Buy Generic Aralen Online

Generic Aralen Information

Introduction

Aralen is a tablet formulation that contains the antimalarial agent chloroquine phosphate. In the United Kingdom it is primarily prescribed for the prevention and treatment of malaria caused by Plasmodium species. Chloroquine also possesses antiviral and antiparasitic activity, which has prompted investigation of its role in emerging infections such as COVID‑19; however, it is not licensed for that indication in the UK. The medication is classified under antiviral and antiparasitic groups, reflecting its broad pharmacological profile.

What is Aralen?

Aralen is a branded preparation of the synthetic 4‑aminoquinoline chloroquine phosphate. The active compound is identical to that used in other chloroquine products such as Nivaquine and the older WHO‑recommended Formulation A. Aralen was originally manufactured by Sanofi‑Aventis and is distributed in several countries under that name. While brand‑name tablets are available, generic chloroquine tablets containing the same active ingredient are also widely marketed. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for patients requiring malaria prophylaxis or therapy.

How Aralen Works

Chloroquine accumulates in acidic intracellular vesicles, most notably the food vacuole of malaria parasites. By raising the pH within the vacuole, it interferes with haemoglobin digestion and prevents the polymerisation of toxic haem into haemozoin. This disruption leads to accumulation of toxic haem and parasite death. In human cells, chloroquine can also interfere with viral entry and replication by increasing endosomal pH, a mechanism that underlies its experimental antiviral investigations. The drug has a high volume of distribution, reaches peak plasma concentrations within 2–4 hours after oral administration, and is metabolised in the liver to desethyl‑chloroquine before renal excretion.

Conditions Treated with Aralen

• Malaria prophylaxis – Recommended for travelers to regions with chloroquine‑sensitive Plasmodium falciparum (e.g., parts of Central America, the Caribbean, and certain African islands).
• Uncomplicated malaria – Used to treat acute infections caused by chloroquine‑sensitive strains of P. vivax, P. ovale, and P. malariae.
• Rheumatoid arthritis and systemic lupus erythematosus (off‑label) – Low‑dose chloroquine has been employed in some autoimmune conditions, though hydroxychloroquine is preferred in the UK.

Chloroquine is not approved for the treatment or prevention of COVID‑19 by the Medicines and Healthcare products Regulatory Agency (MHRA). Its antiviral activity remains investigational, and current UK clinical guidance does not endorse its routine use for SARS‑CoV‑2 infection.

Who is Aralen For?

• Adults planning short‑term travel to chloroquine‑sensitive malaria zones who require a well‑tolerated prophylactic regimen.
• Patients diagnosed with uncomplicated malaria caused by chloroquine‑sensitive parasites, provided they have no contraindications such as retinal disease or severe cardiac conduction abnormalities.
• Individuals with a documented need for low‑dose chloroquine in selected autoimmune disorders, after specialist assessment.

Aralen should be avoided in patients with known hypersensitivity to chloroquine, pre‑existing retinopathy, severe hepatic or renal impairment, and in those taking medications that prolong the QT interval without appropriate cardiac monitoring.

Risks, Side Effects, and Interactions

Common

• Gastro‑intestinal upset (nausea, abdominal pain, diarrhoea)
• Headache or dizziness
• Pruritus or mild skin rash

These effects are usually transient and may be mitigated by taking the tablet with food or a glass of milk.

Rare

• Retinal toxicity – Progressive pigmentary retinopathy with visual field defects; risk increases with cumulative dose > 1 g/kg.
• Hypoglycaemia – Enhanced insulin sensitivity may cause low blood glucose, especially in diabetic patients on oral hypoglycaemic agents.

Routine ophthalmologic screening is recommended for patients on long‑term chloroquine therapy.

Serious

• Cardiac arrhythmias – QT‑interval prolongation leading to torsades de pointes, particularly when combined with other QT‑prolonging drugs (e.g., macrolide antibiotics, certain antipsychotics).
• Severe cutaneous reactions – Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hematologic effects – Agranulocytosis or severe thrombocytopenia, though extremely uncommon.

Any sudden visual changes, palpitations, or widespread skin eruption require immediate medical assessment.

Drug‑Drug Interactions

• QT‑prolonging agents (e.g., azithromycin, quinidine, fluoroquinolones) – increase risk of ventricular arrhythmias.
• Antacids containing aluminium or magnesium – may reduce chloroquine absorption; separate dosing by at least 2 hours.
• Cytochrome P450 inhibitors (e.g., ketoconazole) – raise chloroquine plasma levels, potentially intensifying toxicity.
• Insulin or oral hypoglycaemic agents – monitor blood glucose closely to avoid hypoglycaemia.

Practical Use: Dosing, Missed Dose, Overdose

• Prophylaxis – 300 mg (one tablet) taken 1 hour before departure, then 300 mg once weekly throughout the travel period, and a final dose on the day of return.
• Treatment of malaria – 600 mg (two tablets) at time , followed by 600 mg at 6 hours, 24 hours, and 48 hours. Adjustments may be required for renal or hepatic impairment.

If a weekly prophylactic dose is missed, take it as soon as remembered unless the next scheduled dose is within 24 hours; in that case, skip the missed dose and continue the regular schedule. Do not double‑dose.

In case of suspected overdose (e.g., ingestion of > 4 g), seek emergency medical care immediately. Activated charcoal may be administered if presentation is within one hour. Monitor cardiac rhythm, blood glucose, and visual function.

Food does not significantly affect absorption, but taking the tablet with meals can lessen gastrointestinal discomfort. Alcohol consumption should be limited, as both alcohol and chloroquine may potentiate hepatotoxicity and central nervous system effects.

Buying Aralen from Our Online Pharmacy

Patients residing in the United Kingdom can obtain Aralen through our online pharmacy. We operate as a pharmacy‑broker service, partnering with licensed overseas suppliers that meet stringent UK quality standards.

• Affordability – Prices are set close to manufacturing cost, offering substantial savings compared with domestic brand‑name products.
• Verified quality – All batches are sourced from GMP‑certified facilities and undergo independent laboratory testing before dispatch.
• Discreet, reliable delivery – Orders are packaged neutrally and shipped via express courier (delivery within 7 days) or standard airmail (approximately 3 weeks). Tracking information is provided for every shipment.
• Privacy‑focused service – Our platform respects patient confidentiality; no personal health details are shared beyond what is required for safe dispensing.

For individuals with limited access to traditional pharmacies or who seek a generic alternative for malaria prophylaxis, our online pharmacy offers a safe, convenient solution.

FAQ

• Can Aralen be used for COVID‑19 prevention?
  No. Current UK regulatory guidance does not approve chloroquine, including Aralen, for the prevention or treatment of COVID‑19. Ongoing research has not demonstrated a clear benefit, and safety concerns remain.

• What does an Aralen tablet look like?
  The branded tablet is typically round, film‑coated, and bears the imprint “AR‑310”. Generic chloroquine tablets may vary in shape, colour, and imprint depending on the manufacturer.

• Is there a risk of resistance when using Aralen for malaria prophylaxis?
  Yes. In regions where Plasmodium falciparum has developed chloroquine resistance, prophylaxis with Aralen is ineffective. Travelers should verify the susceptibility profile of their destination and consider alternative agents if resistance is prevalent.

• How should Aralen be stored in a hot climate?
  The medication should be kept in a cool, dry place below 30 °C (86 °F). If storage conditions exceed this range, potency may decline, so using a climate‑controlled container is advisable during prolonged travel in tropical environments.

• Does Aralen contain any allergens such as lactose or gluten?
  In the UK formulation, the inactive ingredients include microcrystalline cellulose, magnesium stearate, and talc; it does not contain lactose, gluten, or common food allergens. However, formulations from other regions may differ, so checking the specific product label is recommended.

• Can Aralen affect routine blood tests?
  Chloroquine can cause mild elevations in liver enzymes and may interfere with glucose readings, especially when patients are on insulin. It does not typically alter complete blood counts, but clinicians may monitor hepatic function during prolonged therapy.

• Are there special considerations for pregnant travelers?
  Chloroquine is classified as pregnancy category B1 in the UK, indicating no evidence of fetal risk at therapeutic doses. Nonetheless, pregnant women should discuss malaria prophylaxis options with a healthcare professional, as alternative agents may be preferred based on regional resistance patterns.

• What are the customs rules for importing Aralen into the UK?
  Individuals may import a personal supply of medication for personal use, provided the quantity does not exceed a three‑month supply and the product is for a legitimate medical purpose. Importation must comply with the Medicines and Healthcare products Regulatory Agency (MHRA) guidelines, and the medication must be accompanied by a valid prescription where required.

• How long does it take for visual side effects to appear?
  Retinal toxicity usually develops after years of cumulative exposure, with risk increasing after a total dose of 1 gram per kilogram of body weight. Early changes may be asymptomatic; therefore, regular ophthalmologic examinations are essential for patients on long‑term therapy.

• Is there a difference between chloroquine and hydroxychloroquine formulations?
  Both are 4‑aminoquinoline derivatives, but hydroxychloroquine has an additional hydroxyl group, which generally results in a better safety profile, especially regarding retinal toxicity. Hydroxychloroquine is the preferred agent for autoimmune diseases in the UK, whereas chloroquine (Aralen) remains primarily indicated for malaria.

• Can I travel with Aralen in my hand luggage?
  Yes. The tablets are permitted in hand baggage when accompanied by a copy of the prescription or a doctor’s letter confirming medical necessity. Ensure the container is clearly labelled and that you comply with airline liquid restrictions for any accompanying liquids.

Glossary

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.

QT interval

A measurement on an electrocardiogram that reflects the time taken for ventricular depolarisation and repolarisation; prolongation can predispose to dangerous heart arrhythmias.

Retinal toxicity

Damage to the light‑sensing layer of the eye caused by drug accumulation, potentially leading to irreversible vision loss if not detected early.

GMP (Good Manufacturing Practice)

International quality standards that ensure medicinal products are consistently produced and controlled according to quality criteria.

⚠️ Disclaimer

The information provided about Aralen is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Aralen for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.