Generic Skelaxin

Metaxalone is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain. Metaxalone is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

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  • Category: Mental Illness
  • Active ingredient: Metaxalone
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  • Delivery time: Airmail (10 - 21 days), EMS Trackable (5-9 days)

Buy Generic Skelaxin Online

Generic Skelaxin 400mg
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400mg x 90 pills£125.27
400mg x 60 pills£89.41
400mg x 30 pills£59.03

Generic Skelaxin information

Introduction

Skelaxin is a prescription medication marketed primarily for relief of musculoskeletal discomfort. Its active compound is Metaxalone, a centrally acting skeletal muscle relaxant. Although listed under the broader medication group “mental illness” in some classification systems, clinical use of Metaxalone focuses on the reduction of muscle tone and alleviation of associated pain. In the United Kingdom, Skelaxin is prescribed by doctors for conditions such as acute low‑back strain, soft‑tissue injuries and other situations where involuntary muscle contraction contributes to symptom severity.

What is Skelaxin?

Skelaxin is a pharmaceutical preparation that contains the generic active ingredient Metaxalone (chemical name: (4‑chlorophenyl)‑(2‑hydroxy‑2‑phenyl‑acetyl)‑hydrazine). It is formulated as oral tablets, typically 400 mg strength, and is produced by manufacturers who hold marketing authorisation from the United Kingdom Medicines and Healthcare products Regulatory Agency (MHRA). While several brand‑name products (e.g., Skelaxin in the United States and Metaxalone® in Europe) have been available, the tablets sold under the Skelaxin name are bioequivalent to these branded versions.

How Skelaxin Works

Metaxalone exerts its therapeutic effect by modulating neuronal pathways that influence skeletal muscle tone. The exact mechanism is not fully delineated, but evidence indicates a central depressant effect on spinal interneurons, reducing the frequency of reflexogenic muscle contraction without directly affecting the contractile apparatus of the muscle itself. This action results in:

  • Decreased muscle spasm frequency – leading to smoother movement and less pain.
  • Lowered central pain perception – via inhibition of nociceptive transmission in the dorsal horn.

Pharmacokinetic data from the UK Medicines Information (UKMI) show that Metaxolone is well absorbed orally, reaching peak plasma concentrations within 2–3 hours. Its elimination half‑life ranges from 4 to 6 hours, allowing dosing up to three times daily while maintaining therapeutic concentrations. Metabolism occurs primarily in the liver through oxidative pathways, and metabolites are eliminated renally.

Conditions Treced with Skelaxin

Skelaxin is approved for the following indications in the UK:

Condition Clinical relevance (UK) Reason for use
Acute low‑back strain 10% of all NHS musculoskeletal referrals annually Reduces spasms that limit mobility and increase pain scores.
Soft‑tissue muscle injuries (e.g., hamstring, calf strains) Common in community sports and occupational settings Provides symptomatic relief while allowing physiotherapy to proceed.
Post‑operative muscle spasms (after orthopaedic surgery) Affects up‑ to 20 % of patients undergoing joint replacement Facilitates early mobilisation and reduces opioid requirement.

No robust evidence supports routine use of Metaxalone for primary psychiatric or mental‑illness conditions; therefore, current prescribing practice confines its use to the musculoskeletal domain.

Suitable Candidates for Skelaxin Treatment

  • Adults (≥ 18 years) with acute or sub‑acute muscular pain where spasm is a predominant feature.
  • Patients without severe hepatic impairment (as Metaxalone is metabolised in the liver).
  • Individuals who have failed or wish to minimise opioid analgesia for muscle‑related pain.
  • Contra‑indications include known hypersensitivity to Metaxalone, severe liver disease, and concomitant use of monoamine oxidase inhibitors (MAOIs). Pregnant or lactating patients should be assessed on a case‑by‑case basis, as safety data are limited.

Risks, Side Effects, and Interactions

Common adverse events

  • Drowsiness – reported in up to 30 % of users; may affect activities requiring alertness (e.g., driving).
  • Nausea and gastrointestinal upset – usually mild and transient, occurring in 10–15 % of patients.
  • Mild headache – observed in less than 10 % of treatment courses.

Rare adverse events

  • Allergic skin reactions (e.g., urticaria, maculopapular rash) – incidence < 1 %.
  • Hepatotoxicity – isolated cases of elevated liver enzymes; routine monitoring is advised for prolonged treatment.
  • Serious dizziness or vertigo – may indicate over‑dose or interaction with other central depressants.

Serious adverse events

  • Hepatic failure – extremely rare but reported when Metaxalone is combined with potent hepatotoxic agents.
  • Severe hypersensitivity reactions (e.g., angioedema, anaphylaxis) – life‑threatening, requiring emergency medical attention.
  • Acute central nervous system depression – in context of concurrent CNS depressants (e.g., benzodiazepines, high‑dose antihistamines).
Clinically relevant drug–drug interactions
  • CNS depressants – additive sedation; dose adjustments or avoidance recommended.
  • Warfarin – possible increase in bleeding risk due to altered protein binding; monitor INR closely if co‑administered.
  • MAOIs – contraindicated; concurrent use can precipitate hypertensive crisis.
  • Hepatotoxic agents (e.g., isoniazid, ketoconazole) – may compound liver enzyme elevation; periodic liver function testing advised.

Practical Use: Dosing, Missed Dose, Overdose

  • Standard dosing – The usual adult regimen is 400 mg (one tablet) taken three times daily after meals, with at least 4 hours between doses. The dose can be halved for patients > 70 kg or with mild hepatic impairment, under medical supervision.
  • Missed dose – If a dose is forgotten, take it as soon as remembered unless the next scheduled dose is due within 2 hours. In that case, skip the missed dose and resume the regular schedule; do not double the dose.
  • Overdose – Symptoms may include severe drowsiness, hypotension, and respiratory depression. Immediate medical assistance is essential. Management is supportive, focusing on airway protection, monitoring vital signs, and, if necessary, activated charcoal administration within 1 hour of ingestion.
  • Precautions – Avoid alcohol while taking Skelaxin, as it can intensify central nervous system depression. Food enhances absorption; therefore, tablets should be taken with a light meal rather than on an empty stomach. Patients with chronic liver disease should have baseline and periodic liver function tests.

Buying Skelaxin from Our Online Pharmacy

Skelaxin can be purchased directly from our online pharmacy in the UK. Our service offers several advantages for patients who need reliable, discreet access to this medication:

  • Affordable pricing – Generic Metaxalone tablets are supplied at near‑manufacturer cost, providing a cost‑effective alternative to brand‑name options.
  • Verified quality – All products are sourced from licensed overseas manufacturers that fulfil MHRA and European Union Good Manufacturing Practice (GMP) standards.
  • Guaranteed delivery – Orders are dispatched within 24 hours using a confidential packaging system. Standard shipping typically arrives within 7 business days (express), while regular airmail may require up to 3 weeks.
  • Discrete privacy protection – As a pharmacy broker, we collaborate with overseas licensed pharmacies, ensuring that the medication reaches you in plain, unbranded packaging that respects personal privacy while complying with UK import regulations.

These features make our online pharmacy a safe, accessible route for individuals who may have limited availability through conventional NHS outlets or private insurance formularies.

FAQ

  • Is Skelaxin available in both branded and generic forms in the UK?
    Skelaxin is marketed as a generic product containing Metaxalone. While the same active ingredient is sold under various brand names in other jurisdictions, in the UK the tablets you receive are therapeutically equivalent to those branded versions, with the advantage of a lower price point.

  • What are the physical characteristics of a Skelaxin tablet?
    The standard Skelaxin tablet is a white, round, film‑coated tablet, bearing the imprint “400 MG.” Inactive ingredients typically include lactose monohydrate, microcrystalline cellulose, and magnesium stearate.

  • Can Skelaxin be stored in a refrigerator?
    No. Skelaxin tablets should be kept at room temperature (15 – 25 °C), protected from direct sunlight, excess moisture and heat. Storing in a refrigerator offers no therapeutic benefit and may affect tablet integrity.

  • Does Skelaxin have any special handling requirements for air travel?
    When travelling, keep the medication in its original packaging, store it in a cool, dry place within your carry‑on luggage, and avoid exposure to extreme temperatures (e.g., airline cargo holds).

  • Are there any labeling differences between UK‑sourced and overseas‑sourced Skelaxin?
    UK‑sourced batches carry the MHRA licence number and NHS branding. Overseas suppliers may use a different batch code but must still display the active ingredient, strength, and expiry date in compliance with EU regulations.

  • What are the UK import rules for personal use of Skelaxin?
    Personal import of a one‑month supply (≤ 90 days) for a prescribed medication is generally permitted, provided the medication is for personal use, labelled correctly, and the importer retains a copy of the prescription. Importation for larger quantities may require a special licence.

  • Does Skelaxin affect standard workplace drug‑testing procedures?
    Metaxalone is not listed among substances typically screened for in routine workplace drug tests (e.g., cannabinoids, opiates, cocaine). However, if a test specifically screens for muscle‑relaxant agents, disclosure of prescribed use is advisable.

  • Is Skelaxin suitable for use in patients with mild asthma?
    Metaxalone does not possess bronchodilatory or bronchoconstrictive properties, so there is no known interaction with asthma inhalers. Patients with well‑controlled mild asthma can safely use Skelaxin, but any new respiratory symptoms should be reported to a healthcare professional.

  • What is the historical development of Metaxalone?
    Metaxalone was first synthesized in the 195s by R. B. Macleod as a non‑central nervous system‑acting muscle relaxant. Early clinical trials demonstrated its efficacy in reducing muscle spasm without the dependence risk associated with older agents such as carisoprodol.

  • How does Skelaxin compare to other muscle‑relaxant drugs like baclofen?
    Unlike baclofen, which acts as a GABA‑B receptor agonist and is often used for spasticity, Metaxalone (Skelaxin) primarily depresses central spinal interneurons and is favoured for acute soft‑tissue injuries. Baclofen carries a higher risk of weakness and withdrawal seizures, whereas Skelaxin’s side‑effect profile is milder, with dizziness and drowsiness being the most common.

  • Can Skelaxin be split or crushed for patients with swallowing difficulties?
    The tablets should not be split or crushed because the film coating ensures consistent release and absorption. For patients with dysphagia, a prescriber may arrange for a liquid formulation, though such preparations are not commercially available in the UK and would need special compounding.

Glossary

Central depressant effect
A reduction in neuronal excitability within the central nervous system that leads to decreased muscle tone and spasm frequency.
Bioequivalence
The property of two drug products to exhibit the same bioavailability, implying that they deliver the same amount of active ingredient to the body at the same rate.
Gastro‑intestinal (GI) upset
A collective term for discomfort of the digestive tract, including nausea, abdominal pain, or dyspepsia, commonly reported with oral medications.
Therapeutic window
The range of drug concentrations in which the medication is effective without causing unacceptable side effects.

⚠️ Disclaimer

The information provided about Skelaxin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Skelaxin for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

Information about ordering Generic Skelaxin online

Buy placing an order on our website you must agree to the following: Your are above 18 years old, You do not have any contraindications to metaxalone so you can use Generic Skelaxin safely, We do not provide any paper instructions, side effect warnings or usage directions with medication Skelaxin. They are available only online on our website. We do not provide any doctors consultation -- please consult with your doctor before using this medication. We provide you a cheap alternative to save cost but we cannot replace real practioning medical specialist. When you order Generic Skelaxin without a prescription you agreee that you will get generic pills manufactured in Inida, they will be shipped to you in anonymous package except you ordered traceable delivery. From our side we guarantee quality of Generic Skelaxin - metaxalone medication that is sold through our site. We do our best and send medication in a valid condition and safely packed, however we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions do not hesitate to call us or use Live chat. After you place your order we may call you back for verification purposes.

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