Generic Clomipramine

Clomipramine is a tricyclic antidepressant mainly used to treat OCD. It helps balance serotonin and norepinephrine in the brain, reducing obsessive thoughts and anxiety. Common side effects include dry mouth, drowsiness, and dizziness. Regular monitoring is advised due to possible serious side effects.

Buy online · Medical info

  • Category: Mental Illness
  • Active ingredient: Clomipramine
  • Available Dosage: 10mg, 25mg, 50mg
  • Payment options: VISA, Mastercard, Amex, JCB, Dinners
  • Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)

Buy Generic Clomipramine Online

Generic Clomipramine 10mg
Package Price
10mg x 360 pills
Free Airmail shipping
CA $293.29
10mg x 180 pillsCA $166.10
10mg x 120 pillsCA $119.96
10mg x 90 pillsCA $96.89
10mg x 60 pillsCA $66.44
Generic Clomipramine 25mg
Package Price
25mg x 360 pills
Free Airmail shipping
CA $413.75
25mg x 180 pillsCA $243.61
25mg x 120 pillsCA $180.87
25mg x 90 pillsCA $148.10
25mg x 60 pillsCA $115.35
25mg x 30 pillsCA $69.06
Generic Clomipramine 50mg
Package Price
50mg x 360 pills
Free Airmail shipping
CA $534.21
50mg x 180 pills
Free Airmail shipping
CA $307.29
50mg x 120 pillsCA $223.31
50mg x 90 pillsCA $179.94
50mg x 60 pillsCA $135.65
50mg x 30 pillsCA $78.30

Generic Clomipramine information

Introduction

Clomipramine is a tricyclic antidepressant (TCA) that is primarily prescribed for the management of obsessive‑compulsive disorder (OCD) and, where clinically appropriate, for depression and panic disorder. It is listed in the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) pharmacopoeia and is classified within the mental‑illness medication group. Although its principal indication in the United Kingdom is OCD, the drug’s pharmacological profile also supports use in anxiety‑related conditions that are refractory to first‑line selective‑serotonin reuptake inhibitors (SSRIs).

What is Clomipramine?

Clomipramine is the generic version of Anafranil (the widely recognised brand name), containing the same active compound, Clomipramine. The substance was first synthesised in the 196s by Swiss chemist Paul Charpentier and has been marketed worldwide for more than five decades. Our online pharmacy provides this generic alternative as a cost‑effective treatment option, matching the efficacy of the original brand while delivering savings that approach the manufacturer’s wholesale price.

How Clomipramine Works

Clomipramine exerts its therapeutic effect principally by inhibiting the re‑uptake of serotonin (5‑HT) and, to a lesser extent, norepinephrine, into presynaptic neurons. This increases synaptic concentrations of these monoamines, enhancing signalling in cortico‑striatal‑thalamic circuits that are implicated in OCD pathology. The drug also blocks several neuronal receptors (e.g., histamine H1, muscarinic M1, α1‑adrenergic), which contributes to its sedative and anticholinergic side‑effect profile. Clinically, serotonergic modulation produces symptom relief within 4–6 weeks for OCD, while the broader antidepressant effect may be evident after 6–8 weeks. The terminal elimination half‑life in adults is approximately 30 hours, allowing once‑daily dosing, and the drug is cleared mainly by the hepatic cytochrome P450 system (CYP2D6, CYP1A2).

Conditions Treated with Clomipramine

  • Obsessive‑Compulsive Disorder (OCD) – The most robust evidence supports clomipramine for adult‑level OCD, especially when patients have inadequate response to SSRIs. UK psychiatric guidelines (NICE CG31) list clomipramine as a second‑line option.
  • Major Depressive Disorder (MDD) – Although not first‑line in current UK practice, clomipramine may be prescribed for treatment‑ resistant depression when other agents are ineffective or contraindicated.
  • Panic Disorder – Limited data suggest benefit in severe, refractory panic attacks, but use is off‑label in the UK.

Epidemiologically, OCD affects roughly 2–3 % of the adult population in the United Kingdom, representing an estimated 1.2 million individuals who may require pharmacotherapy.

Is Clomipramine the Right Medication for You?

Clomipramine is suitable for adult patients who:

  • Have a confirmed diagnosis of OCD with moderate‑to‑severe symptoms (Y‑BOCS ≥ 16) and have not achieved satisfactory improvement from an adequate trial of an SSRI.
  • Present with depressive or anxiety symptoms that are refractory to standard therapies and can tolerate the anticholinergic burden.
  • Are free from absolute contraindications such as recent myocardial infarction, uncontrolled arrhythmia, or concurrent use of monoamine‑oxidase inhibitors (MAOIs).

The medication may be inappropriate for:

  • Patients with narrow‑angle glaucoma, known urinary retention, or prostatic hypertrophy, due to its strong anticholinergic activity.
  • Individuals on potent CYP2D6 inhibitors (e.g., paroxetine, quinidine) without dose adjustment, because plasma levels can rise to potentially toxic concentrations.
  • Pregnant or lactating women, where the risk‑benefit balance must be carefully evaluated by a specialist.

Risks, Side Effects, and Interactions

Common adverse events

  • Dry mouth – May be alleviated by frequent water intake and sugar‑free gum.
  • Constipation – Encourage high‑fiber diet and adequate hydration; laxatives may be required.
  • Sedation / drowsiness – Advise caution when operating machinery, especially during the initial titration weeks.
  • Weight gain – Monitor body weight regularly; lifestyle counselling is recommended.
  • Sweating (especially night sweats) – Can be managed with breathable clothing and temperature‑controlled environments.

Rare adverse events

  • Hyponatraemia – Particularly in older adults; periodic electrolyte monitoring is advised.
  • Seizures – Patients with a history of epilepsy should be evaluated before initiation.
  • Serotonin syndrome – Possible when combined with other serotonergic agents; characterised by hyperthermia, agitation, and clonus.

Serious adverse events

  • Cardiac arrhythmias – QT‑prolongation and ventricular tachycardia have been reported; baseline ECG and periodic monitoring are advisable for patients with cardiac risk factors.
  • Severe hypotension – May occur with overdose or when combined with antihypertensive drugs; instruct patients to rise slowly from sitting/lying positions.
  • Acute overdose – Can lead to life‑threatening cardiotoxicity; requires immediate emergency department presentation.
Clinically relevant drug‑drug interactions
  • Monoamine‑oxidase inhibitors (MAOIs) – Must be discontinued ≥ 14 days before starting clomipramine.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol, linezolid) – Increase risk of serotonin syndrome; dose reduction or avoidance is required.
  • CYP2D6 inhibitors (e.g., paroxetine, quinidine, fluoxetine) – Can raise clomipramine plasma levels; consider lowering the clomipramine dose or switching the interacting drug.
  • Anticholinergic drugs (e.g., antihistamines, atropine) – Additive anticholinergic burden may exacerbate constipation, urinary retention, and confusion.

Practical Use: Dosing, Missed Dose, Overdose

  • Typical adult starting dose for OCD: 25 mg once daily, taken in the evening. Dose may be increased by 25 mg increments every 1–2 weeks to a maximum of 250 mg/day, guided by clinical response and tolerability.
  • Missed dose: If a dose is remembered within 6 hours of the usual dosing time, take the missed tablet immediately; otherwise, skip and resume the regular schedule to avoid double dosing.
  • Overdose: Immediate medical attention is essential. Symptoms may include profound sedation, cardiac conduction delays, seizures, and respiratory depression. If an overdose is suspected, contact NHS 111 or present at the nearest emergency department.
  • Precautions:
    • Take with food or a light snack if gastrointestinal irritation occurs.
    • Avoid alcohol, which can potentiate central nervous system depression.
    • Review comorbid conditions (e.g., diabetes, cardiovascular disease) before dose escalation.

Buying Clomipramine from Our Online Pharmacy

Clomipramine can be purchased from our online pharmacy in UK with a service that prioritises safety, affordability and discretion.

  • Affordable pricing – Generic clomipramine is sourced directly from manufacturers, keeping the unit cost close to the original wholesale price, and passing savings to the patient.
  • Verified quality – All batches are supplied by MHRA‑approved overseas licensed pharmacies; certificates of analysis and packaging integrity are retained for each shipment.
  • Guaranteed delivery – Discreet, traceable parcels are delivered within 7 days via express courier for UK addresses, or within approximately 3 weeks for regular airmail to EU territories.
  • Pharmacy broker model – As a pharmacy‑broker service, we work with a network of licensed international suppliers, enabling patients with limited local pharmacy access to obtain essential medicines while respecting privacy and data protection standards.

FAQ

  • Is Clomipramine available in both brand‑name and generic forms in the UK?
    Yes. The original brand, Anafranil, is marketed by Lundbeck, while generic versions contain the identical active ingredient and are produced by several authorised pharmaceutical manufacturers.

  • What is the appearance of a standard Clomipramine tablet?
    In most European formulations the tablet is a white, round, film‑coated disc, embossed with “CL 25” (for 25 mg strength). In other regions the colour or shape may vary according to the local supplier’s imprint standards.

  • Does Clomipramine require refrigeration?
    No. The medication should be stored at controlled room temperature (15 – 25 °C), protected from direct light and humidity. Cold storage is not recommended and may affect tablet integrity.

  • How should I store Clomipramine when travelling abroad?
    Keep the product in a sealed, moisture‑proof container, away from excessive heat (e.g., in a luggage compartment). A small insulated pouch can help maintain a stable temperature, especially on long‑haul flights.

  • Can Clomipramine be imported for personal use under UK law?
    Personal import of a prescription‑only medication is permitted when the product is licensed in the EU/UK and the importer holds a valid prescription. Importing without appropriate documentation contravenes the Medicines Act 1968.

  • Are there specific warnings for Clomipramine use in older adults?
    Yes. Elderly patients are more vulnerable to anticholinergic effects, orthostatic hypotension and hyponatraemia; lower starting doses (15 mg) and careful titration are recommended, along with routine monitoring of electrolytes and cardiac function.

  • What are the differences in formulation between the EU and US markets?
    The core active ingredient is identical, but some EU products use a film‑coated tablet, whereas US versions may be a hard tablet with a different set of excipients (e.g., lactose, magnesium stearate). These variations can influence tolerability in patients with excipient allergies.

  • Does Clomipramine affect drug testing for employment?
    Clomipramine is not covered by standard workplace drug‑screen panels (e.g., amphetamines, opiates). However, specific serotonin‑reuptake inhibitor panels may detect its presence if requested.

  • Has Clomipramine been involved in any major clinical trials?
    Yes. The pivotal double‑blind, placebo‑controlled study by Ross et al. (1979) demonstrated superior efficacy of clomipramine over placebo in OCD, leading to its approval by the FDA and MHRA. Subsequent large‑scale meta‑analyses confirm its statistically significant benefits compared with SSRIs for severe OCD.

  • What is the shelf‑life of a typical Clomipramine pack?
    Most tablets carry an expiry date of 24 months from the date of manufacture, provided they are stored under recommended conditions.

Glossary

Serotonin reuptake inhibition
The process by which a drug blocks the transporter responsible for pulling serotonin back into the presynaptic neuron, thereby increasing its concentration in the synaptic cleft.
Tricyclic antidepressant (TCA)
A class of older antidepressants characterised by a three‑ring (tricyclic) molecular structure; they act on multiple neurotransmitter systems, notably serotonin and norepinephrine.
Therapeutic window
The range of drug concentrations in which the medication is effective without causing unacceptable toxicity; for clomipramine this is typically .1–.3 µg/mL plasma levels.
CYP450 enzyme
A family of liver enzymes that metabolise many medicines; clomipramine is primarily processed by CYP2D6 and CYP1A2, making it susceptible to interactions with drugs that inhibit or induce these isoforms.

⚠️ Disclaimer

The information provided about Clomipramine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Clomipramine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Information about ordering Generic Clomipramine online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to clomipramine so you can use Generic Clomipramine safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Clomipramine. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Clomipramine without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Clomipramine - clomipramine medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.