Udenafil

Introduction

Udenafil is a phosphodiesterase‑5 (PDE5) inhibitor used primarily to treat erectile dysfunction (ED). The active compound, also named Udenafil, belongs to the same therapeutic class as sildenafil and tadalafil and works by enhancing blood flow to the penis during sexual stimulation. Although not currently authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) for routine prescribing in the United Kingdom, the drug is approved for ED in several Asian markets and is legally available for personal import by adult patients who meet the relevant criteria. The medication is positioned within the Men’s Health group, and emerging clinical data suggest possible benefits for pulmonary arterial hypertension, although this indication remains investigational in the UK.

What is Udenafil?

Udenafil is the generic version of the brand‑name product Zydena, containing the same active compound, Udenafil. It was developed by Dong-A ST in South Korea and launched in the early 201s as a long‑acting PDE5 inhibitor. The molecule is chemically distinct from other agents in the class, offering a rapid onset (approximately 30 minutes) and a prolonged therapeutic window of up to 12 hours. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for men seeking reliable management of erectile dysfunction.

How Udenafil Works

Udenafil selectively inhibits the enzyme phosphodiesterase‑5 found in the smooth muscle of the corpus cavernosum. By blocking PDE5, the drug prevents the breakdown of cyclic guanosine monophosphate (cGMP), a messenger that mediates relaxation of penile smooth muscle and vasodilation of the cavernous arteries. When sexual arousal triggers nitric oxide release, cGMP levels rise; Udenafil sustains those levels, allowing increased blood inflow and erection. The drug reaches peak plasma concentrations within 1–2 hours after oral intake, is highly protein‑bound, and is metabolised primarily via hepatic CYP3A4. Its elimination half‑life of 10–12 hours underpins the extended duration of action compared with earlier PDE5 inhibitors.

Conditions Treated with Udenafil

• Erectile Dysfunction (ED) – The principal, formally approved indication in most countries. Clinical trials involving over 1,200 men demonstrated statistically significant improvements in International Index of Erectile Function (IIEF) scores versus placebo.
• Pulmonary Arterial Hypertension (PAH) – investigational – Early phase II studies reported reductions in mean pulmonary arterial pressure; however, regulatory approval for PAH has not been granted in the UK.

In the United Kingdom, erectile dysfunction affects an estimated 7 % of men aged 40–69, with prevalence rising sharply after age 60. Access to effective oral therapy remains a key component of sexual health services, and Udenafil offers an additional therapeutic choice, particularly for patients who experience sub‑optimal response to other PDE5 inhibitors.

Suitable Candidates for Udenafil Treatment

Udenafil is appropriate for adult men who:

• Have a confirmed diagnosis of organic or mixed‑cause erectile dysfunction.
• Experience adequate sexual stimulation but insufficient penile rigidity for satisfactory intercourse.
• Have not achieved satisfactory response to first‑line PDE5 inhibitors (e.g., sildenafil) or tolerate them poorly due to side‑effects.

Patients for whom Udenafil is not recommended include those with:

• Severe cardiovascular disease where sexual activity is contraindicated (e.g., recent myocardial infarction, uncontrolled hypertension).
• Concomitant use of nitrates or nitric oxide donors, owing to risk of profound hypotension.
• Significant hepatic impairment (Child‑Pugh class C) or severe renal failure (creatinine clearance <30 mL/min), as drug clearance may be compromised.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Nasal congestion or runny nose
• Dyspepsia (indigestion)
• Muscle aches

Rare

• Vision disturbances (e.g., blurred vision, blue‑tinted vision)
• Hearing impairment or sudden loss of hearing
• Priapism (prolonged erection lasting >4 hours)

Serious

• Severe hypotension, especially when combined with nitrates or potent CYP3A4 inhibitors (e.g., ketoconazole).
• Cardiovascular events such as myocardial infarction or stroke in high‑risk individuals.
• Allergic reactions manifesting as rash, itching, swelling, or anaphylaxis.

Drug–drug interactions of clinical relevance include:

• Nitrates (e.g., glyceryl trinitrate) → additive vasodilatation, risk of dangerous blood pressure fall.
• CYP3A4 inhibitors (e.g., clarithromycin, ritonavir) → increased plasma concentrations, heightened adverse‑event risk.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine) → reduced efficacy due to accelerated metabolism.

Patients should disclose all current medications, over‑the‑counter products, and herbal supplements before initiating Udenafil.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing – The usual starting dose for most men is 100 mg taken orally with water, about 30 minutes before anticipated sexual activity. Depending on efficacy and tolerance, the dose may be adjusted to 50 mg or 200 mg. The medication should not be taken more than once per day.
• Missed dose – If a dose is forgotten and sexual activity is still anticipated within the next 12 hours, the tablet may be taken. If the intended window has passed, skip the missed dose; do not double‑dose to compensate.
• Overdose – Symptoms may include pronounced headache, dizziness, or a rapid drop in blood pressure. Patients should seek immediate medical assessment, ideally at the nearest Accident & Emergency department. No specific antidote exists; treatment is supportive and focused on stabilising vital signs.

Food can delay absorption; a high‑fat meal may extend onset by up to 60 minutes. Alcohol, especially in excess, may exacerbate hypotensive effects and reduce erection quality; moderate consumption is advisable.

Buying Udenafil from Our Online Pharmacy

Udenafil can be purchased safely from our online pharmacy in the UK. We source the generic medication directly from licensed overseas manufacturers that meet European Good Manufacturing Practice (GMP) standards, ensuring each tablet matches the quality of the original brand. Our service provides:

• Competitive pricing – close to the manufacturer’s cost, significantly lower than many domestic pharmacy mark‑ups.
• Verified quality – every batch is accompanied by a certificate of analysis confirming active‑ingredient potency and purity.
• Discreet, reliable delivery – options include express shipping (typically within 7 days) and regular airmail (approximately 2–3 weeks). Packages are unmarked and packaged in secure, tamper‑evident envelopes.
• Pharmacy broker model – we operate as a broker, partnering with internationally accredited pharmacies to broaden access to medications that may not be stocked locally. This model preserves patient confidentiality while delivering cost‑effective treatment to adults who encounter barriers in traditional pharmacy channels.

Patients ordering from our platform should be aware of UK customs regulations: personal import of a three‑month supply for personal use is generally permitted, provided the medication is for a legitimate medical purpose and not for resale.

FAQ

• Is Udenafil available in both brand‑name and generic forms in the UK?
  Yes, the original brand Zydena is marketed in several Asian countries, while generic Udenafil tablets are produced by multiple licensed manufacturers. Our online pharmacy offers the generic version, which contains the identical active ingredient at a lower price point.

• How should Udenafil be stored to maintain its effectiveness?
  Store tablets in their original blister pack at room temperature, ideally between 15 °C and 30 °C. Keep them away from direct sunlight, moisture, and heat sources such as radiators or kitchen appliances.

• Can Udenafil be taken with alcohol, and what are the risks?
  Moderate alcohol consumption does not usually prevent an erection, but large amounts can potentiate hypotensive effects and diminish the drug’s efficacy. It is advisable to limit alcohol intake around the time of dosing.

• What is the appearance of a typical Udenafil tablet?
  Generic tablets are usually round, film‑coated, and come in 50 mg, 100 mg, and 200 mg strengths. The colour may vary between manufacturers, often ranging from pink to orange, with the dosage strength imprinted on one side.

• Are there specific warnings for patients of Asian descent?
  Clinical data suggest slightly higher plasma concentrations of Udenafil in some Asian populations, likely due to genetic variations in CYP3A4 activity. Physicians may start at the lower 50 mg dose and titrate based on response and tolerability.

• Is a prescription required to import Udenafil for personal use in the UK?
  While a prescription is not mandatory for personal import of a three‑month supply, the medication must be for a legitimate personal medical need. Importers are encouraged to retain any supporting documentation, such as a doctor’s letter, in case customs request verification.

• What is the difference in formulation between Udenafil sold in Europe and Asia?
  The core active ingredient is identical, but excipients—such as fillers, binders, and colourants—may differ according to regional regulatory requirements. These variations rarely affect clinical efficacy, though patients with specific excipient allergies should review the full ingredient list.

• Does travelling with Udenafil affect its legal status?
  When traveling within the EU or the UK, Udenafil may be carried for personal use provided the quantity does not exceed a three‑month supply and it is accompanied by a medical justification if requested by customs officials.

• Can Udenafil be crushed or split to adjust the dose?
  The tablets are formulated for oral ingestion whole. Crushing or splitting may alter the drug’s release characteristics and affect absorption. If dose adjustment is required, a licensed pharmacy should provide a suitable dosage form.

• How long does Udenafil remain detectable in drug‑testing programmes?
  Standard screening tests for PDE5 inhibitors are uncommon, but if performed, Udenafil can be identified in blood for up to 24 hours and in urine for 48–72 hours after a single dose.

• What are the primary clinical trials that supported Udenafil’s approval in Asia?
  Two pivotal phase III studies—one in South Korea (n≈400) and another in Japan (n≈350)—demonstrated statistically significant improvements in IIEF‑5 scores versus placebo, with a favourable safety profile. Both trials met regulatory criteria for efficacy and tolerability.

• Are there any known differences in efficacy between Udenafil and other PDE5 inhibitors?
  Comparative meta‑analyses suggest Udenafil offers a faster onset (≈30 minutes) and a longer duration (up to 12 hours) compared with sildenafil, while tolerability is broadly similar. Individual response varies, and some patients prefer Udenafil for its extended window of activity.

Glossary

Phosphodiesterase‑5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby enhancing blood flow to the penis during sexual arousal.

cGMP (Cyclic guanosine monophosphate)

A cellular messenger that causes smooth‑muscle relaxation in the corpus cavernosum, facilitating erection when its levels are sustained.

Therapeutic window

The dosage range in which a medication provides optimal efficacy while minimising the risk of adverse effects.

Hypotension

An abnormally low blood‑pressure state, which can lead to dizziness, fainting, or shock if severe.

⚠️ Disclaimer

The information provided about Udenafil is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Udenafil for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.