Top Avana

Introduction

Top Avana is a combination medication that contains the active ingredients avanafil and dapoxetine. It is positioned within the men’s health therapeutic area, specifically addressing erectile dysfunction (ED) and premature ejaculation (PE). In the United Kingdom, the product is supplied by specialist manufacturers that hold licences from the Medicines and Healthcare products Regulatory Agency (MHRA). Avanafil, a phosphodiesterase‑type 5 (PDE5) inhibitor, produces an erection by enhancing the nitric‑oxide/cGMP pathway in penile tissue. Dapoxetine, a short‑acting selective serotonin re‑uptake inhibitor (SSRI), works centrally to increase the latency time before ejaculation. Together, these agents provide a dual‑action approach for men who experience both conditions, a scenario that is common in clinical practice.

What is Top Avana?

Top Avana is a fixed‑dose combination tablet that delivers avanafil (typically 100 mg) together with dapoxetine (60 mg). The formulation is classified as a combination drug under UK pharmaceutical law and is manufactured by companies that specialise in generic men’s‑health products. While the brand name “Top Avana” is marketed in the UK, the active compounds are identical to those found in the original branded products – avanafil is sold under names such as Stendra® and dapoxetine under Priligy®. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Top Avana Works

Avanafil belongs to the PDE5‑inhibitor class. By competitively binding to the PDE5 enzyme in the corpus cavernosum, avanafil prevents the degradation of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels cause smooth‑muscle relaxation, increased arterial inflow, and consequently an erection when sexual stimulation is present. Avanafil has a rapid absorption profile, reaching peak plasma concentrations within 30–45 minutes, and its effect can be felt as early as 15 minutes after ingestion. The drug is metabolised primarily by cytochrome P450 3A4 (CYP3A4) and has an elimination half‑life of approximately 5 hours.

Dapoxetine acts on the central serotonergic system. It is a short‑acting SSRI that increases synaptic serotonin, which in turn modulates the ejaculatory reflex arc. The onset of action is usually 1–2 hours after oral intake, and the drug is cleared quickly, with a half‑life of about 1.5 hours, allowing flexible dosing around sexual activity. By temporarily raising the threshold for ejaculation, dapoxetine prolongs intravaginal ejaculatory latency time (IELT) without causing the sexual dysfunction sometimes seen with longer‑acting SSRIs.

The combination of these mechanisms addresses two distinct physiological pathways: avanafil restores the ability to achieve and maintain an erection, while dapoxetine lengthens the ejaculatory interval. When taken together, the agents do not interfere with each other’s pharmacokinetics, allowing simultaneous use without dose‑adjustment in most patients.

Conditions Treated with Top Avana

• Erectile Dysfunction (ED) – A prevalent condition affecting an estimated 20 % of men in the UK aged 40 – 70 years. Avanafil’s rapid onset and high selectivity for PDE5 make it effective for men who require a fast‑acting oral therapy.
• Premature Ejaculation (PE) – The most common male sexual dysfunction, with prevalence rates up to 30 % in the general male population. Dapoxetine is the only SSRI approved in the EU and UK specifically for PE, improving IELT and perceived control.

Clinical guidelines from the British Association of Sexual and Reproductive Health (BASRH) recommend a stepwise approach: lifestyle optimisation, followed by pharmacological therapy if needed. Top Avana aligns with these recommendations by offering a single tablet that tackles both conditions, which can be advantageous for men who present with co‑existing ED and PE.

Who is Top Avana For?

Top Avana is appropriate for adult men who:

• Have a documented diagnosis of erectile dysfunction and seek an oral therapy with rapid onset.
• Experience premature ejaculation, defined by an IELT of less than 1 minute or by self‑reported distress, and have not responded adequately to non‑pharmacological strategies.
• Prefer a single‑tablet regimen rather than separate prescriptions for a PDE5 inhibitor and an SSRI.

The medication is not recommended for:

• Men taking nitrates (e.g., nitroglycerin) or who have severe uncontrolled hypertension, as the vasodilatory effect of avanafil can precipitate hypotension.
• Patients with a known hypersensitivity to either avanafil, dapoxetine, or any excipients in the formulation.
• Individuals with severe hepatic impairment (Child‑Pugh C) or those on potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole), because drug exposure may increase significantly.

Clinicians should assess cardiovascular risk, medication history, and renal/hepatic function before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache – Usually mild and transient; linked to vasodilation from PDE5 inhibition.
• Flushing – Warmth and redness, particularly in the facial area.
• Nasal congestion – Resulting from smooth‑muscle relaxation in nasal mucosa.
• Dyspepsia – Mild gastrointestinal discomfort, more common with dapoxetine.
• Transient visual disturbances – E.g., blurred vision or a mild change in colour perception; typically resolves without intervention.

Rare

• Priapism – Persistent erection lasting > 4 hours; requires urgent medical attention.
• Hypotension – Particularly when combined with alpha‑blockers or antihypertensive agents.
• Syncope – Fainting episodes may occur in the presence of severe blood pressure drops.
• Mood changes – Dapoxetine can occasionally cause anxiety, irritability, or depressive symptoms, especially with abrupt cessation.

Serious

• Cardiovascular events – Myocardial infarction, stroke, or severe arrhythmia in patients with underlying heart disease.
• Severe allergic reaction – Angio‑edema, urticaria, or anaphylaxis requiring emergency treatment.
• Serotonin syndrome – Rare but possible if dapoxetine is combined with other serotonergic agents (e.g., tramadol, linezolid).

Patients should seek immediate medical care if any of the serious adverse events develop.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing – The usual starting regimen is one tablet (100 mg avanafil + 60 mg dapoxetine) taken approximately 30 minutes before sexual activity. The tablet may be taken with or without food; however, a high‑fat meal can delay avanafil absorption by up to 30 minutes.
• Maximum frequency – Do not exceed one tablet per 24 hours. For men who require more frequent sexual activity, the safety of repeated dosing has not been established.
• Missed dose – If a dose is forgotten, it should be taken as soon as possible provided there is still at least 2 hours before planned sexual activity. If the scheduled time has passed, skip the missed dose and resume the regular dosing schedule; do not double‑dose.
• Overdose – In the event of accidental ingestion of more than one tablet, seek immediate medical attention. Symptoms of overdose may include severe hypotension, prolonged erection, or pronounced central nervous system effects (e.g., dizziness, confusion).
• Precautions – Avoid concomitant use of nitrates, potent CYP3A4 inhibitors, or other PDE5 inhibitors. Alcohol consumption does not contraindicate use but excessive intake may impair sexual performance and increase the risk of side‑effects such as dizziness.

Buying Top Avana from Our Online Pharmacy

Top Avana can be purchased from our online pharmacy in UK. Our service offers:

• Affordable pricing – Products are sourced near manufacturer cost, providing a lower price point than many brick‑and‑mortar pharmacies.
• Verified quality – We work exclusively with licensed overseas suppliers that adhere to Good Manufacturing Practice (GMP) standards. Each batch is subject to third‑party testing for potency and purity.
• Guaranteed delivery – Discreet packaging is shipped via express courier (delivery in ~ 7 days) or regular airmail (≈ 3 weeks). Tracking information is provided for all orders.
• Online‑only access – For patients who have limited availability of generic men’s‑health medications through the NHS or private pharmacies, our pharmacy broker service facilitates a convenient, privacy‑focused purchasing pathway.

We operate as a pharmacy‑broker service, collaborating with overseas licensed pharmacies and accredited suppliers. This model enables a discreet service that respects patient privacy while maintaining regulatory compliance.

FAQ

• What is the typical onset time for avanafil within Top Avana?
  Avanafil begins to work within 15 minutes of ingestion, with peak plasma levels reached at about 30–45 minutes. Most men report a satisfactory erection within this window if sexual stimulation occurs.

• Can Top Avana be stored in a bathroom cabinet?
  The tablets should be kept at room temperature (15 °C–30 °C) away from excess moisture. Storing them in a bathroom, where humidity is often high, may degrade the active ingredients over time.

• Does Top Avana contain any gluten or lactose?
  The formulation’s inactive excipients are free from gluten and lactose, making it suitable for most individuals with dietary sensitivities. However, patients with rare excipient allergies should review the full ingredient list.

• Is it safe to travel with Top Avana in hand luggage?
  Yes. The tablets are classified as non‑controlled medication and may be carried in carry‑on luggage. Keep them in the original packaging and have a copy of the product information for customs inspection, if required.

• How does dapoxetine differ from other SSRIs used for depression?
  Dapoxetine has a much shorter half‑life (≈ 1.5 hours) and is designed for on‑demand use before sexual activity, unlike chronic‑use SSRIs such as sertraline or fluoxetine which are taken daily.

• Are there regional differences in the tablet appearance of Top Avana?
  In the UK, the tablet is typically round, blue‑coloured, and debossed with “100 mg + 60 mg”. European‑market versions may have slight colour variations but contain the same active strengths.

• Can Top Avana be imported for personal use without a prescription?
  Under UK law, personal importation of a single‑course medication for personal use is permitted provided the quantity does not exceed a three‑month supply and the product is for a legitimate medical purpose. Users should verify that the supplier complies with MHRA import guidelines.

• Does Top Avana affect drug testing for employment?
  Avanafil and dapoxetine are not typically screened for in standard workplace drug tests. However, if a laboratory includes a comprehensive panel that tests for PDE5 inhibitors or SSRIs, a positive result could be reported.

• What is the impact of chronic alcohol consumption on Top Avana’s efficacy?
  Chronic heavy alcohol intake can impair erectile function and may blunt the effectiveness of avanafil. Additionally, alcohol can increase the risk of dizziness and hypotension when combined with the medication.

• Is there any evidence that Top Avana improves relationship satisfaction?
  Clinical studies of combined PDE5 inhibitor and SSRI therapy have shown improvements in sexual satisfaction scores for couples where both partners experience ED and PE. While Top Avana itself has not yet been the focus of large‑scale trials, the pharmacological rationale supports potential benefits in relational contexts.

Glossary

Phosphodiesterase‑type 5 (PDE5) inhibitor

 A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby facilitating erection when sexual stimulation is present.

Selective serotonin re‑uptake inhibitor (SSRI)

 A medication that increases serotonin levels in the brain by inhibiting its re‑absorption, used here to delay the ejaculatory reflex.

Intravaginal ejaculatory latency time (IELT)

 The measured interval from vaginal penetration to ejaculation; a key objective parameter in the treatment of premature ejaculation.

Cytochrome P450 3A4 (CYP3A4)

 A liver enzyme responsible for metabolising many medicines, including avanafil. Inhibition or induction of CYP3A4 can alter drug plasma concentrations.

⚠️ Disclaimer

The information provided about Top Avana is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Top Avana for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.