Generic Prilosec

Prilosec relieves symptoms of gastroesophageal reflux disease decreasing the amount of acid in the stomach.

Buy online · Medical info

  • Category: Gastro Health
  • Active ingredient: Omeprazole
  • Available Dosage: 10mg, 20mg, 40mg
  • Payment options: VISA, Mastercard, Amex, JCB, Dinners
  • Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)

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Medical Conditions

Generic Prilosec information

Introduction

Prilosec is a widely prescribed medication in the United Kingdom for the management of acid‑related gastrointestinal disorders. Its active ingredient, omeprazole, belongs to the proton‑pump inhibitor (PPI) class, which reduces gastric acid secretion. Produced by AstraZeneca and marketed under the “Gastro Health” therapeutic group, Prilosec is indicated for conditions such as gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, and eradication regimens for Helicobacter pylori infection. The drug’s efficacy, safety profile, and once‑daily dosing have made it a cornerstone of modern gastro‑enterology practice.


What is Prilosec?

Prilosec is a brand‑name formulation that contains 20 mg of omeprazole per delayed‑release tablet. It was developed in the late 198s and received marketing approval in the UK in 1995. The product is manufactured by AstraZeneca and distributed through authorised UK wholesalers.

Omeprazole, the sole active compound, functions as a selective inhibitor of the gastric H⁺/K⁺‑ATPase enzyme (the “proton pump”) located in the secretory canaliculi of parietal cells. While Prilosec is the original brand, the same molecule is available under numerous other brand names, including Losec, Mopral, and Zegerid. Generic omeprazole tablets are widely sold across Europe and provide a cost‑effective alternative to the branded product.


How Prilosec Works

When a tablet is ingested, the enteric coating protects omeprazole from degradation by stomach acid. The coating dissolves in the more neutral environment of the small intestine, releasing the drug. Omeprazole then diffuses into the parietal cell and is converted to its active sulfenamide form. This active moiety forms a covalent disulfide bond with cysteine residues on the H⁺/K⁺‑ATPase enzyme, rendering the pump inactive.

The inhibition is irreversible; the affected proton pumps remain suppressed until new enzyme molecules are synthesised, typically within 24–48 hours. Consequently, gastric acid output is reduced by up to 90 % after several days of continuous dosing. Clinical effect generally begins within 1 hour, with maximal acid suppression occurring after 3–5 days of therapy. Omeprazole has a plasma half‑life of .5–1 hour, but its pharmacodynamic effect persists far longer due to the irreversible enzyme inhibition.


Conditions Treated with Prilosec

  • Gastro‑oesophageal reflux disease (GERD) – Persistent heartburn, regurgitation, and oesophagitis caused by reflux of gastric contents. In the UK, approximately 10 % of adults experience weekly symptoms, creating a substantial demand for effective acid suppression.
  • Erosive oesophagitis – Endoscopically confirmed damage to the oesophageal lining. Healing rates exceed 80 % after 8 weeks of standard‑dose Prilosec.
  • Peptic ulcer disease – Ulcers of the stomach or duodenum, often linked to H. pylori infection or non‑steroidal anti‑inflammatory drug (NSAID) use. Omeprazole promotes ulcer healing and reduces recurrence.
  • Prevention of NSAID‑induced ulceration – Co‑prescription with NSAIDs in high‑risk patients (e.g., older adults, previous ulcer history).
  • Helicobacter pylori eradication – Part of triple therapy (omeprazole + clarithromycin + amoxicillin/metronidazole) for first‑line eradication, improving bacterial clearance rates.
  • Zollinger‑Ellison syndrome – A rare gastrinoma causing excessive acid secretion; high‑dose omeprazole achieves control of acid output.

These indications are supported by NICE (National Institute for Health and Care Excellence) technology appraisal guidance and the British National Formulary (BNF).


Suitable Candidates for Prilosec Treatment

Prilosec is appropriate for adult patients who:

  • Experience frequent heartburn or acid regurgitation affecting quality of life.
  • Have endoscopically proven erosive oesophagitis (Los Angeles grades A–D).
  • Require ulcer healing after confirmation of gastric or duodenal ulceration.
  • Are prescribed long‑term NSAIDs and possess risk factors for gastrointestinal bleeding (age ≥ 60, prior ulcer, anticoagulant therapy).
  • Participate in a H. pylori eradication regimen as directed by their clinician.

Contra‑indications or cautionary scenarios include:

  • Known hypersensitivity to omeprazole or any excipients.
  • Severe hepatic impairment (Child‑Pugh C), where dose adjustment may be necessary.
  • Pregnancy or lactation – use only if the potential benefit outweighs the risk, following professional guidance.
  • Concomitant use of drugs that require an acidic environment for absorption (e.g., ketoconazole, atazanavir) unless appropriate alternatives are selected.

Risks, Side Effects, and Interactions

Common

  • Headache – Often mild and transient, occurring in up to 10 % of users.
  • Diarrhoea – Usually self‑limiting; may result from altered gastric pH affecting gut flora.
  • Nausea or abdominal discomfort – Frequently reported during the first week of therapy.
  • Flatulence – Gas accumulation due to changes in intestinal bacterial metabolism.

Rare

  • Clostridioides difficile infection – Prolonged acid suppression can predispose to overgrowth of pathogenic bacteria; incidence remains low (<.1 %).
  • Hypomagnesemia – Chronic use (>1 year) may lead to clinically significant magnesium depletion, potentially causing muscle cramps or cardiac arrhythmia.
  • Vitamin B12 deficiency – Reduced gastric acidity impairs absorption of intrinsic factor‑bound B12; monitoring advisable for long‑term therapy.

Serious

  • Acute interstitial nephritis – Presents with renal impairment, eosinophilia, and systemic symptoms; requires prompt discontinuation.
  • Stevens‑Johnson syndrome / toxic epidermal necrolysis – Extremely rare mucocutaneous reactions necessitating immediate medical attention.
  • Fracture risk – Long‑term PPI exposure has been associated with an increased incidence of hip, wrist, and vertebral fractures, particularly in the elderly.
Clinically Relevant Drug–Drug Interactions
  • Clopidogrel – Omeprazole may reduce conversion of clopidogrel to its active metabolite, potentially diminishing antiplatelet effect. Consider alternative PPIs (e.g., pantoprazole) if combined therapy is required.
  • Warfarin – Enhanced anticoagulant effect reported; INR monitoring is recommended when initiating or discontinuing Prilosec.
  • Antiretrovirals (atazanavir, rilpivirine) – Decreased plasma concentrations due to increased gastric pH; dose adjustment or alternative therapy may be needed.
  • Ketoconazole/Itraconazole – Reduced absorption leading to sub‑therapeutic antifungal levels; avoid co‑administration.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard adult dosing – 20 mg once daily, taken before the first meal of the day. For H. pylori eradication or Zollinger‑Ellison syndrome, higher doses (40 mg twice daily) may be prescribed.
  • Duration of therapy – For uncomplicated GERD, a 4‑to‑8‑week course is typical. Chronic conditions may require maintenance dosing under clinical supervision.
  • Missed dose – Take the missed tablet as soon as remembered, unless the next scheduled dose is within 12 hours. In that case, skip the missed dose and resume the regular schedule; do not double‑dose.
  • Overdose – Single‑dose overdose (> 10 g) has produced minimal toxicity because omeprazole is rapidly metabolised. Nevertheless, contact NHS 111 or a local poison control centre if an overdose is suspected.
  • Food and alcohol – Prilosec should be taken on an empty stomach to maximise acid suppression. Moderate alcohol intake does not directly affect efficacy but may exacerbate gastrointestinal symptoms.
  • Renal or hepatic impairment – No dose adjustment is required for mild‑to‑moderate hepatic dysfunction; severe hepatic impairment warrants caution. No adjustment for renal impairment unless accompanied by hepatic failure.

Buying Prilosec from Our Online Pharmacy

Patients across the United Kingdom can obtain Prilosec through our online pharmacy. Key advantages include:

  • Competitive pricing – Our cost structure mirrors manufacturer‑level pricing, delivering a significant saving compared with high‑street pharmacy rates.
  • Verified quality – All tablets are sourced from GMP‑certified manufacturers and undergo third‑party batch testing before dispatch.
  • Reliable delivery – Discreet packaging is shipped via express courier (delivery within 7 days) or standard airmail (approximately 3 weeks). Tracking information is provided for every order.
  • International access – As a pharmacy broker service, we partner with licensed overseas suppliers, expanding the availability of generic Omeprazole for patients who encounter supply constraints locally.
  • Privacy‑focused service – Orders are processed without sharing personal health data beyond what is legally required, ensuring confidentiality throughout the purchase journey.

Our online pharmacy operates under UK pharmacy regulations, working with registered pharmacists to confirm that each transaction complies with legal and safety standards.


FAQ

  • Is Prilosec available in both brand‑name and generic forms in the UK?
    Yes. Prilosec is the original brand, while generic omeprazole tablets containing the same active ingredient are sold under various manufacturers’ labels. Generic versions are typically more affordable and are considered therapeutically equivalent.

  • What temperature range is appropriate for storing Prilosec tablets?
    Store at controlled room temperature, between 15 °C and 30 °C. Avoid exposure to excessive heat, direct sunlight, and moisture, which can compromise the enteric coating.

  • Can Prilosec tablets be crushed or chewed to aid swallowing?
    No. The enteric coating protects omeprazole from stomach acid. Crushing or chewing destroys this coating, reducing efficacy and increasing the risk of gastric irritation.

  • How long does it take for symptom relief after starting Prilosec?
    Partial relief may be felt within the first day, but maximal acid suppression and full symptom control usually require 3–5 days of consistent daily dosing.

  • Are there any known differences between European and US formulations of omeprazole?
    Both regions use delayed‑release tablets, but excipient composition (e.g., fillers, dyes) may vary to meet local regulatory standards. Clinical efficacy remains comparable.

  • What should a traveler do if they need Prilosec while abroad?
    Carry a sufficient supply in original packaging, stored at room temperature. If additional tablets are required, they can be ordered from our online pharmacy and shipped internationally, respecting the destination country’s import regulations.

  • Is there a risk of developing tolerance to Prilosec over time?
    Tolerance, defined as diminished response, is uncommon with PPIs. However, rebound hyperacidity can occur after abrupt discontinuation, so dose tapering is recommended for long‑term users.

  • Does Prilosec interact with dietary supplements such as calcium carbonate?
    Calcium carbonate requires an acidic environment for optimal absorption; concomitant use may slightly reduce calcium uptake. Separating administration by at least 2 hours minimizes this effect.

  • Can Prilosec affect laboratory test results?
    Yes. Omeprazole can raise serum gastrin levels and may cause false‑negative results in certain stool antigen tests for H. pylori. Inform the laboratory if you are taking a PPI.

  • Why do some manufacturers add a pink dye to Prilosec tablets?
    The pink coloration is purely cosmetic, aiding identification of the product and differentiating it from other PPIs. It does not influence therapeutic activity.


Glossary

Enteric coating
A protective polymer layer that resists dissolution in the acidic stomach but dissolves in the more neutral pH of the small intestine, ensuring the drug reaches its site of absorption intact.
Proton‑pump inhibitor (PPI)
A class of medications that irreversibly block the H⁺/K⁺‑ATPase enzyme in gastric parietal cells, leading to a profound and sustained reduction in gastric acid secretion.
Rebound hyperacidity
An increase in gastric acid production that can occur after abrupt cessation of a PPI, often presenting as renewed heartburn or dyspepsia.
CYP2C19
A liver enzyme that metabolises omeprazole; genetic variations can affect drug clearance and influence both efficacy and the risk of adverse effects.

⚠️ Disclaimer

The information provided about Prilosec is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Prilosec for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Alternative names or trademarks of Generic Prilosec

Prilosec may be marketed under different names in various countries. All of them contain Omeprazole as main ingredient. Some of them are the following:

Omeprazole, Gastroguard, Logastric, Omeprazen, Pepticum, Prilosec, Zoltum

Information about ordering Generic Prilosec online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to omeprazole so you can use Generic Prilosec safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Prilosec. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Prilosec without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Prilosec - omeprazole medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.

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