Generic Motilium

Introduction

Motilium (domperidone) is a prescription‑only medication classified within the Gastro Health group. It is used primarily to relieve nausea, vomiting and to improve gastric emptying in adults living in the United Kingdom. The active compound, domperidone, antagonises peripheral dopamine‑D₂ receptors, which reduces the stimulus for the vomiting centre and accelerates gastrointestinal motility. In addition to its anti‑emetic properties, clinicians sometimes prescribe the drug for dyspepsia associated with delayed gastric emptying and for lactation support, although the latter use is off‑label in the UK.

What is Motilium?

Motilium is the brand name for tablets that contain the active ingredient domperidone (10 mg per tablet). It was first developed by Janssen Pharmaceutica and is marketed in the UK by several licensed pharmaceutical companies. The formulation is a film‑coated tablet, supplied in packs of 28 or 56 tablets. Domperidone is the same molecule found in other internationally recognised brands such as Motilid, Domperidone Orifarm and Domperidone Sandoz.

Motilium belongs to the pharmacological class of peripheral dopamine‑2 receptor antagonists. It is distinct from central anti‑emetics such as metoclopramide because it does not readily cross the blood‑brain barrier, limiting central nervous system side effects.

How Motilium Works

Domperidone blocks dopamine‑D₂ receptors located on the chemoreceptor trigger zone (CTZ) of the medulla and on the smooth muscle of the gastrointestinal tract By inhibiting dopamine signalling in the CTZ, the drug diminishes the reflex that initiates nausea and vomiting. Simultaneously, D₂ antagonism in the gut increases the amplitude of gastric contractions, thereby promoting gastric emptying and reducing symptoms of functional dyspepsia.

Peak plasma concentrations are reached within 30–60 minutes after oral intake, and the drug’s half‑life is approximately 7–9 hours in individuals with normal hepatic function. Domperidone is extensively metabolised by CYP3A4 and eliminated primarily in the faeces.

Conditions Treated with Motilium

• Nausea and vomiting of idiopathic or drug‑induced origin – common after chemotherapy, postoperative periods, or when prescribed dopamine‑agonist medications.
• Gastroparesis (delayed gastric emptying) – especially in patients with diabetic autonomic neuropathy where reduced motility leads to early satiety and bloating.
• Functional dyspepsia – characterised by epigastric pain, fullness, or post‑prandial discomfort when gastric emptying is impaired.
• Off‑label: Lactation failure – some clinicians prescribe domperidone to increase prolactin secretion, though UK guidance recommends caution due to cardiac safety concerns.

In the UK, gastroparesis affects an estimated 5 % of people with long‑standing diabetes, while drug‑induced nausea is reported in up to 20 % of hospitalised patients, highlighting the clinical relevance of an effective peripheral anti‑emetic.

Who is Motilium For?

Motilium is appropriate for adult patients who experience nausea, vomiting, or delayed gastric emptying when non‑pharmacological measures have failed. Typical candidates include:

• Adults receiving chemotherapy or radiotherapy who develop acute nausea.
• Post‑operative patients with persistent emesis despite anti‑emetic prophylaxis.
• Individuals with diabetic gastroparesis confirmed by gastric scintigraphy or breath testing.
• Patients with functional dyspepsia where motility impairment is a dominant feature.

Motilium should be avoided or used with caution in:

• Persons with known prolonged QT interval or significant cardiac disease.
• Those taking strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) because plasma domperidone levels may rise.
• Pregnant or breastfeeding women unless the benefit clearly outweighs the risk, as safety data are limited.
• Children and adolescents, because the drug is not licensed for use under 18 years in the UK.

Risks, Side Effects, and Interactions

Common

• Dry mouth
• Abdominal cramps or discomfort
• Diarrhoea or constipation
• Headache

These events are generally mild, transient and resolve without medical intervention.

Rare

• Elevated prolactin levels leading to galactorrhoea or menstrual irregularities
• Skin rash or pruritus
• Dizziness or light‑headedness

If symptoms persist beyond a few days, patients should seek advice from a pharmacist or physician.

Serious

• Cardiac arrhythmias (e.g., torsades de pointes) associated with QT‑interval prolongation, particularly when combined with other QT‑prolonging agents.
• Extrapyramidal symptoms – extremely uncommon owing to limited central penetration but reported in isolated cases.
• Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome).

Any sign of palpitations, fainting, or severe skin reaction warrants immediate medical attention.

Clinically Relevant Interactions

• CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, erythromycin, HIV protease inhibitors) – increase domperidone serum concentrations.
• Other QT‑prolonging drugs (quinidine, sotalol, certain antipsychotics) – additive risk of ventricular arrhythmia.
• Antacids containing magnesium or aluminium – may reduce domperidone absorption; advise a 2‑hour interval between ingestion.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to avoid harmful interactions.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose for nausea/vomiting: 10 mg taken 30 minutes before meals, up to three times daily (maximum 30 mg per day).
• Gastroparesis: 10 mg taken 30 minutes before each main meal, up to three times daily; dose may be increased to 20 mg three times daily under specialist supervision.
• Maximum duration: In the UK, treatment is generally limited to 7 days for acute nausea; longer courses require cardiology assessment and ECG monitoring.

Missed dose: Take the missed tablet as soon as remembered, unless it is close to the time of the next scheduled dose. Do not double‑dose to compensate.

Overdose: Symptoms may include severe dizziness, fainting, or cardiac arrhythmia. Seek emergency medical care immediately; activated charcoal may be considered if presentation is early.

Practical precautions:

• Take tablets with a full glass of water; avoid crushing or chewing.
• Food can delay absorption; therefore, the recommended pre‑meal timing is essential for consistent effect.
• Alcohol potentiates gastrointestinal irritation and may increase the risk of QT prolongation; limit intake while on therapy.
• Patients with hepatic impairment may require dose reduction because of reduced metabolism.

Buying Motilium from Our Online Pharmacy

Motilium can be obtained safely from our online pharmacy in the UK. We source the medication from licensed, GMP‑certified manufacturers and provide it at a price close to the manufacturer’s cost, making the generic alternative financially accessible.

Key advantages of purchasing through our online pharmacy include:

• Verified quality: All batches are checked against European Pharmacopeia standards before dispatch.
• Discreet, reliable delivery: Options include 7‑day express shipping for urgent needs or standard airmail (approximately 3 weeks) for routine orders, each packaged in plain, tamper‑evident containers.
• Privacy‑focused broker service: We collaborate with overseas licensed pharmacies, ensuring a seamless, confidential supply chain that respects patient anonymity.
• Customer support: Our UK‑based team answer product‑related queries, clarify dosing guidelines, and assist with tracking shipments.

Our service is designed for individuals who encounter limited availability through conventional pharmacies or who seek a cost‑effective generic formulation without compromising safety.

FAQ

• Can Motilium be taken while traveling internationally?
  Yes, the tablets are stable at room temperature and can be carried in hand luggage. Keep the medication in its original packaging with the patient information leaflet to avoid customs questions, and store it away from excessive heat or humidity.

• What does the Motilium tablet look like?
  The generic tablets are typically white, film‑coated, round, and imprint “10 mg” on one side. Different manufacturers may use slight variations in colour or imprint, but the active strength remains 10 mg.

• Are there any food restrictions when using Motilium?
  The tablet should be swallowed with a glass of water about 30 minutes before a meal. High‑fat meals can delay absorption, so adhering to the pre‑meal timing ensures consistent therapeutic effect.

• Is it safe to store Motilium in a bathroom cabinet?
  No. Moisture and temperature fluctuations in a bathroom can degrade the tablet coating and potency. Store the medication in a cool, dry place such as a bedroom drawer or kitchen cupboard away from direct sunlight.

• How does the UK regulatory body view domperidone safety?
  The Medicines and Healthcare products Regulatory Agency (MHRA) limits the total daily dose to 30 mg and recommends ECG monitoring for patients at risk of QT prolongation. These guidelines aim to minimise cardiac adverse events while preserving therapeutic benefit.

• Can Motilium cause a positive result on drug‑testing panels?
  Domperidone is not classified as a substance of abuse and is not included in standard occupational drug‑testing panels. Therefore, routine screening for employment or sporting purposes is unlikely to detect it.

• What is the history behind domperidone’s development?
  Domperidone was first synthesised in the 197s by Janssen Pharmaceutica as a peripheral dopamine antagonist. Its anti‑emetic properties were quickly recognised, leading to global marketing under various brand names, including Motilium.

• How does Motilium compare with metoclopramide?
  Both agents enhance gastric motility, but domperidone has limited central nervous system penetration, resulting in a lower risk of extrapyramidal side effects. Metoclopramide, by contrast, crosses the blood‑brain barrier and may cause tardive dyskinesia with prolonged use.

• Are there regional formulation differences for Motilium?
  In the European Union, domperidone tablets contain lactose as a filler, whereas some Asian formulations replace lactose with starch to suit local dietary restrictions. Patients with lactose intolerance should review the excipient list on the product leaflet.

• What are the legal considerations for importing Motilium for personal use?
  UK law permits the importation of a 3‑month supply of prescription medication for personal use, provided the individual holds a valid prescription from a UK‑registered prescriber. Importing larger quantities without appropriate documentation may breach customs regulations.

• Does Motilium have any effect on blood sugar levels?
  Domperidone does not directly alter glucose metabolism. However, improved gastric emptying may affect the timing of carbohydrate absorption, which could modestly influence post‑prandial glucose peaks in diabetic patients. Monitoring blood sugar after initiating therapy is advisable.

Glossary

Dopamine‑2 (D₂) receptor

A protein on nerve cells that, when activated by dopamine, can suppress gastrointestinal motility and trigger the vomiting reflex. Antagonists block this effect, promoting stomach emptying.

QT interval

A measurement on an electrocardiogram that reflects the time taken for the heart’s ventricles to repolarise. Prolongation can predispose to dangerous arrhythmias.

CYP3A4

An enzyme in the liver and intestines that metabolises many drugs. Inhibitors of CYP3A4 can raise plasma levels of domperidone, increasing the risk of side effects.

Off‑label use

Prescribing a medication for an indication that has not been formally approved by regulatory agencies, based on clinical judgment or emerging evidence.

⚠️ Disclaimer

The information provided about Motilium is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Motilium for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.