Generic Dexilant

Introduction

Dexilant (active compound Dexlansoprazole) belongs to the “Gastro Health” group of medicines. It is a proton‑pump inhibitor (PPI) indicated for the treatment of acid‑related disorders of the upper gastrointestinal tract. In the United Kingdom, Dexilant is prescribed to reduce gastric acid secretion, thereby providing symptomatic relief and allowing healing of the mucosa. The drug is marketed by AstraZeneca and is also available as a generic formulation of Dexlansoprazole.

What is Dexilant?

Dexilant is a delayed‑release tablet that contains the active ingredient Dexlansoprazole, a stereoisomer of lansoprazole. It is classified as a proton‑pump inhibitor (P) and works by inhibiting the H⁺/K⁺‑ATPase enzyme in gastric parietal cells. The formulation utilizes a dual‑release technology: an initial release at a low‑pH environment (~pH 5) followed by a second release in the more alkaline distal small intestine. Dexilant is produced by AstraZeneca and, in the United Kingdom, is also distributed as a generic Dexlansoprazole tablet. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Dexilant Works

Dexlansoprazole is a weak base that, after oral absorption, accumulates within the secretory canaliculi of gastric parietal cells. In the acidic environment (pH < 2) it becomes protonated and binds covalently to cysteine residues on the H⁺/K⁺‑ATPase (the gastric proton pump). This irreversible inhibition blocks the final step of acid secretion, leading to a sustained rise in gastric pH.

The dual‑release formulation creates two peaks of plasma concentration: the first peak appears within 1–2 hours, providing rapid onset, while the second peak occurs around 4–6 hours, extending the duration of acid suppression for up to 24 hours. Dexlansoprazole has a terminal half‑life of approximately 1–2 hours, but the functional inhibition of the proton pump persists far longer because new pumps must be synthesized for acid secretion to resume.

Conditions Treated with Dexilant

• Gastro‑oesophageal reflux disease (GERD) – Persistent heartburn and regurgitation caused by reflux of gastric contents. Dexilant reduces esophageal exposure to acid, allowing symptom control and mucosal healing.
• Erosive oesophagitis – Endoscopically confirmed erosions in the distal oesophagus. The drug promotes healing of erosive lesions and reduces the risk of recurrence.
• Maintenance of healed erosive oesophagitis – Once healing is achieved, a lower maintenance dose prevents relapse.
• Symptomatic non‑erosive reflux disease (NERD) – Patients experience reflux symptoms without visible mucosal damage; acid suppression can still provide relief.

In the UK, GERD affects up to 20 % of the adult population, with a substantialterm acid suppression. The proven efficacy of Dexilant in both healing and maintenance phases makes it a valuable option within national treatment pathways.

Who is Dexilant For?

• Adults with diagnosed GERD or erosive oesophagitis – Particularly those who have not responded adequately to once‑daily PPIs or who benefit from the dual‑release profile.
• Patients requiring long‑term maintenance therapy – Individuals with recurrent symptoms after healing benefit from the prolonged acid suppression offered by Dexilant.
• People who prefer a single daily dose – The dual‑release mechanism allows once‑daily dosing, improving adherence compared with regimens that require multiple daily administrations.
• Patients with concomitant conditions requiring acid suppression – For example, those on non‑steroidal anti‑inflammatory drugs (NSAIDs) who need mucosal protection.

Contra‑indications and cautionary scenarios

• Known hypersensitivity to Dexlansoprazole or any component of the tablet.
• Severe hepatic impairment (Child‑Pugh class C) – dose adjustment may be required.
• Pregnancy and lactation – use only if the potential benefit outweighs the risk; limited safety data are available.

Risks, Side Effects, and Interactions

Common

• Headache
• Diarrhoea or constipation
• Abdominal pain or flatulence
• Nausea

These events are generally mild, transient, and resolve without intervention.

Rare

• Vitamin B12 deficiency (long‑term use)
• Hypomagnesemia (prolonged therapy)
• Elevated liver enzymes (transient elevations)

Monitoring of serum magnesium and vitamin B12 is advised for patients on continuous therapy exceeding one year.

Serious

• Clostridioides difficile infection – Reduced gastric acidity can alter gut flora, increasing infection risk, especially in hospitalised patients.
• Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome, anaphylaxis) – Immediate medical attention required.
• Fracture risk – Chronic PPI use has been associated with a modest increase in hip, wrist, and vertebral fractures, likely due to impaired calcium absorption.

Clinically Relevant Drug‑Drug Interactions

• Clopidogrel – PPIs may reduce the antiplatelet effect; consider alternative acid suppression if dual therapy is essential.
• Warfarin – Dexlansoprazole can increase INR; regular coagulation monitoring is recommended.
• Antiretrovirals (atazanavir, rilpivirine) – Reduced plasma concentrations may occur; dose adjustment of the antiretroviral may be necessary.
• Ketoconazole, Itraconazole, Voriconazole – Require an acidic environment for absorption; concomitant Dexilant may markedly reduce their bioavailability.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before initiating therapy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose for GERD and erosive oesophagitis: 60 mg orally once daily, taken with or without food.
• Maintenance dose after healing: 30 mg once daily is often sufficient, but the prescribing clinician may continue 60 mg based on symptom control.

Missed dose – Take the forgotten tablet as soon as you remember, unless it is close to the time of the next scheduled dose. In that case, skip the missed tablet and continue with the regular dosing schedule. Do not double‑dose.

Overdose – Symptoms may include dizziness, rapid heartbeat, or severe gastrointestinal upset. Management is primarily supportive; activated charcoal can be considered if the overdose is recent and the patient is alert. Seek urgent medical advice.

Precautions

• Food does not significantly affect Dexilant absorption; tablets may be taken with or without meals.
• Alcohol consumption is not contraindicated, but excessive intake may exacerbate gastric irritation.
• Renal impairment does not require dose modification, but hepatic dysfunction may prolong drug exposure.

Buying Dexilant from Our Online Pharmacy

Dexilant (generic Dexlansoprazole) can be purchased securely from our online pharmacy in the UK. We specialise in providing affordable, high‑quality medicines that are sourced from licensed overseas suppliers who meet stringent UK standards.

• Cost‑effective pricing – Prices are close to manufacturer cost, offering a significant saving compared with standard retail pharmacies.
• Verified quality – Every batch undergoes authenticity checks and is stored under controlled conditions to preserve potency.
• Reliable delivery – Discreet packaging is dispatched via express courier (typically within 7 days) or standard airmail (approximately 2‑3 weeks), with tracking available for all orders.
• Privacy‑focused service – As a pharmacy broker, we collaborate with overseas licensed pharmacies, ensuring a confidential purchasing experience that respects patient anonymity.

Our platform is designed for patients who have limited access to traditional pharmacies, seek a cost‑saving alternative, or require an international supply chain for continued therapy.

FAQ

• Is Dexilant available in both brand‑name and generic forms in the UK?
  Yes, Dexilant is marketed under the AstraZeneca brand, while generic tablets containing the same active ingredient Dexlansoprazole are also authorised for sale. Generic versions are typically less expensive and are supplied by multiple licensed manufacturers.

• What does the dual‑release tablet look like?
  The tablet is coated, round, and bicoloured: one half is white and the other half is blue. The coating distinguishes the immediate‑release portion from the delayed‑release segment.

• Does Dexilant require refrigeration?
  No, Dexilant should be stored at controlled room temperature (15‑30 °C). Protect it from excessive heat, moisture, and direct sunlight; a bathroom cabinet is unsuitable due to humidity.

• Can I travel internationally with Dexilant?
  Yes, you may carry Dexilant for personal while traveling. Keep the medication in its original packaging, include a copy of the prescription or a pharmacist’s note if requested, and ensure it is within the allowed quantity for personal import (generally up to a three‑month supply).

• Are there any differences between Dexilant formulations sold in the US, EU, and Asia?
  The core active ingredient (Dexlansoprazole) and the dual‑release mechanism are consistent across regions. However, inactive excipients such as colourants or binders may vary to comply with local regulatory requirements.

• What should I do if I develop a rash while taking Dexilant?
  A mild rash is often self‑limited, but any skin eruption that spreads, becomes painful, or is accompanied by fever warrants immediate medical evaluation, as it could signal a hypersensitivity reaction.

• How does Dexilant affect laboratory tests?
  Dexilant may interfere with gastric pH‑dependent tests, but it does not typically alter standard blood chemistry. However, it can affect the absorption of certain drugs used in diagnostic procedures, such as antifungal agents that rely on acidic conditions.

• Is it safe to take Dexilant with calcium supplements?
  Calcium carbonate requires an acidic environment for optimal absorption; taking it together with Dexilant may reduce calcium uptake. If supplementation is needed, calcium citrate (which does not depend on stomach acidity) is a preferred alternative.

• Can Dexilant be taken by patients with a history of H. pylori infection?
  Yes, Dexilant can be part of a triple therapy regimen (PPI + clarithromycin + amoxicillin) for H. pylori eradication. The dual‑release PPI provides potent acid suppression, enhancing antibiotic efficacy.

• What are the regulations for importing Dexilant for personal use into the UK?
  Individuals may import a three‑month supply of a prescription‑only medicine for personal use, provided the product is authorised in the UK, the import is not for resale, and the medication is obtained from a reputable source. Our online pharmacy ensures compliance with these regulations.

Glossary

Proton‑pump inhibitor (PPI)

A class of drugs that irreversibly block the H⁺/K⁺‑ATPase enzyme in gastric parietal cells, markedly reducing stomach acid production.

Dual‑release formulation

A tablet design that provides two distinct phases of drug release, delivering an initial dose followed by a delayed second dose to prolong therapeutic effect.

Hypomagnesemia

A condition characterised by low serum magnesium levels, which can lead to muscle cramps, cardiac arrhythmias, and seizures if severe.

Clostridioides difficile infection

A bacterial infection of the colon that can cause severe diarrhoea and colitis, often associated with disruption of normal gut flora by antibiotics or acid‑suppressing agents.

⚠️ Disclaimer

The information provided about Dexilant is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Dexilant for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.