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Generic Keftab Information
Introduction
Keftab is an oral antibiotic containing the active compound cephalexin. It belongs to the β‑lactam class known as cephalosporins, which are widely used to treat bacterial infections. In the United Kingdom, Keftab is prescribed for a range of common infections, including skin and soft‑tissue infections, respiratory tract infections, and urinary tract infections. The medication is manufactured by a licensed international supplier and distributed in the UK under strict quality‑assured conditions.
What is Keftab?
Keftab is the generic version of the well‑known brand Keflex, containing the same active compound cephalexin. Our online pharmacy provides this generic alternative as a cost‑effective treatment option. Cephalexin is a first‑generation cephalosporin that has been on the market since the early 197s and is listed in the British National Formulary (BNF) for a variety of bacterial infections. Keftab is supplied as immediate‑release tablets (typically 250 mg or 500 mg) and, where required, as oral suspension.
How Keftab Works
Cephalexin interferes with bacterial cell‑wall synthesis. It binds to penicillin‑binding proteins (PBPs) located on the inner membrane of susceptible Gram‑positive and limited Gram‑negative bacteria. This binding blocks the transpeptidation step that cross‑links peptidoglycan strands, weakening the cell wall and causing osmotic lysis. Because human cells lack a peptidoglycan wall, the drug exhibits selective toxicity.
The onset of antibacterial activity occurs within 30–60 minutes after oral ingestion, with peak plasma concentrations reached in about 1 hour for the 500 mg dose. Cephalexin is eliminated primarily by the kidneys; the elimination half‑life in adults with normal renal function is approximately 1 hour, allowing for convenient twice‑daily dosing in most infections.
Conditions Treated with Keftab
- Skin and soft‑tissue infections – cellulitis, impetigo, infected wounds, and erysipelas caused by Staphylococcus aureus (penicillin‑susceptible) or Streptococcus pyogenes. In the UK, skin infections account for roughly 400 000 primary‑care consultations each year (NHS Digital, 2023).
- Upper respiratory tract infections – acute bacterial sinusitis, otitis media, and uncomplicated pharyngitis when a bacterial aetiology is confirmed or strongly suspected.
- Lower respiratory tract infections – community‑acquired pneumonia (non‑severe) caused by susceptible organisms such as Streptococcus pneumoniae and Haemophilus influenzae.
- Urinary tract infections – uncomplicated cystitis due to E. coli or Proteus spp. In England, UTIs affect about 1 in 5 women annually (Public Health England, 2022).
- Bone and joint infections – early‑stage osteomyelitis or septic arthritis when the pathogen is known to be cephalexin‑sensitive.
The drug’s effectiveness stems from its reliable activity against the typical causative organisms of these conditions and its favourable pharmacokinetic profile, which enables predictable dosing and high patient adherence.
Who is Keftab For?
- Adults with confirmed or highly suspected bacterial infections that are listed in the approved indications above.
- Patients without severe renal impairment (creatinine clearance > 30 mL/min) because standard dosing provides adequate drug exposure without accumulation.
- Individuals who are allergic to penicillins but tolerant of cephalosporins – cross‑reactivity is low (≈ 1–2 %).
- People seeking an affordable generic alternative to brand‑name cephalexin formulations.
Keftab is not appropriate for:
- Patients with a documented hypersensitivity to cephalexin, other cephalosporins, or β‑lactam antibiotics.
- Those with severe renal failure (creatinine clearance < 30 mL/min) without dose adjustment.
- Infections caused by β‑lactam‑producing organisms (e.g., Pseudomonas aeruginosa, methicillin‑resistant Staphylococcus aureus).
- Pregnant or breastfeeding women unless the benefit clearly outweighs the risk; current data suggest cephalexin is relatively safe, but professional guidance is essential.
Risks, Side Effects, and Interactions
Common
- Gastro‑intestinal upset (nausea, mild diarrhoea, abdominal discomfort) – observed in up to 10 % of treated patients.
- Skin rash or mild urticaria – typically transient and self‑limiting.
- Vaginal yeast infection – indirect result of altered vaginal flora.
Rare
- Clostridioides difficile‑associated diarrhoea – incidence ≤ .1 % but potentially severe; patients should be advised to seek medical attention for persistent watery stools.
- Transient elevation of liver enzymes – usually asymptomatic and resolves after therapy completion.
Serious
- Anaphylaxis or severe hypersensitivity reactions – may present with bronchospasm, angio‑edema, or hypotension; immediate emergency care required.
- Serum‑sickness‑like reactions – fever, arthralgia, and rash occurring days after exposure.
Drug–Drug Interactions
- Probenecid – reduces renal excretion of cephalexin, increasing plasma concentrations; dose adjustment may be required.
- Warfarin – cephalexin can potentiate anticoagulant effect; INR should be monitored closely.
- Oral contraceptives – limited evidence suggests a marginal reduction in contraceptive efficacy; a backup method is advisable.
- Renal‑eliminated drugs (e.g., aminoglycosides, certain antivirals) – concurrent use may require renal function monitoring.
Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to their prescriber.
Practical Use: Dosing, Missed Dose, Overdose
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Standard adult dosing (based on indication):
- 250 mg every 6 hours for uncomplicated skin infections.
- 500 mg every 12 hours for respiratory or urinary tract infections.
- Dosage may be increased to 1 g every 6 hours for severe infections, provided renal function is normal.
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Administration – tablets should be swallowed whole with a glass of water. The oral suspension should be shaken well before each use; it may be taken with or without food, though taking with food can reduce mild stomach upset.
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Missed dose – If a dose is forgotten within 4 hours of the scheduled time, take it as soon as remembered. If the next dose is due sooner, skip the missed dose and resume the regular schedule; do not double‑dose.
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Overdose – Symptoms may include nausea, vomiting, and diarrhoea. In severe cases, renal failure can occur. Immediate medical attention is advised; supportive care (e.g., fluid replacement, electrolyte monitoring) is the mainstay of treatment.
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Special precautions –
- Avoid alcohol excess, which can exacerbate gastrointestinal irritation.
- Patients with chronic kidney disease should have dosing adjusted according to creatinine clearance (e.g., 250 mg every 12 hours if clearance < 30 mL/min).
- Storage: keep tablets in a dry place at 15‑30 °C; the suspension requires refrigeration (2‑8 °C) and should be discarded after 14 days once opened.
Buying Keftab from Our Online Pharmacy
Keftab can be purchased securely from our online pharmacy in the UK. We specialise in providing verified generic medications at prices close to the manufacturer’s cost, ensuring that patients receive high‑quality treatment without the premium charged by branded products.
Key benefits of ordering through our service include:
- Affordable pricing – wholesale‑level rates with transparent cost breakdowns.
- Verified quality – all batches are sourced from GMP‑certified overseas manufacturers and undergo independent testing before dispatch.
- Guaranteed delivery – discreet packaging, with express delivery available within 7 days for most UK postcodes and standard international shipping (approximately 3 weeks) for overseas addresses.
- Pharmacy‑broker model – we partner with licensed overseas pharmacies, enabling access to medicines that may be scarce or more expensive in the local market while maintaining full regulatory compliance.
- Privacy‑focused service – no unnecessary personal data is retained after order fulfilment; shipments are unmarked and packaged to protect confidentiality.
Our online platform is user‑friendly, with clear product descriptions, dosage information, and a secure checkout process. Patients who encounter difficulty obtaining Keftab through conventional channels can rely on our service for a reliable, cost‑effective solution.
FAQ
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Can Keftab be taken with food?
Yes, Keftab may be taken with or without meals. Eating can lessen mild stomach upset, but it does not affect the drug’s absorption significantly. -
What does the Keftab tablet look like?
The 250 mg tablet is typically round, white, and debossed with “250”. The 500 mg tablet is round, white, and marked “500”. Inactive ingredients include microcrystalline cellulose, maize starch, and magnesium stearate. -
Is a cold chain required for Keftab tablets?
No, tablets are stable at room temperature (15‑30 °C) and do not require refrigeration. Only the oral suspension needs to be stored in a refrigerator after opening. -
How long can I keep an unopened pack of Keftab?
The expiry date is printed on the packaging and is usually 24 months from the date of manufacture. Store the pack in a dry place away from direct sunlight. -
Can I travel internationally with Keftab?
Yes, Keftab can be taken while traveling. Carry the medication in its original packaging with a copy of the prescription or a physician’s letter if required by customs. Keep it in carry‑on luggage to avoid temperature extremes. -
Are there any known differences between UK and EU formulations?
The active ingredient and dosage strength are identical across regions. Minor variations may exist in excipients due to local manufacturing practices, but these do not alter therapeutic efficacy. -
What specific warnings exist for patients of Asian descent?
No ethnicity‑specific contraindications have been identified for cephalexin. However, individuals with a known higher prevalence of glucose‑6‑phosphate dehydrogenase (G6PD) deficiency should discuss any potential risks with a clinician, although cephalexin is generally safe in this population. -
Is Keftab detectable in drug‑testing programmes?
Cephalexin is not a controlled substance and does not appear on standard occupational drug‑screening panels. It will not cause a positive result for illegal drugs. -
Can I use Keftab if I am lactose intolerant?
The tablet formulation does not contain lactose. The oral suspension may contain small amounts of sorbitol, which is generally well tolerated, but patients with severe intolerance should verify the ingredient list. -
What clinical trials established Keftab’s efficacy?
Early pivotal studies in the 197s demonstrated cephalexin’s superiority to placebo in treating streptococcal pharyngitis and cellul, with cure rates exceeding 90 %. Subsequent meta‑analyses have confirmed comparable efficacy to other first‑generation cephalosporins in a variety of infections. -
How does Keftab compare to older antibiotics like penicillin V?
Cephalexin offers broader coverage against β‑lactamase‑producing organisms and retains activity against many strains resistant to penicillin V. Its safety profile is similar, with a slightly higher incidence of mild gastrointestinal side effects.
Glossary
- Cephalosporin
- A class of β‑lactam antibiotics that inhibit bacterial cell‑wall synthesis; cephalexin is a first‑generation member.
- Penicillin‑binding proteins (PBPs)
- Enzymes located in bacterial cell membranes that catalyse the cross‑linking of peptidoglycan strands; they are the primary targets of β‑lactam antibiotics.
- Creatinine clearance
- A measure of kidney function used to adjust dosing of renally excreted drugs; expressed in millilitres per minute (mL/min).
- Cross‑reactivity
- The possibility that an allergic reaction to one drug (e.g., penicillin) may also occur with a related drug (e.g., cephalosporins) due to structural similarity.
⚠️ Disclaimer
The information provided about Keftab is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Keftab for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.