Generic Priligy

Introduction

Priligy is a prescription‑only medication approved in the United Kingdom for the treatment of premature ejaculation (PE) in adult men. Its active ingredient is dapoxetine, a short‑acting selective serotonin reuptake inhibitor (SSRI) developed specifically to improve ejaculatory control without the long‑term side‑effects typical of other SSRIs. Priligy is listed under the “Bestsellers” and “Men’s Health” groups, reflecting its widespread use among men seeking a pharmacological option for PE. The drug is manufactured by Janssen‑Cilag, a subsidiary of Johnson & Johnson, and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA).

What is Priligy?

Priligy is a tablet formulation containing 30 mg or 60 mg of dapoxetine. It is classified as a short‑acting SSRI and is the only SSRI that has received a dedicated licensing indication for premature ejaculation in the EU and UK. Dapoxetine was originally synthesized by the pharmaceutical company GlaxoSmithKline and later licensed to Janssen‑Cilag for commercial development. The medication is taken on an “as‑needed” basis, typically one hour before anticipated sexual activity, and does not require daily dosing.

How Priligy Works

Dapoxetine inhibits the re‑uptake of serotonin (5‑HT) at neuronal synapses, modestly increasing serotonergic activity in the central nervous system. Higher serotonin levels delay the ejaculatory reflex by reducing spinal cord excitability, thereby extending the latency time between erection and ejaculation. Because dapoxetine has a rapid absorption phase (peak plasma concentration within 1–2 hours) and a short elimination half‑life of about 19 hours, its pharmacological effect is confined to the period surrounding sexual activity, limiting systemic exposure and reducing the risk of chronic SSRI‑related adverse events.

Conditions Treated with Priligy

• Premature ejaculation (PE) – the primary and sole approved indication in the UK. PE is defined as ejaculation that occurs within one minute of vaginal penetration (lifelong) or a clinically significant reduction in latency after a period of normal function (acquired). Epidemiological surveys estimate a prevalence of 20–30 % among UK men, representing a substantial unmet need for effective therapy.
• Off‑label explorations – while not approved, some clinicians have investigated dapoxetine for other conditions associated with serotonergic dysregulation (e.g., certain anxiety disorders). Such uses remain experimental and are not endorsed by regulatory agencies.

Suitable Candidates for Priligy Treatment

• Adult men (≥18 years) diagnosed with lifelong or acquired premature ejaculation who report distress or relationship difficulty.
• Individuals who have trialed behavioral techniques (e.g., pause‑squeeze, pelvic floor exercises) without satisfactory improvement.
• Patients without contraindications such as concurrent use of monoamine oxidase inhibitors (MAOIs), other SSRIs, or potent CYP2D6 inhibitors.

Priligy is not appropriate for:

• Men with uncontrolled severe depression, bipolar disorder, or a history of suicidal ideation, as SSRI exposure may exacerbate mood symptoms.
• Patients with significant cardiovascular disease, uncontrolled hypertension, or hepatic impairment, where the drug’s metabolism could be unsafe.
• Individuals currently consuming excessive alcohol, as the combination increases the risk of dizziness, hypotension, and syncope.

Risks, Side Effects, and Interactions

Common

• Nausea
• Headache
• Dizziness or light‑headedness
• Diarrhoea

These events typically occur within the first two doses and often diminish with continued use.

Rare

• Insomnia or altered sleep patterns
• Nasal congestion or rhinorrhoea
• Decreased libido or sexual dysfunction (other than the intended effect)

Serious

• Syncope or fainting, especially when standing quickly after taking the tablet.
• Cardiac arrhythmias or prolonged QT interval (rare, primarily in patients with pre‑existing cardiac disease).
• Severe hypersensitivity reactions, including rash, angio‑edema, or anaphylaxis.

Clinically Relevant Drug–Drug Interactions

• MAO inhibitors (e.g., phenelzine, tranylcypromine) – risk of serotonin syndrome; avoid concurrent use.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine) – increase dapoxetine plasma levels, raising adverse‑event risk.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) – may modestly raise dapoxetine concentrations.
• Alcohol – potentiates dizziness, syncope, and hypotensive episodes; patients should limit intake to ≤2 units on the day of dosing.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing: Start with a single 30 mg tablet taken 1–3 hours before sexual activity. If well tolerated and insufficient effect, the dose may be increased to 60 mg per tablet after at least one week. Do not exceed one tablet per day.
• Missed dose: Because Priligy is taken “as needed,” a missed dose simply means the sexual activity in question will proceed without pharmacological support. Do not take an extra tablet later in the day to compensate.
• Overdose: Symptoms may include severe nausea, vomiting, dizziness, and cardiac irregularities. Seek urgent medical attention; supportive care (gastric lavage, activated charcoal) may be administered under professional supervision.
• Food and alcohol: A light to moderate meal does not significantly affect absorption, but a high‑fat meal may delay onset. Alcohol should be limited, as described above.
• Comorbidities: Patients with liver or kidney impairment should be evaluated carefully; dose reduction may be required, or alternative therapies considered.

Buying Priligy from Our Online Pharmacy

Priligy can be purchased safely from our online pharmacy in the UK. We specialise in providing verified, high‑quality medications at a price close to the manufacturer’s cost, thanks to our partnership with licensed overseas suppliers. Key benefits include:

• Affordable pricing – generic dapoxetine tablets are sourced directly from GMP‑certified manufacturers, reducing mark‑up.
• Verified quality – each batch is inspected for authenticity and potency before dispatch.
• Discreet, reliable delivery – orders are packaged in neutral envelopes and shipped via express (7 days) or regular (≈3 weeks) services, with tracking available.
• Pharmacy broker model – we operate as a broker, connecting UK patients with reputable international pharmacies while maintaining full compliance with UK import regulations. This model enables access to medicines that may be limited in local pharmacies, especially for men seeking a cost‑effective solution for premature ejaculation.

FAQ

• Can Priligy be taken with other SSRIs for depression?
  No. Combining dapoxetine with other SSRIs can lead to excessive serotonergic activity, increasing the risk of serotonin syndrome and severe side‑effects.

• What should I do if I experience dizziness after taking Priligy?
  Sit or lie down immediately, avoid sudden standing, and refrain from driving or operating machinery until the sensation resolves. If dizziness persists, contact a healthcare professional.

• Is there a difference in tablet appearance between the 30 mg and 60 mg strengths?
  Yes. The 30 mg tablets are typically round and white, while the 60 mg tablets are larger, biconvex, and often marked with “60 mg” in a contrasting colour to aid identification.

• Does dapoxetine require refrigeration during storage?
  No. Priligy should be stored at controlled room temperature (15 °C–30 °C), away from moisture and direct sunlight. Refrigeration is unnecessary and may affect tablet integrity.

• Can I travel internationally with Priligy in my hand luggage?
  Yes, provided you keep the medication in its original packaging with the label visible, and you carry a copy of the prescription or a pharmacist’s verification letter if requested by customs authorities.

• Are there any known differences in formulation between EU‑approved and non‑EU dapoxetine products?
  EU‑approved tablets contain the same active ingredient and meet the same GMP standards. Some non‑EU products may use different inactive excipients, which could affect tolerability for individuals with specific allergies.

• What is the legal limit for personal import of prescription medicines into the UK?
  Under the Medicines and Healthcare products Regulatory Agency (MHRA) guidelines, a patient may import up to a three‑month supply for personal use, provided a valid prescription exists. Our pharmacy ensures compliance with these limits.

• How long does it take for Priligy to reach its peak blood concentration?
  Peak plasma levels are generally achieved within 1 to 2 hours after oral ingestion, aligning with the recommended 1–3 hour pre‑activity window.

• Can dapoxetine affect drug testing for employment or sports?
  Dapoxetine is not typically screened for in standard workplace drug panels. However, certain sports anti‑doping agencies list SSRIs as prohibited substances in competition; athletes should consult their governing body.

• Is there any evidence that Priligy improves relationship satisfaction?
  Clinical trials have demonstrated that men achieving a longer intravaginal ejaculatory latency time (IELT) report improved sexual confidence and reduced anxiety, which correlate with higher relationship satisfaction scores.

Glossary

Selective serotonin reuptake inhibitor (SSRI)

A class of drugs that block the re‑absorption of serotonin into neurons, increasing its availability in the brain and modulating mood and physiological responses.

Intravaginal ejaculatory latency time (IELT)

The measured interval between vaginal penetration and ejaculation; it is the primary objective endpoint in clinical trials of premature ejaculation treatments.

Serotonin syndrome

A potentially life‑threatening condition caused by excessive serotonergic activity, presenting with agitation, hyperthermia, tachycardia, and neuromuscular abnormalities.

CYP450 enzymes

A family of liver enzymes (e.g., CYP2D6, CYP3A4) that metabolise many medications; inhibitors or inducers of these enzymes can alter drug plasma concentrations.

⚠️ Disclaimer

The information provided about Priligy is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Priligy for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.