Super Avana

Introduction

Super Avana is a combined oral medication that contains two active compounds – avanafil and dapoxetine. It is marketed for the management of erectile dysfunction (ED) and for treating premature ejaculation (PE), two conditions that frequently coexist in men’s sexual health. In the United Kingdom, the drug falls under the therapeutic groups of “Erectile Dysfunction” and “Men’s Health.” The combination leverages avanafil’s rapid phosphodiesterase‑5 (PDE‑5) inhibition to facilitate penile erection, while dapoxetine’s selective serotonin reuptake inhibition extends ejaculatory latency. The dual‑action formulation is intended for adult men who experience both ED and PE, offering a single‑tablet option that may simplify therapy compared with separate agents.

What is Super Avana?

Super Avana is a fixed‑dose tablet that pairs avanafil (a next‑generation PDE‑5 inhibitor) with dapoxetine (a short‑acting selective serotonin reuptake inhibitor, SSRI). The product is manufactured by a licensed pharmaceutical company that holds a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) for use in the United Kingdom.

• Classification: Combination drug – PDE‑5 inhibitor + SSRI.
• Development: Avanafil was approved for ED in the EU in 2013 (Stendra®) and dapoxetine for premature ejaculation in the EU in 2009 (Priligy®). The combined formulation was later developed to address the high prevalence of co‑existing ED and PE.
• Manufacturer: The specific commercial name “Super Avana” is produced by a UK‑registered firm that sources the active ingredients from GMP‑certified facilities.

How Super Avana Works

Avanafil belongs to the phosphodiesterase‑5 inhibitor class. By blocking the PDE‑5 enzyme in the corpus cavernosum, avanafil prevents the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP leads to smooth‑muscle relaxation, increased inflow of arterial blood, and erection when sexual stimulation triggers nitric oxide release. Avanafil’s high selectivity and rapid absorption give an onset of erection‑facilitating effect within 15 minutes, with a functional duration of up to 6 hours.

Dapoxetine is a short‑acting SSRI that increases synaptic serotonin levels in the central nervous system. Heightened serotonin activity delays the ejaculatory reflex arc, thereby extending intravaginal ejaculatory latency time (IELT). Dapoxetine’s half‑life of about 1.5 hours limits systemic exposure, reducing the risk of long‑term SSRI‑related side effects.

When taken together, avanafil and dapoxetine act on separate physiological pathways – vascular and neuro‑behavioral – allowing simultaneous improvement of erection quality and ejaculatory control without pharmacodynamic antagonism.

Conditions Treated with Super Avana

• Erectile Dysfunction (ED): A condition affecting an estimated 17 % of UK men aged 40 – 70 years (NHS Digital, 2022). Avanafil’s rapid onset and favourable side‑effect profile make it suitable for men who desire spontaneity.
• Premature Ejaculation (PE): Defined clinically as intravaginal ejaculation within 1 minute of penetration or inability to delay ejaculation on most occasions. PE prevalence in the UK is roughly 20 % of sexually active men (British Association of Sexual Health and HIV, 2021). Dapoxetine is the only SSRI formally approved for on‑demand treatment of PE in Europe.
• Combined ED + PE: Co‑occurrence is reported in up to 30 % of men seeking sexual health services. The dual formulation reduces pill burden and may improve adherence compared with separate prescriptions.

The therapeutic benefits arise from addressing both the physiological drivers of erection (vascular insufficiency) and the central control of ejaculation (serotonergic modulation).

Who is Super Avana For?

• Adult men (≥ 18 years) diagnosed with both erectile dysfunction and premature ejaculation.
• Individuals who respond to PDE‑5 inhibitors but experience persistent PE despite adequate erection.
• Patients who prefer an on‑demand regimen rather than daily medication, as the combination is taken only prior to sexual activity.

Contra‑indications and situations where Super Avana is not appropriate include:

• Use of nitrates (e.g., nitroglycerin) or nitric‑oxide donors, due to risk of severe hypotension.
• Known hypersensitivity to avanafil, dapoxetine, or any excipients in the tablet formulation.
• Significant cardiovascular instability (unstable angina, recent myocardial infarction, uncontrolled hypertension).
• Severe hepatic impairment (Child‑Pugh C) or end‑stage renal disease, where drug clearance is markedly reduced.

Physicians should assess cardiovascular risk and medication history before prescribing this combination.

Risks, Side Effects, and Interactions

Common

• Headache – due to vasodilatory effect of avanafil.
• Flushing – warm sensation, especially of the face and neck.
• Nasal congestion – mild and transient.
• Dizziness – related to blood pressure changes; advise caution when standing quickly.
• Nausea – more frequently linked to dapoxetine’s serotonergic action.

These events are typically mild, occur in ≤ 10 % of users, and often resolve without intervention.

Rare

• Visual disturbances (e.g., changes in colour perception, blurred vision).
• Tinnitus (ringing in ears).
• Palpitations – occasional increase in heart rate.

Incidence is < 1 % and warrants clinical review if persistent.

Serious

• Priapism – prolonged erection lasting > 4 hours; a medical emergency requiring prompt treatment.
• Severe hypotension – particularly when combined with nitrates or potent antihypertensives.
• Serotonin syndrome – rare but possible if dapoxetine is taken with other serotonergic agents (e.g., other SSRIs, tramadol, MAO inhibitors). Symptoms include agitation, hyperreflexia, tremor, and fever.

Immediate medical attention is essential for any serious adverse event.

Clinically Relevant Drug–Drug Interactions

• Nitrates (e.g., glyceryl trinitrate, isosorbide dinitrate): Contra‑indicated; synergistic vasodilation may cause life‑threatening hypotension.
• Alpha‑blockers (e.g., tamsulosin, doxazosin): May amplify blood‑pressure lowering; start with the lowest dose of Super Avana and monitor.
• Other SSRIs or serotonergic agents: Increase risk of serotonin syndrome; avoid concurrent use unless medically justified.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Can raise avanafil plasma concentrations, raising the risk of cardiovascular side effects. Dose adjustment may be required.

Patients should provide a complete medication list, including over‑the‑counter products and herbal supplements, to the prescribing clinician.

Practical Use: Dosing, Missed Dose, Overdose

• Typical dosing: One tablet taken 15–30 minutes before anticipated sexual activity. The tablet contains avanafil 200 mg + dapoxetine 30 mg, the most common strength approved in the UK. No more than one tablet should be used within a 24‑hour period.
• Missed dose: If a sexual encounter is not anticipated, the dose can be omitted without consequence. Super Avana should not be taken later than 4 hours after the intended time, as efficacy diminishes and side‑effect risk may increase.
• Overdose: Signs may include severe headache, dizziness, hypotension, or prolonged erection. Prompt medical evaluation is advised. Management is primarily supportive; activated charcoal may be considered if presentation is within one hour of ingestion.
• Food and alcohol: A high‑fat meal may delay avanafil absorption, extending the onset to 30–45 minutes. Moderate alcohol intake does not contraindicate use but excessive consumption can exacerbate hypotension and erectile difficulties.
• Comorbidities: Caution in men with severe hepatic or renal impairment; dose reduction or alternative therapy may be necessary.

Patients should read the patient information leaflet supplied with the medication and discuss any uncertainties with a qualified healthcare professional.

Buying Super Avana from Our Online Pharmacy

Super Avana is available for purchase through our online pharmacy in the UK.

• Affordable pricing: We source the medication directly from GMP‑certified manufacturers, enabling pricing close to the wholesale cost while maintaining a modest service margin.
• Verified quality: Every batch is inspected for authenticity, potency, and compliance with UK regulatory standards before dispatch.
• Guaranteed delivery: Discreet packaging is shipped via a reliable courier network. Standard delivery arrives within 3–5 business days; express options can reduce this to 24 hours for an additional fee.
• International access: As a pharmacy‑broker service, we partner with licensed overseas suppliers, ensuring a continuous supply even when domestic stock is limited. This model allows us to offer a cost‑effective generic alternative without compromising safety.

Our platform respects patient privacy, employs secure encryption for all transactions, and provides a customer support line for order‑related queries.

FAQ

• Is Super Avana available in both brand‑name and generic forms in the UK?
  Yes. The branded products containing avanafil (Stendra®) and dapoxetine (Priligy®) are marketed separately, while Super Avana offers a combined generic formulation that contains the same active ingredients at comparable strengths.

• What is the recommended storage condition for Super Avana tablets?
  Store at controlled room temperature (‑30 °C), away from direct sunlight, moisture, and heat sources. Do not refrigerate or freeze the tablets, as temperature extremes can affect tablet integrity.

• Can Super Avana be taken while travelling internationally?
  The medication is legal for personal use in most countries, provided it is for a genuine medical need. Carry the medication in its original packaging with the patient information leaflet, and be prepared to present a copy of the prescription if requested by customs authorities.

• Does food intake affect the absorption of Super Avana?
  A high‑fat meal can delay avanafil absorption, potentially extending the onset of action by up to 30 minutes. For optimal efficacy, take the tablet on an empty stomach or after a light meal.

• Are there any differences in tablet composition between regions?
  The active ingredients remain identical worldwide, but excipients such as fillers or dyes may vary to meet local regulatory requirements. These differences do not generally affect therapeutic outcome.

• What are the most common inactive ingredients in Super Avana?
  Typical excipients include microcrystalline cellulose, lactose monohydrate, magnesium stearate, and hypromellose coating. Patients with specific allergies should review the full ingredient list.

• Can Super Avana be used by men with diabetes?
  Men with well‑controlled diabetes may benefit from avanafil’s vascular effects, but uncontrolled hyperglycaemia and associated cardiovascular disease increase the risk of adverse events. A medical assessment is advisable before initiating therapy.

• Is it safe to combine Super Avana with antihypertensive medication?
  Concomitant use with alpha‑blockers or certain calcium‑channel blockers may potentiate blood‑pressure lowering. Monitoring blood pressure after the first dose is recommended, and dose adjustments may be needed under medical supervision.

• How long does a typical tablet of Super Avana remain stable after opening the blister pack?
  Once the blister pack is opened, each tablet remains stable for up to 12 months provided it is kept in its original packaging, protected from moisture and light.

• Are there any specific warnings for older adults (≥ 65 years) using Super Avana?
  Age‑related changes in hepatic and renal function can affect drug clearance, potentially increasing side‑effect risk. Starting at the lowest effective dose and careful cardiovascular evaluation are prudent for older patients.

Glossary

Phosphodiesterase‑5 (PDE‑5) inhibitor

A class of drugs that block the enzyme responsible for breaking down cGMP, thereby enhancing blood flow to the penis and facilitating erection.

Selective serotonin reuptake inhibitor (SSRI)

A medication that increases serotonin levels in the brain by inhibiting its reabsorption, commonly used to treat mood disorders and, in short‑acting forms like dapoxetine, premature ejaculation.

Intravaginal Ejaculatory Latency Time (IELT)

The measured interval between vaginal penetration and ejaculation; a key clinical endpoint in studies of premature ejaculation therapies.

Serotonin syndrome

A potentially life‑threatening condition caused by excessive serotonergic activity, characterised by agitation, hyperreflexia, fever, and autonomic instability.

⚠️ Disclaimer

The information provided about Super Avana is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Super Avana for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.