Generic Vardenafil With Dapoxetine

Introduction

Vardenafil with dapoxetine is a fixed‑dose oral tablet that combines two pharmacologically distinct agents: the phosphodiesterase‑5 (PDE5) vardenafil and the short‑acting selective serotonin reuptake inhibitor (SSRI) dapoxetine. The product is positioned within the men’s health therapeutic area, principally to treat erectile dysfunction (ED) that is associated with premature ejaculation (PE). In the United Kingdom, the combination is prescribed when a single‑agent approach does not achieve satisfactory sexual performance for both partners. The medication is manufactured by several licensed pharmaceutical companies that hold marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA).

What is Vardenafil With Dapoxetine?

Vardenafil with dapoxetine is a single tablet that contains 10 mg of vardenafil and 30 mg of dapoxetine (dose strengths may vary according to national authorisation). Vardenafil belongs to the PDE5‑inhibitor class, the same family as the brand Levitra®. Dapoxetine is the active ingredient in the branded product Priligy®. By integrating these two agents, the tablet targets two separate aspects of male sexual function: the physiological erection mechanism and the control of ejaculatory latency.

The combination was developed to provide a convenient, once‑daily (or on‑demand) therapy that reduces the need for patients to coordinate two separate medications. It is classified as a prescription‑only medicine (POM) in the UK and is supplied by registered pharmacies after appropriate clinical evaluation.

How Vardenafil With Dapoxetine Works

Vardenafil component

Vardenafil blocks the enzyme phosphodiesterase‑5, which normally degrades cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. Sexual stimulation releases nitric oxide, activating guanylate cyclase and raising cGMP levels. Elevated cGMP relaxes smooth muscle, allowing arterial inflow and erection. By inhibiting PDE5, vardenafil prolongs cGMP activity, facilitating an erection that is maintained for the duration of sexual activity. The onset of action is typically 30–60 minutes, with a therapeutic window of up to 12 hours.

Dapoxetine component

Dapoxetine selectively inhibits serotonin reuptake for a short period (half‑life ≈ 1.5 hours). Increased serotonergic tone in the central nervous system delays the ejaculatory reflex by modulating spinal and supraspinal pathways that control emission and ejaculation. Clinical trials have shown that dapoxetine increases the intravaginal ejaculatory latency time (IELT) by an average of 2–3 minutes when taken on demand.

Combined effect

When the two agents are co‑administered, vardenafil creates a favourable erectile environment while dapoxetine prolongs the ejaculatory interval. This synergistic action enables men with both ED and PE to achieve satisfactory penetration and maintain intercourse without the need for separate dosing schedules. The combined tablet is taken approximately one hour before sexual activity, with or without a light meal.

Conditions Treated with Vardenafil With Dapoxetine

• Erectile Dysfunction (ED) – Affects an estimated 17 % of men aged 40–59 in the UK, rising to 42 % in those over 70. Vardenafil restores the vasodilatory pathway required for erection.
• Premature Ejaculation (PE) – Defined by ejaculation occurring within one minute of penetration, or before the man wishes. Roughly 30 % of UK men report symptoms of PE at some point. Dapoxetine lengthens IELT and improves perceived control.

The fixed‑dose formulation is approved for the combined indication of “ED associated with premature ejaculation.” It is not licensed for the treatment of isolated ED or PE alone, although clinicians may prescribe the individual components separately when only one condition is present.

Who is Vardenafil With Dapoxetine For?

• Men aged 18 – 70 years who experience both an inability to achieve/maintain a satisfactory erection and ejaculation that occurs earlier than desired.
• Patients whose lifestyle or relationship dynamics make the coordination of two separate medications impractical (e.g., infrequent sexual activity, travel, or lack of routine).
• Individuals who have trialled monotherapy (either a PDE5 inhibitor or dapoxetine alone) and report insufficient improvement in either erection quality or ejaculatory control.

Contra‑indications include: use of nitrates or nitric oxide donors, severe uncontrolled hypertension, recent myocardial infarction, hereditary retinal disorders, and known hypersensitivity to either active ingredient. Men with severe hepatic or renal impairment may require dose adjustment or alternative therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness
• Diarrhoea or loose stools

These events are usually mild to moderate, transient, and resolve without medical intervention in most users.

Rare

• Visual disturbances (e.g., colour vision changes, blurred vision)
• Auditory symptoms (tinnitus, hearing loss)
• Priapism (prolonged erection lasting > 4 hours)
• Elevated liver enzymes

Patients experiencing any of these should seek medical advice promptly.

Serious

• Cardiovascular events (myocardial infarction, stroke, severe arrhythmia) – mainly in patients with pre‑existing heart disease.
• Severe hypotension, especially when combined with nitrates.
• Anaphylaxis or severe hypersensitivity reactions (rash, swelling, airway compromise).

Any sign of a serious adverse reaction warrants immediate emergency care.

Drug–Drug Interactions

• Nitrates (e.g., glyceryl trinitrate, isosorbide dinitrate): Concomitant use can cause life‑threatening hypotension.
• Alpha‑blockers (e.g., tamsulosin, alfuzosin): May potentiate blood pressure falls; dose titration recommended.
• Other PDE5 inhibitors: Concurrent use increases risk of priapism and systemic side effects.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Can raise vardenafil levels, enhancing adverse effects.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): May increase dapoxetine exposure, leading to heightened nausea or dizziness.

A comprehensive medication review is essential before initiating therapy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dose: One tablet containing 10 mg vardenafil + 30 mg dapoxetine, taken 30–60 minutes before sexual activity. Do not exceed one tablet within a 24‑hour period.
• Dose adjustments: For men > 65 years, or those with mild‑moderate hepatic/renal impairment, a reduced dose of 5 mg vardenafil + 30 mg dapoxetine may be advised.
• Missed dose: Because the medication is taken on demand, a missed dose simply means the tablet was not consumed before the intended activity. Do not take an extra tablet later in the day.
• Overdose: Symptoms may include severe headache, hypotension, fainting, or prolonged erection. If overdose is suspected, seek urgent medical attention or contact the NHS 111 service.
• Food & alcohol: A high‑fat meal can delay vardenafil absorption, modestly reducing its effectiveness. Moderate alcohol intake (≤ 2 units) is permissible; excessive alcohol may impair erection and increase side‑effect risk.
• Comorbidities: Patients with cardiovascular disease should have a cardiac assessment before use. Those with diabetes, hypertension, or dyslipidaemia should continue their usual management while using the combination therapy.

Buying Vardenafil With Dapoxetine from Our Online Pharmacy

Vardenafil with dapoxetine can be purchased from our online pharmacy in the UK. Our service offers:

• Affordable pricing – Close to manufacturer cost, providing a cost‑effective alternative to brand‑name products.
• Verified quality – All tablets are sourced from licensed, MHRA‑approved suppliers with batch‑to‑batch conformity.
• Discreet, reliable delivery – Orders are packaged in unbranded envelopes and dispatched via express (typically 7 days) or regular airmail (approximately 3 weeks) services, with tracking available.
• Online‑only access – For patients who cannot obtain the medication through local pharmacies due to stock shortages or regional prescribing restrictions, our pharmacy broker model connects you with overseas licensed pharmacies that legally export the product to the UK.

The platform respects patient privacy, employs secure encrypted data transmission, and provides a straightforward checkout experience. This approach enables individuals with limited pharmacy access to obtain a clinically appropriate therapy without compromising safety or affordability.

FAQ

• Can Vardenafil With Dapoxetine be taken with a high‑fat meal?
  Yes, the tablet can be taken after any meal, but a high‑fat breakfast may delay the onset of vardenafil’s effect by up to 30 minutes. Planning the dose about an hour before intercourse can help maintain the expected timing.

• What does the tablet look like and how is it packaged?
  The tablet is typically round, film‑coated, and scored for easy splitting. It is packaged in blister packs of 10 or 20 tablets within a cardboard box that displays the batch number, expiry date, and regulatory information.

• Are there any differences between UK‑approved and overseas formulations?
  UK‑approved versions must meet MHRA standards for strength, purity, and excipients. Some overseas manufacturers may use alternative inactive ingredients (e.g., different colourants) that are still compliant with EU pharmacopoeia, but the active‑ingredient content is identical.

• Is it safe to travel internationally with this medication?
  Yes, provided the tablet remains in its original packaging with a clear label indicating the active ingredients. Carry a copy of the prescription (or a doctor’s letter where required) and keep the medication in hand luggage to avoid temperature extremes.

• How should the medication be stored in hot climates?
  Store the tablets at a controlled room temperature (15–30 °C). If the ambient temperature exceeds 30 °C for prolonged periods, place the blister pack in a insulated container or a cool, dry cupboard to preserve potency.

• Can Vardenafil With Dapoxetine affect drug testing for employment?
  Routine workplace drug screens target substances such as opioids, cannabinoids, amphetamines, cocaine, and benzodiazepines. Vardenafil and dapoxetine are not included in standard panels and should not cause a positive result.

• What is the history behind the development of this combination therapy?
  The concept emerged in the early 201s after clinical observations that men with concurrent ED and PE benefited from simultaneous PDE5 inhibition and serotonergic modulation. Phase III trials demonstrated superior sexual satisfaction scores compared with monotherapy, leading to regulatory approval in several EU countries, including the UK.

• How does Vardenafil With Dapoxetine compare with taking Levitra and Priligy separately?
  Pharmacokinetic studies show that the fixed‑dose tablet provides comparable systemic exposure to each individual drug when taken at equivalent doses. The combined tablet offers convenience, reduced pill burden, and potentially better adherence, while maintaining efficacy and safety profiles similar to the separate agents.

• Is there a generic version of this combination available in the UK?
  Yes, generic formulations containing vardenafil and dapoxetine are manufactured by multiple licensed suppliers. They contain the same active ingredients as branded products and must meet identical regulatory standards, offering a lower‑cost option for patients.

• What should I do if I experience a prolonged erection lasting more than four hours?
  A prolonged erection (priapism) is a medical emergency. Apply a cold compress to the pelvis, avoid further sexual stimulation, and seek immediate medical attention at the nearest emergency department or call NHS 111.

• Are there any specific warnings for men with history of depression?
  Dapoxetine, as an SSRI, can influence mood. Men with a prior history of major depressive disorder should discuss the risk‑benefit profile with a clinician, as the short‑acting nature of dapoxetine generally carries a lower risk of mood alteration than long‑acting SSRIs.

Glossary

Phosphodiesterase‑5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby promoting smooth‑muscle relaxation in the penis to facilitate erection.

Intravaginal Ejaculatory Latency Time (IELT)

The measured interval from the start of vaginal penetration to ejaculation; a key endpoint in studies of premature ejaculation therapies.

Priapism

A prolonged and often painful erection lasting more than four hours without sexual stimulation; requires urgent medical management to prevent tissue damage.

CYP450 Enzymes

A family of liver enzymes (e.g., CYP3A4, CYP2D6) that metabolise many medications; inhibitors or inducers of these enzymes can alter drug levels and affect safety.

⚠️ Disclaimer

The information provided about Vardenafil With Dapoxetine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Vardenafil With Dapoxetine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.