Enclomiphene

1 medicine

Enclomiphene is the isomer of clomifene used to raise testosterone in men with secondary hypogonadism, and it shares clomifene's caution around visual disturbances and mood changes.

Androxal

Enclomiphene

50mg

Androxal is a hormones medication containing Enclomiphene, available as 50mg tablets.

from $0.77 / tablet View

Key facts

  • Enclomiphene is one of the two isomers that make up clomifene. It is used in men with secondary hypogonadism, low testosterone caused by reduced signalling from the brain rather than by a problem in the testes themselves.
  • Unlike testosterone replacement, enclomiphene raises the body's own testosterone production and, in most men, does not suppress sperm production, which matters for those who wish to preserve fertility.
  • As a member of the clomifene family, it shares the same caution around visual disturbances and mood changes; report any change in vision or unusual mood swings to your prescriber.
  • Seek urgent care for sudden vision changes, blurred vision or seeing flashing lights.

What enclomiphene treats

Enclomiphene treats secondary hypogonadism in men, low testosterone that results from insufficient stimulation of the testes by the pituitary hormones luteinising hormone and follicle-stimulating hormone. It is used as an alternative to testosterone replacement in men who want to raise their testosterone level while maintaining natural sperm production and fertility.

How enclomiphene works

Enclomiphene blocks oestrogen receptors in the hypothalamus and pituitary gland. Oestrogen normally provides feedback that dampens the release of luteinising hormone and follicle-stimulating hormone. By blocking this feedback signal, enclomiphene causes the pituitary to release more of these hormones, which in turn stimulates the testes to produce more testosterone.

Before you take it

  • Do not take enclomiphene if you have primary hypogonadism, where the testes themselves are unable to respond to hormone signalling, since it will not raise testosterone in that situation.
  • Tell your prescriber about any history of visual disturbances, mood disorders, liver disease or blood clots before starting.
  • Baseline and follow-up blood tests for testosterone, luteinising hormone and follicle-stimulating hormone are used to confirm the medicine is working and to guide the dose.
  • Tell your prescriber about other medicines you take, and mention any plans around fertility so treatment can be tailored accordingly.

Side effects

Common effects include headache, hot flushes, mood changes and mild visual disturbances.

Stop and seek urgent medical care for any of these:

  • Sudden vision changes, blurred vision or seeing flashing lights or spots.
  • Severe or worsening mood changes, including new low mood or irritability.
  • Leg swelling, pain or redness, which can signal a blood clot.
  • Yellowing of the skin or eyes.

Safety essentials

  • As a clomifene-class medicine, enclomiphene carries the same visual-disturbance and mood-change caution: report any change in vision or unusual mood swings promptly, and have vision checked if disturbances persist.
  • Response is monitored with follow-up hormone blood tests; do not adjust the dose yourself based on symptoms alone.
  • Tell your prescriber if you notice new mood symptoms, since these should be assessed rather than managed by stopping treatment on your own.

This page is educational and does not replace advice from a doctor or pharmacist who knows your health history.