Generic Citalopram

Citalopram is a medication used to treat those with depression. It helps with one's well being and positive everyday energy. Citalopram was approved for use in medicine in the United States in 1998 and is sold under many different brand names. Citalopram should be taken exactly as prescribed and following prescription label instructions. Citalopram is not approved for use in children.

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Generic Citalopram information

Introduction

Citalopram (active ingredient Citalopram Hydrobromide) belongs to the antidepressant class of selective serotonin reuptake inhibitors (SSRIs). It is prescribed primarily for the management of major depressive disorder (MDD) in adults and is widely used across the United Kingdom’s NHS and private practice. The drug is also employed off‑label for anxiety‑related conditions and certain chronic pain syndromes, reflecting its broader impact on central nervous system serotonin pathways. As a generic product, it offers the same clinical benefit as branded preparations while providing a cost‑effective alternative for patients and prescribers.


What is Citalopram?

Citalopram is the generic version of the original brand Celexa, which was first marketed by Lundbeck & Lans. Both the generic and branded tablets contain the same pharmacologically active compound, Citalopram Hydrobromide, and are classified as SSRIs (selective serotonin reuptake inhibitors). Our online pharmacy provides this generic alternative as a cost‑effective treatment option, delivering the identical active ingredient at near‑manufacturer pricing.


How Citalopram Works

Citalopram inhibits the serotonin transporter (SERT) on presynaptic neurons, reducing the re‑absorption of serotonin from the synaptic cleft. By increasing extracellular serotonin concentrations, the drug enhances serotonergic neurotransmission, which is associated with mood elevation, anxiety reduction, and improved cognitive function.

Pharmacokinetic highlights for adult patients in the UK:

  • Absorption: Peak plasma levels are reached 2–4 hours after oral ingestion.
  • Distribution: The drug is widely distributed, crossing the blood–brain barrier to exert central effects.
  • Metabolism: Hepatic cytochrome P450 enzyme CYP2C19 and CYP3A4 mediate primary metabolism; metabolites are inactive.
  • Elimination: The elimination half‑life averages 35 hours, permitting once‑daily dosing with stable plasma concentrations after approximately one week of continuous therapy.

The gradual elevation of synaptic serotonin aligns with the clinical observation that therapeutic benefits often emerge after 2–4 weeks of regular dosing.


Conditions Treated with Citalopram

Major Depressive Disorder (MDD)

MDD is the principal approved indication for Citalopram in the UK, as recognized by the National Institute for Health and Care Excellence (NICE). Epidemiological data suggest that around 1 in 10 adults experience a depressive episode each year, underlining the drug’s public‑health relevance. Citalopram’s robust serotonin re‑uptake inhibition alleviates core depressive symptoms—persistent sadness, loss of interest, and impaired concentration—allowing patients to regain functional capacity.

Generalised Anxiety Disorder (GAD) (off‑label)

Although not formally licensed for anxiety in the UK, clinical practice frequently includes Citalopram for GAD when SSRIs are indicated. Anxiety reduction derives from the same serotonergic modulation that improves mood, dampening limbic over‑activation.

Panic Disorder (off‑label)

Selective serotonin re‑uptake inhibition can moderate panic attacks by stabilising autonomic output and reducing catastrophic thinking patterns.

Premenstrual Dysphoric Disorder (PMDD) (off‑label)

Citalopram has demonstrated efficacy in mitigating mood lability and irritability associated with the luteal phase of the menstrual cycle.

The drug’s broad serotonergic action explains its effectiveness across these disorders, each of which involves dysregulation of central serotonin pathways.


Suitable Candidates for Citalopram Treatment

Adult patients (≥ 18 years) with a confirmed diagnosis of major depressive disorder are the primary candidates. Clinical scenarios in which Citalopram is particularly recommended include:

  • First‑line therapy for moderate to severe MDD when non‑pharmacological interventions (e.g., psychotherapy) are insufficient or when rapid symptom control is desired.
  • Patients who have previously tolerated other SSRIs without marked side‑effects, supporting a class‑effect expectation.
  • Individuals with comorbid anxiety symptoms where a single agent can address both mood and anxiety components.

Contra‑indications and cautionary contexts:

  • Pregnant or breastfeeding women – NICE advises avoidance unless benefits outweigh risks; specialist obstetric review is essential.
  • Patients with known hypersensitivity to Citalopram Hydrobromide or any excipients in the tablet formulation.
  • Individuals taking monoamine oxidase inhibitors (MAOIs) within 14 days of each other, due to the risk of serotonin syndrome.
  • Severe hepatic impairment – reduced metabolism may increase plasma concentrations and toxicity.

A thorough clinical assessment, including baseline ECG (to monitor QTc prolongation) and psychiatric evaluation, remains mandatory before initiation.


Risks, Side Effects, and Interactions

Common

  • Nausea and gastrointestinal upset
  • Dry mouth
  • Insomnia or somnolence (dose‑dependent)
  • Fatigue
  • Sexual dysfunction (reduced libido, delayed ejaculation, orgasmic difficulty)
  • Tremor

These events are typically mild to moderate, often transient, and may resolve with dose titration or symptomatic management.

Rare

  • Hyponatraemia (particularly in elderly females)
  • Orthostatic hypotension
  • Serotonin syndrome (if combined with other serotonergic agents)
  • Abnormal bleeding (especially with concomitant anticoagulants or NSAIDs)

Serious

  • QTc prolongation and torsades de pointes – higher doses (> 20 mg) have been linked to increased cardiac risk; baseline ECG is advised for patients with cardiac disease or electrolyte disturbance.
  • Severe allergic reactions (angio‑edema, anaphylaxis)
  • Manic switching in patients with undiagnosed bipolar disorder
Clinically Relevant Drug–Drug Interactions
  • Other serotonergic drugs (e.g., tramadol, linezolid, other SSRIs, SNRIs, MAOIs) – risk of serotonin syndrome.
  • CYP2C19 or CYP3A4 inhibitors (e.g., fluconazole, erythromycin, omeprazole) – may increase Citalopram plasma levels, raising toxicity risk.
  • CYP2C19 inducers (e.g., carbamazepine, rifampicin) – may lower therapeutic exposure, potentially reducing efficacy.
  • Warfarin or other anticoagulants – heightened bleeding risk; monitoring required.

Patients should disclose all current medications, including over‑the‑counter products and herbal preparations, to their prescriber prior to starting Citalopram.


Practical Use: Dosing, Missed Dose, Overdose

Standard Dosing (general adult guidance)

  • Initial dose: 10 mg once daily, preferably taken in the morning to minimise insomnia.
  • Titration: Increase after 1–2 weeks to 20 mg daily if therapeutic response is inadequate and side‑effects are tolerable.
  • Maximum recommended dose: 40 mg once daily; higher doses are discouraged in the UK due to QTc prolongation concerns.

Dose adjustments are recommended for:

  • Older adults (> 65 years) – start with 10 mg and consider maximum 20 mg.
  • Renal or hepatic impairment – lower initial dose, careful monitoring.

Missed Dose

If a dose is forgotten, patients should take it as soon as they remember unless the next scheduled dose is within 12 hours. In that case, the missed dose should be omitted. Doubling the dose to compensate is contraindicated.

Overdose Management

In the event of a suspected overdose (e.g., ingestion of > 2 times the prescribed dose), immediate medical attention is required. Overdose may present with:

  • Severe dizziness, tachycardia, or arrhythmia
  • Seizures or loss of consciousness
  • Prolonged QTc interval

Management includes supportive care, activated charcoal (if within appropriate time window), and continuous cardiac monitoring. Contact the National Poisons Information Service (NPIS) at 0332 111 555 for advice.

Practical Precautions

  • Food & Alcohol: Citalopram can be taken with or without food; however, alcohol may exacerbate central nervous system depression and should be limited.
  • Comorbidities: Patients with uncontrolled diabetes, hypertension, or cardiovascular disease require regular follow‑up to detect potential adverse interactions.

Buying Citalopram from Our Online Pharmacy

Citalopram can be purchased securely from our online pharmacy in the UK. Key benefits of choosing this service include:

  • Affordable pricing – generic tablets are offered at near‑manufacturer cost, providing a transparent, lower‑price option than many domestic chains.
  • Verified quality – all stock is sourced from licensed overseas suppliers who meet EU‑wide Good Manufacturing Practice (GMP) standards, ensuring each tablet contains the correct amount of Citalopram Hydrobromide.
  • Guaranteed delivery – discreet, tamper‑evident packaging is dispatched via express (≤ 7 days) or regular airmail (≈ 3 weeks) services, with tracking to confirm receipt.
  • Pharmacy‑broker model – we act as a broker between you and accredited overseas pharmacies, allowing a seamless, privacy‑focused transaction that complies with UK personal import regulations for medicines.

For patients lacking immediate access to a local pharmacy, limited NHS stock, or those seeking a cost‑effective generic alternative, this channel provides a safe, regulated route to obtain Citalopram.


FAQ

  • Is Citalopram available in both brand‑name and generic forms in the UK?
    Yes, Citalopram is sold under the original brand name Celexa and as a generic version containing the same active ingredient, Citalopram Hydrobromide. Generic tablets are typically priced lower than the branded product while delivering equivalent therapeutic effect.

  • What is the typical appearance of a Citalopram tablet?
    In the UK, generic Citalopram tablets are usually white, round, and film‑coated, bearing the imprint “10 MG” or “20 MG” depending on strength. Brand‑name Celexa tablets may display a blue film coating with the Celexa name embossed.

  • How should Citalopram be stored to maintain stability?
    Store the medication at a controlled room temperature (15 °C – 25 °C), away from direct sunlight, humidity, and heat sources. Do not refrigerate or freeze tablets, as moisture can degrade the film coating and active compound.

  • Can Citalopram be taken while travelling across time zones?
    Yes, Citalopram can be used during international travel. Keep the medication in your carry‑on bag rather than checked luggage to avoid temperature extremes, and maintain a consistent dosing schedule despite jet‑lag by using an alarm or a travel‑friendly medication diary.

  • Are there specific warnings for Citalopram use in Asian populations?
    Studies indicate that Asian patients may exhibit higher plasma concentrations at standard doses due to genetic variations in CYP2C19 metabolism. Consequently, clinicians often initiate therapy at 5 mg and monitor levels closely before uptitration.

  • Does Citalopram interact with over‑the‑counter sleep aids?
    Some over‑the‑counter antihistamine sleep aids (e.g., diphenhydramine) possess anticholinergic activity that can exacerbate Citalopram‑related sedation or confusion. Patients should consult a pharmacist before combining these products.

  • What packaging does Citalopram come in when ordered online?
    Our online pharmacy ships Citalopram in sealed, tamper‑evident blister packs inside a discreet, recyclable padded envelope. Each parcel includes a patient information leaflet detailing dosage, side‑effects, and safety information.

  • Can Citalopram be imported for personal use under UK law?
    Yes, individuals in the UK may legally import a three‑month supply of a prescription‑only medicine for personal use when the medication is obtained from a licensed pharmacy in another EU or EEA country, provided a valid prescription is presented. Our service ensures compliance with applicable import regulations.

  • How does Citalopram compare to older antidepressants such as tricyclics?
    Compared with tricyclic antidepressants, Citalopram shows a more favourable side‑effect profile, especially reduced anticholinergic effects, lower cardiotoxicity, and a safer overdose margin. Moreover, selective serotonin re‑uptake inhibition offers a more targeted mechanism, leading to fewer pharmacodynamic drug interactions.

  • What is the evidence behind Citalopram’s use for premenstrual mood disorders?
    Randomised controlled trials in the 199s and early 200s demonstrated that Citalopram significantly reduces emotional lability, irritability, and depressive symptoms in women with PMDD, achieving responder rates comparable to other SSRIs. These findings support its off‑label utilisation in this population.

  • Does the formulation of Citalopram differ between the US and EU markets?
    The EU‑approved formulation contains 1 % (w/w) polyethylene glycol as a film‑coating agent, whereas the US version may use a different polymer (e.g., hypromellose). Both meet their respective pharmacopoeial standards, but minor excipient variations can affect tolerability in hypersensitive individuals.


Glossary

Selective Serotonin Reuptake Inhibitor (SSRI)
A class of medications that block the reabsorption of serotonin into neurons, increasing its availability in the brain and improving mood and anxiety symptoms.
Therapeutic Window
The range of drug concentration in which a medication is effective without causing unacceptable side‑effects.
Serotonin Syndrome
A potentially life‑threatening condition caused by excess serotonergic activity, characterised by agitation, hyperreflexia, fever, and autonomic instability.
QTc Prolongation
An extension of the corrected QT interval on an electrocardiogram, which can increase the risk of torsades de pointes, a dangerous ventricular arrhythmia.

⚠️ Disclaimer

The information provided about Citalopram is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Citalopram for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Information about ordering Generic Citalopram online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to citalopram hydrobromide so you can use Generic Citalopram safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Citalopram. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Citalopram without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Citalopram - citalopram hydrobromide medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.