Alopecia Areata
1 medicine
Alopecia areata is an autoimmune condition in which the immune system attacks hair follicles, causing patchy hair loss on the scalp or body. Regrowth is possible, and JAK inhibitors like baricitinib can help severe cases.
Key facts
- Alopecia areata is an autoimmune condition where the immune system attacks hair follicles, usually producing one or more smooth, round bald patches on the scalp, beard, or elsewhere.
- Hair follicles aren't permanently destroyed, so regrowth is possible, especially when patches are small and recent.
- Genetic susceptibility is a strong factor, and the condition shares genetic overlap with other autoimmune conditions such as thyroid disease and vitiligo.
- Baricitinib, a JAK1/JAK2 inhibitor, is a newer option for adults with severe, long-standing disease; corticosteroids have long been the mainstay treatment.
What drives the hair loss
Alopecia areata sits within the broader family of autoimmune conditions. Immune cells, mainly T-lymphocytes, cluster around the follicle bulb and trigger inflammation. Genetic susceptibility is a strong factor: alopecia areata tends to cluster in families and shares genetic overlap with other autoimmune conditions such as thyroid disease and vitiligo. Emotional stress and viral illness are commonly reported triggers but are rarely the sole cause.
Treating alopecia areata
For years, treatment was limited mainly to corticosteroids. A more targeted option now exists: baricitinib, a JAK1/JAK2 inhibitor that damps the inflammatory signalling that attacks follicles. Clinical trials showed meaningful hair regrowth in adults with severe, long-standing alopecia areata. Results vary and response takes months, so realistic expectations matter.
When to see a doctor
If patches are small and have appeared recently, spontaneous regrowth is common without any treatment, so a first step is often simply watching and waiting. See a doctor if patches spread quickly, cover a large area, or affect the eyebrows and eyelashes, since earlier treatment tends to work better than starting late. A dermatologist can also rule out other causes of patchy hair loss, such as fungal scalp infections or traction from tight hairstyles, which need different treatment altogether.
This page is educational and does not replace advice from a doctor or pharmacist who knows your health history.