Genegra

Introduction

Genegra is a pharmaceutical product containing the active compound sildenafil. It belongs to the therapeutic groups of erectile dysfunction (ED) and men’s health. In the United Kingdom, Genegra is used principally to improve erectile function in adult males, and it may also be prescribed off‑label for pulmonary arterial hypertension under specialist advice. The medication is manufactured by licensed suppliers that follow UK standards for quality and safety.

What is Genegra?

Genegra is the generic version of Viagra®, the well‑known brand name originally developed by Pfizer, and it contains the same active compound sildenafil. Our online pharmacy provides this generic alternative as a cost‑effective treatment option. The product is classified as a phosphodiesterase‑type 5 (PDE5) inhibitor and is produced by pharmaceutical manufacturers authorized to supply medicines to the UK market.

How Genegra Works

Sildenafil inhibits the enzyme phosphodiesterase‑type 5, which normally degrades cyclic guanosine monophosphate (cG c). By blocking PDE5, Genegra increases cG c levels in the smooth muscle cells of the corpora cavernosa. Elevated cG c causes relaxation of these muscles, allowing increased blood flow into the penile tissue during sexual stimulation.

• Onset of action: 30–60 minutes after oral ingestion under fasting conditions.
• Duration of effect: Up to 4–5 hours, depending on individual metabolism.
• Clearance: Sildenafil is metabolised primarily by hepatic cytochrome P450 3A4 and has an elimination half‑life of about 4 hours.

Conditions Treated with Genegra

• Erectile Dysfunction (ED): The primary approved indication in the UK. ED affects an estimated 20 % of men aged 40–70, leading to reduced quality of life and relational stress. Sildenafil improves the ability to achieve and maintain an erection sufficient for sexual activity.
• Pulmonary Arterial Hypertension (PAH): Although not a routine indication for the generic formulation, sildenafil is recognised by the National Institute for Health and Care Excellence (NICE) for PAH in specialist settings. By dilating pulmonary vessels, it lowers pulmonary arterial pressure.

Genegra’s efficacy in these conditions is supported by large, randomized controlled trials and systematic reviews published in peer‑reviewed journals such as The Journal of Sexual Medicine and Circulation.

Who is Genegra For?

• Adult males with diagnosed erectile dysfunction who are able to engage in sexual activity and have no contraindications to PDE5 inhibition.
• Patients with pulmonary arterial hypertension under specialist supervision, when sildenafil is deemed appropriate.
• Individuals seeking a generic, lower‑cost alternative to brand‑name products without compromising therapeutic effect.

Genegra may not be suitable for men with:

• Severe cardiovascular disease (e.g., recent myocardial infarction, uncontrolled angina).
• Use of nitrates or nitric‑oxide donors.
• Severe hepatic impairment or renal failure (eGFR < 30 mL/min).
• Known hypersensitivity to sildenafil or any tablet excipients.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Indigestion or dyspepsia
• Nasal congestion
• Visual disturbances (blurred vision, colour tinge)

Rare

• Priapism (prolonged erection lasting > 4 hours)
• Sudden hearing loss
• Myalgia or back pain due to vasodilation
• Dermatological reactions (rash, urticaria)

Serious

• Cardiovascular events (acute myocardial infarction, stroke) in patients with pre‑existing disease
• Severe hypotension when combined with nitrates
• Vision loss (ischemic optic neuropathy)
• Allergic anaphylaxis

Drug–Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect → risk of profound hypotension.
• Alpha‑blockers (e.g., tamsulosin): may cause blood pressure changes; dose titration advised.
• CYP 3A4 inhibitors (e.g., ketoconazole, ritonavir): increase sildenafil plasma concentrations → dose reduction recommended.
• CYP 3A4 inducers (e.g., rifampicin, carbamazepine): lower plasma concentrations → may reduce efficacy.

Patients should disclose all concomitant medications to a healthcare professional before starting Genegra.

Practical Use: Dosing, Missed Dose, Overdose

• Standard starting dose for ED: 50 mg taken orally about one hour before sexual activity. The dose may be adjusted to 25 mg or 100 mg based on efficacy and tolerability.
• Maximum daily dose: 100 mg. No more than one dose per 24 hours.
• Pulmonary arterial hypertension dosing: Typically 20 mg three times daily; prescribed only by specialists.

Missed dose: If a dose is forgotten, it should be taken as soon as remembered, provided at least 4 hours have elapsed since the previous dose. Do not take a double dose to compensate.

Overdose: Symptoms may include severe headache, hypotension, tachycardia, or prolonged erection. Seek immediate medical attention. Supportive care and monitoring are the primary interventions.

Precautions:

• Take with water; food does not significantly affect absorption, though high‑fat meals may delay onset.
• Avoid excessive alcohol, which can impair erectile response and increase hypotensive risk.
• Patients with cardiovascular disease should discuss activity levels with their clinician.

Buying Genegra from Our Online Pharmacy

Genegra can be purchased from our online pharmacy in the UK. The service offers:

• Affordable pricing: Near manufacturer cost, often 30 %‑40 % lower than brand‑name equivalents.
• Verified quality: All tablets are sourced from licensed overseas pharmacies that meet UK regulatory standards and are subject to third‑party quality testing.
• Guaranteed delivery: Discreet packaging with tracking; express delivery within 7 days for most destinations, regular airmail in ~3 weeks.
• Online‑only access: Enables patients who have limited pharmacy options or insurance coverage to obtain a reliable generic medication.

Our pharmacy operates as a pharmacy broker service, partnering with internationally accredited suppliers while maintaining strict privacy protocols. This model ensures a confidential, cost‑effective route for individuals seeking Genegra without compromising safety.

FAQ

• Is Genegra available in both brand‑name and generic forms in the UK?
  Yes. The original brand‑name product is Viagra® produced by Pfizer. Generic versions such as Genegra contain the same active ingredient, sildenafil, and are typically more affordable.

• What is the best way to store Genegra tablets?
  Store at controlled room temperature (15‑30 °C). Keep the tablets in the original blister pack, away from moisture, direct sunlight, and heat sources. Do not refrigerate.

• Does Genegra require any special packaging when shipped internationally?
  The medication is packed in discreet, tamper‑evident envelopes with protection against humidity. No additional temperature control is needed for standard UK climate conditions.

• Can Genegra be safely imported into the UK for personal use?
  Personal import of a three‑month supply of a licensed medication for personal use is permitted under UK law, provided the product complies with MHRA standards. Our online pharmacy ensures all shipments meet these requirements.

• Are there any known differences in formulation between European and non‑European versions of sildenafil?
  European formulations must adhere to the EU Pharmacopoeia, which specifies tablet colour, hardness, and inactive excipients. Some non‑European versions may use alternative fillers, but the active dose of sildenafil remains equivalent.

• What are the implications of taking Genegra before a blood pressure test?
  Sildenafil can cause a transient, mild reduction in blood pressure. For accurate measurements, it is advisable to wait at least two hours after ingestion before the test.

• Does Genegra have any effect on athletic drug testing?
  Sildenafil is not on the World Anti‑Doping Agency (WADA) prohibited list. However, athletes should disclose all medications to their governing body to avoid potential misunderstandings.

• How does the onset of action of Genegra compare with older PDE5 inhibitors like tadalafil?
  Sildenafil (Genegra) typically works within 30–60 minutes, whereas tadalafil may take up to 2 hours but offers a longer duration of up to 36 hours. Choice of agent depends on patient preference and clinical context.

• Is there any evidence that Genegra improves sexual confidence beyond physiological effects?
  Clinical studies have shown that successful treatment of ED with sildenafil is associated with improved self‑esteem and relationship satisfaction, likely due to restored sexual function.

• What is the history of sildenafil’s development?
  Sildenafil was first synthesized by Pfizer in the early 199s as a potential treatment for angina. Unexpected erectile effects led to its development as the first oral therapy for ED, gaining FDA approval in 1998 under the brand name Viagra®.

Glossary

Phosphodiesterase‑type 5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, enhancing cG c levels and promoting smooth muscle relaxation in the penis and pulmonary vasculature.

cG c (cyclic guanosine monophosphate)

A second messenger that mediates smooth muscle relaxation; increased by sildenafil to facilitate erection.

Priapism

A prolonged, painful erection lasting more than four hours, requiring urgent medical intervention to prevent tissue damage.

⚠️ Disclaimer

The information provided about Genegra is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Genegra for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.