Generic Fildena Professional

Introduction

Fildena Professional is a pharmaceutical product indicated for the treatment of erectile dysfunction (ED) in adult men. It contains the active compound sildenafil, a phosphodiesterase type 5 (PDE‑5) inhibitor that enhances penile blood flow during sexual stimulation. In the United Kingdom, ED affects an estimated 20 % of men aged 40 – 70 years, making effective, accessible therapy an important aspect of men’s health care. Fildena Professional belongs to the therapeutic group “Erectile Dysfunction, Men's Health” and is manufactured by companies that specialize in generic formulations of well‑established medicines.

What is Fildena Professional?

Fildena Professional is a tablet formulation whose sole active ingredient is sildenafil citrate, typically supplied at a dosage of 100 mg per tablet. The product is classified as a prescription‑only medicine (POM) under UK law, falling within the PDE‑5 inhibitor class. Development of sildenafil originated in the early 199s, culminating in the brand‑name Viagra® (Pfizer) which received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) in 1998. Since then, numerous generic manufacturers, including the producer of Fildena Professional, have secured marketing authorisation for sildenafil‑based tablets, offering chemically identical therapy at lower cost.

How Fildena Professional Works

Sildenafil selectively blocks the enzyme phosphodiesterase type 5. Under normal sexual arousal, nitric oxide is released in the corpus cavernosum, stimulating the production of cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscle, allowing blood to fill the erectile tissues. PDE‑5 degrades cGMP, limiting the erection. By inhibiting PDE‑5, sildenafil preserves cGMP levels, prolonging smooth‑muscle relaxation and enhancing penile inflow.

Key pharmacokinetic points:

• Onset: Clinical effect usually begins 30–60 minutes after oral ingestion.
• Peak plasma concentration: Occurs 1–2 hours post‑dose.
• Duration of action: Therapeutic benefit may persist for up to 4–6 hours.
• Elimination: Primarily hepatic metabolism via CYP3A4, with a half‑life of approximately 4 hours.

Food, especially high‑fat meals, can delay absorption and reduce peak concentrations, potentially postponing onset by up to 2 hours.

Conditions Treated with Fildena Professional

• Erectile Dysfunction (ED): The primary approved indication. ED is defined as the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sildenafil improves erectile response in men with vascular, neurogenic, or psychogenic origins of ED.
• Pulmonary Arterial Hypertension (PAH) (off‑label): Although sildenafil is licensed for PAH under the brand name Revatio®, some clinicians prescribe it off‑label for this indication. In the UK, formal approval for PAH requires specific dosing and monitoring; Fildena Professional is not marketed for PAH.

Epidemiology in the UK: The British Society for Sexual Medicine estimates that around 1 million men experience moderate‑to‑severe ED, with prevalence rising sharply after age 50. Sildenafil’s proven efficacy and safety profile make it a first‑line oral therapy for most patients.

Who is Fildena Professional For?

• Men with diagnosed erectile dysfunction who desire oral pharmacotherapy and have no contraindications to PDE‑5.
• Patients with stable cardiovascular disease (e.g., controlled hypertension, stable angina) who have been cleared by a clinician, because sildenafil does not adversely affect myocardial oxygen demand at therapeutic doses.
• Individuals who have failed or cannot tolerate alternative ED treatments such as alprostadil gels or intra‑urethral suppositories.

When it may be inappropriate:

• Patients taking nitrates (e.g., nitroglycerin) or nitric‑oxide donors, because concurrent use can cause severe hypotension.
• Men with severe uncontrolled hypertension (> 180/110 mmHg) or recent (< 30 days) myocardial infarction or stroke.
• Those with known hypersensitivity to sildenafil or any tablet excipients.
• Patients with severe hepatic impairment (Child‑Pugh C) where metabolism is markedly reduced.

Clinicians should evaluate renal function, cardiovascular status, and concomitant medications before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Vision disturbances (e.g., bluish tint, blurred vision)

These events are typically mild, dose‑related, and resolve without intervention.

Rare

• Priapism (erection lasting > 4 hours) – requires immediate medical attention.
• Sudden hearing loss or tinnitus.
• Severe cutaneous reactions (e.g., Stevens‑Johnson syndrome).

Serious

• Cardiovascular events (e.g., myocardial infarction, stroke) in patients with pre‑existing disease; causality is difficult to establish but warrants vigilance.
• Severe hypotension, especially when combined with nitrates or α‑blockers.

Clinically Relevant Drug–Drug Interactions

• Nitrates (nitrogin, isosorbide dinitrate): Concomitant use can precipitate life‑threatening hypotension.
• α‑Blockers (e.g., tamsulosin, doxazosin): May augment blood‑pressure‑lowering effects; stagger dosing by at least 4 hours.
• CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole, ritonavir): Increase sildenafil plasma concentrations; dose reduction to 50 mg or less is advised.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine): Decrease effectiveness; consider alternative therapy.

Patients should disclose all medications, including over‑the‑counter and herbal supplements, to avoid harmful interactions.

Practical Use: Dosing, Missed Dose, Overdose

• Standard starting dose: 50 mg taken as a single tablet about 1 hour before planned sexual activity.
• Dose titration: Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum recommended frequency is one tablet per 24 hours.
• Missed dose: Because sildenafil is taken only when sexual activity is anticipated, there is no “daily” schedule. If a dose is forgotten, it should be taken only when sexual activity is planned and not more than one tablet within 24 hours.
• Overdose: Symptoms may include severe hypotension, prolonged erection, dizziness, or visual disturbances. Seek urgent medical care; treatment is supportive, with monitoring of blood pressure and cardiac status.

Precautions:

• Avoid excessive alcohol, which can impair erectile response and increase hypotensive risk.
• High‑fat meals may delay onset; consider taking on an empty stomach for more predictable timing.
• renal impairment (creatinine clearance < 30 mL/min) should start at 25 mg.

Buying Fildena Professional from Our Online Pharmacy

Patients in the United Kingdom who encounter limited availability or high costs for brand‑name ED drugs can obtain Fildena Professional through our online pharmacy.

• Affordable pricing: We source the medication directly from reputable overseas manufacturers, allowing us to offer it at near‑manufacturer cost, substantially lower than many UK retail pharmacies.
• Verified quality: All tablets are supplied by licensed suppliers that comply with Good Manufacturing Practice (GMP) standards, and each batch undergoes independent quality verification.
• Discreet, reliable delivery: Orders are packaged in unmarked envelopes and dispatched via express courier (typically 7 days) or standard airmail (approximately 3 weeks). Tracking information is provided for every shipment.
• Pharmacy‑broker model: Our service operates as a broker, linking UK customers with internationally licensed pharmacies. This structure enables us to provide a confidential, cost‑effective solution for patients who might otherwise lack access to generic sildenafil.

Choosing our online pharmacy ensures you receive a clinically equivalent, high‑quality product without the premium price of brand‑name equivalents.

FAQ

• Is Fildena Professional available in both brand‑name and generic forms in the UK?
  Yes. The original brand‑name product is Viagra®, while Fildena Professional is a generic formulation containing the same active ingredient, sildenafil. Generic versions are typically more affordable while delivering identical therapeutic effects.

*What should I do if I travel abroad with Fildena Professional?**
Keep the tablets in their original packaging, store them at room temperature, and carry them in hand luggage to avoid temperature extremes. Be aware of the UK’s personal import limits (up to a three‑month supply for personal use) and declare the medication if required by customs.

• Can Fildena Professional be stored in a refrigerator?
  No. Sildenafil tablets are stable at standard room temperature (15‑30 °C). Refrigeration is unnecessary and may cause condensation, potentially affecting tablet integrity.

• Does the tablet contain any allergens such as lactose or gluten?
  In most formulations, inactive ingredients include magnesium stearate, microcrystalline cellulose, and silicon dioxide. Specific allergen content can vary by manufacturer; patients with known sensitivities should review the supplier’s full ingredient list before use.

• Are there any differences in formulation between Asian and European versions of sildenafil?
  The active dose of sildenafil (e.g., 100 mg) is consistent worldwide, but excipient profiles may differ due to local regulatory requirements. These variations do not affect clinical efficacy but could influence tolerability in individuals sensitive to certain fillers.

• How long does it take for Fildena Professional to be eliminated from the body?
  The elimination half‑life of sildenafil is roughly 4 hours; however, detectable levels may persist for up to 24 hours, especially in individuals with hepatic impairment.

• Will taking Fildena Professional affect a standard drug test?
  Sildenafil is not screened for in routine employment drug tests, which typically target substances such as opioids, cannabis, cocaine, amphetamines, and benzodiazepines.

• Is there a maximum lifetime exposure limit for sildenafil?
  No specific lifetime limit exists. Long‑term use is considered safe when prescribed appropriately and monitored for cardiovascular health, as supported by extensive post‑marketing surveillance data.

• Can Fildena Professional be used in conjunction with herbal supplements like ginkgo biloba?
  Ginkgo biloba has mild antiplatelet activity, which could theoretically increase bleeding risk when combined with drugs that affect platelet function. While the interaction with sildenafil is not well documented, patients should discuss all supplement use with a healthcare professional.

• What is the historical significance of sildenafil’s development?
  Sildenafil was originally investigated as a treatment for angina pectoris. During clinical trials, researchers observed a pronounced effect on penile erection, leading to its repurposing and approval for erectile dysfunction—a landmark event that transformed sexual medicine worldwide.

Glossary

Phosphodiesterase type 5 (PDE‑5) inhibitor

A class of drugs that block the enzyme responsible for breaking down cGMP, thereby promoting smooth‑muscle relaxation and increased blood flow in the penis.

cGMP (cyclic guanosine monophosphate)

A second messenger molecule that mediates the relaxation of smooth muscle tissue during sexual arousal.

Good Manufacturing Practice (GMP)

International quality standards that ensure pharmaceutical products are consistently produced and controlled according to strict guidelines.

Priapism

A prolonged and often painful erection lasting more than four hours, requiring urgent medical management to prevent permanent tissue damage.

⚠️ Disclaimer

The information provided about Fildena Professional is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Fildena Professional for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.