Generic Zyvox
Zyvox is an oxazolidinones antibiotic to treat infections caused by Enterococcus and Streptococcus.
- Category: Antibiotics
- Active ingredient: Linezolid
- Payment options: VISA, Mastercard, Amex, JCB, Dinners
- Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)
Buy Generic Zyvox Online
Package | Price | |
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600mg x 32 pills Free Airmail shipping | $262.08 | |
600mg x 20 pills | $196.56 | |
600mg x 12 pills | $137.59 |
Generic Zyvox information
Introduction
Zyvox (linezolid) is an oxazolidinone antibiotic approved for the treatment of serious Gram‑positive infections, including those caused by resistant strains such as methicillin‑resistant Staphylococcus aureus (MRSA) and vancomycin‑resistant Enterococcus (VRE). In the United Kingdom, it is prescribed when first‑line agents are ineffective or contraindicated. Zyvox is manufactured by Pfizer and belongs to the broader antibiotic group known as oxazolidinones. In addition to skin and soft‑tissue infections, the drug is indicated for certain types of pneumonia and for infections caused by susceptible Streptococcus species.
What is Zyvox?
Zyvox is a brand‑name formulation containing the active compound linezolid. It is classified as a synthetic, bacteriostatic antibiotic belonging to the oxazolidinone class. Developed in the late 199s by Pharmacia & Upjohn and later marketed worldwide by Pfizer, Zyvox was the first oxazolidinone to receive regulatory approval. The medication is supplied as oral tablets (typically 600 mg) and as an intravenous (IV) solution for hospital use. Both formulations deliver the same amount of linezolid and are interchangeable based on clinical need.
How Zyvox Works
Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit. This binding prevents the formation of the initiation complex required for translation, thereby halting the production of essential proteins. Because the drug acts at an early stage of protein assembly, it exerts a bacteriostatic effect against most susceptible Gram‑positive organisms and a bactericidal effect at higher concentrations or against certain strains.
The onset of action is rapid; therapeutic plasma concentrations are achieved within 1–2 hours after oral administration, and steady‑state levels are reached after 2–3 days of once‑daily dosing. Linezolid is metabolised primarily by oxidation (non‑enzymatic) and is eliminated through renal excretion (30 %) and non‑renal pathways (70 %). Its half‑life averages 5–7 hours, supporting once‑daily dosing regimens in most adult patients.
Conditions Treated with Zyvox
- Complicated Skin and Skin‑Structure Infections (cSSSI): Includes cellulitis, abscesses, and wound infections caused by MRSA or other resistant Gram‑positive bacteria. In the UK, cSSSI accounts for a substantial proportion of hospital admissions, and linezolid offers an oral alternative to intravenous therapy.
- Hospital‑Acquired or Ventilator‑Associated Pneumonia (HAP/VAP): Specifically when the pathogen is identified as linezolid‑susceptible Staphylococcus aureus (including MRSA). Pneumonia caused by resistant organisms remains a leading cause of intensive‑care mortality.
- Infections due to Vancomycin‑Resistant Enterococci (VRE): Linezolid retains activity against many VRE strains, providing a vital therapeutic option when other agents fail.
- Other Gram‑Positive Infections: Occasionally prescribed for streptococcal bacteremia, endocarditis, or osteomyelitis when susceptibility data support its use.
The effectiveness of Zyvox in these settings stems from its excellent tissue penetration—including lung, bone, and skin—its oral bioavailability (~100 %), and its activity against bacteria that harbour common resistance mechanisms (e.g., mecA, vanA/B genes).
Who is Zyvox For?
Zyvox is appropriate for adult patients who require treatment for severe infections caused by susceptible Gram‑positive organisms, particularly when:
- First‑line beta‑lactam or glycopeptide agents are unsuitable due to allergy, intolerance, or confirmed resistance.
- An oral antibiotic is preferred to reduce hospital stay or allow outpatient management, given linezolid’s high oral bioavailability.
- The infection involves deep‑seated tissues (bone, lung) where good penetration is essential.
Contra‑indications include patients with known hypersensitivity to linezolid or any component of the formulation, and those on monoamine oxidase inhibitor (MAOI) therapy due to the risk of serotonin syndrome. Caution is advised in individuals with pre‑existing hematologic abnormalities, severe renal impairment (creatinine clearance < 30 mL/min), or uncontrolled hypertension, as these conditions increase the likelihood of adverse events.
Risks, Side Effects, and Interactions
Common
- Gastro‑intestinal upset: Nausea, vomiting, diarrhoea, and abdominal discomfort are reported in up to 20 % of patients.
- Headache: Frequently observed, often mild and transient.
- Myelosuppression: Mild reductions in platelet count, leukocytes, or haemoglobin may develop after 2 weeks of therapy.
Rare
- Peripheral and optic neuropathy: Typically associated with prolonged treatment (> 28 days) and may be irreversible if not identified early.
- Lactic acidosis: Uncommon but serious; more likely in patients with mitochondrial disorders or severe renal dysfunction.
Serious
- Serotonin syndrome: May occur when linezolid is combined with serotonergic agents (e.g., SSRIs, SNRIs, tricyclic antidepressants, meperidine). Symptoms include agitation, hyperthermia, muscle rigidity, and autonomic instability.
- Severe thrombocytopenia: Platelet counts can fall below 50 × 10⁹/L, increasing bleeding risk.
- Hypotensive episodes: Rare but documented, especially in patients receiving concomitant antihypertensive therapy.
Clinically Relevant Drug‑Drug Interactions
- Serotonergic drugs: Co‑administration with SSRIs, SNRIs, tricyclics, linezolid‑MAOI activity can precipitate serotonin syndrome; a wash‑out period of at least 14 days is recommended when switching.
- Rifampicin: Induces hepatic enzymes that may lower linezolid plasma concentrations, potentially reducing efficacy.
- MAOIs (e.g., phenelzine, tranylcypromine): Concurrent use is contraindicated due to additive MAO inhibition.
- Selective adrenergic agents (e.g., norepinephrine): May augment hypertensive effects.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their healthcare professional before initiating Zyvox.
Practical Use: Dosing, Missed Dose, Overdose
- Standard adult dosing: 600 mg once daily, administered either orally (tablet) or intravenously (infusion over 30–60 minutes). Duration of therapy depends on the infection type, typically 10‑14 days for cSSSI and 7‑10 days for pneumonia.
- Renal or hepatic impairment: No routine dose adjustment is required for mild to moderate impairment dysfunction (creatinine clearance < 30 mL/min), some clinicians reduce the dose to 600 mg every 12 hours, though evidence is limited.
- Missed dose: If a dose is missed by less than 6 hours, take it as soon as remembered. If more than 6 hours have elapsed, skip the missed dose and resume the regular once‑daily schedule; do not double‑dose.
- Overdose: Acute overdose may manifest as severe nausea, vomiting, dizziness, and hypotension. Management is primarily supportive—monitor vital signs, provide intravenous fluids, and treat symptomatic complications. No specific antidote exists.
- Food and alcohol: Food does not significantly affect absorption; tablets can be taken with or without meals. Moderate alcohol intake does not alter efficacy but patients should avoid excessive alcohol, especially if hepatic function is compromised.
- Precautions: Routine complete blood counts are recommended weekly for patients on therapy beyond 2 weeks. Visual acuity should be assessed before treatment and periodically thereafter for those on prolonged courses.
Buying Zyvox from Our Online Pharmacy
Zyvox can be obtained safely and discreetly from our online pharmacy in the UK. We specialise in providing verified, cost‑effective generic linezolid that meets the same stringent quality standards as the original brand.
- Affordable pricing: Our supply chain sources the medication near manufacturer cost, passing savings directly to you.
- Verified quality: Each batch is sourced from licensed overseas pharmacies that adhere to Good Manufacturing Practice (GMP) and is inspected by independent quality‑control laboratories.
- Guaranteed delivery: We offer discreet packaging with tracking; standard delivery typically arrives within 7 days, while express options are available for urgent needs.
- Online‑only access: By operating as a pharmacy‑broker service, we can provide international medications that may not be stocked locally, ensuring continuity of care for patients with limited access.
Our service respects patient privacy and adheres to UK import regulations for personal use. All orders are processed by qualified pharmacists who verify the legitimacy of each prescription and ensure that the medication complies with UK safety standards.
FAQ
-
Is Zyvox available in both brand‑name and generic forms in the UK?
Yes. The original brand‑name product is marketed as Zyvox by Pfizer, while generic versions containing the same active compound linezolid are also approved and widely distributed. Generic formulations are generally less expensive while maintaining equivalent efficacy. -
Does Zyvox require refrigeration?
No. Both the oral tablets and the IV solution are stable at controlled room temperature (15‑30 °C). The IV solution should be protected from light and used within the expiry period indicated on the packaging. -
What does a Zyvox tablet look like?
The standard oral tablet is a white, round, film‑coated pill bearing the imprint “LZD 600”. Appearance may vary slightly between manufacturers, but the strength and composition remain consistent. -
Can Zyvox be taken while travelling abroad?
Yes, provided you carry a copy of the prescription and the medication remains in its original, tamper‑evident packaging. Keep tablets in a carry‑on bag to avoid temperature extremes in checked luggage. -
Are there differences in linezolid formulation between the EU and the US?
Formulation differences are minimal; both regions require the same amount of active linezolid per tablet (600 mg). Inactive ingredients such as lactose, microcrystalline cellulose, and magnesium stearate may vary slightly due to local excipient availability, but these changes do not affect therapeutic performance. -
What are the legal limits for importing Zyvox for personal use into the UK?
UK regulations allow individuals to import a three‑month supply of prescription medication for personal use, provided a valid prescription is presented. Our pharmacy ensures that shipments comply with these limits and includes all necessary documentation. -
Does linezolid interact with dietary supplements containing tryptophan?
Tryptophan is a precursor for serotonin. Combined with linezolid’s MAO‑inhibitory activity, high‑dose tryptophan supplements could theoretically increase the risk of serotonin syndrome. It is advisable to avoid such supplements or discuss them with a healthcare professional. -
How long has linezolid been on the market?
Linezolid received its first regulatory approval in 200 (US FDA) and was subsequently approved in the EU in 2001. Over two decades of clinical experience have established its role in managing resistant Gram‑positive infections. -
Is Zyvox safe for patients with mild liver disease?
Linezolid is metabolised primarily by non‑enzymatic oxidation, and mild hepatic impairment does not usually necessitate dose adjustment. However, patients with severe liver dysfunction should be monitored closely, as drug clearance may be reduced. -
What is the environmental impact of disposing unused Zyvox tablets?
Unused antibiotics should not be flushed down the toilet or thrown in household waste, as they can contribute to antimicrobial resistance in the environment. Return‑to‑pharmacy programmes or designated hazardous‑waste collection points are the recommended disposal methods.
Glossary
- Oxazolidinone
- A class of synthetic antibiotics that inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit.
- Serotonin syndrome
- A potentially life‑threatening condition caused by excess serotonergic activity, characterised by agitation, hyperthermia, sweating, and neuromuscular abnormalities.
- Myelosuppression
- A reduction in bone‑marrow activity leading to decreased production of blood cells (red cells, white cells, platelets).
- Pharmacokinetics
- The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.
⚠️ Disclaimer
The information provided about Zyvox is for general knowledge only. does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Zyvox for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.