Generic Grifulvin

Grifulvin is an antifungal medication which used to treat fungal infections of the skin, scalp, and nails.

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  • Category: Anti Fungal
  • Active ingredient: Griseofulvin
  • Payment options: VISA, Mastercard, Amex, JCB, Dinners
  • Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)

Buy Generic Grifulvin Online

Generic Grifulvin 250mg
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250mg x 360 pills
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R 3524.09
250mg x 180 pillsR 1966.29
250mg x 120 pillsR 1425.73
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250mg x 60 pillsR 885.34

Generic Grifulvin information

Introduction

Grifulvin is an oral antifungal medication used primarily to treat dermatophyte infections of the skin, hair and nails. The active compound is Griseofulvin, a synthetic allylamine that interferes with fungal cell division. In the United Kingdom, Grifulvin is classified as a prescription‑only medicine (POM) and is supplied by several licensed manufacturers. Although its main indication is for cutaneous and cutaneous‑appendage mycoses, the drug has been evaluated for occasional off‑label uses such as certain deep‑seated fungal infections.

What is Grifulvin?

Grifulvin is a tablet formulation that contains the antifungal agent Griseofulvin. It belongs to the anti‑fungal therapeutic group and is marketed as a generic product.

Grifulvin is the generic version of Gris‑PEG and Kefluc, containing the same active compound Griseofulvin. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The medication is manufactured in compliance with EU Good Manufacturing Practice (GMP) standards and is authorised for sale in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA).

How Grifulvin Works

Griseofulvin exerts its antifungal effect by binding to fungal microtubules. This binding disrupts the assembly of the mitotic spindle, which is essential for fungal cell division. As a result, fungal hyphae are unable to replicate, and existing colonies gradually die off.

Key pharmacokinetic points:

  • Absorption: Oral absorption is enhanced when taken with a fatty meal; bioavailability ranges from 25 % (fasted) to 50 % (with food).
  • Distribution: The drug concentrates in keratinous tissues (skin, hair, nails) because it has a high affinity for keratin. Therapeutic concentrations are therefore achieved at the site of infection.
  • Metabolism & Elimination: Griseofulvin is metabolised in the liver via oxidative pathways and excreted primarily in the feces (≈ 60 %) and to a lesser extent in urine (≈ 30 %). The elimination half‑life is 6–24 hours, allowing once‑daily or twice‑daily dosing schedules.

The delayed onset of clinical improvement (2–4 weeks for skin infections, 6–12 weeks for nail infections) reflects the time needed for infected keratin to be replaced by healthy tissue.

Conditions Treated with Grifulvin

  • Tinea corporis (ringworm of the body) – Common in the UK, especially among schoolchildren and outdoor workers. Grifulvin penetrates the epidermis to eradicate the causative dermatophytes (e.g., Trichophyton rubrum, Microsporum canis).
  • Tinea capitis (scalp ringworm) – Particularly prevalent in pre‑school children. Griseofulvin remains the first‑line oral therapy because it reaches the hair shaft where fungi reside.
  • Tinea pedis and Tinea unguium (athlete’s foot and nail onychomycosis) – Chronic infections of the foot and nails that respond to prolonged therapy (6–12 weeks).
  • Intertriginous and mucosal dermatophytosis – Involvement of skin folds or oral mucosa when topical agents are insufficient.

These indications are approved by the MHRA and supported by clinical guidelines from the British Association of Dermatologists (BAD).

Who is Grifulvin For?

Grifulvin is suited to patients who have confirmed dermatophyte infections that are extensive, recurrent, or involve hair and nails where topical agents cannot achieve adequate drug concentrations. Typical candidates include:

  • Children aged 6 years and older with tinea capitis or extensive tinea corporis, provided weight‑based dosing is applied.
  • Adults with onychomycosis affecting multiple nails or causing functional impairment.
  • Immunocompromised individuals (e.g., patients receiving systemic steroids) whose infections are recalcitrant to topical therapy.

Contra‑indications or cautionary situations:

  • Patients with severe hepatic impairment (Child‑Pugh class C) because metabolism is hepatic.
  • Pregnant or breastfeeding women: Griseofulvin crosses the placenta and is excreted in breast milk; it is generally avoided unless the benefit clearly outweighs the risk.
  • Individuals with a known hypersensitivity to Griseofulvin or any excipients in the tablet formulation.

Risks, Side Effects, and Interactions

Common

  • Gastrointestinal upset – Nausea, abdominal cramps, and loss of appetite occur in up to 15 % of patients.
  • Headache – Reported in 5–10 % of users, usually mild and transient.
  • Photosensitivity – Increased susceptibility to sunburn; patients are advised to use sun protection.

Rare

  • Hepatotoxicity – Elevated liver enzymes may appear; routine monitoring is recommended for long‑term therapy.
  • Hematologic effects – Leukopenia or thrombocytopenia has been documented in isolated cases.
  • Peripheral neuropathy – Uncommon but possible with prolonged high‑dose regimens.

Serious

  • Severe allergic reactions – Anaphylaxis, angioedema, or Stevens‑Johnson syndrome require immediate medical attention.
  • Drug‑induced liver failure – Extremely rare but fatal; early detection of symptoms (jaundice, dark urine) is crucial.

Drug–Drug Interactions

  • Cytochrome P450 inducers (e.g., rifampicin, carbamazepine, phenytoin) can reduce Griseofulvin plasma levels, compromising efficacy.
  • Warfarin – Griseofulvin may potentiate anticoagulant effect; INR should be monitored closely.
  • Oral contraceptives – Griseofulvin can decrease estrogen levels, reducing contraceptive reliability; additional barrier methods are recommended.
  • Cimetidine – May increase Griseofulvin concentrations, raising the risk of toxicity.

Patients should disclose all concomitant medications, including over‑the‑counter supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard adult dosing for skin infections: 500 mg orally once daily after a fatty meal for 2–4 weeks. For nail infections, 500 mg once daily for 6–12 weeks is usual.
  • Pediatric dosing (≥ 6 years): 20 mg/kg per day, divided into two doses (morning and evening) for tinea capitis, typically for 4–6 weeks.
  • Renal impairment: No dose adjustment required unless severe hepatic dysfunction is present.

Missed dose – Take the missed tablet as soon as remembered unless the next scheduled dose is within 4 hours; in that case, skip the missed dose and continue the regular schedule. Do not double the dose.

Overdose – Symptoms may include severe nausea, vomiting, diarrhoea, and dizziness. If an overdose is suspected, seek immediate medical assistance; activated charcoal may be administered in an emergency department.

Food and alcohol – Taking Grifulvin with a high‑fat meal improves absorption. Alcohol should be avoided, as it may increase the risk of hepatotoxicity and exacerbate photosensitivity.

Buying Grifulvin from Our Online Pharmacy

Grifulvin can be obtained safely from our online pharmacy in the UK. Our service offers several advantages for patients who need reliable access to this antifungal:

  • Affordable pricing – We source the medication close to manufacturer cost, passing savings directly to you.
  • Verified quality – All batches are supplied by MHRA‑approved overseas licensed pharmacies, ensuring authenticity and compliance with international standards.
  • Guaranteed delivery – Discreet packaging and reliable shipping options (express delivery within 7 days, regular airmail in approximately 3 weeks).
  • Online‑only access – We specialise in providing international medications that may not be stocked by local high‑street pharmacies, while maintaining strict privacy protections.

Our pharmacy operates as a broker service, partnering with licensed suppliers worldwide. This model enables us to offer a discreet, cost‑effective solution for individuals with limited access through conventional pharmacy channels.

FAQ

  • Can Grifulvin be taken with other antifungal agents?
    Grifulvin may be co‑administered with topical antifungals to enhance overall treatment efficacy, especially in nail infections. However, simultaneous systemic antifungal therapy (e.g., terbinafine) can increase the risk of hepatic toxicity and should only be used under specialist supervision.

  • What does the tablet look like and how is it scored?
    Grifulvin tablets are typically round, bicoloured (white core with a light blue coating), and bear the imprint “GR‑500”. Most formulations are not scored, so tablets should be swallowed whole to avoid dose variability.

  • Is Grifulvin stable at high temperatures during travel?
    The drug remains stable at temperatures up to 30 °C (86 °F) for short periods. When traveling to hot climates, keep the medication in a sealed container away from direct sunlight and, if possible, in a temperature‑controlled bag.

  • Are there any specific warnings for patients of Asian descent?
    Some pharmacogenomic studies suggest a slightly higher incidence of hepatic enzyme elevation in Asian populations taking Griseofulvin. Liver function tests should be monitored more frequently in these patients, particularly during prolonged courses.

  • Does Grifulvin appear on standard drug‑testing panels for employment?
    Griseofulvin is not a controlled substance and does not normally trigger positive results on routine workplace drug screens. However, specialized toxicology assays could theoretically detect the compound if specifically requested.

  • How does Grifulvin compare with newer oral antifungals such as itraconazole?
    Griseofulvin has a narrower spectrum and requires longer treatment durations, but it is inexpensive and has a long safety record. Itraconazole offers a broader spectrum and shorter courses but carries higher risks of drug interactions and hepatotoxicity. Choice of therapy depends on infection type, patient comorbidities, and cost considerations.

  • What are the recommended storage conditions for Grifulvin?
    Store tablets at controlled room temperature (15–30 °C), protected from moisture and light. Do not refrigerate or freeze. Keep the container tightly closed and out of reach of children.

  • Can Grifulvin be imported for personal use in the UK?
    Personal import of prescription medicines is allowed under the MHRA’s “Personal Use Importation Scheme” provided the supply is for a maximum of three months’ treatment, the medication is for a genuine personal need, and the total value does not exceed the prescribed limit.

  • Are there any known differences in excipients between UK‑manufactured and overseas versions?
    UK‑licensed formulations typically contain lactose, magnesium stearate, and microcrystalline cellulose as fillers. Some overseas versions may use alternative binders such as sodium starch glycolate. Patients with specific excipient allergies should verify the ingredient list before purchase.

  • What is the historical significance of Griseofulvin in dermatology?
    Discovered in 1939 from the mold Penicillium griseofulvum, Griseofulvin was the first systemic antifungal approved for dermatophyte infections. Its introduction transformed management of tinea capitis, which previously required lengthy topical regimens with limited success.

Glossary

Keratinophilic
Refers to fungi that preferentially grow in keratin‑rich tissues such as skin, hair and nails. Griseofulvin’s high affinity for keratin enables it to concentrate at infection sites.
Hepatotoxicity
Chemical‑induced liver injury. In the context of Grifulvin, monitoring liver enzymes (ALT, AST) is advisable during extended therapy.
Photosensitivity
An increased skin reaction to ultraviolet (UV) radiation, leading to sunburn‑like symptoms. Patients should use sunscreen and protective clothing while on Grifulvin.
Pharmacokinetic half‑life
The time required for the plasma concentration of a drug to reduce by 50 %. Griseofulvin’s half‑life varies between 6 and 24 hours, influencing dosing frequency.

⚠️ Disclaimer

The information provided about Grifulvin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Grifulvin for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Information about ordering Generic Grifulvin online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to griseofulvin so you can use Generic Grifulvin safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Grifulvin. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Grifulvin without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Grifulvin - griseofulvin medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.