Buy Generic Glucophage Sr Online

Generic Glucophage Sr Information

Introduction

Glucophage SR is a sustained‑release tablet containing the biguanide metformin, indicated primarily for the management of type 2 diabetes mellitus in adults. In the United Kingdom, it is prescribed to improve glycaemic control when diet, exercise, and weight loss are insufficient. Metformin belongs to the diabetes medication group and is also used off‑label for conditions such as polycystic ovary syndrome (PCOS) and metabolic syndrome. The product is marketed by Boehringer Ingelheim and is available in several dosage strengths (e.g., 500 mg, 850 mg, 100 mg) designed to release the active ingredient slowly over time, reducing gastrointestinal upset compared with immediate‑release formulations.

What is Glucophage SR?

Glucophage SR is a prolonged‑release oral tablet that delivers metformin in a manner that allows once‑daily dosing for many patients.

• Classification: Antihyperglycaemic agent, biguanide class.
• Active compound: Metformin hydrochloride.
• Manufacturer: Boehringer Ingelheim (global brand).
• Formulation: Tablet containing metformin plus standard excipients such as povidone, magnesium stearate, and hydroxypropyl methylcellulose, which control the release profile.

Glucophage SR provides the same therapeutic effect as immediate‑release metformin but with a smoother plasma concentration curve, which can improve tolerability for patients who experience nausea or diarrhoea with the standard formulation.

How Glucophage SR Works

Metformin acts primarily by inhibiting hepatic gluconeogenesis – the liver’s production of glucose from non‑carbohydrate precursors. It also enhances peripheral insulin sensitivity, increasing glucose uptake in skeletal muscle and adipose tissue. These actions lower fasting plasma glucose and reduce post‑prandial glucose excursions without stimulating insulin secretion, thereby minimizing the risk of hypoglycaemia when used alone.

The sustained‑release matrix of Glucophage SR releases metformin gradually over 12–24 hours, which leads to a more stable trough concentration and a reduced peak‑to‑trough fluctuation. The drug is eliminated unchanged by the kidneys; renal clearance accounts for approximately 90 % of the dose, and a half‑life of 4–8 hours is observed with SR formulations. Because the tablet is taken with the evening meal, most patients experience fewer gastrointestinal adverse events than with immediate‑release dosing.

Conditions Treated with Glucophage SR

• Type 2 Diabetes Mellitus (T2DM): First‑line oral therapy for adults when lifestyle interventions are inadequate. In the UK, approximately 4.9 million adults have diagnosed T2DM, making metformin the most prescribed glucose‑lowering drug.
• Prediabetes (Impaired Glucose Tolerance): Evidence from the Diabetes Prevention Programme shows metformin reduces progression to T2DM by 31 % in high‑risk individuals.
• Polycystic Ovary Syndrome (PCOS): Metformin improves ovulatory function and insulin resistance in women with PCOS, although it is not licensed for this use in the UK.
• Metabolic Syndrome: Beneficial effects on weight, lipid profile, and insulin sensitivity make metformin a valuable adjunct in managing this cluster of risk factors.

The sustained‑release formulation is especially useful for patients who require consistent glycaemic control and prefer a once‑daily regimen.

Who is Glucophage SR For?

• Adults with newly diagnosed T2DM who have a body‑mass index (BMI) ≥ 25 kg/m² and no contraindications to metformin.
• Patients already on immediate‑release metformin who experience gastrointestinal discomfort; switching to the SR formulation can improve tolerability.
• Individuals requiring once‑daily dosing due to work schedules or adherence challenges.
• Patients with stable renal function (eGFR ≥ 45 mL/min/1.73 m²) because metformin clearance depends on kidney performance.

Glucophage SR is not appropriate for:

• Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²).
• Those with a known hypersensitivity to metformin or any tablet excipient.
• Individuals with acute or chronic metabolic acidosis, including diabetic keto‑acidosis.

Clinical guidelines (NICE NG28) recommend metformin as the first pharmacological step unless contraindicated.

Risks, Side Effects, and Interactions

Common adverse events

• Nausea, abdominal discomfort, and diarrhoea (often milder than with immediate‑release).
• Metallic taste.
• Mild headache.

These effects usually resolve within the first few weeks as the body adapts. Taking the tablet with a substantial evening meal can minimise gastrointestinal upset.

Rare adverse events

• Vitamin B12 deficiency with long‑term use; periodic monitoring of serum B12 is advised.
• Elevated liver enzymes – routine liver function tests are recommended at baseline and annually.

Serious adverse events

• Lactic acidosis: A rare but potentially fatal accumulation of lactate, occurring predominantly in patients with severe renal impairment, hepatic failure, or acute hypoxia. Symptoms include weakness, unexplained rapid breathing, and abdominal pain. Immediate medical attention is required.
• Hypersensitivity reactions: Rash, pruritus, or angioedema may indicate an allergic response and necessitate drug discontinuation.

Clinically relevant drug–drug interactions

• Contrast agents (iodinated) used in radiographic studies can precipitate acute renal failure, raising the risk of metformin‑associated lactic acidosis. Metformin should be withheld for at least 48 hours after contrast administration and resumed only after renal function is confirmed.
• Cimetidine, trimethoprim, and certain antiretrovirals (e.g., lopinavir/ritonavir) can reduce metformin clearance, increasing plasma concentrations; dose adjustments may be required.
• Alcohol: Excessive intake may potentiate lactic acidosis, especially in the context of impaired hepatic function.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements.

Practical Use: Dosing, Missed Dose, Overdose

• Starting dose: 500 mg SR once daily with the evening meal; may be increased by 500 mg weekly up to a maximum of 200 mg per day (e.g., 100 mg + 100 mg) based on glycaemic response and tolerance.
• Renal dose adjustments:
  • eGFR 45‑60 mL/min/1.73 m² – maximum 100 mg/day.
  • eGFR 30‑44 mL/min/1.73 m² – consider 500 mg daily, with close monitoring.
• Missed dose: Take the missed tablet as soon as it is remembered, unless it is within 2 hours of the next scheduled dose; in that case, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose: Symptoms may include severe gastrointestinal distress, lethargy, and respiratory compromise. Immediate medical evaluation is essential; treatment focuses on supportive care and correction of metabolic acidosis.

Patients should avoid taking the tablet with antacids that contain aluminium or magnesium within 30 minutes, as these may interfere with absorption. Alcohol consumption should be moderate, and regular physical activity is encouraged as part of comprehensive diabetes management.

Buying Glucophage SR from Our Online Pharmacy

Glucophage SR can be obtained safely from our online pharmacy in UK. Our service offers:

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For patients facing limited access through local pharmacies or seeking a cost‑effective generic alternative, our platform provides a reliable route to obtain Glucophage SR.

FAQ

• Can Glucophage SR be taken with other diabetes medications?
  Yes, metformin is often combined with sulfonylureas, DPP‑4 inhibitors, or SGLT‑2 inhibitors to achieve additional glucose lowering. Combination therapy should be guided by a healthcare professional to avoid additive side effects such as hypoglycaemia.

• Is there a difference in taste between immediate‑release and sustained‑release tablets?
  The SR tablet is coated and designed to dissolve slowly in the gastrointestinal tract, resulting in minimal taste impact. Immediate‑release tablets may have a faint bitter after‑taste if they dissolve in the mouth before swallowing.

• What should I do if I travel abroad with Glucophage SR?
  Keep the medication in its original packaging, store it at room temperature, and carry a copy of the prescription or a doctor’s note if asked by customs. The UK’s Personal Importation Scheme permits up to a three‑month supply for personal use.

• Does Glucophage SR have the same inactive ingredients worldwide?
  While the active metformin dose is consistent, excipients may vary slightly between regions to meet local regulatory requirements. The core ingredients (e.g., povidone, magnesium stearate) remain the same, ensuring comparable bioavailability.

• Can I split a Glucophage SR tablet to adjust the dose?
  No. The sustained‑release matrix is formulated to release metformin over an extended period; splitting the tablet destroys this mechanism and may lead to dose dumping and increased side‑effects. Use whole tablets as prescribed.

• Is Glucophage SR safe for patients with mild liver disease?
  Metformin is largely renally cleared and does not undergo extensive hepatic metabolism, making it generally safe in mild liver dysfunction. However, severe hepatic impairment is a contraindication due to the increased risk of lactic acidosis.

• How long does it take for Glucophage SR to improve blood sugar levels?
  Most patients observe a reduction in fasting glucose within 1‑2 weeks, with maximal effect achieved after 4‑8 weeks of consistent therapy. Ongoing monitoring of HbA1c at three‑month intervals is recommended.

• Does the sustained‑release formulation affect weight loss?
  Metformin, irrespective of formulation, modestly promotes weight reduction by improving insulin sensitivity and reducing appetite. The SR version does not diminish this benefit and may enhance adherence, indirectly supporting weight management.

• Are there any special storage conditions for Glucophage SR in hot climates?
  Store the tablets at a temperature not exceeding 30 °C and protect them from moisture. If you reside in a particularly warm region, keep the medication in a cool, dry place such as a drawer away from direct sunlight.

• Can Glucophage SR be used during pregnancy?
  Metformin is classified as category B in the UK and may be continued in pregnancy if it was already prescribed before conception, particularly in women with PCOS or gestational diabetes. Decision-making should be individualized by the obstetric team.

Glossary

Biguanide

A class of oral antihyperglycaemic agents that lower blood glucose primarily by reducing hepatic glucose production. Metformin is the most widely used biguanide.

eGFR (estimated Glomerular Filtration Rate)

A calculated measurement of kidney function based on serum creatinine, age, sex, and body size; used to adjust metformin dosing and assess safety.

Lactic Acidosis

A rare metabolic complication characterised by accumulation of lactic acid in the blood, leading to a pH < 7.35. Metformin‑associated lactic acidosis is most likely when renal clearance is impaired.

Sustained‑Release (SR) Formulation

A tablet design that prolongs drug release over several hours, allowing once‑daily dosing and often reducing peak‑related side effects.

⚠️ Disclaimer

The information provided about Glucophage SR is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Glucophage SR for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.