Generic Maxolon

Introduction

Maxolon is a medication used primarily to stimulate movement of the stomach and intestines, thereby relieving symptoms such as nausea, vomiting, and delayed gastric emptying. The product contains the active compound metoclopramide and belongs to the Gastro Health group of drugs. In the United Kingdom, Maxolon is prescribed for a range of gastrointestinal disorders and for certain procedural uses, such as preventing chemotherapy‑induced nausea. The formulation is manufactured by several licensed pharmaceutical companies; the exact source may vary depending on the supplier.

What is Maxolon?

Maxolon is a oral tablet (or injectable solution, where available) that delivers the dopamine‑type‑2 (D₂) receptor antagonist metoclopramide. It was originally developed in the 196s and has been incorporated into the British National Formulary (BNF) for the treatment of nausea, vomiting, and gastroparesis.

Maxolon is the generic version of the original brand‑name drug Reglan, as well as other well‑known metoclopramide products such as Metozolv and Donormin. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The medication is classified as a pro‑kinetic and anti‑emetic agent. It is supplied in 5 mg and 10 mg tablets, and in some markets a 5 mg/5 mL oral solution and a 10 mg/mL injectable preparation are also available.

How Maxolon Works

Metoclopramide exerts its therapeutic effect through three principal mechanisms:

1. D₂‑receptor antagonism in the chemoreceptor trigger zone (CTZ). By blocking dopamine receptors in the brainstem, the drug suppresses the vomiting reflex.
2. Serotonin (5‑HT₄) receptor agonism in the gastrointestinal tract. Stimulation of these receptors enhances acetylcholine release, which increases the tone and coordinated contractions of the upper GI tract, accelerating gastric emptying.
3. Increased lower‑esophageal sphincter (LES) pressure. This action reduces the incidence of gastro‑oesophageal reflux, contributing to relief of heartburn‑type symptoms.

Onset of anti‑emetic activity generally occurs within 15–30 minutes after oral dosing, with peak plasma concentrations reached at about 1–2 hours. The drug’s elimination half‑life is approximately 5–6 hours, allowing for multiple daily dosing regimens while maintaining therapeutic plasma levels.

Conditions Treated with Maxolon

• Nausea and vomiting of various origins – including postoperative, migraine‑related, and chemotherapy‑induced episodes. In the UK, nausea accounts for a substantial proportion of emergency department visits; metoclopramide provides a rapid, non‑opioid option.
• Gastroparesis (delayed gastric emptying) – particularly in diabetic patients where sluggish stomach motility can cause early satiety, bloating, and unpredictable glucose control.
• Functional dyspepsia with predominant post‑prandial fullness – where enhanced gastric motility improves symptom burden.
• Pre‑operative and post‑operative preparation – to reduce the risk of aspiration by promoting gastric emptying before anesthesia.
• Adjunct in radiographic studies – such as upper GI series, where rapid gastric clearance improves imaging quality.

Each of these indications is supported by UK clinical guidelines (e.g., NICE NG15) that recommend metoclopramide when first‑line anti‑emetics (such as ondansetron) are unsuitable or unavailable.

Suitable Candidates for Maxolon Treatment

• Adults (≥ 18 years) experiencing acute or chronic nausea/vomiting not adequately controlled by lifestyle measures.
• Patients with diagnosed gastroparesis confirmed by gastric emptying studies or clinical evaluation.
• Individuals scheduled for procedural sedation who require accelerated gastric emptying to lower aspiration risk.
• Those with functional dyspepsia where delayed gastric emptying is a contributing factor.

Contra‑indications or cautionary use

• Known hypersensitivity to metoclopramide or any excipients.
• History of tardive dyskinesia or extrapyramidal disorders.
• Severe renal impairment (creatinine clearance < 30 mL/min) – dose reduction is necessary.
• Pheochromocytoma – dopamine blockade may precipitate hypertensive crises.
• Infants under 1 month – safety has not been established.

Pregnant or lactating women should only use Maxolon when the potential benefit outweighs the risk, as advised by a healthcare professional.

Risks, Side Effects, and Interactions

Common

• Drowsiness or fatigue
• Dry mouth
• Diarrhoea or constipation (variable GI motility)
• Restlessness or mild anxiety

Rare

• Extrapyramidal symptoms (e.g., acute dystonia, akathisia) – more frequent in younger patients or with high‑dose regimens.
• Hyperprolactinaemia leading to galactorrhoea or menstrual irregularities.

Serious

• Tardive dyskinesia – irreversible, often irreversible involuntary movements of the face and tongue, particularly with prolonged therapy (> 12 weeks).
• Neuroleptic malignant syndrome (very rare).
• Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome).

Drug–drug interactions

• CNS depressants (e.g., benzodiazepines, antihistamines) may potentiate sedation.
• Anticholinergic agents may counteract pro‑kinetic effects.
• MAO inhibitors – concurrent use can increase the risk of hypertensive crises.
• Cytochrome P450 2D6 substrates (e.g., codeine, tramadol) – metoclopramide may inhibit metabolism, raising plasma concentrations of the co‑administered drug.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to avoid adverse interactions.

Practical Use: Dosing, Missed Dose, Overdose

• Standard oral dosing for nausea/vomiting: 10 mg taken up to three times daily before meals. For gastroparesis, the same dose may be prescribed up to four times daily, but treatment should not exceed 12 weeks without specialist review.
• Injectable formulation (10 mg/mL): 10 mg administered intravenously over 1–2 minutes, typically in a clinical setting.
• Missed dose – If a dose is forgotten, take it as soon as remembered unless it is within 6 hours of the next scheduled dose; in that case, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose – Symptoms may include excessive drowsiness, extrapyramidal reactions, or cardiac arrhythmias. Immediate medical attention is required; supportive care and administration of activated charcoal may be considered in a hospital setting.

Precautions

• Take tablets with a small amount of water, preferably 30 minutes before meals to maximise gastric emptying.
• Avoid alcohol, as it can intensify central nervous system depression.
• Patients with liver disease may require dose adjustment due to altered metabolism.
• Do not operate heavy machinery or drive until individual tolerance to the medication is known.

Buying Maxolon from Our Online Pharmacy

Maxolon can be purchased safely from our online pharmacy in the UK. Our service combines several key advantages:

• Affordable pricing – We source the generic formulation at near‑manufacturer cost, passing savings directly to you.
• Verified quality – All stock is supplied by licensed, GMP‑certified overseas pharmacies that adhere to EU‑wide quality standards.
• Guaranteed delivery – Discreet packaging is dispatched via express courier (typically 7 days) or regular airmail (approximately 3 weeks), with tracking available for every order.
• Online‑only access – For patients who encounter limited availability through local pharmacies or who prefer a private, digital purchase experience, our broker service bridges the gap between international suppliers and UK consumers.

By choosing our pharmacy, you receive a trustworthy, cost‑effective supply of Maxolon while maintaining privacy and regulatory compliance.

FAQ

• Is Maxolon available in both tablet and injectable forms in the UK?
  Yes, Maxolon is offered as oral tablets (5 mg and 10 mg) and as a sterile injectable solution for clinical use. The formulation you receive will depend on the prescribed route and the prescribing clinician’s recommendation.

• Do I need to refrigerate Maxolon tablets after they arrive?
  No refrigeration is required. Store the tablets at controlled room temperature, away from excess moisture, heat, and direct sunlight. The packaging includes a moisture‑absorbing packet to protect the product during transport.

• What does the packaging look like when ordered online?
  Tablets are supplied in a child‑resistant, blister‑packed strip enclosed within a discreet, tamper‑evident box. The outer box bears only the product name, dosage strength, and batch information, without any branding that could reveal the contents.

• Can Maxolon be imported for personal use without a UK prescription?
  Personal importation of medicines for non‑commercial use is permitted under UK law when the total quantity does not exceed a 3‑month supply. However, a valid prescription from a UK‑registered prescriber is typically required for customs clearance.

• Are there any special warnings for people of Asian descent?
  No ethnicity‑specific contraindications have been identified for metoclopramide. However, as with all patients, clinicians may consider genetic variations that affect drug metabolism (e.g., CYP2D6 polymorphisms) when prescribing.

• Does the formulation differ between European and non‑European suppliers?
  The active ingredient, metoclopramide, is identical, but excipients such as lactose or magnesium stearate may vary. Regional formulations comply with the respective regulatory authorities (e.g., EMA, FDA).

• How long can I safely store Maxolon before it expires?
  The shelf‑life is typically 24 months from the date of manufacture, provided the product remains sealed and stored under recommended conditions. The exact expiry date is printed on each blister pack.

• What should I do if I develop an involuntary movement while taking Maxolon?
  Contact a healthcare professional immediately. Involuntary movements may signal early extrapyramidal side effects, which can progress to tardive dyskinesia if not addressed promptly. Discontinuation and alternative therapy are often required.

• Can Maxolon affect drug testing for employment?
  Metoclopramide is not a prohibited substance in standard workplace drug screens. Routine urine or blood tests for common illicit drugs will not detect metoclopramide, as it is a prescription medication.

• Is there any evidence that Maxolon reduces chemotherapy‑induced nausea better than other agents?
  Clinical trials have demonstrated that metoclopramide, when combined with a 5‑HT₃ antagonist, provides comparable control of acute chemotherapy‑induced nausea to other anti‑emetic regimens. It is frequently used as a second‑line agent when patients cannot tolerate other drugs.

• What research led to the development of metoclopramide?
  Metoclopramide was first synthesized in the early 196s by the pharmaceutical company AstraZeneca (then part of Imperial Chemical Industries). Early studies identified its dopamine‑antagonist properties, prompting its approval for gastro‑intestinal motility disorders in 197.

Glossary

D₂‑receptor antagonist

A substance that blocks dopamine type‑2 receptors, reducing dopamine‑mediated signalling in the brain and gastrointestinal tract.

Gastroparesis

A condition where stomach muscles contract weakly or irregularly, delaying the movement of food into the small intestine.

Tardive dyskinesia

A potentially irreversible movement disorder characterized by repetitive, involuntary movements, often of the face and tongue, associated with long‑term dopamine‑blocking agents.

Pro‑kinetic

A drug that enhances the frequency or amplitude of gastrointestinal motility, facilitating faster transit of contents through the digestive tract.

⚠️ Disclaimer

The information provided about Maxolon is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Maxolon for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.