Generic Reglan

Introduction

Reglan is a medication used primarily to enhance gastrointestinal motility and to treat nausea and vomiting of various origins. Its active compound, metoclopramide, belongs to the gastro‑health group of drugs and is licensed for use in the United Kingdom. In addition to its core indication for gastroparesis and reflux, Reglan is also employed in the management of postoperative nausea, chemotherapy‑induced vomiting, and as an adjunct in diagnostic procedures such as upper‑gastrointestinal endoscopy. The drug is manufactured by several licensed producers and is available both as a branded product and as a generic alternative.

What is Reglan?

Reglan is the trade name for a formulation that contains the active ingredient metoclopramide. Metoclopramide is a dopamine‑type 2 (D₂) receptor antagonist with pro‑kinetic activity. The medication was first developed in the 196s and has been marketed worldwide under a variety of brand names, including Maxolon, Primperan, and Metoclop. The generic version sold through pharmacies contains the same amount of metoclopramide per tablet or injection as the original branded preparations, offering a cost‑effective option for patients who require regular therapy.

Reglan is the generic version of the well‑known brand Maxolon, containing the same active compound metoclopramide. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Reglan Works

Metoclopramide acts by antagonising central and peripheral D₂ receptors. In the central nervous system, blockade of D₂ receptors in the chemoreceptor trigger zone reduces the emetic response, thereby suppressing nausea and vomiting. Peripherally, the drug enhances the release of acetylcholine in the gastrointestinal tract, which increases the amplitude of gastric contractions and accelerates gastric emptying.

Key pharmacokinetic points:

• Onset of action – oral tablets begin to exert pro‑kinetic effects within 30 minutes, with maximal effect at 1–2 hours.
• Duration – the therapeutic effect lasts approximately 4–6 hours, which underlies the typical dosing interval of 6–8 hours.
• Metabolism and clearance – metoclopramide is metabolised primarily by hepatic CYP2D6, and renal excretion eliminates the majority of the drug within 24 hours in individuals with normal kidney function.

These mechanisms explain why Reglan is effective for conditions that involve delayed gastric emptying or reflex‑mediated nausea.

Conditions Treated with Reglan

• Gastroparesis – a chronic condition characterised by delayed stomach emptying, commonly seen in diabetic patients. In the UK, gastroparesis affects an estimated 5–10 % of individuals with long‑standing diabetes, and metoclopramide improves symptoms such as early satiety, bloating, and nausea.
• Gastro‑oesophageal reflux disease (GERD) – when reflux is linked to impaired gastric motility, Reglan can reduce the frequency of heartburn episodes by promoting faster gastric clearance.
• Post‑operative nausea and vomiting (PONV) – up to 30 % of surgical patients experience PONV; a single dose of metoclopramide given before anaesthesia reduces this risk.
• Chemotherapy‑induced nausea and vomiting (CINV) – metoclopramide is used as part of a multi‑drug regimen for moderate‑to‑severe CINV when newer anti‑emetics are unavailable or contraindicated.
• Adjunct in diagnostic endoscopy – a short course of metoclopramide improves visibility during upper‑GI endoscopy by clearing residual food from the stomach.

The drug’s ability to accelerate gastric emptying and suppress the emetic centre makes it suitable across these diverse clinical scenarios.

Who is Reglan For?

Reglan is most appropriate for adult patients who require pharmacological enhancement of gastric motility or control of nausea that is not adequately managed by non‑pharmacological measures. Typical candidates include:

• Individuals with diabetic gastroparesis who experience persistent nausea, vomiting, or early satiety despite dietary modification.
• Patients scheduled for elective surgery who have a history of PONV and can benefit from prophylactic anti‑emetic therapy.
• Oncology patients undergoing moderate‑to‑high emetogenic chemotherapy when other anti‑emetics are contraindicated (e.g., due to hypersensitivity).
• People with refractory GERD where acid suppression alone has not resolved symptoms, and delayed gastric emptying is identified as a contributing factor.

Contra‑indications – Reglan should not be used in patients with known hypersensitivity to metoclopramide, severe renal impairment (creatinine clearance < 30 mL/min), or a history of extrapyramidal disorders such as tardive dyskinesia. Caution is also warranted in elderly patients, who are more susceptible to central nervous system side effects.

Risks, Side Effects, and Interactions

Common

• Dry mouth – occurs in roughly 10 % of users; can be alleviated by adequate hydration.
• Drowsiness or fatigue – mild sedation may affect tasks requiring alertness, such as driving.
• Diarrhoea – accelerated intestinal transit may lead to loose stools, especially at higher doses.

Rare

• Extrapyramidal symptoms (EPS) – includes acute dystonia, parkinsonism, and akathisia; reported in < 1 % of patients, usually within the first few days of therapy.
• Hyperprolactinemia – elevated prolactin can cause galactorrhoea or menstrual irregularities, more common in women taking prolonged courses.

Serious

• Tardive dyskinesia – a potentially irreversible movement disorder that may develop after weeks to months of continuous use, particularly in the elderly or in patients receiving high cumulative doses. Prompt discontinuation is essential if symptoms emerge.
• Severe allergic reaction – anaphylaxis, though extremely rare, necessitates immediate medical attention.

Drug–Drug Interactions

• CYP2D6 substrates (e.g., codeine, tramadol) – metoclopramide can inhibit metabolism, leading to increased plasma concentrations of these analgesics.
• Anticholinergic agents – concurrent use may blunt the pro‑kinetic effect of metoclopramide.
• Other dopamine antagonists (e.g., haloperidol) – additive risk of EPS and sedation.
• Monoamine oxidase inhibitors (MAOIs) – may potentiate central nervous system effects; a wash‑out period of at least 14 days is recommended.

Patients should disclose all current medications, including over‑the‑counter and herbal products, to their healthcare provider before initiating Reglan.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing – for gastroparesis, a typical oral dose is 10 mg three times daily (30 mg / day). For acute nausea, a single 10 mg dose may be administered, with a repeat dose after 30 minutes if needed (maximum 30 mg per day). Intravenous formulations are used in hospital settings at .1 mg/kg over 1–2 minutes.
• Missed dose – if a dose is forgotten, take it as soon as remembered unless it is close to the time of the next scheduled dose. Do not double the dose to compensate.
• Overdose – symptoms may include severe drowsiness, extrapyramidal signs, or anaphylaxis. Seek urgent medical attention; treatment is symptomatic, and activated charcoal may be considered if ingestion was recent.
• Food and alcohol – metoclopramide can be taken with or without food; however, high‑fat meals may delay absorption. Alcohol does not interact pharmacokinetically but may exacerbate central nervous system depression.
• Renal or hepatic impairment – dose reduction (e.g., 5 mg three times daily) is advisable in patients with moderate renal insufficiency; severe impairment requires specialist supervision.

Buying Reglan from Our Online Pharmacy

Reglan can be purchased from our online pharmacy in the UK as a generic metoclopramide product. Our service provides:

• Affordable pricing – the cost is close to the manufacturer’s price, offering a financially sensible alternative to branded preparations.
• Verified quality – all units are sourced from licensed overseas suppliers that meet European GMP standards, ensuring product integrity.
• Guaranteed delivery – discreet packaging is dispatched within 7 days for express shipping, and typical regular airmail arrives within 3 weeks.
• Online‑only access – we operate as a pharmacy broker service, collaborating with overseas licensed pharmacies to make international medications available to UK residents who may lack local supply.

Our discreet delivery respects patient privacy while maintaining a reliable and transparent supply chain.

FAQ

• What tablet strengths are available for Reglan?
  Metoclopramide tablets are commonly supplied in 5 mg and 10 mg strengths. The 10 mg tablets are the most frequently prescribed for adult gastro‑intestinal indications, while the 5 mg strength may be used for dose titration in sensitive individuals.

• Does Reglan require special storage conditions?
  The medication should be stored at controlled room temperature (15–25 °C) in a dry place, protected from direct sunlight and moisture. No refrigeration or freezing is needed.

• Can Reglan be taken while travelling abroad?
  Yes. When travelling, keep the medication in its original packaging with a copy of the prescription (if applicable) and avoid exposure to extreme temperatures. Consider carrying a small supply in hand luggage to mitigate potential delays in customs.

• Are there differences in formulation between the UK and other regions?
  In the UK, generic metoclopramide tablets contain lactose as an inactive ingredient, whereas some Asian formulations use mannitol. Patients with specific excipient sensitivities should review the product leaflet for regional formulation details.

• What are the brand names most recognised for metoclopramide in the UK?
  The most widely recognised brands include Maxolon and Primperan. These contain the same active ingredient as Reglan and are often used interchangeably in clinical practice.

• Is metoclopramide detected in standard drug tests?
  Metoclopramide is not included in routine employment drug‑screening panels. However, specialised testing could identify the compound if specifically requested.

• Can Reglan be used in pregnancy?
  Metoclopramide is classified as a Category B medication in the UK, indicating limited evidence of safety. It may be prescribed during pregnancy for severe nausea when benefits outweigh potential risks, but always under specialist guidance.

• How does the risk of tardive dyskinesia change with treatment duration?
  The risk rises markedly after prolonged exposure (> 3 months) and with cumulative doses exceeding 150 mg. Regular neurological assessment is recommended for patients on long‑term therapy.

• What is the typical time to symptom relief after a single dose for nausea?
  Most patients notice a reduction in nausea within 30 minutes, with maximal effect occurring at approximately 1 hour post‑dose.

• Is there a difference between tablets and oral liquid formulations?
  The oral liquid (syrup) provides the same amount of metoclopramide per millilitre as the tablet, facilitating dose adjustment for paediatric or frail patients. Bioavailability is comparable between the two forms.

Glossary

Dopamine D₂ receptor antagonist

A drug that blocks the type 2 dopamine receptors, reducing dopaminergic signalling in the brain and gastrointestinal tract.

Pro‑kinetic

An agent that stimulates motility of the gastrointestinal tract, thereby accelerating the movement of food through the stomach and intestines.

Extrapyramidal symptoms (EPS)

Drug‑induced movement disorders that include dystonia, parkinsonism, akathisia, and tremor, often linked to dopamine antagonism.

Tardive dyskinesia

A potentially irreversible, involuntary, repetitive movement disorder that may develop after long‑term exposure to dopamine‑blocking agents.

⚠️ Disclaimer

The information provided about Reglan is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Reglan for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.