Tadalafil With Dapoxetine

Introduction

Tadalafil With Dapoxetine is a fixed‑dose combination designed for the treatment of erectile dysfunction (ED) and premature ejaculation (PE) in adult men. The product contains two active compounds – tadalafil, a phosphodiesterase‑type 5 (PDE5) inhibitor, and dapoxetine, a short‑acting selective serotonin reuptake inhibitor (SSRI). Both agents are classified within the men’s health therapeutic area and are marketed for co‑existing sexual dysfunctions. In the United Kingdom, the combination is used when a single agent does not fully address the patient’s needs, offering a coordinated pharmacological approach to improve sexual performance and confidence.

What is Tadalafil With Dapoxetine?

Tadalafil With Dapoxetine is the generic version of the original combination marketed under various brand‑name programmes that pair Cialis (tadalafil) with Priligy (dapoxetine). The product contains the same active ingredients in equivalent strengths, providing an identical therapeutic profile at a lower cost. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for men who experience both ED and PE.

How Tadalafil With Dapoxetine Works

• Tadalafil blocks the enzyme phosphodiesterase‑type 5, preventing the breakdown of cyclic guanosine monophosphate (cGMP) in penile smooth muscle. Elevated cGMP leads to relaxation of the corpora cavernosa, allowing blood to fill the penis and producing an erection in response to sexual stimulation.
• Dapoxetine increases serotonin availability in the central nervous system by transiently inhibiting the serotonin re‑uptake transporter. Enhanced serotonergic tone prolongs the intravaginal ejaculatory latency time (IELT), reducing the urgency to ejaculate.

When combined, tadalafil facilitates the mechanical aspect of erection, while dapoxetine extends the duration of sexual activity, providing a synergistic effect for men with concurrent ED and PE. The onset of tadalafil’s action is typically within 30 minutes, with a duration of up to 36 hours, whereas dapoxetine reaches peak plasma concentrations within 1–3 hours and is cleared within 24 hours, allowing flexible timing around sexual activity.

Conditions Treated with Tadalafil With Dapoxetine

• Erectile Dysfunction (ED): A condition affecting up to 20 % of men aged 40–70 in the UK, characterised by the inability to achieve or maintain a satisfactory erection.
• Premature Ejaculation (PE): The most common male sexual dysfunction, reported by approximately 30 % of men in the UK, defined by ejaculation that occurs sooner than desired, often within one minute of penetration.

Clinical trials have demonstrated that the combination improves both erection quality and IELT compared with either agent alone, offering a comprehensive solution for patients with dual diagnoses.

Who is Tadalafil With Dapoxetine For?

• Men aged 18 years and older who have a confirmed diagnosis of both ED and PE.
• Patients who have responded inadequately to monotherapy (tadalafil or dapoxetine alone) and require combined pharmacological support.
• Individuals with stable cardiovascular status, allowing the safe use of PDE5 inhibitors.
• Men who are not contraindicated for short‑acting SSRIs, such as those with a history of severe depression, bipolar disorder, or concomitant use of monoamine oxidase inhibitors (MAOIs).

The combination is not appropriate for patients with nitrate therapy, severe renal impairment (eGFR < 30 mL/min/1.73 m²), uncontrolled hypertension, retinal disorders, or known hypersensitivity to either component.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness
• Reduced ejaculatory latency (when dapoxetine dose is sub‑therapeutic)

These effects are generally mild and self‑limiting, often resolving within a few hours.

Rare

• Myalgia or back pain (related to tadalafil)
• Visual disturbances (blue‑green tint perception)
• Upper respiratory tract infections
• Mild mood changes (e.g., increased anxiety)

Patients should report any persistent or worsening symptoms to a healthcare professional.

Serious

• Priapism (prolonged erection > 4 hours) – requires emergency medical attention.
• Sudden vision loss (non‑arteritic anterior ischemic optic neuropathy).
• Severe hypotension, especially when combined with nitrates or potent antihypertensives.
• Allergic reactions (rash, angio‑edema, anaphylaxis).

If any serious adverse event occurs, seek immediate medical care.

Drug–Drug Interactions

• Nitrates (e.g., nitroglycerin) – co‑administration may cause dangerous hypotension.
• Alpha‑blockers – may potentiate blood pressure lowering effects.
• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – can increase tadalafil plasma concentrations, raising risk of adverse events.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) – may elevate dapoxetine levels, enhancing serotonergic side effects.
• Other serotonergic agents – concurrent use can increase the risk of serotonin syndrome; avoid combination with tramadol, meperidine, or other SSRIs.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, before initiating therapy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing: Tadalafil 10 mg taken at least 30 minutes before sexual activity (or 2.5 mg daily for continuous use) plus dapoxetine 30 mg taken 1–3 hours before intercourse. The combination is not intended for use more than once per day.
• Missed dose: If a dose is forgotten and sexual activity is not imminent, do not take an extra tablet. Wait until the next scheduled dose.
• Overdose: Signs may include severe headache, prolonged erection, marked hypotension, or intense nausea. Seek urgent medical attention; supportive care and observation are the mainstays of management.

Precautions:

• Food does not significantly affect tadalafil absorption but high‑fat meals may delay dapoxetine onset.
• Moderate alcohol consumption is permissible, but excessive intake can exacerbate dizziness and hypotension.
• Patients with hepatic impairment should use the lowest effective dose and assess tolerability.

Buying Tadalafil With Dapoxetine from Our Online Pharmacy

Tadalafil With Dapoxetine can be purchased from our online pharmacy in UK. Our service offers:

• Affordable pricing: Near‑manufacturer cost, with transparent fees and no hidden mark‑ups.
• Verified quality: All products are sourced from licensed overseas suppliers that meet EU‑GMP standards.
• Guaranteed delivery: Discreet packaging shipped within 7 days express or ≈ 3 weeks via regular airmail for remote locations.
• Online‑only access: Enables patients who lack local pharmacy availability or insurance coverage to obtain the medication safely.

We operate as a pharmacy broker service, partnering with overseas licensed pharmacies to provide a discreet, privacy‑respecting solution for men who require this combination therapy.

FAQ

• Is Tadalafil With Dapoxetine available in both brand‑name and generic forms in the UK?
  Yes, the combination is marketed under brand‑name programmes that pair Cialis (tadalafil) with Priligy (dapoxetine). Generic equivalents containing the same active ingredients are also available, offering a more affordable option.

• What is the best way to store Tadalafil With Dapoxetine?
  The tablets should be kept at room temperature, protected from moisture, direct sunlight, and heat. Do not store them in bathrooms or near radiators, as excessive humidity can degrade the active compounds.

• Can the medication be taken with a high‑fat meal?
  Tadalafil absorption is not significantly altered by food, but a high‑fat meal may delay the onset of dapoxetine. For optimal timing, patients may choose to take dapoxetine on an empty stomach or after a light meal.

• Does travelling abroad affect the legality of importing Tadalafil With Dapoxetine into the UK?
  Personal import of a three‑month supply for personal use is permitted under UK regulations, provided the product is obtained from a licensed overseas supplier and accompanied by a declaration of personal use.

• Are there any special warnings for men with liver disease?
  Dapoxetine is metabolised primarily by hepatic enzymes; severe liver impairment may increase drug exposure and the risk of side effects. Dose reduction or avoidance is recommended in patients with advanced hepatic dysfunction.

• What distinguishes the UK formulation from those sold in the EU or US?
  UK‑marketed tablets conform to the EU‑GMP standards, with identical inactive ingredients to EU products. US formulations may contain different filler agents due to regulatory variances, but the active ingredient strength remains consistent.

• Can the combination be used by men who are on antidepressant therapy?
  Co‑administration with other SSRIs or SNRIs may raise the risk of serotonin syndrome. A thorough medication review is essential, and alternative antidepressant classes should be considered if combined use is required.

• Is there any impact of the medication on drug testing for employment?
  Routine workplace drug screens do not detect tadalafil or dapoxetine, as they are not classified as controlled substances. However, specialized tests could identify these compounds if specifically requested.

• How long does it take for Tadalafil With Dapoxetine to reach steady‑state concentrations?
  Tadalafil reaches steady state after approximately 4–5 days of daily dosing, while dapoxetine attains steady state within 2–3 days due to its shorter half‑life.

• What are the environmental considerations for disposing of unused tablets?
  Unused medication should be returned to a pharmacy disposal program or placed in a sealed container and discarded with household waste, avoiding flushing down the toilet to reduce environmental contamination.

Glossary

Phosphodiesterase‑type 5 (PDE5) Inhibitor

A class of drugs that block the PDE5 enzyme, enhancing cGMP levels and promoting smooth‑muscle relaxation in the penis, thereby facilitating erections.

Selective Serotonin Reuptake Inhibitor (SSRI)

A medication that increases serotonin concentrations in the brain by inhibiting its re‑absorption, used here to delay ejaculation.

Intravaginal Ejaculatory Latency Time (IELT)

The measured interval from vaginal penetration to ejaculation; a key endpoint in premature ejaculation studies.

Serotonin Syndrome

A potentially life‑threatening condition caused by excessive serotonergic activity, characterised by agitation, hyperthermia, tremor, and autonomic instability.

⚠️ Disclaimer

The information provided about Tadalafil With Dapoxetine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Tadalafil With Dapoxetine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.