Generic Nimotop

Nimotop is a calcium channel blocker used to treat to prevent brain damage caused by reduced blood flow due to aneurysm, etc.

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  • Category: Cardiovascular
  • Active ingredient: Nimodipine
  • Payment options: VISA, Mastercard, Amex, JCB, Dinners
  • Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)

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Generic Nimotop information

Introduction

Nimotop is a prescription medication used primarily to prevent complications after a subarachnoid haemorrhage (SAH). The product contains the calcium‑channel blocker nimodipine, which belongs to the cardiovascular therapeutic group. In the United Kingdom, Nimotop is prescribed by neurologists and intensive‑care specialists to reduce the risk of delayed cerebral ischaemia following aneurysmal SAH. The drug is manufactured by various licensed pharmaceutical companies and is also available under other brand names worldwide.

What is Nimotop?

Nimotop is a brand‑name formulation of the active compound nimodipine. Nimodipine is a dihydropyridine calcium‑channel antagonist that selectively dilates cerebral blood vessels. The medication is supplied as oral tablets, typically 30 mg each, and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK.

Manufacturer: Several companies produce Nimotop; the specific manufacturer listed on the packaging will be indicated on the label.

Classification: Cardiovascular drug – cerebral vasodilator.

Development: Nimodipine was first synthesised in the 197s and received approval for SAH‑related indications in the early 199s after pivotal clinical trials demonstrated a reduction in poor neurological outcome.

How Nimotop Works

Nimodipine blocks L‑type voltage‑gated calcium channels located on the smooth muscle cells of cerebral arteries. By inhibiting calcium influx, the drug reduces vascular smooth‑muscle contraction, leading to vasodilation of small intracranial vessels. This effect improves cerebral blood flow in the vulnerable period after SAH, limiting secondary ischaemic injury.

Onset: Therapeutic plasma concentrations are reached within 30–60 minutes after oral ingestion.
Duration: The half‑life is approximately 8–9 hours, supporting a twice‑daily dosing schedule.
Clearance: Nimodipine is metabolised mainly by hepatic CYP3A4 enzymes and excreted in urine and bile.

Conditions Treated with Nimotop

  • Aneurysmal subarachnoid haemorrhage (SAH) – The only approved indication in the UK. Clinical trials (e.g., the International Cooperative Study on SAH) showed that nimodipine reduces the incidence of delayed cerebral ischaemia and improves functional outcomes.
  • Off‑label use in certain types of vasospasm – Some neurologists employ nimodipine for refractory cerebral vasospasm after traumatic brain injury, though this is not an MHRA‑approved indication.

SAH incidence in the UK is about 10 cases per 100,000 population per year, equating to roughly 6,000 new patients annually. Early administration of Nimotop (within 4 hours of haemorrhage) is standard practice to mitigate the high morbidity and mortality associated with vasospasm.

Who is Nimotop For?

  • Adults (≥18 years) who have suffered a confirmed aneurysmal SAH and are admitted to a neurosurgical or intensive‑care unit.
  • Patients undergoing surgical clipping or endovascular coiling where the risk of delayed cerebral ischaemia is high.
  • Individuals without severe hepatic impairment (CYP3A4 activity required for clearance).

Contra‑indications or caution include: known hypersensitivity to nimodipine or other dihydropyridines, severe hypotension, concurrent use of potent CYP3A4 inhibitors (e.g., clarithromycin, itraconazole), and pregnancy (category C).

Risks, Side Effects, and Interactions

Common

  • Headache
  • Dizziness or light‑headedness (often related to blood‑pressure lowering)
  • Nausea or mild gastrointestinal upset
  • Flushing

Rare

  • Hypotension requiring medical intervention
  • Bradycardia
  • Elevated liver enzymes (transaminases)

Serious

  • Severe hypotensive shock (rare, usually in combination with other antihypertensives)
  • Allergic reactions such as angio‑edema or anaphylaxis
  • Hepatic failure (extremely uncommon, reported in patients with pre‑existing liver disease)
Drug–Drug Interactions
  • CYP3A4 inhibitors (e.g., macrolide antibiotics, azole antifungals, protease inhibitors) increase nimodipine plasma levels, raising the risk of hypotension.
  • Other antihypertensives (beta‑blockers, ACE inhibitors, other calcium‑channel blockers) may have additive blood‑pressure‑lowering effects.
  • Antacids containing aluminium or magnesium can reduce oral absorption; separate administration by at least 2 hours is advised.

Patients should disclose all current medicines, including over‑the‑counter and herbal products, to their healthcare provider before starting Nimotop.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard dosing: 30 mg orally every 4 hours (six doses per day) for 21 days, initiated as soon as possible after SAH diagnosis.
  • Missed dose: Take the missed tablet as soon as remembered if at least 2 hours remain before the next scheduled dose. Do not double‑dose.
  • Overdose: Symptoms may include profound hypotension, bradycardia, and syncope. Seek emergency medical attention; treatment is supportive with intravenous fluids and vasopressors if needed.
  • Food and alcohol: Nimotop may be taken with or without food; however, high‑fat meals can delay absorption. Alcohol can potentiate hypotensive effects and should be avoided while on therapy.
  • Comorbidities: In patients with moderate hepatic impairment, dose reduction or extended dosing interval may be required; specialist guidance is essential.

Buying Nimotop from Our Online Pharmacy

Nimotop can be purchased from our online pharmacy in the UK with a streamlined, discreet ordering process. Key advantages include:

  • Affordable pricing – close to manufacturer cost, offering a lower price than many brick‑and‑mortar pharmacies.
  • Verified quality – we source only from licensed overseas suppliers who meet UK‑MRA standards for safety and potency.
  • Guaranteed delivery – options for express delivery (typically within 7 days) and regular airmail (approximately 3 weeks). All packages are sealed, unmarked, and shipped in discreet packaging to protect privacy.
  • Online‑only access – useful for patients who lack local availability or whose NHS supply is limited. As a pharmacy‑broker service, we act as an intermediary between you and the licensed international pharmacy, ensuring compliance with import regulations while maintaining confidentiality.

FAQ

  • Can Nimotop be taken with other blood‑pressure medicines?
    Yes, but concurrent use may amplify the blood‑pressure‑lowering effect. Your clinician should monitor blood pressure closely and adjust doses if necessary.

  • What should I do if I experience severe dizziness while on Nimotop?
    Severe dizziness can signal hypotension. Sit or lie down, avoid standing quickly, and contact your healthcare provider for assessment.

  • Is Nimotop stable at room temperature, or does it require refrigeration?
    Nimotop tablets are stable at controlled room temperature (15‑30 °C). They should be kept away from excessive heat, moisture, and direct sunlight.

  • How long can I store Nimotop after receiving it from the pharmacy?
    The expiry date is printed on the blister pack. Do not use the medication beyond this date, and store it as directed to preserve potency.

  • Are there any known differences between Nimotop tablets produced in Europe versus Asia?
    Formulation standards (tablet strength, excipients) are required to meet the respective regional pharmacopoeias. Both meet stringent quality criteria, but inactive ingredients may vary slightly, which can affect tolerability in sensitive individuals.

  • What is the mechanism behind nimodipine’s preferential effect on cerebral vessels?
    Nimodipine has higher affinity for cerebral arterial smooth muscle compared with peripheral vessels, likely due to its lipophilicity and ability to cross the blood‑brain barrier. This selective vasodilation reduces the risk of cerebral ischaemia after SAH.

  • Can I travel internationally with Nimotop tablets?
    Yes, but keep the medication in its original packaging with a copy of the prescription (or a doctor’s note) to satisfy customs authorities. Carry it in hand luggage to avoid temperature extremes.

  • Does Nimotop interact with common over‑the‑counter pain relievers?
    Paracetamol has no known interaction. Non‑steroidal anti‑inflammatory drugs (NSAIDs) may increase the risk of renal impairment when combined with prolonged hypotension; use NSAIDs only under medical advice.

  • Why is Nimotop prescribed for exactly 21 days after SAH?
    Clinical evidence indicates that the risk of delayed cerebral vasospasm peaks between days 3 and 14 post‑haemorrhage and declines thereafter. A 21‑day course covers the high‑risk period while limiting unnecessary exposure.

  • Is there any evidence that Nimotop improves long‑term cognitive outcomes after SAH?
    Long‑term follow‑up studies suggest that patients receiving nimodipine have a modestly lower incidence of persistent neurological deficits, including cognitive impairment, compared with untreated cohorts.

Glossary

Calcium‑channel blocker
A class of drugs that inhibit calcium influx into vascular smooth‑muscle cells, causing relaxation and vasodilation.
Delayed cerebral ischaemia (DCI)
A reduction in cerebral blood flow occurring days after SAH, often due to vasospasm, which can cause neurological deterioration.
CYP3A4
An enzyme in the liver responsible for metabolising many medications, including nimodipine. Inhibitors of this enzyme can raise drug levels.
Half‑life
The time required for the plasma concentration of a drug to decrease by 50 %. For nimodipine, it is roughly 8–9 hours.

⚠️ Disclaimer

The information provided about Nimotop is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Nimotop for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Information about ordering Generic Nimotop online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to nimodipine so you can use Generic Nimotop safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Nimotop. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Nimotop without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Nimotop - nimodipine medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.

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