; inhibitors or inducers of CYP3A4 can alter the plasma levels of medications like diltiazem.

⚠️ Disclaimer

The information provided about Cardizem is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cardizem for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.